Methotrexate

Product NDC: 16729-277
11-digit product format: 167290277
Labeler code: 16729
Product ID: 16729-277_2bae3cfe-7aa0-c14c-e063-6294a90a19f4
Type: HUMAN PRESCRIPTION DRUG
Nonproprietary name: Methotrexate
Dosage form: INJECTION
Route: INTRA-ARTERIAL; INTRAMUSCULAR; INTRATHECAL; INTRAVENOUS
Labeler: Accord Healthcare, Inc.
Application: ANDA040716
Marketing category: ANDA
Marketing start: 2014-03-07
Substance: METHOTREXATE
Active strength: 25 mg/mL
Pharmacologic classes: Folate Analog Metabolic Inhibitor [EPC], Folic Acid Metabolism Inhibitors [MoA]
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-product	Trade name	Ingredient	Strength	Dosage form / route	TE codes	RLD / RS	Approval date
A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	METHOTREXATE SODIUM	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-product	TE code
A040716-001	AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Trade name	Strength	Dosage form / route	Product TE source text	RLD / RS	Approval date	Source SHA-256
2026-08-18 06:07:40	2026-07	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`caaa826d4ba7…`
2026-02-19 14:30 UTC	2026-02	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`5bbf6a4d5a75…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`8072bd15b7f6…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`4b0b4de00fa7…`
2019-12-13 00:20 UTC	2019-12	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`74a2ff9319b5…`
2022-03-09 01:35 UTC	2022-03	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`bb7c543d1eb4…`
2021-12-28 21:50 UTC	2021-12	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`782e0a99824c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`87673890dc5c…`
2021-03-12 10:30 UTC	2021-03	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`5aa47cf7b7d7…`
2020-12-22 03:56 UTC	2020-12	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`8869cabd3fbd…`
2020-11-12 02:37 UTC	2020-11	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`c0c555d07b60…`
2019-12-14 00:12 UTC	2019-12	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`3f01610625f2…`
2019-09-15 20:21 UTC	2019-09	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`b00525d2431f…`
2019-07-19 19:46 UTC	2019-07	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`ea99ee380514…`
2024-03-16 18:09 UTC · 4 captures of this ZIP	2024-03	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`6a51e52b5d6a…`
2024-02-18 07:12 UTC	2024-02	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`1c564ffb4f44…`
2023-12-20 04:57 UTC	2023-12	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`ea1830bbd6c7…`
2023-11-28 05:40 UTC · 2 captures of this ZIP	2023-11	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`a72a2bbeb626…`
2023-10-25 00:34 UTC · 2 captures of this ZIP	2023-10	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`9b2671bbb829…`
2023-07-15 15:27 UTC · 2 captures of this ZIP	2023-07	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`a67488948f0b…`
2023-06-13 01:57 UTC · 3 captures of this ZIP	2023-06	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`3f0d92c62455…`
2023-05-13 08:27 UTC	2023-05	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`053a50430f4f…`
2023-01-26 05:58 UTC	2023-01	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`3bdfa0b2c4d7…`
2022-11-12 20:34 UTC · 5 captures of this ZIP	2022-11	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`3a93d1ddd44b…`
2022-10-28 04:53 UTC	2022-10	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`f41ea6bd6efb…`
2022-09-29 23:25 UTC	2022-09	A040716-001	METHOTREXATE SODIUM PRESERVATIVE FREE	EQ 1GM BASE/40ML (EQ 25MG BASE/ML)	INJECTABLE / INJECTION	AP	RS	2007-04-30	`e64feba35796…`

