Marcaine

Product NDC
0362-0557
11-digit product format
003620557
Labeler code
0362
Product ID
0362-0557_2095bcd0-0dc6-4b6e-a86c-23140421e3d0
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
bupivacaine hydrochloride and epinephrine bitartrate
Dosage form
INJECTION, SOLUTION
Route
SUBMUCOSAL
Labeler
Septodont, Inc.
Application
ANDA077250
Marketing category
ANDA
Marketing start
2018-06-12
Substance
BUPIVACAINE HYDROCHLORIDE ANHYDROUS; EPINEPHRINE BITARTRATE
Active strength
5; .005 mg/mL; mg/mL
Pharmacologic classes
Adrenergic alpha-Agonists [MoA], Adrenergic beta-Agonists [MoA], Amide Local Anesthetic [EPC], Amides [CS], Catecholamine [EPC], Catecholamines [CS], Local Anesthesia [PE], alpha-Adrenergic Agonist [EPC], beta-Adrenergic Agonist [EPC]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A077250-001VIVACAINEBUPIVACAINE HYDROCHLORIDE; EPINEPHRINE BITARTRATE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-27

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07A077250-001VIVACAINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-27caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A077250-001VIVACAINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-27011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A077250-001VIVACAINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-2731067a03dcf5…
2025-08-23 18:47 UTC2025-08A077250-001VIVACAINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-276a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A077250-001VIVACAINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-27fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A077250-001VIVACAINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-27b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A077250-001VIVACAINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-2703ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A077250-001VIVACAINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-272680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A077250-001VIVACAINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-275bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A077250-001VIVACAINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-27d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A077250-001VIVACAINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-27d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A077250-001VIVACAINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-2779d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A077250-001VIVACAINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-27301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A077250-001VIVACAINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-271e350fbaab3a…
2024-05-31 18:47 UTC2024-05A077250-001VIVACAINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-278072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-275c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-275d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-274b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-2774a2ff9319b5…
2022-03-09 01:35 UTC2022-03A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-27bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-27782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-2787673890dc5c…
2021-03-12 10:30 UTC2021-03A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-275aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-278869cabd3fbd…
2020-11-12 02:37 UTC2020-11A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-27c0c555d07b60…
2019-12-14 00:12 UTC2019-12A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-273f01610625f2…
2019-09-15 20:21 UTC2019-09A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONAP2006-09-27b00525d2431f…
2019-07-19 19:46 UTC2019-07A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONAP2006-09-27ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A077250-001VIVACAINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-276a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A077250-001VIVACAINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-271c564ffb4f44…
2023-12-20 04:57 UTC2023-12A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-27ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-27a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-279b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-27a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-273f0d92c62455…
2023-05-13 08:27 UTC2023-05A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-27053a50430f4f…
2023-01-26 05:58 UTC2023-01A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-273bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-273a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-27f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A077250-001BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE0.5%;0.0091MG/MLINJECTABLE / INJECTIONRS2006-09-27e64feba35796…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2019-09-15 20:21 UTC2019-09A077250-001AP1b00525d2431f…
2019-07-19 19:46 UTC2019-07A077250-001AP1ea99ee380514…

