ProHance

Product NDC
0270-1111
11-digit product format
002701111
Labeler code
0270
Product ID
0270-1111_2124d0de-8f96-6f0d-6c42-7296def2661f
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
gadoteridol
Dosage form
INJECTION, SOLUTION
Route
INTRAVENOUS
Labeler
BRACCO DIAGNOSTICS INC
Application
NDA020131
Marketing category
NDA
Marketing start
1992-11-16
Substance
GADOTERIDOL
Active strength
279.3 mg/mL
Pharmacologic classes
Magnetic Resonance Contrast Activity [MoA], Paramagnetic Contrast Agent [EPC]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N020131-001PROHANCEGADOTERIDOL279.3MG/MLINJECTABLE / INJECTIONAPRLD, RS1992-11-16

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
N020131-001AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONAPRLD, RS1992-11-16011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONAPRLD, RS1992-11-1631067a03dcf5…
2025-08-23 18:47 UTC2025-08N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONAPRLD, RS1992-11-166a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONAPRLD, RS1992-11-16fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONAPRLD, RS1992-11-16b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-1603ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-162680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-165bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-16d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-16d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-1679d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-16301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-161e350fbaab3a…
2024-05-31 18:47 UTC2024-05N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-168072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-165c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-165d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-164b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-1674a2ff9319b5…
2022-03-09 01:35 UTC2022-03N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-16bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-16782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-1687673890dc5c…
2021-03-12 10:30 UTC2021-03N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-165aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-168869cabd3fbd…
2020-11-12 02:37 UTC2020-11N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-16c0c555d07b60…
2019-12-14 00:12 UTC2019-12N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-163f01610625f2…
2019-09-15 20:21 UTC2019-09N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-16b00525d2431f…
2019-07-19 19:46 UTC2019-07N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-16ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-166a51e52b5d6a…
2024-02-18 07:12 UTC2024-02N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-161c564ffb4f44…
2023-12-20 04:57 UTC2023-12N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-16ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-16a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-169b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-16a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-163f0d92c62455…
2023-05-13 08:27 UTC2023-05N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-16053a50430f4f…
2023-01-26 05:58 UTC2023-01N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-163bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-163a93d1ddd44b…
2022-10-28 04:53 UTC2022-10N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-16f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-16e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07N020131-001PROHANCE279.3MG/MLINJECTABLE / INJECTIONRLD, RS1992-11-16cb3db0bc1861…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02N020131-001AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N020131-001AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08N020131-001AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N020131-001AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N020131-001AP1b8a1b40f171c…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06N020131-001AP1a50c72e98297…

Additional Listing Data#

Finished product
Yes
Brand name base
ProHance
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
GADOTERIDOL279.3 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
0199MV609FInternal UNII lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
778aee03-7d4c-481a-be8a-a75db0702f5aAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
310ea0a0-696d-16b8-2ba5-caf071dc63f9Product name220251120
77dc03a4-fbfc-e6a3-fe95-285bbae40d75Product name220250814
63824380-0c95-43c9-abef-b7f6abfb9c23Product name120211028

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
0270-1111-70ProHance50 mL in 1 VIAL, PHARMACY BULK PACKAGEINJECTION, SOLUTION5028
0270-1111-70ProHance5 in 1 BOXINJECTION, SOLUTION528
0270-1111-85ProHance5 in 1 BOXINJECTION, SOLUTION528
0270-1111-85ProHance100 mL in 1 VIAL, PHARMACY BULK PACKAGEINJECTION, SOLUTION10028
0270-1111-01ProHance5 in 1 BOXINJECTION, SOLUTION524
0270-1111-01ProHance10 mL in 1 VIAL, SINGLE-DOSEINJECTION, SOLUTION1024
0270-1111-02ProHance15 mL in 1 VIAL, SINGLE-DOSEINJECTION, SOLUTION1524
0270-1111-02ProHance5 in 1 BOXINJECTION, SOLUTION524
0270-1111-03ProHance5 in 1 BOXINJECTION, SOLUTION524
0270-1111-03ProHance20 mL in 1 VIAL, SINGLE-DOSEINJECTION, SOLUTION2024
0270-1111-04ProHance5 in 1 BOXINJECTION, SOLUTION524
0270-1111-04ProHance5 mL in 1 VIAL, SINGLE-DOSEINJECTION, SOLUTION524

