Systane Balance

Product NDC: 0065-1433
11-digit product format: 000651433
Labeler code: 0065
Product ID: 0065-1433_f81c8282-0871-46fb-8124-83666457a4f2
Type: HUMAN OTC DRUG
Nonproprietary name: propylene glycol
Dosage form: EMULSION
Route: OPHTHALMIC
Labeler: Alcon Laboratories, Inc.
Application: M018
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2010-06-25
Substance: PROPYLENE GLYCOL
Active strength: .06 mg/mL
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 4 matching rows.

Dataset, Scope, Product NDC table
Dataset	Scope	Product NDC	Package NDC	Code	Status	Source date
excluded product	product	0065-1433		D	Discontinued by firm	2026-10-16
excluded package	package	0065-1433	0065-1433-43	D	Discontinued by firm	2026-10-16
excluded package	package	0065-1433	0065-1433-45	D	Discontinued by firm	2026-10-16
excluded package	package	0065-1433	0065-1433-46	D	Discontinued by firm	2026-10-16

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 48 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Dataset, Scope table
Captured / source date	Dataset	Scope	Package NDC	Snapshot	Source SHA-256
2025-12-14 17:58 UTC · source 2025-12-05	excluded product	product		`d630ba8d3edf…`	`732f749b63fb…`
2025-12-14 17:58 UTC · source 2025-12-05	excluded package	package	0065-1433-43	`d630ba8d3edf…`	`732f749b63fb…`
2025-12-14 17:58 UTC · source 2025-12-05	excluded package	package	0065-1433-46	`d630ba8d3edf…`	`732f749b63fb…`
2025-12-14 17:58 UTC · source 2025-12-05	excluded package	package	0065-1433-45	`d630ba8d3edf…`	`732f749b63fb…`
2025-08-27 00:01 UTC · source 2025-08-26	excluded product	product		`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-08-27 00:01 UTC · source 2025-08-26	excluded package	package	0065-1433-43	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-08-27 00:01 UTC · source 2025-08-26	excluded package	package	0065-1433-46	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-08-27 00:01 UTC · source 2025-08-26	excluded package	package	0065-1433-45	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-04-01 02:39 UTC · source 2025-03-31	excluded product	product		`2ef7874e63bc…`	`57b86245f4fa…`
2025-04-01 02:39 UTC · source 2025-03-31	excluded package	package	0065-1433-43	`2ef7874e63bc…`	`57b86245f4fa…`
2025-04-01 02:39 UTC · source 2025-03-31	excluded package	package	0065-1433-46	`2ef7874e63bc…`	`57b86245f4fa…`
2025-04-01 02:39 UTC · source 2025-03-31	excluded package	package	0065-1433-45	`2ef7874e63bc…`	`57b86245f4fa…`
2025-03-28 20:22 UTC · source 2025-03-28	excluded product	product		`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-28 20:22 UTC · source 2025-03-28	excluded package	package	0065-1433-43	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-28 20:22 UTC · source 2025-03-28	excluded package	package	0065-1433-46	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-28 20:22 UTC · source 2025-03-28	excluded package	package	0065-1433-45	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-22 03:12 UTC · source 2025-03-21	excluded product	product		`cfe11265f3b6…`	`090c488252e2…`
2025-03-22 03:12 UTC · source 2025-03-21	excluded package	package	0065-1433-43	`cfe11265f3b6…`	`090c488252e2…`
2025-03-22 03:12 UTC · source 2025-03-21	excluded package	package	0065-1433-46	`cfe11265f3b6…`	`090c488252e2…`
2025-03-22 03:12 UTC · source 2025-03-21	excluded package	package	0065-1433-45	`cfe11265f3b6…`	`090c488252e2…`
2025-03-10 12:48 UTC · source 2025-03-10	excluded product	product		`cdf11ea48f46…`	`ba0047e9e063…`
2025-03-10 12:48 UTC · source 2025-03-10	excluded package	package	0065-1433-43	`cdf11ea48f46…`	`ba0047e9e063…`
2025-03-10 12:48 UTC · source 2025-03-10	excluded package	package	0065-1433-46	`cdf11ea48f46…`	`ba0047e9e063…`
2025-03-10 12:48 UTC · source 2025-03-10	excluded package	package	0065-1433-45	`cdf11ea48f46…`	`ba0047e9e063…`
2025-02-02 03:52 UTC · source 2025-01-31	excluded product	product		`302b2466d912…`	`e7b80fea0513…`
2025-02-02 03:52 UTC · source 2025-01-31	excluded package	package	0065-1433-43	`302b2466d912…`	`e7b80fea0513…`
2025-02-02 03:52 UTC · source 2025-01-31	excluded package	package	0065-1433-46	`302b2466d912…`	`e7b80fea0513…`
2025-02-02 03:52 UTC · source 2025-01-31	excluded package	package	0065-1433-45	`302b2466d912…`	`e7b80fea0513…`
2025-01-20 13:05 UTC · source 2025-01-20	excluded product	product		`ed331223b511…`	`672a5bd82f5f…`
2025-01-20 13:05 UTC · source 2025-01-20	excluded package	package	0065-1433-43	`ed331223b511…`	`672a5bd82f5f…`
2025-01-20 13:05 UTC · source 2025-01-20	excluded package	package	0065-1433-46	`ed331223b511…`	`672a5bd82f5f…`
2025-01-20 13:05 UTC · source 2025-01-20	excluded package	package	0065-1433-45	`ed331223b511…`	`672a5bd82f5f…`
2025-01-11 03:41 UTC · source 2025-01-10	excluded product	product		`0efc9e666f02…`	`f202fb6c5f17…`
2025-01-11 03:41 UTC · source 2025-01-10	excluded package	package	0065-1433-43	`0efc9e666f02…`	`f202fb6c5f17…`
2025-01-11 03:41 UTC · source 2025-01-10	excluded package	package	0065-1433-46	`0efc9e666f02…`	`f202fb6c5f17…`
2025-01-11 03:41 UTC · source 2025-01-10	excluded package	package	0065-1433-45	`0efc9e666f02…`	`f202fb6c5f17…`
2024-11-09 02:27 UTC · source 2024-11-08	excluded product	product		`ad56d346431e…`	`cc804d4bbf1e…`
2024-11-09 02:27 UTC · source 2024-11-08	excluded package	package	0065-1433-43	`ad56d346431e…`	`cc804d4bbf1e…`
2024-11-09 02:27 UTC · source 2024-11-08	excluded package	package	0065-1433-46	`ad56d346431e…`	`cc804d4bbf1e…`
2024-11-09 02:27 UTC · source 2024-11-08	excluded package	package	0065-1433-45	`ad56d346431e…`	`cc804d4bbf1e…`
2024-10-04 04:10 UTC · source 2024-10-03	excluded product	product		`367a005e9d99…`	`383a685ebd0f…`
2024-10-04 04:10 UTC · source 2024-10-03	excluded package	package	0065-1433-43	`367a005e9d99…`	`383a685ebd0f…`
2024-10-04 04:10 UTC · source 2024-10-03	excluded package	package	0065-1433-46	`367a005e9d99…`	`383a685ebd0f…`
2024-10-04 04:10 UTC · source 2024-10-03	excluded package	package	0065-1433-45	`367a005e9d99…`	`383a685ebd0f…`
2024-07-10 04:00 UTC · source 2024-07-09	excluded product	product		`557ba5c1ecfa…`	`9c80585c8c6e…`
2024-07-10 04:00 UTC · source 2024-07-09	excluded package	package	0065-1433-43	`557ba5c1ecfa…`	`9c80585c8c6e…`
2024-07-10 04:00 UTC · source 2024-07-09	excluded package	package	0065-1433-46	`557ba5c1ecfa…`	`9c80585c8c6e…`
2024-07-10 04:00 UTC · source 2024-07-09	excluded package	package	0065-1433-45	`557ba5c1ecfa…`	`9c80585c8c6e…`

