Signature Care Nasal Decongestant

Product NDC: 21130-801
11-digit product format: 211300801
Labeler code: 21130
Product ID: 21130-801_5e43b82c-f0c4-4389-8f86-2d8c62da7231
Type: HUMAN OTC DRUG
Nonproprietary name: Oxymetazoline HCl
Dosage form: SPRAY, METERED
Route: NASAL
Labeler: Safeway
Application: M012
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2015-07-09
Substance: OXYMETAZOLINE HYDROCHLORIDE
Active strength: .05 g/100mL
Pharmacologic classes: Imidazolines [CS], Increased Sympathetic Activity [PE], Vasoconstriction [PE], Vasoconstrictor [EPC]
NDC exclude flag: No
Listing certified through: 2027-12-31
Current FDA listing: Yes

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: Signature Care Nasal Decongestant
Listing expiration: 2027-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
OXYMETAZOLINE HYDROCHLORIDE	.05 g/100mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
K89MJ0S5VY	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1000990	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
23f0a5b3-59ae-4eb3-9b7d-e6a492060337	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
e67be450-f8e4-4bc1-88bd-1259d379f55f	Product name	1	20210127
c53f3286-4062-4cf5-8355-399519c639a6	Product name	1	20170424
a993dfc5-f219-4460-bde6-30dd724d9ef0	Product name	1	20160818
9869efd7-d6dd-0665-5b67-53adbe6ef15e	Product name	1	20140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	Strength	SPL version
21130-801-10	Signature Care Nasal Decongestant	30 mL in 1 BOTTLE, PUMP	SPRAY, METERED	30		4
21130-801-10	Signature Care Nasal Decongestant	1 in 1 CARTON	SPRAY, METERED	1		4

