MALARONE

Product NDC
0173-0675
11-digit product format
001730675
Labeler code
0173
Product ID
0173-0675_39349dbb-ccca-45a2-bc2b-8bd69602d7b8
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
atovaquone and proguanil hydrochloride
Dosage form
TABLET, FILM COATED
Route
ORAL
Labeler
GlaxoSmithKline LLC
Application
NDA021078
Marketing category
NDA
Marketing start
2000-07-26
Substance
ATOVAQUONE; PROGUANIL HYDROCHLORIDE
Active strength
250; 100 mg/1; mg/1
Pharmacologic classes
Antimalarial [EPC], Antimalarial [EPC], Antiprotozoal [EPC], Dihydrofolate Reductase Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2027-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N021078-001MALARONEATOVAQUONE; PROGUANIL HYDROCHLORIDE250MG;100MGTABLET / ORALABRLD, RS2000-07-14
N021078-002MALARONE PEDIATRICATOVAQUONE; PROGUANIL HYDROCHLORIDE62.5MG;25MGTABLET / ORALABRLD2000-07-14

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 2 matching rows.

Application-product, TE code table
Application-productTE code
N021078-001AB
N021078-002AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-01 22:54:322026-06N021078-001MALARONE250MG;100MGTABLET / ORALABRLD, RS2000-07-14a50c72e98297…
2026-08-01 22:54:322026-06N021078-002MALARONE PEDIATRIC62.5MG;25MGTABLET / ORALABRLD2000-07-14a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-01 22:54:322026-06N021078-001AB1a50c72e98297…
2026-08-01 22:54:322026-06N021078-002AB1a50c72e98297…

openFDA label cross-check#

Cross-check layer: openFDA label JSON enriches search and identifies hydration gaps. The DailyMed Structured Product Label remains the canonical label presentation on FDA.report. Every label matching the complete exact-identifier union is deduplicated and paginated below.

Matched openFDA labels page 1 of 1 · 3 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
MALARONEATOVAQUONE AND PROGUANIL HYDROCHLORIDEGlaxoSmithKline LLCfc22e8d8-3bfb-4f70-a599-dd81262a48872026-06-10Warnings, Adverse reactionsExact identifier
application applno (NDA): 021078
application number: NDA021078
ndc (product): 0173-0675
Atovaquone and Proguanil HClATOVAQUONE AND PROGUANIL HYDROCHLORIDEA-S Medication Solutions593baf3d-bd9e-4a44-8f90-125aa4a7a99e2023-10-23Warnings, Adverse reactionsExact identifier
application applno (NDA): 021078
application number: NDA021078
Atovaquone and Proguanil HClATOVAQUONE AND PROGUANIL HYDROCHLORIDEPrasco Laboratories7069521a-c7f9-4e8d-99b8-0cb5c971e7cf2022-05-06Warnings, Adverse reactionsExact identifier
application applno (NDA): 021078
application number: NDA021078

Additional Listing Data#

Finished product
Yes
Brand name base
MALARONE
Listing expiration
2027-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
ATOVAQUONE250 mg/1
PROGUANIL HYDROCHLORIDE100 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
R71Y86M0WTInternal UNII lookup
Y883P1Z2LTInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 4 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
864675Internal RxNorm lookup
864679Internal RxNorm lookup
864681Internal RxNorm lookup
864685Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
fc22e8d8-3bfb-4f70-a599-dd81262a4887Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
4a3a9d58-de64-b317-9153-f2c3fc3a43c9Product name820220517
7beb5026-9819-5e26-fae7-eca2788430deProduct name220150108

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
0173-0675-01MALARONE100 in 1 BOTTLETABLET, FILM COATED10030
0173-0675-02MALARONE24 in 1 DOSE PACKTABLET, FILM COATED2430

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
0173-0675-01EA - Each0173-0675ae16b280-a550-4841-992e-9dc7c46b150512012-07-24
0173-0675-02EA - Each0173-0675831eb8bb-6309-43b2-9322-fa16627662f312012-07-24