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: Systane Balance
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
PROPYLENE GLYCOL	.06 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
6DC9Q167V3	Internal UNII lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
c7b1a03a-a5f2-409e-a34a-d6f166671de5	Available on FDA.report

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	SPL version
0065-1433-02	Systane Balance	1 in 1 CARTON	EMULSION	1	11
0065-1433-02	Systane Balance	10 mL in 1 BOTTLE, DROPPER	EMULSION	10	11
0065-1433-07	Systane Balance	2 in 1 CARTON	EMULSION	2	11
0065-1433-07	Systane Balance	10 mL in 1 BOTTLE, DROPPER	EMULSION	10	11
0065-1433-11	Systane Balance	1 in 1 CARTON	EMULSION	1	11
0065-1433-11	Systane Balance	1.5 mL in 1 BOTTLE, DROPPER	EMULSION	1.5	11

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDC	Billing unit	Product NDC	DailyMed indexing SPL	SPL version	Effective
0065-1433-02	ML - Milliliter	0065-1433	f20bcd99-ce3e-4284-902c-4a9d6bfe2012	1	2012-07-24
0065-1433-07	ML - Milliliter	0065-1433	96f7134b-7666-4307-bd08-b5a10f070b9f	1	2016-02-04
0065-1433-43	ML - Milliliter	0065-1433	3d6143e4-8e60-4cda-9bd5-d599c1d09986	1	2017-04-05

