REFRESH OPTIVE Advanced

Product NDC: 0023-4307
11-digit product format: 000234307
Labeler code: 0023
Product ID: 0023-4307_82284b10-2578-4490-bb19-e38da030a102
Type: HUMAN OTC DRUG
Nonproprietary name: carboxymethylcellulose sodium, glycerin, and polysorbate 80
Dosage form: SOLUTION/ DROPS
Route: OPHTHALMIC
Labeler: Allergan, Inc.
Application: M018
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2011-11-30
Substance: CARBOXYMETHYLCELLULOSE SODIUM; GLYCERIN; POLYSORBATE 80
Active strength: 5; 10; 5 mg/mL; mg/mL; mg/mL
Pharmacologic classes: Allergens [CS], Cell-mediated Immunity [PE], Glycerol [CS], Increased Histamine Release [PE], Increased IgG Production [PE], Non-Standardized Chemical Allergen [EPC]
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 2 matching rows.

Dataset, Scope, Product NDC table
Dataset	Scope	Product NDC	Package NDC	Code	Status	Reporting period	Source date
excluded package	package	0023-4307	0023-4307-03	D	Discontinued by firm		2026-10-15
excluded package	package	0023-4307	0023-4307-15	D	Discontinued by firm		2026-10-15

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 24 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Package NDC, Snapshot table
Captured / source date	Package NDC	Snapshot	Source SHA-256
2025-12-14 17:58 UTC · source 2025-12-05	0023-4307-03	`d630ba8d3edf…`	`732f749b63fb…`
2025-12-14 17:58 UTC · source 2025-12-05	0023-4307-15	`d630ba8d3edf…`	`732f749b63fb…`
2025-08-27 00:01 UTC · source 2025-08-26	0023-4307-15	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-08-27 00:01 UTC · source 2025-08-26	0023-4307-03	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-04-01 02:39 UTC · source 2025-03-31	0023-4307-15	`2ef7874e63bc…`	`57b86245f4fa…`
2025-04-01 02:39 UTC · source 2025-03-31	0023-4307-03	`2ef7874e63bc…`	`57b86245f4fa…`
2025-03-28 20:22 UTC · source 2025-03-28	0023-4307-15	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-28 20:22 UTC · source 2025-03-28	0023-4307-03	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-22 03:12 UTC · source 2025-03-21	0023-4307-15	`cfe11265f3b6…`	`090c488252e2…`
2025-03-22 03:12 UTC · source 2025-03-21	0023-4307-03	`cfe11265f3b6…`	`090c488252e2…`
2025-03-10 12:48 UTC · source 2025-03-10	0023-4307-15	`cdf11ea48f46…`	`ba0047e9e063…`
2025-03-10 12:48 UTC · source 2025-03-10	0023-4307-03	`cdf11ea48f46…`	`ba0047e9e063…`
2025-02-02 03:52 UTC · source 2025-01-31	0023-4307-15	`302b2466d912…`	`e7b80fea0513…`
2025-02-02 03:52 UTC · source 2025-01-31	0023-4307-03	`302b2466d912…`	`e7b80fea0513…`
2025-01-20 13:05 UTC · source 2025-01-20	0023-4307-15	`ed331223b511…`	`672a5bd82f5f…`
2025-01-20 13:05 UTC · source 2025-01-20	0023-4307-03	`ed331223b511…`	`672a5bd82f5f…`
2025-01-11 03:41 UTC · source 2025-01-10	0023-4307-15	`0efc9e666f02…`	`f202fb6c5f17…`
2025-01-11 03:41 UTC · source 2025-01-10	0023-4307-03	`0efc9e666f02…`	`f202fb6c5f17…`
2024-11-09 02:27 UTC · source 2024-11-08	0023-4307-02	`ad56d346431e…`	`cc804d4bbf1e…`
2024-11-09 02:27 UTC · source 2024-11-08	0023-4307-15	`ad56d346431e…`	`cc804d4bbf1e…`
2024-11-09 02:27 UTC · source 2024-11-08	0023-4307-03	`ad56d346431e…`	`cc804d4bbf1e…`
2024-10-04 04:10 UTC · source 2024-10-03	0023-4307-02	`367a005e9d99…`	`383a685ebd0f…`
2024-10-04 04:10 UTC · source 2024-10-03	0023-4307-15	`367a005e9d99…`	`383a685ebd0f…`
2024-10-04 04:10 UTC · source 2024-10-03	0023-4307-03	`367a005e9d99…`	`383a685ebd0f…`

