UNBLEMISH Invisible Matte Defense

Product NDC: 14222-2131
11-digit product format: 142222131
Labeler code: 14222
Product ID: 14222-2131_e6fcc289-8076-4e3b-9eb6-0ec9b1ed4f5c
Type: HUMAN OTC DRUG
Nonproprietary name: HOMOSALATE, OCTOCRYLENE, OCTISALATE, AVOBENZONE
Dosage form: GEL
Route: TOPICAL
Labeler: Rodan & Fields
Application: M020
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2020-03-10
Substance: HOMOSALATE; OCTOCRYLENE; OCTISALATE; AVOBENZONE
Active strength: .1; .1; .05; .03 g/mL; g/mL; g/mL; g/mL
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: UNBLEMISH Invisible Matte Defense
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
HOMOSALATE	.1 g/mL
OCTOCRYLENE	.1 g/mL
OCTISALATE	.05 g/mL
AVOBENZONE	.03 g/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 4 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
V06SV4M95S	Internal UNII lookup
5A68WGF6WM	Internal UNII lookup
4X49Y0596W	Internal UNII lookup
G63QQF2NOX	Internal UNII lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
9dfe7d50-f347-4671-9657-5e4fbe42b441	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
a46239a7-5963-4008-8cbb-6b9000f497eb	Product name	1	20250721
b382b4e1-6b48-45f6-bffc-e61b00b0ce19	Product name	3	20250317
d9d61457-6a5a-41fc-b418-e5479a2904b7	Product name	2	20230303
32012d5c-25ac-49c7-9d4c-1313177fff7c	Product name	1	20230112
13e7e7e3-e885-4c79-af6d-dad1aedbb06e	Product name	1	20220128
4a7d44fe-774d-404b-aad0-8a90fe78375a	Product name	4	20211025
3f45980c-c196-47e5-0e5e-48b7c57327c5	Product name	5	20200428
d12e2d7c-bd6b-45d4-94f9-6df8e1b8b27b	Product name	3	20200203
ee5c6de5-d9cd-454f-b250-7b19e5cf2992	Product name	4	20190619
ad75fcfd-a339-42a1-9c60-43ba2c654cfa	Product name	1	20170810

FDA-Initiated Inactive NDC Indexing#

NDC, Effective, Action table
NDC	Effective	Action	Document	Indexing SPL	Related label
14222-2131-1	2023-11-29	C162847	48780-1	0191ceaa-71ac-198a-e063-dbdaa90aec3e	Drug Facts
14222-2131-1	2023-07-28	C162847	48780-1	0191ceaa-71ac-198a-e063-dbdaa90aec3e	Drug Facts

