Home NDC 0023-4291 LASTACAFT
Product NDC 0023-4291
11-digit product format 000234291
Labeler code 0023
Product ID 0023-4291_447257d6-c313-499e-8a48-499badb37766
Type HUMAN OTC DRUG
Nonproprietary name alcaftadine
Dosage form SOLUTION/ DROPS
Route OPHTHALMIC
Labeler Allergan, Inc.
Application NDA022134
Marketing category NDA
Marketing start 2021-12-01
Substance ALCAFTADINE
Active strength 2.5 mg/mL
Pharmacologic classes Histamine H1 Receptor Antagonists [MoA], Histamine-1 Receptor Antagonist [EPC]
NDC exclude flag No
Listing certified through 2026-12-31
Current FDA listing Yes Source provenance: Browse the complete Orange Book source catalog · source snapshot 1 .
Orange Book products# Current product rows page 1 of 1 · 1 matching rows.
Application-product, Trade name, Ingredient table Application-product Trade name Ingredient Strength Dosage form / route TE codes RLD / RS Approval date N022134-001 LASTACAFT ALCAFTADINE 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28
Orange Book patents# Current patent rows page 1 of 1 · 2 matching rows.
Application-product, Patent, Expiration table Application-product Patent Expiration Use code Coverage / status Submission date N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 N022134-001 8664215 2027-12-23 U-3267 2014-03-21
Observed Orange Book product history# Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.
Product history page 1 of 2 · 41 observed states.
Captured, Edition, Application-product table Captured Edition Application-product Trade name Strength Dosage form / route Product TE source text RLD / RS Approval date Source SHA-256 2026-02-19 14:30 UTC 2026-02 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 011fe1cb6892…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 31067a03dcf5…2025-08-23 18:47 UTC 2025-08 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 6a471c1ec25d…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 fd3edfee7708…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 b8a1b40f171c…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 03ed91905a0d…2024-12-13 21:23 UTC · 2 captures of this ZIP 2024-12 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 2680178bc6a6…2024-09-14 05:58 UTC · 2 captures of this ZIP 2024-09 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 5bbf6a4d5a75…2024-11-08 22:44 UTC · 3 captures of this ZIP 2024-11 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 d8e5a09893c0…2024-10-29 15:01 UTC 2024-10 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 d06236e962d9…2024-08-13 05:28 UTC · 3 captures of this ZIP 2024-08 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 79d66fd596c7…2024-07-13 05:37 UTC · 2 captures of this ZIP 2024-07 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 301d65b070ca…2024-06-18 03:08 UTC · 5 captures of this ZIP 2024-06 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 1e350fbaab3a…2024-05-31 18:47 UTC 2024-05 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 8072bd15b7f6…2022-06-29 02:47 UTC · 2 captures of this ZIP 2022-06 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 5c6f7cd8ea54…2022-04-08 23:34 UTC 2022-04 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 5d02ea3f76ae…2022-04-04 05:41 UTC 2022-04 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 4b0b4de00fa7…2019-12-13 00:20 UTC 2019-12 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 74a2ff9319b5…2022-03-09 01:35 UTC 2022-03 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 bb7c543d1eb4…2021-12-28 21:50 UTC 2021-12 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 782e0a99824c…2021-05-05 16:15 UTC · 3 captures of this ZIP 2021-05 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 87673890dc5c…2021-03-12 10:30 UTC 2021-03 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 5aa47cf7b7d7…2020-12-22 03:56 UTC 2020-12 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 8869cabd3fbd…2020-11-12 02:37 UTC 2020-11 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 c0c555d07b60…2019-12-14 00:12 UTC 2019-12 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 3f01610625f2…2019-09-15 20:21 UTC 2019-09 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 b00525d2431f…2019-07-19 19:46 UTC 2019-07 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 ea99ee380514…2024-03-16 18:09 UTC · 4 captures of this ZIP 2024-03 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 6a51e52b5d6a…2024-02-18 07:12 UTC 2024-02 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 1c564ffb4f44…2023-12-20 04:57 UTC 2023-12 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 ea1830bbd6c7…2023-11-28 05:40 UTC · 2 captures of this ZIP 2023-11 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 a72a2bbeb626…2023-10-25 00:34 UTC · 2 captures of this ZIP 2023-10 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 9b2671bbb829…2023-07-15 15:27 UTC · 2 captures of this ZIP 2023-07 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 a67488948f0b…2023-06-13 01:57 UTC · 3 captures of this ZIP 2023-06 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 3f0d92c62455…2023-05-13 08:27 UTC 2023-05 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 053a50430f4f…2023-01-26 05:58 UTC 2023-01 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 3bdfa0b2c4d7…2022-11-12 20:34 UTC · 5 captures of this ZIP 2022-11 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 3a93d1ddd44b…2022-10-28 04:53 UTC 2022-10 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 f41ea6bd6efb…2022-09-29 23:25 UTC 2022-09 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 e64feba35796…2022-07-09 03:26 UTC · 3 captures of this ZIP 2022-07 N022134-001 LASTACAFT 0.25% SOLUTION/DROPS / OPHTHALMIC RLD, RS 2010-07-28 cb3db0bc1861…
Observed Orange Book patent history# Patent history page 1 of 2 · 78 observed states.
