UNBLEMISH Invisible Matte Defense

Product NDC: 14222-2131
11-digit product format: 142222131
Labeler code: 14222
Product ID: 14222-2131_e6fcc289-8076-4e3b-9eb6-0ec9b1ed4f5c
Type: HUMAN OTC DRUG
Nonproprietary name: HOMOSALATE, OCTOCRYLENE, OCTISALATE, AVOBENZONE
Dosage form: GEL
Route: TOPICAL
Labeler: Rodan & Fields
Application: M020
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2020-03-10
Substance: HOMOSALATE; OCTOCRYLENE; OCTISALATE; AVOBENZONE
Active strength: .1; .1; .05; .03 g/mL; g/mL; g/mL; g/mL
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: UNBLEMISH Invisible Matte Defense
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
HOMOSALATE	.1 g/mL
OCTOCRYLENE	.1 g/mL
OCTISALATE	.05 g/mL
AVOBENZONE	.03 g/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 4 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
V06SV4M95S	Internal UNII lookup
5A68WGF6WM	Internal UNII lookup
4X49Y0596W	Internal UNII lookup
G63QQF2NOX	Internal UNII lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
9dfe7d50-f347-4671-9657-5e4fbe42b441	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
a46239a7-5963-4008-8cbb-6b9000f497eb	Product name	1	20250721
b382b4e1-6b48-45f6-bffc-e61b00b0ce19	Product name	3	20250317
d9d61457-6a5a-41fc-b418-e5479a2904b7	Product name	2	20230303
32012d5c-25ac-49c7-9d4c-1313177fff7c	Product name	1	20230112
13e7e7e3-e885-4c79-af6d-dad1aedbb06e	Product name	1	20220128
4a7d44fe-774d-404b-aad0-8a90fe78375a	Product name	4	20211025
3f45980c-c196-47e5-0e5e-48b7c57327c5	Product name	5	20200428
d12e2d7c-bd6b-45d4-94f9-6df8e1b8b27b	Product name	3	20200203
ee5c6de5-d9cd-454f-b250-7b19e5cf2992	Product name	4	20190619
ad75fcfd-a339-42a1-9c60-43ba2c654cfa	Product name	1	20170810

FDA-Initiated Inactive NDC Indexing#

NDC, Effective, Action table
NDC	Effective	Action	Document	Indexing SPL	Related label
14222-2131-1	2023-11-29	C162847	48780-1	0191ceaa-71ac-198a-e063-dbdaa90aec3e	Drug Facts
14222-2131-1	2023-07-28	C162847	48780-1	0191ceaa-71ac-198a-e063-dbdaa90aec3e	Drug Facts