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: REFRESH OPTIVE Advanced
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
CARBOXYMETHYLCELLULOSE SODIUM	5 mg/mL
GLYCERIN	10 mg/mL
POLYSORBATE 80	5 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 3 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
K679OBS311	Internal UNII lookup
PDC6A3C0OX	Internal UNII lookup
6OZP39ZG8H	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1241471	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
aaa943e4-7c38-4c5a-b7c0-5a656d8cafc0	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
08c722ec-780f-bb7b-8f14-3d4f7bf0e098	Product name	2	20240205
e2f276e5-439f-b432-b5e5-b0cfa993da69	Product name	3	20220609
4585a4fb-0028-3d95-020c-9b1c40bf15e0	Product name	1	20140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	SPL version
0023-4307-02	REFRESH OPTIVE Advanced	2 mL in 1 BOTTLE	SOLUTION/ DROPS	2	16
0023-4307-02	REFRESH OPTIVE Advanced	1 in 1 CARTON	SOLUTION/ DROPS	1	16
0023-4307-03	REFRESH OPTIVE Advanced	1 in 1 CARTON	SOLUTION/ DROPS	1	16
0023-4307-03	REFRESH OPTIVE Advanced	3 mL in 1 BOTTLE, DROPPER	SOLUTION/ DROPS	3	16
0023-4307-10	REFRESH OPTIVE Advanced	1 in 1 CARTON	SOLUTION/ DROPS	1	16
0023-4307-10	REFRESH OPTIVE Advanced	10 mL in 1 BOTTLE, DROPPER	SOLUTION/ DROPS	10	16
0023-4307-15	REFRESH OPTIVE Advanced	15 mL in 1 BOTTLE	SOLUTION/ DROPS	15	16
0023-4307-15	REFRESH OPTIVE Advanced	1 in 1 CARTON	SOLUTION/ DROPS	1	16
0023-4307-20	REFRESH OPTIVE Advanced	10 mL in 1 BOTTLE, DROPPER	SOLUTION/ DROPS	10	16
0023-4307-20	REFRESH OPTIVE Advanced	2 in 1 CARTON	SOLUTION/ DROPS	2	16

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDC	Billing unit	Product NDC	DailyMed indexing SPL	SPL version	Effective
0023-4307-10	ML - Milliliter	0023-4307	6beddd0f-1e0d-464e-8c0b-660f23fb644e	1	2012-07-24
0023-4307-20	ML - Milliliter	0023-4307	0bf405a2-5414-49d3-9f27-81b625bae77c	1	2013-04-01

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
carboxymethylcellulose sodium	ACTIVE INGREDIENT	K679OBS311	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	6
glycerin	ACTIVE INGREDIENT	PDC6A3C0OX	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	6
polysorbate 80	ACTIVE INGREDIENT	6OZP39ZG8H	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	6
carboxymethylcellulose	ACTIVE MOIETY	05JZI7B19X	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	6
glycerin	ACTIVE MOIETY	PDC6A3C0OX	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	6
polysorbate 80	ACTIVE MOIETY	6OZP39ZG8H	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	6
boric acid	INACTIVE INGREDIENT	R57ZHV85D4	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	6
carbomer copolymer type A	INACTIVE INGREDIENT	71DD5V995L	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	6
castor oil	INACTIVE INGREDIENT	D5340Y2I9G	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	6
erythritol	INACTIVE INGREDIENT	RA96B954X6	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	6
levocarnitine	INACTIVE INGREDIENT	0G389FZZ9M	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	6
sodium chlorite	INACTIVE INGREDIENT	G538EBV4VF	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	6
sodium hydroxide	INACTIVE INGREDIENT	55X04QC32I	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	6
water	INACTIVE INGREDIENT	059QF0KO0R	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	6

