Femring

Product NDC: 0023-5868
11-digit product format: 000235868
Labeler code: 0023
Product ID: 0023-5868_b08979c2-5940-48df-b455-d3b2ca68d74d
Type: HUMAN PRESCRIPTION DRUG
Nonproprietary name: estradiol acetate
Dosage form: RING
Route: VAGINAL
Labeler: Allergan, Inc.
Application: NDA021367
Marketing category: NDA
Marketing start: 2016-05-02
Marketing end: 2020-02-29
Substance: ESTRADIOL ACETATE
Active strength: 0 mg/d
Pharmacologic classes: Estradiol Congeners [CS],Estrogen [EPC],Estrogen Receptor Agonists [MoA]
NDC exclude flag: No
Listing certified through: 0000-00-00
Current FDA listing: Historical FDA.report record

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 2 matching rows.

Dataset, Scope, Product NDC table
Dataset	Scope	Product NDC	Package NDC	Code	Status	Reporting period	Source date
excluded product	product	0023-5868		D	Discontinued by firm		2026-10-05
excluded package	package	0023-5868	0023-5868-05	D	Discontinued by firm		2026-10-05

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 24 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Dataset, Scope table
Captured / source date	Dataset	Scope	Package NDC	Snapshot	Source SHA-256
2025-12-14 17:58 UTC · source 2025-12-05	excluded product	product		`d630ba8d3edf…`	`732f749b63fb…`
2025-12-14 17:58 UTC · source 2025-12-05	excluded package	package	0023-5868-05	`d630ba8d3edf…`	`732f749b63fb…`
2025-08-27 00:01 UTC · source 2025-08-26	excluded product	product		`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-08-27 00:01 UTC · source 2025-08-26	excluded package	package	0023-5868-05	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-04-01 02:39 UTC · source 2025-03-31	excluded product	product		`2ef7874e63bc…`	`57b86245f4fa…`
2025-04-01 02:39 UTC · source 2025-03-31	excluded package	package	0023-5868-05	`2ef7874e63bc…`	`57b86245f4fa…`
2025-03-28 20:22 UTC · source 2025-03-28	excluded product	product		`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-28 20:22 UTC · source 2025-03-28	excluded package	package	0023-5868-05	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-22 03:12 UTC · source 2025-03-21	excluded product	product		`cfe11265f3b6…`	`090c488252e2…`
2025-03-22 03:12 UTC · source 2025-03-21	excluded package	package	0023-5868-05	`cfe11265f3b6…`	`090c488252e2…`
2025-03-10 12:48 UTC · source 2025-03-10	excluded product	product		`cdf11ea48f46…`	`ba0047e9e063…`
2025-03-10 12:48 UTC · source 2025-03-10	excluded package	package	0023-5868-05	`cdf11ea48f46…`	`ba0047e9e063…`
2025-02-02 03:52 UTC · source 2025-01-31	excluded product	product		`302b2466d912…`	`e7b80fea0513…`
2025-02-02 03:52 UTC · source 2025-01-31	excluded package	package	0023-5868-05	`302b2466d912…`	`e7b80fea0513…`
2025-01-20 13:05 UTC · source 2025-01-20	excluded product	product		`ed331223b511…`	`672a5bd82f5f…`
2025-01-20 13:05 UTC · source 2025-01-20	excluded package	package	0023-5868-05	`ed331223b511…`	`672a5bd82f5f…`
2025-01-11 03:41 UTC · source 2025-01-10	excluded product	product		`0efc9e666f02…`	`f202fb6c5f17…`
2025-01-11 03:41 UTC · source 2025-01-10	excluded package	package	0023-5868-05	`0efc9e666f02…`	`f202fb6c5f17…`
2024-11-09 02:27 UTC · source 2024-11-08	excluded product	product		`ad56d346431e…`	`cc804d4bbf1e…`
2024-11-09 02:27 UTC · source 2024-11-08	excluded package	package	0023-5868-05	`ad56d346431e…`	`cc804d4bbf1e…`
2024-10-04 04:10 UTC · source 2024-10-03	excluded product	product		`367a005e9d99…`	`383a685ebd0f…`
2024-10-04 04:10 UTC · source 2024-10-03	excluded package	package	0023-5868-05	`367a005e9d99…`	`383a685ebd0f…`
2024-07-10 04:00 UTC · source 2024-07-09	excluded product	product		`557ba5c1ecfa…`	`9c80585c8c6e…`
2024-07-10 04:00 UTC · source 2024-07-09	excluded package	package	0023-5868-05	`557ba5c1ecfa…`	`9c80585c8c6e…`

Source provenance: Browse the complete Orange Book source catalog · source snapshot 43.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-product	Trade name	Ingredient	Strength	Dosage form / route	TE codes	RLD / RS	Approval date
N021367-001	FEMRING	ESTRADIOL ACETATE	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL		RLD	2003-03-20
N021367-002	FEMRING	ESTRADIOL ACETATE	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL		RLD, RS	2003-03-20

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 86 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Trade name	Strength	Dosage form / route	RLD / RS	Approval date	Source SHA-256
2026-09-14 22:38:34	2026-08	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`84e616aacf4f…`
2026-08-18 06:07:40	2026-07	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`caaa826d4ba7…`
2026-02-19 14:30 UTC	2026-02	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`6a471c1ec25d…`
2025-08-23 18:47 UTC	2025-08	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`fd3edfee7708…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`b8a1b40f171c…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`03ed91905a0d…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`2680178bc6a6…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`5bbf6a4d5a75…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`5bbf6a4d5a75…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`d8e5a09893c0…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`d06236e962d9…`
2024-10-29 15:01 UTC	2024-10	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`79d66fd596c7…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`301d65b070ca…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`1e350fbaab3a…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`8072bd15b7f6…`
2024-05-31 18:47 UTC	2024-05	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`8072bd15b7f6…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`4b0b4de00fa7…`
2019-12-13 00:20 UTC	2019-12	N021367-001	FEMRING	EQ 0.05MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD	2003-03-20	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N021367-002	FEMRING	EQ 0.1MG BASE/24HR	INSERT, EXTENDED RELEASE / VAGINAL	RLD, RS	2003-03-20	`74a2ff9319b5…`

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDC	Billing unit	Product NDC	DailyMed indexing SPL	SPL version	Effective
0023-5868-05	EA - Each	0023-5868	4c424405-3325-40ce-b7e3-14c25b66c935	1	2017-11-06

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Femring	ESTRADIOL ACETATE	Millicent US, Inc.	7aaa97f9-a9d1-c815-e053-2991aa0afb9e	2025-12-09	Boxed warning, Warnings, Adverse reactions	Exact identifier application applno (NDA): 021367 application number: NDA021367