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
PROPYLENE GLYCOL	ACTIVE INGREDIENT	6DC9Q167V3	SYSTANE BALANCE (PROPYLENE GLYCOL) EMULSION [ALCON LABORATORIES, INC.]	1
PROPYLENE GLYCOL	ACTIVE MOIETY	6DC9Q167V3	SYSTANE BALANCE (PROPYLENE GLYCOL) EMULSION [ALCON LABORATORIES, INC.]	1
BORIC ACID	INACTIVE INGREDIENT	R57ZHV85D4	SYSTANE BALANCE (PROPYLENE GLYCOL) EMULSION [ALCON LABORATORIES, INC.]	1
DIMYRISTOYLPHOSPHATIDYLGLYCEROL, DL-	INACTIVE INGREDIENT	BI71WT9P3R	SYSTANE BALANCE (PROPYLENE GLYCOL) EMULSION [ALCON LABORATORIES, INC.]	1
EDETATE DISODIUM	INACTIVE INGREDIENT	7FLD91C86K	SYSTANE BALANCE (PROPYLENE GLYCOL) EMULSION [ALCON LABORATORIES, INC.]	1
GUAR GUM	INACTIVE INGREDIENT	E89I1637KE	SYSTANE BALANCE (PROPYLENE GLYCOL) EMULSION [ALCON LABORATORIES, INC.]	1
HYDROCHLORIC ACID	INACTIVE INGREDIENT	QTT17582CB	SYSTANE BALANCE (PROPYLENE GLYCOL) EMULSION [ALCON LABORATORIES, INC.]	1
MINERAL OIL	INACTIVE INGREDIENT	T5L8T28FGP	SYSTANE BALANCE (PROPYLENE GLYCOL) EMULSION [ALCON LABORATORIES, INC.]	1
POLYOXYL 40 STEARATE	INACTIVE INGREDIENT	13A4J4NH9I	SYSTANE BALANCE (PROPYLENE GLYCOL) EMULSION [ALCON LABORATORIES, INC.]	1
SODIUM HYDROXIDE	INACTIVE INGREDIENT	55X04QC32I	SYSTANE BALANCE (PROPYLENE GLYCOL) EMULSION [ALCON LABORATORIES, INC.]	1
SORBITAN TRISTEARATE	INACTIVE INGREDIENT	6LUM696811	SYSTANE BALANCE (PROPYLENE GLYCOL) EMULSION [ALCON LABORATORIES, INC.]	1
SORBITOL	INACTIVE INGREDIENT	506T60A25R	SYSTANE BALANCE (PROPYLENE GLYCOL) EMULSION [ALCON LABORATORIES, INC.]	1
WATER	INACTIVE INGREDIENT	059QF0KO0R	SYSTANE BALANCE (PROPYLENE GLYCOL) EMULSION [ALCON LABORATORIES, INC.]	1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
0065-1433	SYSTANE BALANCE (PROPYLENE GLYCOL) EMULSION [ALCON LABORATORIES, INC.]	10	Current NDC, Legacy NDC, 6 package rows	20231216_c7b1a03a-a5f2-409e-a34a-d6f166671de5.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 22 of 25 · 494 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Meijer Maximum Redness Relief and Lubricant	GLYCERIN, NAPHAZOLINE HCI	Meijer Distribution, Inc.	9feb1818-c79b-23bf-e053-2995a90a1084	2023-12-22	Warnings	Exact identifier application number: M018
Meijer Redness Relief	TETRAHYDROZOLINE HCI	Meijer Distribution, Inc.	9fea27a5-b81b-1598-e053-2995a90a6b62	2023-12-22	Warnings	Exact identifier application number: M018
Meijer Seasonal Itching and Redness Relief	TETRAHYDROZOLINE HCI, ZINC SULFATE	Meijer Distribution, Inc.	9fead2de-2fe6-4dab-e053-2995a90a2742	2023-12-22	Warnings	Exact identifier application number: M018
Meijer Artificial Tears	POLYVINYL ALCOHOL, POVIDONE	Meijer Distribution, Inc.	9feb3eec-a36f-8fc7-e053-2a95a90adcd3	2023-12-22	Warnings	Exact identifier application number: M018
Meijer Redness Relief	GLYCERIN, NAPHAZOLINE HCI	Meijer Distribution, Inc.	9fea4e43-7525-bb66-e053-2a95a90acee9	2023-12-22	Warnings	Exact identifier application number: M018
Meijer Ultra Lubricant Eye Drops High Performance	POLYETHYLENE GLYCOL 400, PROPYLENE GLYCOL	Meijer Distribution, Inc.	a0846e3e-687c-fd55-e053-2995a90a673e	2023-12-22	Warnings	Exact identifier application number: M018
Meijer Advanced Redness and Irritation Relief	DEXTRAN 70, POLYETHYLENE GLYCOL 400, POVIDONE, TETRAHYDROZOLINE HCI	Meijer Distribution, Inc.	9fea6d7a-a2cd-d26e-e053-2995a90a15f8	2023-12-22	Warnings	Exact identifier application number: M018
