ARTHROTEC

Product NDC
0025-1411
11-digit product format
000251411
Labeler code
0025
Product ID
0025-1411_2b1bf1d7-4399-46bd-8654-2590513da5c2
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
diclofenac sodium and misoprostol
Dosage form
TABLET, FILM COATED
Route
ORAL
Labeler
Pfizer Laboratories Div Pfizer Inc
Application
NDA020607
Marketing category
NDA
Marketing start
1997-12-24
Substance
DICLOFENAC SODIUM; MISOPROSTOL
Active strength
50; 200 mg/1; ug/1
Pharmacologic classes
Anti-Inflammatory Agents, Non-Steroidal [CS], Cyclooxygenase Inhibitors [MoA], Decreased Prostaglandin Production [PE], Nonsteroidal Anti-inflammatory Drug [EPC], Prostaglandin E1 Analog [EPC], Prostaglandins E, Synthetic [CS]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N020607-001ARTHROTECDICLOFENAC SODIUM; MISOPROSTOL50MG;0.2MGTABLET, DELAYED RELEASE / ORALABRLD1997-12-24
N020607-002ARTHROTECDICLOFENAC SODIUM; MISOPROSTOL75MG;0.2MGTABLET, DELAYED RELEASE / ORALABRLD, RS1997-12-24

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 2 matching rows.

Application-product, TE code table
Application-productTE code
N020607-001AB
N020607-002AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-01 22:54:322026-06N020607-001ARTHROTEC50MG;0.2MGTABLET, DELAYED RELEASE / ORALABRLD1997-12-24a50c72e98297…
2026-08-01 22:54:322026-06N020607-002ARTHROTEC75MG;0.2MGTABLET, DELAYED RELEASE / ORALABRLD, RS1997-12-24a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-01 22:54:322026-06N020607-001AB1a50c72e98297…
2026-08-01 22:54:322026-06N020607-002AB1a50c72e98297…

openFDA label cross-check#

Cross-check layer: openFDA label JSON enriches search and identifies hydration gaps. The DailyMed Structured Product Label remains the canonical label presentation on FDA.report. Every label matching the complete exact-identifier union is deduplicated and paginated below.

Matched openFDA labels page 1 of 1 · 3 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Diclofenac sodium and MisoprostolDICLOFENAC SODIUM AND MISOPROSTOLMylan Pharmaceuticals Inc.a7701e8c-4e16-4165-8b83-de2c08d5ded32026-05-22Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (NDA): 020607
application number: NDA020607
ARTHROTECDICLOFENAC SODIUM AND MISOPROSTOLPfizer Laboratories Div Pfizer Inc600fe842-45d9-4d68-9ef2-456dbbebaa112025-08-14Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (NDA): 020607
application number: NDA020607
ndc (product): 0025-1411
Diclofenac sodium and Misoprostol DRDICLOFENAC SODIUM AND MISOPROSTOLAdvanced Rx Pharmacy of Tennessee, LLC1213d3eb-9870-f144-e063-6394a90a60882024-02-23Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (NDA): 020607
application number: NDA020607

Additional Listing Data#

Finished product
Yes
Brand name base
ARTHROTEC
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
DICLOFENAC SODIUM50 mg/1
MISOPROSTOL200 ug/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
0E43V0BB57Internal UNII lookup
QTG126297QInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 4 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
857706Internal RxNorm lookup
1359105Internal RxNorm lookup
1359107Internal RxNorm lookup
1359109Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
600fe842-45d9-4d68-9ef2-456dbbebaa11Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
111d457e-3138-4512-b0ba-d0cd760c4055Product name320250225
0426261e-1bb9-b78b-abd2-80da765a7e3eProduct name220240513
7b6158ae-c3f4-3d73-c35f-6f5d18b9efd7Product name520240320
73109aa8-3e7c-b7a0-fb29-6f84db91e7d9Product name320231221
0ac2f11f-f58d-baf2-71a0-680993b48a61Product name220231211
855d63c3-b090-4636-8fc7-6d39ad23c44fProduct name120230829
bb58f410-04be-65dd-9211-e89ead899698Product name620230323
0fcbc38a-8b29-3348-1cef-5222ea53484fProduct name420220516
c4e1eedc-aca2-4551-8382-89144ed9d049Product name320220126
8d368a34-1453-43ea-828d-0dbcd72b8794Product name820210622
d6bab9d2-edce-a213-4796-226ab15472c3Product name620200616
2487e6ef-d419-42fc-aaf8-7acc805d2370Product name220170718
e071c814-e5e7-e7ed-ec76-428765d9c66bProduct name220151120
93148e06-b8d7-4e6c-853e-62f807d17fbbProduct name120151014
dbb00be6-fb1c-4b0a-a770-31f7e05e247eProduct name120150316

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
0025-1411-60ARTHROTEC60 in 1 BOTTLETABLET, FILM COATED6038
0025-1411-90ARTHROTEC90 in 1 BOTTLETABLET, FILM COATED9038