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	Strength	SPL version
14222-2131-1	UNBLEMISH Invisible Matte Defense	1 in 1 CARTON	GEL	1		4
14222-2131-1	UNBLEMISH Invisible Matte Defense	30 mL in 1 TUBE	GEL	30		4
14222-2131-2	UNBLEMISH Invisible Matte Defense	1 in 1 CARTON	GEL	1		4
14222-2131-2	UNBLEMISH Invisible Matte Defense	7 mL in 1 TUBE	GEL	7		4
14222-2131-4	UNBLEMISH 30-Day Regimen	15 mL in 1 TUBE	GEL	15 mL	0.1 g in 1mL	1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
14222-2131	UNBLEMISH INVISIBLE MATTE DEFENSE (HOMOSALATE, OCTOCRYLENE, OCTISALATE, AVOBENZONE) GEL [RODAN & FIELDS]	4	Current NDC, Legacy NDC, 4 package rows	20231130_9dfe7d50-f347-4671-9657-5e4fbe42b441.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 3 of 357 · 7,139 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Sunski Hot Block Mineral Sunscreen Stick SPF 50	ZINC OXIDE	Stewart Charley Ventures LLC dba Sunski	04ecc5e7-0d9e-4bc7-b964-4cbcc6ed06a8	2026-09-01	Warnings	Exact identifier application number: M020
Sun Wave Anti Aging Insta Dry SPF 50	AVOBENZONE, HOMOSALATE, OCTISALATE, OCTOCRYLENE	Sun Life Brands, LLC	7e48a3d2-e453-4733-b42b-8bea804cda59	2026-09-01	Warnings	Exact identifier application number: M020
Sun Wave Anti Aging Lite SPF 30	AVOBENZONE, HOMOSALATE, OCTISALATE, OCTOCRYLENE	Sun Life Brands, LLC	7204c24f-aab6-45eb-9bd4-879f715ba075	2026-09-01	Warnings	Exact identifier application number: M020
Sun Wave Anti Aging Lite SPF 50	AVOBENZONE, HOMOSALATE, OCTISALATE, OCTOCRYLENE	Sun Life Brands, LLC	7c1e780a-1831-4f49-a92e-e36017d241a2	2026-09-01	Warnings	Exact identifier application number: M020
Sun Wave Cross Sport Insta Dry SPF 30	AVOBENZONE, HOMOSALATE, OCTISALATE, OCTOCRYLENE	Sun Life Brands, LLC	d45614c8-b09c-417b-b691-082ea2149880	2026-09-01	Warnings	Exact identifier application number: M020
Sun Wave Cross Sport Insta Dry SPF 50	AVOBENZONE, HOMOSALATE, OCTISALATE, OCTOCRYLENE	Sun Life Brands, LLC	999b0b17-be73-4d42-b182-ce038f493301	2026-09-01	Warnings	Exact identifier application number: M020
Sun Wave Cross Sport Insta Dry SPF 30	AVOBENZONE, HOMOSALATE, OCTISALATE, OCTOCRYLENE	Sun Life Brands, LLC	adffff46-4cfb-4c0a-b1a6-75220ee193a5	2026-09-01	Warnings	Exact identifier application number: M020
Sun Wave Cross Sport Insta Dry SPF 50	AVOBENZONE, HOMOSALATE, OCTISALATE, OCTOCRYLENE	Sun Life Brands, LLC	13b2b45b-70e1-46ff-8555-48e1fe98c651	2026-09-01	Warnings	Exact identifier application number: M020
Sun Wave Kids Insta Dry SPF 50	AVOBENZONE, HOMOSALATE, OCTISALATE, OCTOCRYLENE	Sun Life Brands, LLC	5c2a5ca3-e9eb-48ba-8698-592d2c7aa241	2026-09-01	Warnings	Exact identifier application number: M020
Sunceutical SPF 50 Mineral Face Cream	ZINC OXIDE	Baxter Laboratories Pty. Ltd.	2c408728-a1de-d51e-e063-6294a90ade0b	2026-08-31	Warnings	Exact identifier application number: M020
SKIN1004 MADAGASCAR CENTELLA HYALU-CICA WATER-FIT SUN SERUM UV	BUTYL METHOXYDIBENZOYLMETHANE, ETHYLHEXYL SALICYLATE, HOMOSALATE, OCTOCRYLENE	Craver Corporation	38d8c1c9-86b5-1edd-e063-6394a90aeb47	2026-08-30	Warnings	Exact identifier application number: M020
ISNTREE HYALURONIC ACID DAILY SUNGEL	AVOBENZONE, HOMOSALATE, OCTISALATE	ISNTREE Inc.	5a3a17ff-a7fd-f707-e063-6394a90a3182	2026-08-29	Warnings	Exact identifier application number: M020
ISNTREE HYALURONIC ACID NATURAL SUNCREAM	ZINC OXIDE	ISNTREE Inc.	5a3a59b2-18b6-521b-e063-6294a90a2958	2026-08-29	Warnings	Exact identifier application number: M020
Cetaphil Daily Facial Moisturizer with suncreen SPF 35	AVOBENZONE, HOMOSALATE, OCTISALATE, OCTOCRYLENE	Galderma Laboratories, L.P.	f5eb347f-0d46-4de6-8f3f-9010327678ed	2026-08-28	Warnings	Exact identifier application number: M020
Utu Broad Spectrum SPF 30 Moisturizing Body Sunscreen	ZINC OXIDE	Utu Co	59938ace-c97c-d758-e063-6394a90a77e4	2026-08-28	Warnings	Exact identifier application number: M020
Utu Broad Spectrum SPF 30 Moisturizing Face Mineral Zinc Oxide Sunscreen Unscented	ZINC OXIDE	Utu Co	5982e790-7cdb-c96c-e063-6394a90a02d4	2026-08-28	Warnings	Exact identifier application number: M020
Utu Hydrating Sun Balm Broad Spectrum SPF 50	ZINC OXIDE	Utu Co	59d1d0ac-2444-d6f9-e063-6294a90ae80c	2026-08-28	Warnings	Exact identifier application number: M020
Hello Bello Mineral Sunscreen SPF 50	ZINC OXIDE	Topiderm, Inc.	54f12764-5c37-4a05-bf96-209fedb93fd1	2026-08-28	Warnings	Exact identifier application number: M020
ISNTREE HYALURONIC ACID DAILY SUNGEL	AVOBENZONE, HOMOSALATE, OCTISALATE	ISNTREE Inc.	5a02c540-5b3b-9379-e063-6294a90a00f6	2026-08-27	Warnings	Exact identifier application number: M020
MZANK SUNSCREEN DAILY ULTIMATE PROTECTION SPF50	SUNSCREEN SPF50	Guangzhou Meixi Biotechnology Co., Ltd.	5a0b4bd2-f6ad-35dc-e063-6294a90a8a66	2026-08-27	Warnings	Exact identifier application number: M020

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
V06SV4M95S	HOMOSALATE	118-56-9	HOMOSALATE
5A68WGF6WM	OCTOCRYLENE	6197-30-4	OCTOCRYLENE
4X49Y0596W	OCTISALATE	118-60-5	OCTISALATE
G63QQF2NOX	AVOBENZONE	70356-09-1	AVOBENZONE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
200009	benzoyl peroxide 2.5 % Topical Lotion	PSN	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Medicated Liquid Soap	PSN	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
200009	benzoyl peroxide 25 MG/ML Topical Lotion	SCD	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 5 MG/ML Medicated Liquid Soap	SCD	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
200009	benzoyl peroxide 2.5 % Topical Lotion	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Foaming Cleanser	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Mask	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Medicated Liquid Soap	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Topical Gel Cleanser	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
14222-2131-1	14222213101	1 TUBE in 1 CARTON (14222-2131-1) / 30 mL in 1 TUBE	1 tube	2020-03-10	0000-00-00	No	No	Current
14222-2131-2	14222213102	1 TUBE in 1 CARTON (14222-2131-2) / 7 mL in 1 TUBE	1 tube	2020-06-01		No	No	Current
14222-2131-4	14222213104	15 mL in 1 TUBE	15 ml					Historical

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
UNBLEMISH 30-Day Regimen - Rodan & Fields	Rodan & Fields	2026-04-01	HUMAN OTC DRUG LABEL	1
Drug Facts	Rodan & Fields	2023-11-27	HUMAN OTC DRUG LABEL	4