Major Nasal Decongestant

Product NDC: 0904-7427
11-digit product format: 009047427
Labeler code: 0904
Product ID: 0904-7427_9a23ed6c-77ea-4647-b6d5-cba46283822b
Type: HUMAN OTC DRUG
Nonproprietary name: Oxymetazoline hydrochloride
Dosage form: SPRAY
Route: NASAL
Labeler: Major Pharmaceuticals
Application: M012
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2023-12-31
Substance: OXYMETAZOLINE HYDROCHLORIDE
Active strength: .5 mg/mL
Pharmacologic classes: Imidazolines [CS], Increased Sympathetic Activity [PE], Vasoconstriction [PE], Vasoconstrictor [EPC]
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: Major Nasal Decongestant
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
OXYMETAZOLINE HYDROCHLORIDE	.5 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
K89MJ0S5VY	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1000990	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
bcc1a001-4176-485d-aaf0-2037ca65c6b8	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
e67be450-f8e4-4bc1-88bd-1259d379f55f	Product name	1	20210127
c53f3286-4062-4cf5-8355-399519c639a6	Product name	1	20170424
a993dfc5-f219-4460-bde6-30dd724d9ef0	Product name	1	20160818

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	Strength	SPL version
0904-7427-30	Major Nasal Decongestant	30 mL in 1 BOTTLE, PUMP	SPRAY	30		2
0904-7427-30	Major Nasal Decongestant	1 in 1 CARTON	SPRAY	1		2

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDC	Billing unit	Product NDC	DailyMed indexing SPL	SPL version	Effective
0904-7427-30	ML - Milliliter	0904-7427	ef6522af-7151-4ed9-9b70-029ee13d8569	1	2024-07-12

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
0904-7427	MAJOR NASAL DECONGESTANT (OXYMETAZOLINE HYDROCHLORIDE) SPRAY [MAJOR PHARMACEUTICALS]	2	Current NDC, 2 package rows	20231231_bcc1a001-4176-485d-aaf0-2037ca65c6b8.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 34 of 178 · 3,551 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Thieves Chest Rub	CHEST RUB	Young Living Essential Oils, LC.	9b7f125e-6caa-c53e-e053-2a95a90a737e	2026-05-06	Warnings	Exact identifier application number: M012
Maximum Strength Mucus Relief Plus Pain and Headache	ACETAMINOPHEN, GUAIFENESIN	Shield Pharmaceuticals Corp	f20c0db1-dcf3-4bfc-b3e4-930398f82dc9	2026-05-06	Warnings	Exact identifier application number: M012
Nitetime	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE	Publix Super Markets Inc	8aa6492b-1723-4c6b-82ee-4f800301c6ad	2026-05-06	Warnings	Exact identifier application number: M012
Allergy Childrens Allergy	DIPHENHYDRAMINE HYDROCHLORIDE	Dolgencorp, Inc. (DOLLAR GENERAL & REXALL)	047102c4-3d03-4b2d-961d-0ac75980147b	2026-05-06	Warnings	Exact identifier application number: M012
GOOD SENSE COMBO PACK DAYTIME AND NIGHTTIME	ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, DOXYLAMINE SUCCINATE, PHENYLEPHRINE HYDROCHLORIDE	L. Perrigo Company	d25f2649-4f8a-4339-8443-faa0b98bdd70	2026-05-06	Warnings	Exact identifier application number: M012
Allergy Relief 4 Hour	CHLORPHENIRAMINE MALEATE	WinCo Foods, LLC	27e911e1-6d22-4a50-8413-1809c8973cbd	2026-05-06	Warnings	Exact identifier application number: M012
ALKA SELTZER COLD Cold Cough Maximum Strength Fast Gels	ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, PHENYLEPHRINE HYDROCHLORIDE	Bayer HealthCare LLC.	51173330-d537-fb9c-e063-6394a90ae342	2026-05-05	Warnings	Exact identifier application number: M012
Equate daytime severe vaporice cold and flu nighttime severe vapor ice cold and flu	ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, PHENYLEPHRINE HYDROCHLORIDE, DOXYLAMINE SUCCINATE	Wal-Mart Stores Inc	08e74a8d-8e8d-4cda-9adc-ea2ff4068353	2026-05-05	Warnings	Exact identifier application number: M012
GOODSENSE COMBO PACK DAYTIME AND NIGHTTIME	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE, GUAIFENESIN, PHENYLEPHRINE HCL	L. Perrigo Company	e42f9e0d-f990-4c33-af43-75acf5d77638	2026-05-05	Warnings	Exact identifier application number: M012
Rugby Mucus and Chest Congestion 541	GUAIFENESIN	Rugby Laboratories	76472912-b66f-4bb4-937a-4a589683a78c	2026-05-04	Warnings	Exact identifier application number: M012
Sinus Congestion and Pain Daytime Non-Drowsy	ACETAMINOPHEN, PHENYLEPHRINE HYDROCHLORIDE	H E B	e9dd2d7b-0a19-4a42-b51e-b9914f02406e	2026-05-04	Warnings	Exact identifier application number: M012
Sanatos Nighttime	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE	Pharmadel LLC	3dd3ed85-0c0a-8390-e063-6294a90a668e	2026-05-04	Warnings	Exact identifier application number: M012
Good Sense Daytime non drowsy cold and flu	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, PHENYLEPHRINE HCL	L. Perrigo Company	0122cd34-5817-4af5-a51a-8d176dee0a30	2026-05-04	Warnings	Exact identifier application number: M012
COLD AND FLU RELIEF	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, GUAIFENESIN, PHENYLEPHRINE HCL	Safeway	d810a6a9-6112-4e9d-a396-36084b7e110e	2026-05-04	Warnings	Exact identifier application number: M012
Benadryl Allergy Ultratab	DIPHENHYDRAMINE HYDROCHLORIDE	Savings Distributors LLC	8d59d121-62a8-c43b-e053-2a95a90a5847	2026-05-01	Warnings	Exact identifier application number: M012
Tylenol Cold Plus Flu Severe	ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, PHENYLEPHRINE HYDROCHLORIDE	Savings Distributors LLC	8e87f8de-f83e-0f8d-e053-2a95a90a8d6a	2026-05-01	Warnings	Exact identifier application number: M012
Tylenol Sinus Severe	ACETAMINOPHEN, GUAIFENESIN, PHENYLEPHRINE HYDROCHLORIDE	Savings Distributors LLC	8eecb3f0-eb5e-e847-e053-2995a90a86bd	2026-05-01	Warnings	Exact identifier application number: M012
Sinus Pressure and Congestion Relief PE Maximum Strength	PHENYLEPHRINE HCL	Rite Aid Corporation	fccea3c5-42af-4939-82bc-d9409b75f91f	2026-05-01	Warnings	Exact identifier application number: M012
Night Time Cold and Flu original	ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, DOXYLAMINE SUCCINATE	Harris Teeter, LLC	cfaf4b3d-fab4-424d-adbe-aaedca58912d	2026-04-30	Warnings	Exact identifier application number: M012
Nighttime Cold and Flu	ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, DOXYLAMINE SUCCINATE	Harris Teeter, LLC	21e7d323-5b78-43aa-b0fc-34c2a864ab9a	2026-04-30	Warnings	Exact identifier application number: M012