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
0270-1111-01ML - Milliliter0270-1111b81221f6-0be2-4e7c-bff3-67a708733d8412012-07-24
0270-1111-02ML - Milliliter0270-11113f535d43-70e3-452c-8ad1-9a8ab235fdaa12012-07-24
0270-1111-03ML - Milliliter0270-1111587f3ccd-ea66-4641-98f3-62412825fe2212012-07-24
0270-1111-04ML - Milliliter0270-1111fff9fa11-941f-4485-9e03-466a8f4a4f2312012-07-24
0270-1111-16ML - Milliliter0270-1111b2ea1f60-110a-4a95-8f5b-bdae244c4e9c12012-07-24
0270-1111-45ML - Milliliter0270-1111ed36247b-20fd-45eb-9af7-e920576656bb12012-07-24
0270-1111-70ML - Milliliter0270-1111b60d50c7-2c56-40c3-883b-bc3baf41f56512012-07-24
0270-1111-85ML - Milliliter0270-11113d9f7836-6b15-4d0e-b429-aede493ca09212023-08-08

DailyMed Socrata Ingredients#

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
0270-1111PROHANCE (GADOTERIDOL) INJECTION, SOLUTION [BRACCO DIAGNOSTICS INC]28Current NDC, Legacy NDC, 4 package rows20250321_e8b76200-c0aa-491b-aad7-e22d2f68496f.zip
0270-1111PROHANCE (GADOTERIDOL) INJECTION, SOLUTION [BRACCO DIAGNOSTICS INC]24Current NDC, Legacy NDC, 8 package rows20250321_778aee03-7d4c-481a-be8a-a75db0702f5a.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
ProHanceGADOTERIDOLBRACCO DIAGNOSTICS INC778aee03-7d4c-481a-be8a-a75db0702f5a2025-03-14Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (NDA): 020131
application number: NDA020131
ndc (product): 0270-1111
ProHanceGADOTERIDOLBracco Diagnostics Ince8b76200-c0aa-491b-aad7-e22d2f68496f2025-03-14Boxed warning, Warnings, Adverse reactionsExact identifier
ndc (product): 0270-1111

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionMarketing startMarketing endSampleExclude flagStatus
0270-1111-01002701111015 VIAL, SINGLE-DOSE in 1 BOX (0270-1111-01) / 10 mL in 1 VIAL, SINGLE-DOSE1992-11-160000-00-00NoNoCurrent
0270-1111-02002701111025 VIAL, SINGLE-DOSE in 1 BOX (0270-1111-02) / 15 mL in 1 VIAL, SINGLE-DOSE1992-11-160000-00-00NoNoCurrent
0270-1111-03002701111035 VIAL, SINGLE-DOSE in 1 BOX (0270-1111-03) / 20 mL in 1 VIAL, SINGLE-DOSE1992-11-160000-00-00NoNoCurrent
0270-1111-04002701111045 VIAL, SINGLE-DOSE in 1 BOX (0270-1111-04) / 5 mL in 1 VIAL, SINGLE-DOSE1992-11-160000-00-00NoNoCurrent
0270-1111-16002701111165 SYRINGE, GLASS in 1 BOX (0270-1111-16) > 10 mL in 1 SYRINGE, GLASS1992-11-162023-05-31NoNoCurrent
0270-1111-45002701111455 SYRINGE, GLASS in 1 BOX (0270-1111-45) > 17 mL in 1 SYRINGE, GLASS1992-11-160000-00-00NoNoCurrent
0270-1111-70002701111705 VIAL, PHARMACY BULK PACKAGE in 1 BOX (0270-1111-70) / 50 mL in 1 VIAL, PHARMACY BULK PACKAGE2003-10-090000-00-00NoNoCurrent
0270-1111-85002701111855 VIAL, PHARMACY BULK PACKAGE in 1 BOX (0270-1111-85) / 100 mL in 1 VIAL, PHARMACY BULK PACKAGE2022-02-010000-00-00NoNoCurrent