UNBLEMISH Invisible Matte Defense

Product NDC: 14222-2131
11-digit product format: 142222131
Labeler code: 14222
Product ID: 14222-2131_e6fcc289-8076-4e3b-9eb6-0ec9b1ed4f5c
Type: HUMAN OTC DRUG
Nonproprietary name: HOMOSALATE, OCTOCRYLENE, OCTISALATE, AVOBENZONE
Dosage form: GEL
Route: TOPICAL
Labeler: Rodan & Fields
Application: M020
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2020-03-10
Substance: HOMOSALATE; OCTOCRYLENE; OCTISALATE; AVOBENZONE
Active strength: .1; .1; .05; .03 g/mL; g/mL; g/mL; g/mL
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: UNBLEMISH Invisible Matte Defense
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
HOMOSALATE	.1 g/mL
OCTOCRYLENE	.1 g/mL
OCTISALATE	.05 g/mL
AVOBENZONE	.03 g/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 4 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
V06SV4M95S	Internal UNII lookup
5A68WGF6WM	Internal UNII lookup
4X49Y0596W	Internal UNII lookup
G63QQF2NOX	Internal UNII lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
9dfe7d50-f347-4671-9657-5e4fbe42b441	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
a46239a7-5963-4008-8cbb-6b9000f497eb	Product name	1	20250721
b382b4e1-6b48-45f6-bffc-e61b00b0ce19	Product name	3	20250317
d9d61457-6a5a-41fc-b418-e5479a2904b7	Product name	2	20230303
32012d5c-25ac-49c7-9d4c-1313177fff7c	Product name	1	20230112
13e7e7e3-e885-4c79-af6d-dad1aedbb06e	Product name	1	20220128
4a7d44fe-774d-404b-aad0-8a90fe78375a	Product name	4	20211025
3f45980c-c196-47e5-0e5e-48b7c57327c5	Product name	5	20200428
d12e2d7c-bd6b-45d4-94f9-6df8e1b8b27b	Product name	3	20200203
ee5c6de5-d9cd-454f-b250-7b19e5cf2992	Product name	4	20190619
ad75fcfd-a339-42a1-9c60-43ba2c654cfa	Product name	1	20170810

FDA-Initiated Inactive NDC Indexing#

NDC, Effective, Action table
NDC	Effective	Action	Document	Indexing SPL	Related label
14222-2131-1	2023-11-29	C162847	48780-1	0191ceaa-71ac-198a-e063-dbdaa90aec3e	Drug Facts
14222-2131-1	2023-07-28	C162847	48780-1	0191ceaa-71ac-198a-e063-dbdaa90aec3e	Drug Facts