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
0023-4307	REFRESH OPTIVE ADVANCED (CARBOXYMETHYLCELLULOSE SODIUM, GLYCERIN, AND POLYSORBATE 80) SOLUTION/ DROPS [ALLERGAN, INC.]	15	Current NDC, Legacy NDC, 10 package rows	20241210_aaa943e4-7c38-4c5a-b7c0-5a656d8cafc0.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 18 of 25 · 494 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
OASIS Tears Preservative-Free Lubricant Eye	GLYCERIN	OASIS Medical, Inc.	d9d71b1d-82a6-42e7-9ef2-2d041daef936	2024-12-23	Warnings	Exact identifier application number: M018
Ancient Secrets Breathe Again	SODIUM CHLORIDE	LOTUS BRANDS, INC.	c6d2bab0-d363-4c09-a71b-ae15db915b37	2024-12-18	Warnings	Exact identifier application number: M018
TheraTears Extra	CARBOXYMETHYLCELLULOSE SODIUM, UNSPECIFIED FORM	MEDTECH PRODUCTS INC	77f504c1-b8e0-4371-ac3e-9d453d84714b	2024-12-13	Warnings	Exact identifier application number: M018
TheraTears Extra	CARBOXYMETHYLCELLULOSE SODIUM, UNSPECIFIED	MEDTECH PRODUCTS INC	f1845041-9d8d-42a0-a2cb-68def7a5aac7	2024-12-13	Warnings	Exact identifier application number: M018
Fendall Pure Flow	PURIFIED WATER	Honeywell Safety Products USA, Inc.	afda6fc3-7615-b0be-e053-2995a90a6208	2024-12-10	Warnings	Exact identifier application number: M018
Systane Nighttime	MINERAL OIL AND WHITE PETROLATUM	Alcon Laboratories, Inc.	4689c59c-5721-3f91-6c85-e41501998fd0	2024-12-05	Warnings	Exact identifier application number: M018
GenTeal Tears NIGHT-TIME	MINERAL OIL, WHITE PETROLATUM	Alcon Laboratories, Inc.	9d5998a7-4f59-4293-87da-8419650a524d	2024-12-05	Warnings	Exact identifier application number: M018
Visine Red Eye Total Comfort and Tears Dry Eye Relief	TETRAHYDROZOLINE HCL, POLYETHYLENE GLYCOL 400, ZINC SULFATE	Kenvue Brands LLC	0bc0d6e7-9195-db6b-e063-6294a90aef04	2024-11-14	Warnings	Exact identifier application number: M018
Visine Red Eye Comfort	TETRAHYDROZOLINE HYDROCHLORIDE	Kenvue Brands LLC	d7abd7cb-e094-481f-bea5-a5983e2c9ef4	2024-11-13	Warnings	Exact identifier application number: M018
Visine Red Eye Hydrating Comfort Eye Drops	TETRAHYDROZOLINE HYDROCHLORIDE AND POLYETHYLENE GLYCOL 400	Kenvue Brands LLC	a9a90de6-3172-4d34-984b-f4442f880e3d	2024-11-13	Warnings	Exact identifier application number: M018
Visine Dry Eye Relief	POLYETHYLENE GLYCOL 400	Kenvue Brands LLC	2de7a41d-661d-495f-89b4-5690664a3a3d	2024-11-13	Warnings	Exact identifier application number: M018
Visine Dry Eye Relief Eye Drops	POLYETHYLENE GLYCOL 400	Kenvue Brands LLC	d9d3f000-3ce4-4ba2-a7fb-491b44eb3fa1	2024-11-13	Warnings	Exact identifier application number: M018
Visine Dry Eye Relief	POLYETHYLENE GLYCOL 400	Kenvue Brands LLC	a4c57620-778f-4434-9105-ead2f85c5884	2024-11-13	Warnings	Exact identifier application number: M018
Visine A.C. Itchy Eye Relief	TETRAHYDROZOLINE HYDROCHLORIDE AND ZINC SULFATE, UNSPECIFIED FORM	Kenvue Brands LLC	257b9666-0163-499b-9673-bf6f4d6899b1	2024-11-13	Warnings	Exact identifier application number: M018
Eyewash Station Additive Concentrate	CHLORHEXIDINE GLUCONATE AND PROPYLENE GLYCOL	Acme United Corporation	f19fbe28-b928-7c6e-e053-2995a90a43cb	2024-11-09	Warnings	Exact identifier application number: M018
RUGBY EYE WASH	WATER, PURIFIED	A-S Medication Solutions	0773e558-2f46-494c-888a-3bc517202b65	2024-11-08	Warnings	Exact identifier application number: M018
Clear Eyes Triple Relief	POLYVINYL ALCOHOL AND POVIDONE AND TETRAHYDROZOLINE HYDROCHLORIDE	Prestige Brands Holdings, Inc.	1269a1a6-843d-4d08-bb3c-c1f3d2e7080d	2024-10-25	Warnings	Exact identifier application number: M018
Clear Eyes Cooling Redness Relief	GLYCERIN AND NAPHAZOLINE HYDROCHLORIDE	Prestige Brands Holdings, Inc.	38d14e99-e4c8-431b-b106-578eeb38bf3c	2024-10-25	Warnings	Exact identifier application number: M018
EyS Eye Wash	WATER	Eyes-Plus LLC	1443f6bf-3a77-4a19-8585-0ec58efe042f	2024-10-15	Warnings	Exact identifier application number: M018
Eye Wash	WATER SOLUTION	Kroger Company	354402ad-581d-47e7-9fd3-933bef281ff4	2024-10-11	Warnings	Exact identifier application number: M018

