ISOPROTERENOL HYDROCHLORIDE

Product NDC
0548-9502
11-digit product format
005489502
Labeler code
0548
Product ID
0548-9502_03384075-bc26-4df6-b1e3-0e20e8808d65
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Isoproterenol Hydrochloride
Dosage form
INJECTION, SOLUTION
Route
INTRACARDIAC; INTRAMUSCULAR; INTRAVENOUS; SUBCUTANEOUS
Labeler
Amphastar Pharmaceuticals, Inc.
Application
ANDA210106
Marketing category
ANDA
Marketing start
2018-07-16
Substance
ISOPROTERENOL HYDROCHLORIDE
Active strength
.2 mg/mL
Pharmacologic classes
Adrenergic beta-Agonists [MoA], beta-Adrenergic Agonist [EPC]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A210106-001ISOPROTERENOL HYDROCHLORIDEISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A210106-001AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-1831067a03dcf5…
2025-08-23 18:47 UTC2025-08A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-186a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-1803ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-182680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-185bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-1879d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-181e350fbaab3a…
2024-05-31 18:47 UTC2024-05A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-188072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-185c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-185d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-184b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-1874a2ff9319b5…
2022-03-09 01:35 UTC2022-03A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-1887673890dc5c…
2021-03-12 10:30 UTC2021-03A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-185aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-188869cabd3fbd…
2020-11-12 02:37 UTC2020-11A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18c0c555d07b60…
2019-12-14 00:12 UTC2019-12A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-183f01610625f2…
2019-09-15 20:21 UTC2019-09A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18b00525d2431f…
2019-07-19 19:46 UTC2019-07A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-186a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-181c564ffb4f44…
2023-12-20 04:57 UTC2023-12A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-189b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-183f0d92c62455…
2023-05-13 08:27 UTC2023-05A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18053a50430f4f…
2023-01-26 05:58 UTC2023-01A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-183bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-183a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A210106-001ISOPROTERENOL HYDROCHLORIDE0.2MG/MLINJECTABLE / INJECTIONAP2018-06-18e64feba35796…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-18 06:07:402026-07A210106-001AP1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A210106-001AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A210106-001AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08A210106-001AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A210106-001AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A210106-001AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A210106-001AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A210106-001AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A210106-001AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A210106-001AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A210106-001AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A210106-001AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A210106-001AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A210106-001AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05A210106-001AP18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A210106-001AP15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A210106-001AP15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A210106-001AP14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A210106-001AP174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A210106-001AP1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A210106-001AP1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A210106-001AP187673890dc5c…
2021-03-12 10:30 UTC2021-03A210106-001AP15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A210106-001AP18869cabd3fbd…
2020-11-12 02:37 UTC2020-11A210106-001AP1c0c555d07b60…
2019-12-14 00:12 UTC2019-12A210106-001AP13f01610625f2…
2019-09-15 20:21 UTC2019-09A210106-001AP1b00525d2431f…
2019-07-19 19:46 UTC2019-07A210106-001AP1ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A210106-001AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A210106-001AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12A210106-001AP1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A210106-001AP1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A210106-001AP19b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A210106-001AP1a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A210106-001AP13f0d92c62455…
2023-05-13 08:27 UTC2023-05A210106-001AP1053a50430f4f…
2023-01-26 05:58 UTC2023-01A210106-001AP13bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11A210106-001AP13a93d1ddd44b…
2022-10-28 04:53 UTC2022-10A210106-001AP1f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09A210106-001AP1e64feba35796…

Additional Listing Data#

Finished product
Yes
Brand name base
ISOPROTERENOL HYDROCHLORIDE
Listing expiration
2027-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
ISOPROTERENOL HYDROCHLORIDE.2 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
DIA2A74855Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1667909Internal RxNorm lookup
1667915Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
86b2455a-0489-405e-bd0b-9f79d3c5350dAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
7757a57a-4dcc-4536-b5df-2fed4aa930c9Product name920240506

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
0548-9502-00ISOPROTERENOL HYDROCHLORIDE5 mL in 1 VIALINJECTION, SOLUTION52
0548-9502-00ISOPROTERENOL HYDROCHLORIDE10 in 1 CARTONINJECTION, SOLUTION102

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
0548-9502-00ML - Milliliter0548-9502ecfbaf1c-e4e4-4f85-838e-ddfec26a75aa12018-07-03

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
0548-9502ISOPROTERENOL HYDROCHLORIDE INJECTION, SOLUTION [AMPHASTAR PHARMACEUTICALS, INC.]2Current NDC, Legacy NDC, 2 package rows20181012_86b2455a-0489-405e-bd0b-9f79d3c5350d.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
ISOPROTERENOL HYDROCHLORIDEISOPROTERENOL HYDROCHLORIDEAmphastar Pharmaceuticals, Inc.86b2455a-0489-405e-bd0b-9f79d3c5350d2022-10-01Warnings, Adverse reactionsExact identifier
application applno (ANDA): 210106
application number: ANDA210106
ndc (product): 0548-9502

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1667909isoproterenol 0.2 MG in 1 ML InjectionPSN86b2455a-0489-405e-bd0b-9f79d3c5350d2
1667915isoproterenol 1 MG in 5 ML InjectionPSN86b2455a-0489-405e-bd0b-9f79d3c5350d2
16679091 ML isoproterenol hydrochloride 0.2 MG/ML InjectionSCD86b2455a-0489-405e-bd0b-9f79d3c5350d2
16679155 ML isoproterenol hydrochloride 0.2 MG/ML InjectionSCD86b2455a-0489-405e-bd0b-9f79d3c5350d2
1667909isoproterenol 0.2 MG per 1 ML InjectionSY86b2455a-0489-405e-bd0b-9f79d3c5350d2
1667915isoproterenol 1 MG per 5 ML InjectionSY86b2455a-0489-405e-bd0b-9f79d3c5350d2

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
0548-9502-000054895020010 VIAL in 1 CARTON (0548-9502-00) / 5 mL in 1 VIAL10 vial2018-07-160000-00-00NoNoCurrent