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	Strength	SPL version
14222-2131-1	UNBLEMISH Invisible Matte Defense	1 in 1 CARTON	GEL	1		4
14222-2131-1	UNBLEMISH Invisible Matte Defense	30 mL in 1 TUBE	GEL	30		4
14222-2131-2	UNBLEMISH Invisible Matte Defense	1 in 1 CARTON	GEL	1		4
14222-2131-2	UNBLEMISH Invisible Matte Defense	7 mL in 1 TUBE	GEL	7		4
14222-2131-4	UNBLEMISH 30-Day Regimen	15 mL in 1 TUBE	GEL	15 mL	0.1 g in 1mL	1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
14222-2131	UNBLEMISH INVISIBLE MATTE DEFENSE (HOMOSALATE, OCTOCRYLENE, OCTISALATE, AVOBENZONE) GEL [RODAN & FIELDS]	4	Current NDC, Legacy NDC, 4 package rows	20231130_9dfe7d50-f347-4671-9657-5e4fbe42b441.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 73 of 354 · 7,077 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Slip Tint Broad Spectrum SPF 35 Sunscreen Tinted Moisturizer Shade Seven	ZINC OXIDE	Clean Beauty For All, Inc (dba Saie)	310a07bb-d32a-401f-955e-4c2860148a30	2026-01-20	Warnings	Exact identifier application number: M020
Slip Tint Broad Spectrum SPF 35 Sunscreen Tinted Moisturizer Shade Five	ZINC OXIDE	Clean Beauty For All, Inc (dba Saie)	39ae4a97-7f96-4c95-a6de-0c779764fb02	2026-01-20	Warnings	Exact identifier application number: M020
Slip Tint Broad Spectrum SPF 35 Sunscreen Tinted Moisturizer Shade Four and Half	ZINC OXIDE	Clean Beauty For All, Inc (dba Saie)	1922fc3e-055c-e51d-e063-6294a90a00f5	2026-01-20	Warnings	Exact identifier application number: M020
Slip Tint Broad Spectrum SPF 35 Sunscreen Tinted Moisturizer Shade Nine	ZINC OXIDE	Clean Beauty For All, Inc (dba Saie)	9c7a31df-5bdd-403b-b807-1d1a801e1bb6	2026-01-20	Warnings	Exact identifier application number: M020
Slip Tint Broad Spectrum SPF 35 Sunscreen Tinted Moisturizer Shade One	ZINC OXIDE	Clean Beauty For All, Inc (dba Saie)	1922fc51-ae53-acb8-e063-6394a90a14eb	2026-01-20	Warnings	Exact identifier application number: M020
Wrinkle Repair Moisturizer SPF 30 EQB	AVOBENZONE 2% HOMOSALATE 4% OCTISALATE 4% OCTOCRYLENE 2%	Walmart	a067e968-e598-40ef-95f2-c338b5e413dd	2026-01-20	Warnings	Exact identifier application number: M020
Welmedix HomeCare PRO Fragile Skin Dual Mineral Sunscreen	TITANIUM DIOXIDE, ZINC OXIDE	Welmedix LLC	48da4589-0f5a-c25b-e063-6394a90ac18b	2026-01-20	Warnings	Exact identifier application number: M020
SPF 50 Mineral Sunscreen Kids	ZINC OXIDE 14.69%	S&C Hampton Sun LLC	0bdb7d15-dc52-4e23-9417-fe73f17f6110	2026-01-20	Warnings	Exact identifier application number: M020
DEWYTREE URBAN SHADE INVISIBLE SMOOTHING PORE SUNSTIC SUNSTICK	OCTOCRYLENE, HOMOSALATE, ZINC OXIDE, OCTISALATE	DEWYTREE CO. ,LTD	48406e68-eefd-d2c2-e063-6394a90a4ad9	2026-01-20	Warnings	Exact identifier application number: M020
KONEUK SUNSCREEN SPF50	KONEUK SUNSCREEN SPF50	Guangzhou Meixi Biotechnology Co., Ltd.	48dd7f6e-2a4d-2c92-e063-6294a90a4255	2026-01-20	Warnings	Exact identifier application number: M020
CHUDA	AVOBENZONE, HOMOSALATE, OCTINOXATE, OCTISALATE	Premier Ocher LLC	1bc2a2df-a4cd-45e7-93c6-b35dbd8b280f	2026-01-20	Warnings	Exact identifier application number: M020
Dior Forever Skin Glow Flawless Radiant Skin True Foundation SPF 25 2CR Cool Fosy	OCTISALATE, TITANIUM DIOXIDE	Parfums Christian Dior	12edec55-2414-4bbd-bc96-4599a96b96ac	2026-01-19	Warnings	Exact identifier application number: M020
PROJECT REEF SPF-30 Mineral Sunscreen	ZINC OXIDE	Project Reef LLC	a6077e6f-d987-4159-946f-3e2397247659	2026-01-19	Warnings	Exact identifier application number: M020
OUTER REEF MINERAL SUNSCREEN SPF 30	TITANIUM DIOXIDE	Coral Reef Park Co., Inc.	86ee2fdf-8a88-44e6-b12a-36a92360477a	2026-01-19	Warnings	Exact identifier application number: M020
SABAL Mineral Sunscreen Broad Sprectrum SPF 30	ZINC OXIDE	SABAL SUN LLC	f917b446-4e10-4231-826e-fdac32e11186	2026-01-19	Warnings	Exact identifier application number: M020
Plius Daily SPF Moisturizer SPF 30	AVOBENZONE, OCTISALATE, OCTOCRYLENE	PLIUS, Inc	31866de9-afa0-4c11-be65-b61373551493	2026-01-19	Warnings	Exact identifier application number: M020
PROTEKT SPF-50 Sheer Mineral Sunscreen	ZINC OXIDE	Protekt Products, Inc.	6edc0941-bb21-4797-a875-81f727694774	2026-01-19	Warnings	Exact identifier application number: M020
Ultra Violette SPF Mini Mates Duo Pocket Pals Ultra Violette SPF Mini Mates Duo Pocket Pals Contains 1 X Supreme Screen SPF50 20mL (84803-100-21) 1 X Future Screen SPF50 20mL (84803-103-21)	ACTIVE INGREDIENTS SUPREME SCREEN SPF 50 AVOBENZONE 3% HOMOSALATE 7% OCTISALATE 5% OCTOCRYLENE 8% ACTIVE INGREDIENTS FUTURE SCREEN SPF 50 ZINC OXIDE 20%	Grace and Fire USA Inc.	48c1b93c-9c6f-95aa-e063-6294a90a0cfa	2026-01-19	Warnings	Exact identifier application number: M020
ANUA INVISIBLE GLOW FINISH SUNSCREEN	AVOBENZONE, HOMOSALATE, OCTISALATE, OCTOCRYLENE	The Founders Inc.	446ac344-1078-4cd1-e063-6294a90a4bd4	2026-01-19	Warnings	Exact identifier application number: M020
ANUA ZERO-CAST MOISTURIZING FINISH SUNSCREEN	AVOBENZONE, HOMOSALATE, OCTISALATE, OCTOCRYLENE	The Founders Inc.	31af7b5e-2bd6-63ee-e063-6294a90a0806	2026-01-19	Warnings	Exact identifier application number: M020