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	TE code	Order	Source SHA-256
2026-08-18 06:07:40	2026-07	A040716-001	AP	1	`caaa826d4ba7…`
2026-02-19 14:30 UTC	2026-02	A040716-001	AP	1	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	A040716-001	AP	1	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	A040716-001	AP	1	`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	A040716-001	AP	1	`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	A040716-001	AP	1	`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	A040716-001	AP	1	`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	A040716-001	AP	1	`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	A040716-001	AP	1	`5bbf6a4d5a75…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	A040716-001	AP	1	`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	A040716-001	AP	1	`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	A040716-001	AP	1	`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	A040716-001	AP	1	`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	A040716-001	AP	1	`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	A040716-001	AP	1	`8072bd15b7f6…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	A040716-001	AP	1	`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	A040716-001	AP	1	`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	A040716-001	AP	1	`4b0b4de00fa7…`
2019-12-13 00:20 UTC	2019-12	A040716-001	AP	1	`74a2ff9319b5…`
2022-03-09 01:35 UTC	2022-03	A040716-001	AP	1	`bb7c543d1eb4…`
2021-12-28 21:50 UTC	2021-12	A040716-001	AP	1	`782e0a99824c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	A040716-001	AP	1	`87673890dc5c…`
2021-03-12 10:30 UTC	2021-03	A040716-001	AP	1	`5aa47cf7b7d7…`
2020-12-22 03:56 UTC	2020-12	A040716-001	AP	1	`8869cabd3fbd…`
2020-11-12 02:37 UTC	2020-11	A040716-001	AP	1	`c0c555d07b60…`
2019-12-14 00:12 UTC	2019-12	A040716-001	AP	1	`3f01610625f2…`
2019-09-15 20:21 UTC	2019-09	A040716-001	AP	1	`b00525d2431f…`
2019-07-19 19:46 UTC	2019-07	A040716-001	AP	1	`ea99ee380514…`
2024-03-16 18:09 UTC · 4 captures of this ZIP	2024-03	A040716-001	AP	1	`6a51e52b5d6a…`
2024-02-18 07:12 UTC	2024-02	A040716-001	AP	1	`1c564ffb4f44…`
2023-12-20 04:57 UTC	2023-12	A040716-001	AP	1	`ea1830bbd6c7…`
2023-11-28 05:40 UTC · 2 captures of this ZIP	2023-11	A040716-001	AP	1	`a72a2bbeb626…`
2023-10-25 00:34 UTC · 2 captures of this ZIP	2023-10	A040716-001	AP	1	`9b2671bbb829…`
2023-07-15 15:27 UTC · 2 captures of this ZIP	2023-07	A040716-001	AP	1	`a67488948f0b…`
2023-06-13 01:57 UTC · 3 captures of this ZIP	2023-06	A040716-001	AP	1	`3f0d92c62455…`
2023-05-13 08:27 UTC	2023-05	A040716-001	AP	1	`053a50430f4f…`
2023-01-26 05:58 UTC	2023-01	A040716-001	AP	1	`3bdfa0b2c4d7…`
2022-11-12 20:34 UTC · 5 captures of this ZIP	2022-11	A040716-001	AP	1	`3a93d1ddd44b…`
2022-10-28 04:53 UTC	2022-10	A040716-001	AP	1	`f41ea6bd6efb…`
2022-09-29 23:25 UTC	2022-09	A040716-001	AP	1	`e64feba35796…`

Additional Listing Data#

Finished product: Yes
Brand name base: Methotrexate
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
METHOTREXATE	25 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
YL5FZ2Y5U1	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 3 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1655956	Internal RxNorm lookup
1655959	Internal RxNorm lookup
1655960	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
dd035a9f-cd40-4314-b9d8-2294b8a924e2	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
2eb9a854-4fbc-9bbe-3199-41fc1018a1f0	Product name	9	20250224
3082de91-569a-4d57-b379-acbf37f1d5c3	Product name	1	20210312
f76135bc-a210-42d9-851b-1b73cbaccdb3	Product name	1	20200511
423544b2-e325-49ee-8910-4c5dfe41906f	Product name	1	20181120
c9fd924b-0a8d-4d53-bf70-11070e24e4dd	Product name	2	20181120
ce1e7cc6-4850-4cb1-8dde-8010b2fbc359	Product name	1	20181120
eb454f54-2806-4c31-a08b-8dcb08261099	Product name	2	20181120
d9cebc09-c68d-46f5-bdcd-fd82e945cc27	Product name	1	20170705
16ba0c1e-2371-48a4-8b4c-a9a338dfe1f3	Product name	2	20160504
88514aea-9d58-4ed2-b135-9811fb14c8fb	Product name	1	20141209
0eba90a2-1cca-7e7b-28a5-85a09e2bc9a4	Product name	1	20140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	SPL version
16729-277-03	Methotrexate	1 in 1 CARTON	INJECTION	1	6
16729-277-03	Methotrexate	10 mL in 1 VIAL	INJECTION	10	6
16729-277-30	Methotrexate	1 in 1 CARTON	INJECTION	1	6
16729-277-30	Methotrexate	2 mL in 1 VIAL	INJECTION	2	6
16729-277-35	Methotrexate	40 mL in 1 VIAL	INJECTION	40	6
16729-277-35	Methotrexate	1 in 1 CARTON	INJECTION	1	6