Additional Listing Data#

Finished product
Yes
Brand name base
Marcaine
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
BUPIVACAINE HYDROCHLORIDE ANHYDROUS5 mg/mL
EPINEPHRINE BITARTRATE.005 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
AKA908P8J1Internal UNII lookup
30Q7KI53AKInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1670365Internal RxNorm lookup
1673142Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
3e196aa4-0b01-44db-9267-98a995b54743Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
0b4ec9ca-d305-43fc-88dd-7a510313efe0Product name120260105
bb209f42-a85f-4fee-9d3d-c9dded168625Product name120251208
49628fc7-2031-4c28-bd31-0ef3aa8f44a3Product name320251118
cbf85893-59ef-423f-87d4-a573c000a8b9Product name820250731
b5b1095b-40cd-8a9e-b111-502545045b07Product name420250325
e190029e-423b-473c-8e04-2ada59b5b711Product name120250314
5dad6767-dcd1-b0da-8727-7f3f7bc3a435Product name220250303
777d68c6-a5ab-e06c-d314-677b0b9af0c8Product name220240508
e0031c74-3853-42bc-8e10-86dbbe83992eProduct name220231116
f7046b89-2016-499a-adc6-78479172abc6Product name120230425
e3a99641-4540-4894-9108-00cab3c57b7eProduct name120211207
5da98533-f072-406b-9e1b-6ac19eca9926Product name120210622
306b993e-3140-4823-ad5e-88b708f9d2acProduct name120210510
a831e694-3663-4a83-82be-6c309429f750Product name220200608
444b3e50-f226-46ef-bfca-2e7035d140cdProduct name120190611
2686d634-e712-4007-8dbf-3d37c6c4d71fProduct name120181121
fa8b5901-e681-426f-82fe-54f6d81ec698Product name420180619
bd49bb86-2d32-4a7a-a594-eeda2e29af42Product name120180118
c08ab52f-2fc8-4409-9d9f-ed8edc0bd070Product name120171221
c5cd4727-ac49-4409-82b1-5bd8006c3ec7Product name120171122
3becbe78-12d9-4ad2-9b4c-1e36f8d1303aProduct name120170815
597b1cfd-7b31-5048-62be-ca5cd740da2fProduct name120140508
ec2149b3-5c6d-5344-f757-c86411073075Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
0362-0557-05Marcaine50 in 1 CARTONINJECTION, SOLUTION505
0362-0557-05Marcaine1.8 mL in 1 CARTRIDGEINJECTION, SOLUTION1.85

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
0362-0557-05ML - Milliliter0362-0557129dbd53-583f-4c88-93e5-1712962900dd12021-05-05

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
0362-0557MARCAINE (BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATE) INJECTION, SOLUTION [SEPTODONT, INC.]4Current NDC, Legacy NDC, 2 package rows20240217_3e196aa4-0b01-44db-9267-98a995b54743.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
MarcaineBUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATESeptodont, Inc.3e196aa4-0b01-44db-9267-98a995b547432025-10-10Warnings, Adverse reactionsExact identifier
application applno (ANDA): 077250
application number: ANDA077250
ndc (product): 0362-0557
VivacaineBUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE BITARTRATESeptodont, Inc.b4c60d8e-e350-45b2-9d6b-5815eeb6c9942024-02-16Warnings, Adverse reactionsExact identifier
application applno (ANDA): 077250
application number: ANDA077250

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1670365BUPivacaine HCl 0.5 % / EPINEPHrine 1:200,000 in 1.8 ML Dental CartridgePSN3e196aa4-0b01-44db-9267-98a995b547435
1673142Marcaine 0.5 % / EPINEPHrine 1:200,000 in 1.8 ML Dental CartridgePSN3e196aa4-0b01-44db-9267-98a995b547435
16731421.8 ML bupivacaine hydrochloride 5 MG/ML / epinephrine 0.005 MG/ML Cartridge [Marcaine with Epinephrine]SBD3e196aa4-0b01-44db-9267-98a995b547435
16703651.8 ML bupivacaine hydrochloride 5 MG/ML / epinephrine 0.005 MG/ML CartridgeSCD3e196aa4-0b01-44db-9267-98a995b547435
1670365bupivacaine HCl 0.5 % / epinephrine 1:200,000 per 1.8 ML Dental CartridgeSY3e196aa4-0b01-44db-9267-98a995b547435
1673142Marcaine 0.5 % / epinephrine (as bitartrate) 1:200,000 per 1.8 ML Dental CartridgeSY3e196aa4-0b01-44db-9267-98a995b547435

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
0362-0557-050036205570550 CARTRIDGE in 1 CARTON (0362-0557-05) / 1.8 mL in 1 CARTRIDGE50 cartridge2018-06-120000-00-00NoNoCurrent