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
PDC6A3C0OX	GLYCERIN	56-81-5	GLYCERIN
6OZP39ZG8H	POLYSORBATE 80	9005-65-6	POLYSORBATE 80

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1241471	carboxymethylcellulose sodium 0.5 % / glycerin 1 % / polysorbate 80 0.5 % Ophthalmic Solution	PSN	aaa943e4-7c38-4c5a-b7c0-5a656d8cafc0	16
1241471	carboxymethylcellulose sodium 5 MG/ML / glycerin 10 MG/ML / polysorbate 80 5 MG/ML Ophthalmic Solution	SCD	aaa943e4-7c38-4c5a-b7c0-5a656d8cafc0	16
1241471	carboxymethylcellulose sodium 0.5 % / glycerin 1 % / polysorbate 80 0.5 % Ophthalmic Solution	SY	aaa943e4-7c38-4c5a-b7c0-5a656d8cafc0	16

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
0023-4307-02	00023430702	1 BOTTLE in 1 CARTON (0023-4307-02) / 2 mL in 1 BOTTLE	1 bottle	2011-11-30	0000-00-00	Yes	No	Current
0023-4307-03	00023430703	1 BOTTLE, DROPPER in 1 CARTON (0023-4307-03) > 3 mL in 1 BOTTLE, DROPPER		2011-11-30	0000-00-00	Yes	No	Current
0023-4307-10	00023430710	1 BOTTLE, DROPPER in 1 CARTON (0023-4307-10) / 10 mL in 1 BOTTLE, DROPPER		2011-11-30	0000-00-00	No	No	Current
0023-4307-15	00023430715	1 BOTTLE in 1 CARTON (0023-4307-15) > 15 mL in 1 BOTTLE	1 bottle	2011-11-30	0000-00-00	No	No	Current
0023-4307-20	00023430720	2 BOTTLE, DROPPER in 1 CARTON (0023-4307-20) / 10 mL in 1 BOTTLE, DROPPER		2011-11-30	0000-00-00	No	No	Current