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
0025-1411-34EA - Each0025-14117aa71552-aa6a-431a-adcf-dcdd3bb97d3412012-07-24
0025-1411-60EA - Each0025-1411f23a29f8-ca3a-4b09-80e8-2033bf0a94fb12012-07-24
0025-1411-90EA - Each0025-1411e2afd545-63a4-4aba-91ae-f0f32d10b5d212012-07-24

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
IngredientTypeUNIIDailyMed labelSPL versionUploaded
DICLOFENAC SODIUMACTIVE INGREDIENTQTG126297QARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC]21
MISOPROSTOLACTIVE INGREDIENT0E43V0BB57ARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC]21
DICLOFENACACTIVE MOIETY144O8QL0L1ARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC]21
MISOPROSTOLACTIVE MOIETY0E43V0BB57ARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC]21
CELLULOSE, MICROCRYSTALLINEINACTIVE INGREDIENTOP1R32D61UARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC]21
CROSPOVIDONEINACTIVE INGREDIENT68401960MKARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC]21
HYDROGENATED CASTOR OILINACTIVE INGREDIENTZF94AP8MEYARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC]21
HYPROMELLOSESINACTIVE INGREDIENT3NXW29V3WOARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC]21
LACTOSEINACTIVE INGREDIENTJ2B2A4N98GARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC]21
MAGNESIUM STEARATEINACTIVE INGREDIENT70097M6I30ARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC]21
METHACRYLIC ACID - METHYL METHACRYLATE COPOLYMER (1:1)INACTIVE INGREDIENT74G4R6TH13ARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC]21
POVIDONE K30INACTIVE INGREDIENTU725QWY32XARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC]21
SILICON DIOXIDEINACTIVE INGREDIENTETJ7Z6XBU4ARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC]21
SODIUM HYDROXIDEINACTIVE INGREDIENT55X04QC32IARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC]21
STARCH, CORNINACTIVE INGREDIENTO8232NY3SJARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC]21
TALCINACTIVE INGREDIENT7SEV7J4R1UARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC]21
TRIETHYL CITRATEINACTIVE INGREDIENT8Z96QXD6UMARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [G.D. SEARLE LLC DIVISION OF PFIZER INC]21
diclofenac sodiumACTIVE INGREDIENTQTG126297QARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]5
misoprostolACTIVE INGREDIENT0E43V0BB57ARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]5
diclofenacACTIVE MOIETY144O8QL0L1ARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]5
misoprostolACTIVE MOIETY0E43V0BB57ARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]5
cellulose, microcrystallineINACTIVE INGREDIENTOP1R32D61UARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]5
crospovidoneINACTIVE INGREDIENT68401960MKARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]5
hydrogenated castor oilINACTIVE INGREDIENTZF94AP8MEYARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]5
hypromellosesINACTIVE INGREDIENT3NXW29V3WOARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]5
lactoseINACTIVE INGREDIENTJ2B2A4N98GARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]5
magnesium stearateINACTIVE INGREDIENT70097M6I30ARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]5
povidone K30INACTIVE INGREDIENTU725QWY32XARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]5
silicon dioxideINACTIVE INGREDIENTETJ7Z6XBU4ARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]5
sodium hydroxideINACTIVE INGREDIENT55X04QC32IARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]5
starch, cornINACTIVE INGREDIENTO8232NY3SJARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]5
talcINACTIVE INGREDIENT7SEV7J4R1UARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]5
triethyl citrateINACTIVE INGREDIENT8Z96QXD6UMARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [PHYSICIANS TOTAL CARE, INC.]5

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
0025-1411ARTHROTEC (DICLOFENAC SODIUM AND MISOPROSTOL) TABLET, FILM COATED [PFIZER LABORATORIES DIV PFIZER INC]37Current NDC, Legacy NDC, 2 package rows20241205_600fe842-45d9-4d68-9ef2-456dbbebaa11.zip