Captured, Edition, Application-product table Captured Edition Application-product Patent Expiration Use code Coverage / status Submission date Source SHA-256 2026-02-19 14:30 UTC 2026-02 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 011fe1cb6892…2026-02-19 14:30 UTC 2026-02 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 011fe1cb6892…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 31067a03dcf5…2025-12-14 10:44 UTC · 2 captures of this ZIP 2025-12 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 31067a03dcf5…2025-08-23 18:47 UTC 2025-08 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 6a471c1ec25d…2025-08-23 18:47 UTC 2025-08 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 6a471c1ec25d…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 fd3edfee7708…2025-03-22 03:13 UTC · 3 captures of this ZIP 2025-03 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 fd3edfee7708…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 b8a1b40f171c…2025-02-26 10:13 UTC · 3 captures of this ZIP 2025-02 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 b8a1b40f171c…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 03ed91905a0d…2025-01-19 17:59 UTC · 7 captures of this ZIP 2025-01 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 03ed91905a0d…2024-12-13 21:23 UTC · 2 captures of this ZIP 2024-12 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 2680178bc6a6…2024-12-13 21:23 UTC · 2 captures of this ZIP 2024-12 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 2680178bc6a6…2024-09-14 05:58 UTC · 2 captures of this ZIP 2024-09 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 5bbf6a4d5a75…2024-09-14 05:58 UTC · 2 captures of this ZIP 2024-09 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 5bbf6a4d5a75…2024-11-08 22:44 UTC · 3 captures of this ZIP 2024-11 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 d8e5a09893c0…2024-11-08 22:44 UTC · 3 captures of this ZIP 2024-11 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 d8e5a09893c0…2024-10-29 15:01 UTC 2024-10 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 d06236e962d9…2024-10-29 15:01 UTC 2024-10 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 d06236e962d9…2024-08-13 05:28 UTC · 3 captures of this ZIP 2024-08 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 79d66fd596c7…2024-08-13 05:28 UTC · 3 captures of this ZIP 2024-08 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 79d66fd596c7…2024-07-13 05:37 UTC · 2 captures of this ZIP 2024-07 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 301d65b070ca…2024-07-13 05:37 UTC · 2 captures of this ZIP 2024-07 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 301d65b070ca…2024-06-18 03:08 UTC · 5 captures of this ZIP 2024-06 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 1e350fbaab3a…2024-06-18 03:08 UTC · 5 captures of this ZIP 2024-06 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 1e350fbaab3a…2024-05-31 18:47 UTC 2024-05 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 8072bd15b7f6…2024-05-31 18:47 UTC 2024-05 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 8072bd15b7f6…2022-06-29 02:47 UTC · 2 captures of this ZIP 2022-06 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 5c6f7cd8ea54…2022-06-29 02:47 UTC · 2 captures of this ZIP 2022-06 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 5c6f7cd8ea54…2022-04-08 23:34 UTC 2022-04 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 5d02ea3f76ae…2022-04-08 23:34 UTC 2022-04 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 5d02ea3f76ae…2022-04-04 05:41 UTC 2022-04 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 4b0b4de00fa7…2022-04-04 05:41 UTC 2022-04 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 4b0b4de00fa7…2019-12-13 00:20 UTC 2019-12 N022134-001 8664215 2027-12-23 U-1493 2014-03-21 74a2ff9319b5…2022-03-09 01:35 UTC 2022-03 N022134-001 10617695 2027-03-19 U-3267 Drug product 2020-05-12 bb7c543d1eb4…2022-03-09 01:35 UTC 2022-03 N022134-001 8664215 2027-12-23 U-3267 2014-03-21 bb7c543d1eb4…2021-12-28 21:50 UTC 2021-12 N022134-001 10617695 2027-03-19 U-1493 Drug product 2020-05-12 782e0a99824c…2021-12-28 21:50 UTC 2021-12 N022134-001 8664215 2027-12-23 U-1493 2014-03-21 782e0a99824c…2021-05-05 16:15 UTC · 3 captures of this ZIP 2021-05 N022134-001 10617695 2027-03-19 U-1493 Drug product 2020-05-12 87673890dc5c…
Additional Listing Data#
Finished product Yes
Brand name base LASTACAFT
Listing expiration 2026-12-31 Active Ingredients# Ingredient, Strength table Ingredient Strength ALCAFTADINE 2.5 mg/mL
Harmonized UNII identifiers# UNII identifiers page 1 of 1 · 1 matching rows.
