topotecan hydrochloride

Product NDC
16729-151
11-digit product format
167290151
Labeler code
16729
Product ID
16729-151_23a75b4a-a836-a01d-e063-6394a90a67b3
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
topotecan hydrochloride
Dosage form
INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION
Route
INTRAVENOUS
Labeler
Accord Healthcare, Inc.
Application
ANDA202351
Marketing category
ANDA
Marketing start
2013-07-23
Substance
TOPOTECAN HYDROCHLORIDE
Active strength
4 mg/4mL
Pharmacologic classes
Topoisomerase Inhibitor [EPC], Topoisomerase Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A202351-001TOPOTECAN HYDROCHLORIDETOPOTECAN HYDROCHLORIDEEQ 4MG BASE/VIALINJECTABLE / INJECTIONAP2013-06-26

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-productTE code
A202351-001AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-01 22:54:322026-06A202351-001TOPOTECAN HYDROCHLORIDEEQ 4MG BASE/VIALINJECTABLE / INJECTIONAP2013-06-26a50c72e98297…

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-01 22:54:322026-06A202351-001AP1a50c72e98297…

openFDA label cross-check#

Cross-check layer: openFDA label JSON enriches search and identifies hydration gaps. The DailyMed Structured Product Label remains the canonical label presentation on FDA.report. Every label matching the complete exact-identifier union is deduplicated and paginated below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
topotecan hydrochlorideTOPOTECAN HYDROCHLORIDEAccord Healthcare, Inc.729b2b22-1344-44f3-b614-14f6ec3c263e2024-10-04Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202351
application number: ANDA202351
ndc (product): 16729-151

Additional Listing Data#

Finished product
Yes
Brand name base
topotecan hydrochloride
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
TOPOTECAN HYDROCHLORIDE4 mg/4mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
956S425ZCYInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1799416Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
729b2b22-1344-44f3-b614-14f6ec3c263eAvailable on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
f52be47f-7aa7-46c0-b1fa-50c18dd50206Product name120201029
cbf6bf79-4ea9-419f-b7df-eefa780730bfProduct name220180125
19c78384-80c8-23c8-a4e6-c197ed91c59eProduct name120140508
302dcbc5-1902-d63c-93ac-bac5e14c2822Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
16729-151-31topotecan hydrochloride1 in 1 PACKAGEINJECTION, POWDER, LYOPHILIZED,110
16729-151-31topotecan hydrochloride4 mL in 1 VIALINJECTION, POWDER, LYOPHILIZED,410

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
16729-151-31EA - Each16729-15195e2b860-1c5c-4a88-b949-f5c78b5e08b412013-09-04

DailyMed Socrata Ingredients#

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
16729-151TOPOTECAN HYDROCHLORIDE INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION [ACCORD HEALTHCARE, INC.]10Current NDC, Legacy NDC, 2 package rows20241006_729b2b22-1344-44f3-b614-14f6ec3c263e.zip

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1799416topotecan 4 MG InjectionPSN729b2b22-1344-44f3-b614-14f6ec3c263e10
1799416topotecan 4 MG InjectionSCD729b2b22-1344-44f3-b614-14f6ec3c263e10
1799416topotecan (as topotecan hydrochloride) 4 MG InjectionSY729b2b22-1344-44f3-b614-14f6ec3c263e10

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
16729-151-31167290151311 VIAL in 1 PACKAGE (16729-151-31) / 4 mL in 1 VIAL1 vial2013-07-230000-00-00NoNoCurrent