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDC	Billing unit	Product NDC	DailyMed indexing SPL	SPL version	Effective
16729-277-03	ML - Milliliter	16729-277	d5410565-7b82-4c8e-84ea-9bd78573206a	1	2014-04-03
16729-277-30	ML - Milliliter	16729-277	7f4ded3d-08d1-45af-ac05-def9c248147a	1	2014-04-03
16729-277-35	ML - Milliliter	16729-277	80486de1-b61e-4b26-90fd-ebf539e41583	1	2014-04-03

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
METHOTREXATE	ACTIVE INGREDIENT	YL5FZ2Y5U1	METHOTREXATE INJECTION [ACCORD HEALTHCARE, INC.]	1
METHOTREXATE	ACTIVE MOIETY	YL5FZ2Y5U1	METHOTREXATE INJECTION [ACCORD HEALTHCARE, INC.]	1
HYDROCHLORIC ACID	INACTIVE INGREDIENT	QTT17582CB	METHOTREXATE INJECTION [ACCORD HEALTHCARE, INC.]	1
SODIUM CHLORIDE	INACTIVE INGREDIENT	451W47IQ8X	METHOTREXATE INJECTION [ACCORD HEALTHCARE, INC.]	1
SODIUM HYDROXIDE	INACTIVE INGREDIENT	55X04QC32I	METHOTREXATE INJECTION [ACCORD HEALTHCARE, INC.]	1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
16729-277	METHOTREXATE INJECTION [ACCORD HEALTHCARE, INC.]	6	Current NDC, Legacy NDC, 6 package rows	20250116_dd035a9f-cd40-4314-b9d8-2294b8a924e2.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Methotrexate	METHOTREXATE	Accord Healthcare, Inc.	dd035a9f-cd40-4314-b9d8-2294b8a924e2	2025-01-14	Boxed warning, Warnings, Adverse reactions	Exact identifier application applno (ANDA): 040716 application number: ANDA040716 ndc (product): 16729-277

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
YL5FZ2Y5U1	METHOTREXATE	59-05-2	METHOTREXATE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1655956	methotrexate 1 GM in 40 ML Injection	PSN	dd035a9f-cd40-4314-b9d8-2294b8a924e2	6
1655959	methotrexate 250 MG in 10 ML Injection	PSN	dd035a9f-cd40-4314-b9d8-2294b8a924e2	6
1655960	methotrexate 50 MG in 2 ML Injection	PSN	dd035a9f-cd40-4314-b9d8-2294b8a924e2	6
1655959	10 ML methotrexate 25 MG/ML Injection	SCD	dd035a9f-cd40-4314-b9d8-2294b8a924e2	6
1655960	2 ML methotrexate 25 MG/ML Injection	SCD	dd035a9f-cd40-4314-b9d8-2294b8a924e2	6
1655956	40 ML methotrexate 25 MG/ML Injection	SCD	dd035a9f-cd40-4314-b9d8-2294b8a924e2	6
1655956	methotrexate 1 GM per 40 ML Injection	SY	dd035a9f-cd40-4314-b9d8-2294b8a924e2	6
1655959	methotrexate 250 MG per 10 ML Injection	SY	dd035a9f-cd40-4314-b9d8-2294b8a924e2	6
1655960	methotrexate 50 MG per 2 ML Injection	SY	dd035a9f-cd40-4314-b9d8-2294b8a924e2	6

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
16729-277-03	16729027703	1 VIAL in 1 CARTON (16729-277-03) / 10 mL in 1 VIAL	1 vial	2014-03-07	0000-00-00	No	No	Current
16729-277-30	16729027730	1 VIAL in 1 CARTON (16729-277-30) / 2 mL in 1 VIAL	1 vial	2014-03-07	0000-00-00	No	No	Current
16729-277-35	16729027735	1 VIAL in 1 CARTON (16729-277-35) / 40 mL in 1 VIAL	1 vial	2014-03-07	0000-00-00	No	No	Current

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
Methotrexate	Accord Healthcare, Inc. \| Intas Pharmaceuticals Limited	2025-01-14	HUMAN PRESCRIPTION DRUG LABEL	6