Identifier, FDA.report destination table Identifier FDA.report destination 7Z8O94ECSX Internal UNII lookup
Harmonized RxCUI identifiers# RxCUI identifiers page 1 of 1 · 2 matching rows.
Identifier, FDA.report destination table Identifier FDA.report destination 1000085 Internal RxNorm lookup 1000089 Internal RxNorm lookup
Harmonized SPL set identifiers# SPL set identifiers page 1 of 1 · 1 matching rows.
DailyMed Product Concepts# DailyMed Package Descriptions# Package NDC, Product, Description table Package NDC Product Description Form Quantity Strength SPL version 0023-4291-01 LASTACAFT 1 in 1 CARTON SOLUTION/ DROPS 1 4 0023-4291-01 LASTACAFT 1 mL in 1 BOTTLE, PLASTIC SOLUTION/ DROPS 1 4 0023-4291-05 LASTACAFT 1 in 1 CARTON SOLUTION/ DROPS 1 4 0023-4291-05 LASTACAFT 5 mL in 1 BOTTLE, PLASTIC SOLUTION/ DROPS 5 4 0023-4291-06 LASTACAFT 5 mL in 1 BOTTLE, PLASTIC SOLUTION/ DROPS 5 4 0023-4291-06 LASTACAFT 1 in 1 CARTON SOLUTION/ DROPS 1 4 0023-4291-07 LASTACAFT 5 mL in 1 BOTTLE, PLASTIC SOLUTION/ DROPS 5 4 0023-4291-07 LASTACAFT 2 in 1 CARTON SOLUTION/ DROPS 2 4 0023-4291-10 LASTACAFT 2 in 1 CARTON SOLUTION/ DROPS 2 4 0023-4291-10 LASTACAFT 5 mL in 1 BOTTLE, PLASTIC SOLUTION/ DROPS 5 4
DailyMed Dashboard NDC Coverage# NDC, Dashboard title, SPL version table NDC Dashboard title SPL version Validation Dashboard ZIP 0023-4291 LASTACAFT (ALCAFTADINE) SOLUTION/ DROPS [ALLERGAN, INC.] 4 Current NDC, Legacy NDC, 10 package rows 20250215_a3002410-4bf1-4182-9d7c-8193eb7cd215.zip
openFDA label cross-check# OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
Matched openFDA labels page 1 of 1 · 2 matching rows.
DailyMed RxNorm Mappings# Packages# Package NDC, 11-digit format, Description table Package NDC 11-digit format Description Marketing start Marketing end Sample Exclude flag Status 0023-4291-01 00023429101 1 BOTTLE, PLASTIC in 1 CARTON (0023-4291-01) / 1 mL in 1 BOTTLE, PLASTIC 2021-12-01 0000-00-00 Yes No Current 0023-4291-05 00023429105 1 BOTTLE, PLASTIC in 1 CARTON (0023-4291-05) / 5 mL in 1 BOTTLE, PLASTIC 2021-12-01 0000-00-00 No No Current 0023-4291-06 00023429106 1 BOTTLE, PLASTIC in 1 CARTON (0023-4291-06) / 5 mL in 1 BOTTLE, PLASTIC 2021-12-01 0000-00-00 No No Current 0023-4291-07 00023429107 2 BOTTLE, PLASTIC in 1 CARTON (0023-4291-07) / 5 mL in 1 BOTTLE, PLASTIC 2021-12-01 0000-00-00 No No Current 0023-4291-10 00023429110 2 BOTTLE, PLASTIC in 1 CARTON (0023-4291-10) / 5 mL in 1 BOTTLE, PLASTIC 2021-12-01 0000-00-00 No No Current