Meijer Dry Eye Relief	GLYCERIN, HYPROMELLOSE, POLYETHYLENE GLYCOL 400	Meijer Distribution, Inc.	9feaa5e2-6aca-96e8-e053-2a95a90a54bd	2023-12-22	Warnings	Exact identifier application number: M018
Walgreens Multi-Symptom Relief Eye Drops	GLYCERIN, HYPROMELLOSE, POLYETHYLENE GLYCOL 400, TETRAHYDROZOLINE HCL, ZINC SULFATE	Walgreen Co.	a03789ce-66bd-7b12-e053-2995a90af85a	2023-12-20	Warnings	Exact identifier application number: M018
Walgreens Lubricant Eye Drops Preservative Free	DEXTRAN 70, HYPROMELLOSE	Walgreen Company	9b383e41-e116-1c12-e053-2a95a90ab25f	2023-12-20	Warnings	Exact identifier application number: M018
Walgreens Eye Drops Maximum Redness Relief 15mL	GLYCERIN, NAPHAZOLINE HCI	Walgreen Company	949d4a4d-b0f8-81f8-e053-2995a90a818d	2023-12-20	Warnings	Exact identifier application number: M018
Walgreens Eye Drops Seasonal Relief 15mL	TETRAHYDROZOLINE HCI, ZINC SULFATE	Walgreen Co.	947f3706-ef5e-2c53-e053-2a95a90a82bd	2023-12-20	Warnings	Exact identifier application number: M018
Walgreens Eye Drops Advanced Relief 15mL	DEXTRAN 70, POLYETHYLENE GLYCOL 400, POVIDONE, TETRAHYDROZOLINE HCI	Walgreen Company	949f5560-fba7-2da8-e053-2995a90a23c2	2023-12-20	Warnings	Exact identifier application number: M018
Walgreens Lubricant Eye Drops Preservative Free	CARBOXYMETHYLCELLULOSE SODIUM	Walgreen Company	9912b773-e7a5-3a82-e053-2995a90a5b2c	2023-12-20	Warnings	Exact identifier application number: M018
Walgreens Lubricant Eye Drops High Performance 15mL and twin pack	POLYETHYLENE GLYCOL 400, PROPYLENE GLYCOL	Walgreen Company	94ee8310-1c19-dfd4-e053-2a95a90a8356	2023-12-20	Warnings	Exact identifier application number: M018
Walgreens Redness Relief Eye Drops 15mL	GLYCERIN, NAPHAZOLINE HCI	Walgreen Company	94a0d08a-a6db-1088-e053-2995a90ab4fd	2023-12-20	Warnings	Exact identifier application number: M018
Walgreens Eye Drops Original 15mL and twin pack	TETRAHYDROZOLINE HCI	Walgreens Company	94e391f7-db4b-47d2-e053-2a95a90a1b11	2023-12-20	Warnings	Exact identifier application number: M018
Walgreens Lubricant Eye Drops Dry Eye 15mL and twin pack	POLYETHYLENE GLYCOL 400, PROPYLENE GLYCOL	Walgreen Company	94f6e1cd-073c-61ca-e053-2a95a90ae725	2023-12-20	Warnings	Exact identifier application number: M018
Lubricant Eye Drops Preservative Free	CARBOXYMETHYLCELLULOSE SODIUM	Target Corporation	454ce049-49e5-48b1-8499-048e5e7d72d3	2023-12-20	Warnings	Exact identifier application number: M018
Rugby Lubricant Eye Drops	CARBOXYMETHYLCELLULOSE SODIUM	Rugby Laboratories	f9292d5d-e0a3-9287-e053-6294a90a43e9	2023-12-20	Warnings	Exact identifier application number: M018

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
6DC9Q167V3	PROPYLENE GLYCOL	57-55-6	PROPYLENE GLYCOL

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Marketing start	Marketing end	Sample	Exclude flag	Status
0065-1433-02	00065143302	1 BOTTLE, DROPPER in 1 CARTON (0065-1433-02) / 10 mL in 1 BOTTLE, DROPPER	2010-06-25	0000-00-00	No	No	Current
0065-1433-07	00065143307	2 BOTTLE, DROPPER in 1 CARTON (0065-1433-07) / 10 mL in 1 BOTTLE, DROPPER	2010-06-25	0000-00-00	No	No	Current
0065-1433-11	00065143311	1 BOTTLE, DROPPER in 1 CARTON (0065-1433-11) / 1.5 mL in 1 BOTTLE, DROPPER	2010-06-25	0000-00-00	No	No	Current

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
SYSTANE ® BALANCE Lubricant Eye Drops	Alcon Laboratories, Inc. \| Alcon Research LLC \| Alcon Singapore Manufacturing Pte. Ltd.	2025-08-07	HUMAN OTC DRUG LABEL	11