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
IngredientTypeUNIIDailyMed labelSPL versionUploaded
ATOVAQUONEACTIVE INGREDIENTY883P1Z2LTMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [GLAXOSMITHKLINE LLC]16
PROGUANIL HYDROCHLORIDEACTIVE INGREDIENTR71Y86M0WTMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [GLAXOSMITHKLINE LLC]16
ATOVAQUONEACTIVE MOIETYY883P1Z2LTMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [GLAXOSMITHKLINE LLC]16
PROGUANILACTIVE MOIETYS61K3P7B2VMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [GLAXOSMITHKLINE LLC]16
CELLULOSE, MICROCRYSTALLINEINACTIVE INGREDIENTOP1R32D61UMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [GLAXOSMITHKLINE LLC]16
FERRIC OXIDE REDINACTIVE INGREDIENT1K09F3G675MALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [GLAXOSMITHKLINE LLC]16
HYDROXYPROPYL CELLULOSE, LOW SUBSTITUTEDINACTIVE INGREDIENT2165RE0K14MALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [GLAXOSMITHKLINE LLC]16
HYPROMELLOSESINACTIVE INGREDIENT3NXW29V3WOMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [GLAXOSMITHKLINE LLC]16
MAGNESIUM STEARATEINACTIVE INGREDIENT70097M6I30MALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [GLAXOSMITHKLINE LLC]16
POLOXAMER 188INACTIVE INGREDIENTLQA7B6G8JGMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [GLAXOSMITHKLINE LLC]16
POLYETHYLENE GLYCOL 400INACTIVE INGREDIENTB697894SGQMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [GLAXOSMITHKLINE LLC]16
POLYETHYLENE GLYCOL 8000INACTIVE INGREDIENTQ662QK8M3BMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [GLAXOSMITHKLINE LLC]16
POVIDONE K30INACTIVE INGREDIENTU725QWY32XMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [GLAXOSMITHKLINE LLC]16
SODIUM STARCH GLYCOLATE TYPE A POTATOINACTIVE INGREDIENT5856J3G2A2MALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [GLAXOSMITHKLINE LLC]16
TITANIUM DIOXIDEINACTIVE INGREDIENT15FIX9V2JPMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [GLAXOSMITHKLINE LLC]16
ATOVAQUONEACTIVE INGREDIENTY883P1Z2LTMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [PD-RX PHARMACEUTICALS, INC.]12
PROGUANIL HYDROCHLORIDEACTIVE INGREDIENTR71Y86M0WTMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [PD-RX PHARMACEUTICALS, INC.]12
ATOVAQUONEACTIVE MOIETYY883P1Z2LTMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [PD-RX PHARMACEUTICALS, INC.]12
PROGUANILACTIVE MOIETYS61K3P7B2VMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [PD-RX PHARMACEUTICALS, INC.]12
CELLULOSE, MICROCRYSTALLINEINACTIVE INGREDIENTOP1R32D61UMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [PD-RX PHARMACEUTICALS, INC.]12
FERRIC OXIDE REDINACTIVE INGREDIENT1K09F3G675MALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [PD-RX PHARMACEUTICALS, INC.]12
HYDROXYPROPYL CELLULOSE, LOW SUBSTITUTEDINACTIVE INGREDIENT2165RE0K14MALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [PD-RX PHARMACEUTICALS, INC.]12
HYPROMELLOSESINACTIVE INGREDIENT3NXW29V3WOMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [PD-RX PHARMACEUTICALS, INC.]12
MAGNESIUM STEARATEINACTIVE INGREDIENT70097M6I30MALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [PD-RX PHARMACEUTICALS, INC.]12
POLOXAMER 188INACTIVE INGREDIENTLQA7B6G8JGMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [PD-RX PHARMACEUTICALS, INC.]12
POLYETHYLENE GLYCOL 400INACTIVE INGREDIENTB697894SGQMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [PD-RX PHARMACEUTICALS, INC.]12
POLYETHYLENE GLYCOL 8000INACTIVE INGREDIENTQ662QK8M3BMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [PD-RX PHARMACEUTICALS, INC.]12
POVIDONE K30INACTIVE INGREDIENTU725QWY32XMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [PD-RX PHARMACEUTICALS, INC.]12
SODIUM STARCH GLYCOLATE TYPE A POTATOINACTIVE INGREDIENT5856J3G2A2MALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [PD-RX PHARMACEUTICALS, INC.]12
TITANIUM DIOXIDEINACTIVE INGREDIENT15FIX9V2JPMALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [PD-RX PHARMACEUTICALS, INC.]12

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
0173-0675MALARONE (ATOVAQUONE AND PROGUANIL HYDROCHLORIDE) TABLET, FILM COATED [GLAXOSMITHKLINE LLC]28Current NDC, Legacy NDC, 2 package rows20240711_fc22e8d8-3bfb-4f70-a599-dd81262a4887.zip

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
864675atovaquone 250 MG / proguanil HCl 100 MG Oral TabletPSNfc22e8d8-3bfb-4f70-a599-dd81262a488730
864681atovaquone 62.5 MG / proguanil HCl 25 MG Oral TabletPSNfc22e8d8-3bfb-4f70-a599-dd81262a488730
864679MALARONE 250 MG / 100 MG Oral TabletPSNfc22e8d8-3bfb-4f70-a599-dd81262a488730
864685MALARONE Pediatric 62.5 MG / 25 MG Oral TabletPSNfc22e8d8-3bfb-4f70-a599-dd81262a488730
864679atovaquone 250 MG / proguanil hydrochloride 100 MG Oral Tablet [Malarone]SBDfc22e8d8-3bfb-4f70-a599-dd81262a488730
864685atovaquone 62.5 MG / proguanil hydrochloride 25 MG Oral Tablet [Malarone]SBDfc22e8d8-3bfb-4f70-a599-dd81262a488730
864675atovaquone 250 MG / proguanil hydrochloride 100 MG Oral TabletSCDfc22e8d8-3bfb-4f70-a599-dd81262a488730
864681atovaquone 62.5 MG / proguanil hydrochloride 25 MG Oral TabletSCDfc22e8d8-3bfb-4f70-a599-dd81262a488730
864679Malarone 250/100 (atovaquone / proguanil HCl) Oral TabletSYfc22e8d8-3bfb-4f70-a599-dd81262a488730
864679Malarone 250/100 Oral TabletSYfc22e8d8-3bfb-4f70-a599-dd81262a488730
864685Malarone 62.5/25 (atovaquone / proguanil HCl) Oral TabletSYfc22e8d8-3bfb-4f70-a599-dd81262a488730
864685Malarone 62.5/25 Oral TabletSYfc22e8d8-3bfb-4f70-a599-dd81262a488730

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionMarketing startMarketing endSampleExclude flagStatus
0173-0675-0100173067501100 TABLET, FILM COATED in 1 BOTTLE (0173-0675-01) 2000-07-260000-00-00NoNoCurrent
0173-0675-020017306750224 TABLET, FILM COATED in 1 DOSE PACK (0173-0675-02) 2000-07-260000-00-00NoNoCurrent