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
OXYMETAZOLINE HYDROCHLORIDE	ACTIVE INGREDIENT	K89MJ0S5VY	SIGNATURE CARE NASAL DECONGESTANT (OXYMETAZOLINE HCL) SPRAY [SAFEWAY]	1
OXYMETAZOLINE	ACTIVE MOIETY	8VLN5B44ZY	SIGNATURE CARE NASAL DECONGESTANT (OXYMETAZOLINE HCL) SPRAY [SAFEWAY]	1
BENZYL ALCOHOL	INACTIVE INGREDIENT	LKG8494WBH	SIGNATURE CARE NASAL DECONGESTANT (OXYMETAZOLINE HCL) SPRAY [SAFEWAY]	1
CARBOXYMETHYLCELLULOSE SODIUM	INACTIVE INGREDIENT	K679OBS311	SIGNATURE CARE NASAL DECONGESTANT (OXYMETAZOLINE HCL) SPRAY [SAFEWAY]	1
CELLULOSE, MICROCRYSTALLINE	INACTIVE INGREDIENT	OP1R32D61U	SIGNATURE CARE NASAL DECONGESTANT (OXYMETAZOLINE HCL) SPRAY [SAFEWAY]	1
EDETATE DISODIUM	INACTIVE INGREDIENT	7FLD91C86K	SIGNATURE CARE NASAL DECONGESTANT (OXYMETAZOLINE HCL) SPRAY [SAFEWAY]	1
POLYETHYLENE GLYCOLS	INACTIVE INGREDIENT	3WJQ0SDW1A	SIGNATURE CARE NASAL DECONGESTANT (OXYMETAZOLINE HCL) SPRAY [SAFEWAY]	1
POVIDONES	INACTIVE INGREDIENT	FZ989GH94E	SIGNATURE CARE NASAL DECONGESTANT (OXYMETAZOLINE HCL) SPRAY [SAFEWAY]	1
SODIUM PHOSPHATE, DIBASIC	INACTIVE INGREDIENT	GR686LBA74	SIGNATURE CARE NASAL DECONGESTANT (OXYMETAZOLINE HCL) SPRAY [SAFEWAY]	1
SODIUM PHOSPHATE, MONOBASIC	INACTIVE INGREDIENT	3980JIH2SW	SIGNATURE CARE NASAL DECONGESTANT (OXYMETAZOLINE HCL) SPRAY [SAFEWAY]	1
WATER	INACTIVE INGREDIENT	059QF0KO0R	SIGNATURE CARE NASAL DECONGESTANT (OXYMETAZOLINE HCL) SPRAY [SAFEWAY]	1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
21130-801	SIGNATURE CARE NASAL DECONGESTANT (OXYMETAZOLINE HCL) SPRAY, METERED [SAFEWAY]	4	Current NDC, Legacy NDC, 2 package rows	20240906_23f0a5b3-59ae-4eb3-9b7d-e6a492060337.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 94 of 178 · 3,550 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Vapor Stick	CAMPHOR/MENTHOL	China Ningbo Shangge Cosmetics Technology Corp.	33e259d6-b065-a677-e063-6394a90ab314	2025-10-23	Warnings	Exact identifier application number: M012
Severe Nighttime Severe Daytime	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE, PHENYLEPHRINE HCL	CVS Pharmacy	1ec3fc79-4f38-439f-99be-646b82231aa5	2025-10-23	Warnings	Exact identifier application number: M012
Rycontuss	CHLORPHENIRAMINE MALEATE, DEXTROMETHORPHAN HYDROBROMIDE, PHENYLEPHRINE HYDROCHLORIDE	Dextrum Laboratories, Inc	41afb883-1158-9764-e063-6294a90a1712	2025-10-21	Warnings	Exact identifier application number: M012
Acetaminophen, Dextromethorphan HBr, Chlorpheniramine Maleate	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, CHLORPHENIRAMINE MALEATE	CVS Pharmacy, Inc	1532ee21-e114-ded7-e063-6294a90ab025	2025-10-21	Warnings	Exact identifier application number: M012
Guaifenesin and Dextromethorphan Hydrobromide	GUAIFENESIN AND DEXTROMETHORPHAN HYDROBROMIDE	Method Pharmaceuticals	1538bf63-d020-3ba2-e063-6294a90aecc5	2025-10-21	Warnings	Exact identifier application number: M012
Guaifenesin and Dextromethorphan Hydrobromide	GUAIFENESIN AND DEXTROMETHORPHAN HYDROBROMIDE	Method Pharmaceuticals	389230e5-775e-5b0d-e054-00144ff88e88	2025-10-21	Warnings	Exact identifier application number: M012
Guaifenesin	GUAIFENESIN	Method Pharmaceuticals, LLC	1539c3d4-d982-7d4e-e063-6394a90ad7d6	2025-10-21	Warnings	Exact identifier application number: M012
Guaifenesin	GUAIFENESIN	Method Pharmaceuticals, LLC	312ce620-4841-7488-e054-00144ff88e88	2025-10-21	Warnings	Exact identifier application number: M012
M-Dryl	DIPHENHYDRAMINE HYDROCHLORIDE	Method Pharmaceuticals, LLC	5a60c923-8bb7-427f-9636-08ed5474f71b	2025-10-21	Warnings	Exact identifier application number: M012
Allergy Relief	DIPHENHYDRAMINE HCL	ARMY AND AIR FORCE EXCHANGE SERVICE	97ed70a0-b692-4c12-90d6-72b3c87e554c	2025-10-21	Warnings	Exact identifier application number: M012
Daytime Cold and Flu	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, PHENYLEPHRINE HCL	United Natural Foods, Inc. dba UNFI	311e2b6b-21cb-4b4c-a78d-a0732d29602f	2025-10-21	Warnings	Exact identifier application number: M012
Daytime Nighttime Cold Flu Relief	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE, PHENYLEPHRINE HCL	United Natural Foods, Inc. dba UNFI	13910ea1-37dd-43bb-9fe8-e843f59201b7	2025-10-21	Warnings	Exact identifier application number: M012
Allergy Relief	DIPHENHYDRAMINE HCL	Amerisource Bergen	d6f185b6-8538-4eac-98da-83760c34b488	2025-10-20	Warnings	Exact identifier application number: M012
Quantum Health Bing Cherry Flavor	MENTHOL, UNSPECIFIED FORM	Quantum, Inc.	94d40c95-fa2b-42cf-b9f5-a5027d86401d	2025-10-20	Warnings	Exact identifier application number: M012
Quantum Health Meyer Lemon and Honey Flavor	MENTHOL, UNSPECIFIED FORM	Quantum, Inc.	fe780067-5a20-4d55-a108-91237cd9e5f4	2025-10-20	Warnings	Exact identifier application number: M012
OneSsip Diphenhydramine HCl 12.5 mg/ 5 mL Oral Solution (Cherry)	DIPHENHYDRAMINE HCL	MEDWISE LIFESCIENCES INC.	4157e680-37ac-eb4c-e063-6394a90a2a99	2025-10-17	Warnings	Exact identifier application number: M012
Norel AD	ACETAMINOPHEN, CHLORPHENIRAMINE MALEATE, AND PHENYLEPHRINE HCL	U.S. PHARMACEUTICAL CORPORATION	53d9ed3c-212d-4b12-ac35-8bd49382b49d	2025-10-17	Warnings	Exact identifier application number: M012
Severe Congestion, Cough, Cold and Flu Relief Maximum Strength, Nighttime	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, GUAIFENESIN, PHENYLEPHRINE HCL, TRIPROLIDINE HCL	CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED	92c570ff-139f-49ff-a7bd-8a540ecc07c7	2025-10-17	Warnings	Exact identifier application number: M012
NoHist DM	CHLORPHENIRAMINE MALEATE, DEXTROMETHORPHAN HYDROBROMIDE AND PHENYLEPHRINE HYDROCHLORIDE	Larken Laboratories, Inc.	6aafe912-28ff-442f-8e07-b3c5993ac943	2025-10-16	Warnings	Exact identifier application number: M012
Signature Care Original	OXYMETAZOLINE HYDROCHLORIDE	SAFEWAY, INC.	f7ad687b-dcaf-928c-e053-6294a90a6abe	2025-10-16	Warnings	Exact identifier application number: M012

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
K89MJ0S5VY	OXYMETAZOLINE HYDROCHLORIDE	2315-02-8	OXYMETAZOLINE HYDROCHLORIDE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1000990	oxymetazoline HCl 0.05 % Nasal Spray	PSN	23f0a5b3-59ae-4eb3-9b7d-e6a492060337	4
1000990	oxymetazoline hydrochloride 0.5 MG/ML Nasal Spray	SCD	23f0a5b3-59ae-4eb3-9b7d-e6a492060337	4
1000990	oxymetazoline hydrochloride 0.05 % Nasal Spray	SY	23f0a5b3-59ae-4eb3-9b7d-e6a492060337	4

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Marketing start	Marketing end	Sample	Exclude flag	Status
21130-801-10	21130080110	1 BOTTLE, PUMP in 1 CARTON (21130-801-10) / 30 mL in 1 BOTTLE, PUMP	2015-07-09	0000-00-00	No	No	Current