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
K89MJ0S5VY	OXYMETAZOLINE HYDROCHLORIDE	2315-02-8	OXYMETAZOLINE HYDROCHLORIDE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1000990	oxymetazoline HCl 0.05 % Nasal Spray	PSN	4b78b9af-0975-43f8-8b44-daddef0478be	2
1000990	oxymetazoline HCl 0.05 % Nasal Spray	PSN	a302e341-1c00-4c3d-b71f-c4c0b307aa67	2
1000990	oxymetazoline HCl 0.05 % Nasal Spray	PSN	bcc1a001-4176-485d-aaf0-2037ca65c6b8	2
1000990	oxymetazoline hydrochloride 0.5 MG/ML Nasal Spray	SCD	4b78b9af-0975-43f8-8b44-daddef0478be	2
1000990	oxymetazoline hydrochloride 0.5 MG/ML Nasal Spray	SCD	a302e341-1c00-4c3d-b71f-c4c0b307aa67	2
1000990	oxymetazoline hydrochloride 0.5 MG/ML Nasal Spray	SCD	bcc1a001-4176-485d-aaf0-2037ca65c6b8	2
1000990	oxymetazoline hydrochloride 0.05 % Nasal Spray	SY	4b78b9af-0975-43f8-8b44-daddef0478be	2
1000990	oxymetazoline hydrochloride 0.05 % Nasal Spray	SY	a302e341-1c00-4c3d-b71f-c4c0b307aa67	2
1000990	oxymetazoline hydrochloride 0.05 % Nasal Spray	SY	bcc1a001-4176-485d-aaf0-2037ca65c6b8	2
1000990	oxymetazoline HCl 0.05 % Nasal Spray	PSN	36b1a7e0-c8b9-0890-e063-6394a90ab13a	1
1000990	oxymetazoline hydrochloride 0.5 MG/ML Nasal Spray	SCD	36b1a7e0-c8b9-0890-e063-6394a90ab13a	1
1000990	oxymetazoline hydrochloride 0.05 % Nasal Spray	SY	36b1a7e0-c8b9-0890-e063-6394a90ab13a	1

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Marketing start	Sample	Exclude flag	Status
0904-7427-30	00904742730	1 BOTTLE, PUMP in 1 CARTON (0904-7427-30) / 30 mL in 1 BOTTLE, PUMP	2023-12-31	No	No	Current

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
Major Nasal Decongestant Spray No Drip	Preferred Pharmaceuticals Inc.	2026-07-29	HUMAN OTC DRUG LABEL	4
MAJOR NASAL DECONGESTANT	A-S Medication Solutions	2025-08-15	HUMAN OTC DRUG LABEL	2
Major Nasal Decongestant Spray No Drip	NuCare Pharmaceuticals, Inc.	2025-06-03	HUMAN OTC DRUG LABEL	1
Major Nasal Decongestant Spray No Drip	Major Pharmaceuticals	2023-12-14	HUMAN OTC DRUG LABEL	2