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
V06SV4M95S	HOMOSALATE	118-56-9	HOMOSALATE
5A68WGF6WM	OCTOCRYLENE	6197-30-4	OCTOCRYLENE
4X49Y0596W	OCTISALATE	118-60-5	OCTISALATE
G63QQF2NOX	AVOBENZONE	70356-09-1	AVOBENZONE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
200009	benzoyl peroxide 2.5 % Topical Lotion	PSN	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Medicated Liquid Soap	PSN	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
200009	benzoyl peroxide 25 MG/ML Topical Lotion	SCD	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 5 MG/ML Medicated Liquid Soap	SCD	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
200009	benzoyl peroxide 2.5 % Topical Lotion	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Foaming Cleanser	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Mask	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Medicated Liquid Soap	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1
865105	salicylic acid 0.5 % Topical Gel Cleanser	SY	e9a52ccc-6ba0-4417-86cc-b2116a5b8d26	1

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
14222-2131-1	14222213101	1 TUBE in 1 CARTON (14222-2131-1) / 30 mL in 1 TUBE	1 tube	2020-03-10	0000-00-00	No	No	Current
14222-2131-2	14222213102	1 TUBE in 1 CARTON (14222-2131-2) / 7 mL in 1 TUBE	1 tube	2020-06-01		No	No	Current
14222-2131-4	14222213104	15 mL in 1 TUBE	15 ml					Historical

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
UNBLEMISH 30-Day Regimen - Rodan & Fields	Rodan & Fields	2026-04-01	HUMAN OTC DRUG LABEL	1
Drug Facts	Rodan & Fields	2023-11-27	HUMAN OTC DRUG LABEL	4