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	Strength	SPL version
14222-2131-1	UNBLEMISH Invisible Matte Defense	1 in 1 CARTON	GEL	1		4
14222-2131-1	UNBLEMISH Invisible Matte Defense	30 mL in 1 TUBE	GEL	30		4
14222-2131-2	UNBLEMISH Invisible Matte Defense	1 in 1 CARTON	GEL	1		4
14222-2131-2	UNBLEMISH Invisible Matte Defense	7 mL in 1 TUBE	GEL	7		4
14222-2131-4	UNBLEMISH 30-Day Regimen	15 mL in 1 TUBE	GEL	15 mL	0.1 g in 1mL	1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
14222-2131	UNBLEMISH INVISIBLE MATTE DEFENSE (HOMOSALATE, OCTOCRYLENE, OCTISALATE, AVOBENZONE) GEL [RODAN & FIELDS]	4	Current NDC, Legacy NDC, 4 package rows	20231130_9dfe7d50-f347-4671-9657-5e4fbe42b441.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 44 of 357 · 7,139 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
TRUST MD SPF30 STEM CELL FACE	OCTINOXATE OCTISALATE HOMOSALATE AVOBENZONE TITANIUM DIOXIDE	Guangzhou Yapheon Health Industry Co., Ltd.	4f2ca12c-bc6f-61b8-e063-6294a90a0d7e	2026-04-11	Warnings	Exact identifier application number: M020
MIDHA Rice Daily Moisture Sun Cream	AVOBENZONE, HOMOSALATE, OCTISALATE, OCTOCRYLENE	MIDHA Cosmetic Co.,Ltd.	4b394107-7830-c2c6-e063-6294a90a07d9	2026-04-10	Warnings	Exact identifier application number: M020
Abib Dewy tinted sunscreen Glow tube Deep	OCTISALATE, OCTOCRYLENE, ZINC OXIDE	FOURCOMPANY CO., LTD.	4f15d5ba-6396-56bf-e063-6394a90adb06	2026-04-10	Warnings	Exact identifier application number: M020
Abib Dewy tinted sunscreen Glow tube Light	OCTISALATE, OCTOCRYLENE, ZINC OXIDE	FOURCOMPANY CO., LTD.	4f165895-aa84-e215-e063-6394a90a6256	2026-04-10	Warnings	Exact identifier application number: M020
Abib Dewy tinted sunscreen Glow tube Medium	OCTISALATE, OCTOCRYLENE, ZINC OXIDE	FOURCOMPANY CO., LTD.	4f16b8a4-4279-5f79-e063-6294a90a353d	2026-04-10	Warnings	Exact identifier application number: M020
Sheer Touch Sunscreen SPF 30	AVOBENZONE, HOMOSALATE, OCTISALATE	Amazon.com Services LLC	f5ca0416-548c-4be0-a69e-c7e1b52aba95	2026-04-10	Warnings, Adverse reactions	Exact identifier application number: M020
LASPA TINTED MATTE SUNSCREEN SPF 20 LIGHT	ZINC OXIDE	The Green Cricket Inc	c56fd135-f46a-51ce-e053-2a95a90ab7b3	2026-04-10	Warnings	Exact identifier application number: M020
CorTex SunX 50 Thick	AVOBENZONE, HOMOSALATE, OCTISALATE, OCTOCRYLENE	CoreTex Products Inc	f67a6c6c-c314-1c9d-e053-2a95a90a7f1a	2026-04-10	Warnings	Exact identifier application number: M020
Nu Skin 180 Degree UV Block Hydrator SPF 18	OCTINOXATE AND ZINC OXIDE	NSE Products, Inc.	b9635e59-bb08-4167-b7ba-54c3fc712589	2026-04-09	Warnings	Exact identifier application number: M020
Sport Sunscreen SPF 50	AVOBENZONE, HOMOSALATE, OCTISALATE	The Kroger Co.	79c6fe2a-34c2-44cc-81bc-796c4463d2a6	2026-04-09	Warnings, Adverse reactions	Exact identifier application number: M020
Arizona Sun ProductsSurfblok Lip Balm SPF 15	LIP BALM	Arizona Sun Products	11fdbae5-84ec-7b1d-e063-6294a90a2878	2026-04-09	Warnings	Exact identifier application number: M020
Arizona Sun Prickly Pear Lip Balm SPF 15	SUNSCREEN LIP BALM	Arizona Sun Products	11e9cb25-6ff8-a121-e063-6394a90a849e	2026-04-09	Warnings	Exact identifier application number: M020
Arizona Sun Sunscreen SPF 8	SUNSCREEN	Arizona Sun Products	11e8b612-29be-47ed-e063-6394a90ab9e7	2026-04-09	Warnings	Exact identifier application number: M020
Arizona Sun ProductsSurfblok Lip Balm SPF 15	LIP BALM	Arizona Sun Products	11fdcfd0-8b24-7efc-e063-6294a90af7fa	2026-04-09	Warnings	Exact identifier application number: M020
Arizona Sun SPF 45 Cycleblok Sunscreen	SUNSCREEN	Arizona Sun Products	11e71a84-12d1-2d4f-e063-6294a90adcd6	2026-04-09	Warnings	Exact identifier application number: M020
Arizona Sun SPF 45 Bikerblok Sunscreen	SUNSCREEN	Arizona Sun Products	11e6eafd-f967-b748-e063-6394a90aabfd	2026-04-09	Warnings	Exact identifier application number: M020
YSE Beauty Skin Glow Primer SPF 30	AVOBENZONE, HOMOSALATE, OCTISALATE, OCTOCRYLENE	MSS Beauty LLC	6a318e27-14e5-488e-ac19-010f69cb743d	2026-04-09	Warnings	Exact identifier application number: M020
Arizona Sun Sunscreen Kids Water Resistant SPF 30	SUNSCREEN	Arizona Sun Products	116ed17c-3b38-5e96-e063-6294a90a4246	2026-04-09	Warnings	Exact identifier application number: M020
Arizona Sun SPF 45 Surfblok Sunscreen	SUNSCREEN	Arizona Sun Products	11e76815-9316-555d-e063-6294a90aeb81	2026-04-09	Warnings	Exact identifier application number: M020
Arizona Sun Moisturizer SPF 3	MOISTURIZER	Arizona Sun Products	1171af26-3040-552c-e063-6294a90ae220	2026-04-09	Warnings	Exact identifier application number: M020

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
V06SV4M95S	HOMOSALATE	118-56-9	HOMOSALATE
5A68WGF6WM	OCTOCRYLENE	6197-30-4	OCTOCRYLENE
4X49Y0596W	OCTISALATE	118-60-5	OCTISALATE
G63QQF2NOX	AVOBENZONE	70356-09-1	AVOBENZONE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
200009	benzoyl peroxide 2.5 % Topical Lotion	PSN	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Medicated Liquid Soap	PSN	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
200009	benzoyl peroxide 25 MG/ML Topical Lotion	SCD	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 5 MG/ML Medicated Liquid Soap	SCD	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
200009	benzoyl peroxide 2.5 % Topical Lotion	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Foaming Cleanser	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Mask	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Medicated Liquid Soap	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Topical Gel Cleanser	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
14222-2131-1	14222213101	1 TUBE in 1 CARTON (14222-2131-1) / 30 mL in 1 TUBE	1 tube	2020-03-10	0000-00-00	No	No	Current
14222-2131-2	14222213102	1 TUBE in 1 CARTON (14222-2131-2) / 7 mL in 1 TUBE	1 tube	2020-06-01		No	No	Current
14222-2131-4	14222213104	15 mL in 1 TUBE	15 ml					Historical

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
UNBLEMISH 30-Day Regimen - Rodan & Fields	Rodan & Fields	2026-04-01	HUMAN OTC DRUG LABEL	1
Drug Facts	Rodan & Fields	2023-11-27	HUMAN OTC DRUG LABEL	4