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1359107Arthrotec 50 MG / 200 MCG Delayed Release Oral TabletPSN600fe842-45d9-4d68-9ef2-456dbbebaa1138
1359109Arthrotec 75 MG / 200 MCG Delayed Release Oral TabletPSN600fe842-45d9-4d68-9ef2-456dbbebaa1138
857706diclofenac sodium 50 MG / miSOPROStol 0.2 MG Delayed Release Oral TabletPSN600fe842-45d9-4d68-9ef2-456dbbebaa1138
1359105diclofenac sodium 75 MG / miSOPROStol 0.2 MG Delayed Release Oral TabletPSN600fe842-45d9-4d68-9ef2-456dbbebaa1138
1359107diclofenac sodium 50 MG / misoprostol 0.2 MG Delayed Release Oral Tablet [Arthrotec]SBD600fe842-45d9-4d68-9ef2-456dbbebaa1138
1359109diclofenac sodium 75 MG / misoprostol 0.2 MG Delayed Release Oral Tablet [Arthrotec]SBD600fe842-45d9-4d68-9ef2-456dbbebaa1138
857706diclofenac sodium 50 MG / misoprostol 0.2 MG Delayed Release Oral TabletSCD600fe842-45d9-4d68-9ef2-456dbbebaa1138
1359105diclofenac sodium 75 MG / misoprostol 0.2 MG Delayed Release Oral TabletSCD600fe842-45d9-4d68-9ef2-456dbbebaa1138
1359107Arthrotec (diclofenac sodium (enteric coated core) 50 MG / misoprostol (non-enteric coated mantle) 200 MCG) Oral TabletSY600fe842-45d9-4d68-9ef2-456dbbebaa1138
1359109Arthrotec (diclofenac sodium (enteric coated core) 75 MG / misoprostol (non-enteric coated mantle) 200 MCG) Delayed Release Oral TabletSY600fe842-45d9-4d68-9ef2-456dbbebaa1138
857706diclofenac sodium (enteric coated core) 50 MG / misoprostol (non-enteric coated mantle) 200 MCG Oral TabletSY600fe842-45d9-4d68-9ef2-456dbbebaa1138
1359105diclofenac sodium (enteric coated core) 75 MG / misoprostol (non-enteric coated mantle) 200 MCG Oral TabletSY600fe842-45d9-4d68-9ef2-456dbbebaa1138
857706diclofenac sodium 50 MG / misoprostol 200 MCG Delayed Release Oral TabletSY600fe842-45d9-4d68-9ef2-456dbbebaa1138
1359105diclofenac sodium 75 MG / misoprostol 200 MCG Delayed Release Oral TabletSY600fe842-45d9-4d68-9ef2-456dbbebaa1138
1359107Arthrotec 50 MG / 200 MCG Delayed Release Oral TabletPSN4f0a7109-2915-4daa-a752-8f78cf040b375
1359109Arthrotec 75 MG / 200 MCG Delayed Release Oral TabletPSN4f0a7109-2915-4daa-a752-8f78cf040b375
857706diclofenac sodium 50 MG / miSOPROStol 0.2 MG Delayed Release Oral TabletPSN4f0a7109-2915-4daa-a752-8f78cf040b375
1359105diclofenac sodium 75 MG / miSOPROStol 0.2 MG Delayed Release Oral TabletPSN4f0a7109-2915-4daa-a752-8f78cf040b375
1359107diclofenac sodium 50 MG / misoprostol 0.2 MG Delayed Release Oral Tablet [Arthrotec]SBD4f0a7109-2915-4daa-a752-8f78cf040b375
1359109diclofenac sodium 75 MG / misoprostol 0.2 MG Delayed Release Oral Tablet [Arthrotec]SBD4f0a7109-2915-4daa-a752-8f78cf040b375
857706diclofenac sodium 50 MG / misoprostol 0.2 MG Delayed Release Oral TabletSCD4f0a7109-2915-4daa-a752-8f78cf040b375
1359105diclofenac sodium 75 MG / misoprostol 0.2 MG Delayed Release Oral TabletSCD4f0a7109-2915-4daa-a752-8f78cf040b375
1359107Arthrotec (diclofenac sodium (enteric coated core) 50 MG / misoprostol (non-enteric coated mantle) 200 MCG) Oral TabletSY4f0a7109-2915-4daa-a752-8f78cf040b375
1359109Arthrotec (diclofenac sodium (enteric coated core) 75 MG / misoprostol (non-enteric coated mantle) 200 MCG) Delayed Release Oral TabletSY4f0a7109-2915-4daa-a752-8f78cf040b375
857706diclofenac sodium (enteric coated core) 50 MG / misoprostol (non-enteric coated mantle) 200 MCG Oral TabletSY4f0a7109-2915-4daa-a752-8f78cf040b375
1359105diclofenac sodium (enteric coated core) 75 MG / misoprostol (non-enteric coated mantle) 200 MCG Oral TabletSY4f0a7109-2915-4daa-a752-8f78cf040b375
857706diclofenac sodium 50 MG / misoprostol 200 MCG Delayed Release Oral TabletSY4f0a7109-2915-4daa-a752-8f78cf040b375
1359105diclofenac sodium 75 MG / misoprostol 200 MCG Delayed Release Oral TabletSY4f0a7109-2915-4daa-a752-8f78cf040b375

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionMarketing startMarketing endSampleExclude flagStatus
0025-1411-600002514116060 TABLET, FILM COATED in 1 BOTTLE (0025-1411-60) 1997-12-240000-00-00NoNoCurrent
0025-1411-900002514119090 TABLET, FILM COATED in 1 BOTTLE (0025-1411-90) 1997-12-240000-00-00NoNoCurrent