Home NDC 41226-370 HEADACHE RELIEF
Product NDC 41226-370
11-digit product format 412260370
Labeler code 41226
Product ID 41226-370_3992e879-0f22-1e3f-e063-6294a90a67f8
Type HUMAN OTC DRUG
Nonproprietary name ACETAMINOPHEN, ASPIRIN AND CAFFEINE
Dosage form TABLET, COATED
Route ORAL
Labeler Kroger Company
Application M012
Marketing category OTC MONOGRAPH DRUG
Marketing start 2021-04-10
Substance CAFFEINE; ASPIRIN; ACETAMINOPHEN
Active strength 65; 250; 250 mg/1; mg/1; mg/1
Pharmacologic classes Anti-Inflammatory Agents, Non-Steroidal [CS], Central Nervous System Stimulant [EPC], Central Nervous System Stimulation [PE], Cyclooxygenase Inhibitors [MoA], Decreased Platelet Aggregation [PE], Decreased Prostaglandin Production [PE], Methylxanthine [EPC], Nonsteroidal Anti-inflammatory Drug [EPC], Platelet Aggregation Inhibitor [EPC], Xanthines [CS]
NDC exclude flag No
Listing certified through 2026-12-31
Current FDA listing Yes Observed NDC auxiliary status history# This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.
Historic NDC status page 1 of 1 · 9 matching rows.
View current auxiliary records. · View the auxiliary file history.
Captured / source date, Dataset, Scope table Captured / source date Dataset Scope Package NDC Snapshot Source SHA-256 2025-02-02 03:52 UTC · source 2025-01-31 excluded product product 302b2466d912…e7b80fea0513…2025-02-02 03:52 UTC · source 2025-01-31 excluded package package 41226-370-42 302b2466d912…e7b80fea0513…2025-02-02 03:52 UTC · source 2025-01-31 excluded package package 41226-370-01 302b2466d912…e7b80fea0513…2025-01-20 13:05 UTC · source 2025-01-20 excluded product product ed331223b511…672a5bd82f5f…2025-01-20 13:05 UTC · source 2025-01-20 excluded package package 41226-370-42 ed331223b511…672a5bd82f5f…2025-01-20 13:05 UTC · source 2025-01-20 excluded package package 41226-370-01 ed331223b511…672a5bd82f5f…2025-01-11 03:41 UTC · source 2025-01-10 excluded product product 0efc9e666f02…f202fb6c5f17…2025-01-11 03:41 UTC · source 2025-01-10 excluded package package 41226-370-42 0efc9e666f02…f202fb6c5f17…2025-01-11 03:41 UTC · source 2025-01-10 excluded package package 41226-370-01 0efc9e666f02…f202fb6c5f17…
Reported adverse events (FAERS/openFDA)# Adverse event summaries are temporarily unavailable. Other product information remains available.
Additional Listing Data#
Finished product Yes
Brand name base HEADACHE RELIEF
Listing expiration 2026-12-31 Active Ingredients# Ingredient, Strength table Ingredient Strength CAFFEINE 65 mg/1 ASPIRIN 250 mg/1 ACETAMINOPHEN 250 mg/1
Harmonized UNII identifiers# UNII identifiers page 1 of 1 · 3 matching rows.
Identifier, FDA.report destination table Identifier FDA.report destination 3G6A5W338E Internal UNII lookup R16CO5Y76E Internal UNII lookup 362O9ITL9D Internal UNII lookup
Harmonized RxCUI identifiers# RxCUI identifiers page 1 of 1 · 1 matching rows.
Identifier, FDA.report destination table Identifier FDA.report destination 308297 Internal RxNorm lookup
Harmonized SPL set identifiers# SPL set identifiers page 1 of 1 · 1 matching rows.
DailyMed Product Concepts# FDA-Initiated Inactive NDC Indexing# DailyMed Package Descriptions# Package NDC, Product, Description table Package NDC Product Description Form Quantity Strength SPL version 41226-370-01 HEADACHE RELIEF 100 in 1 BOTTLE TABLET, COATED 100 4 41226-370-01 HEADACHE RELIEF 1 in 1 CARTON TABLET, COATED 1 4 41226-370-42 HEADACHE RELIEF 1 in 1 CARTON TABLET, COATED 1 4 41226-370-42 HEADACHE RELIEF 24 in 1 BOTTLE TABLET, COATED 24 4
DailyMed Dashboard NDC Coverage# NDC, Dashboard title, SPL version table NDC Dashboard title SPL version Validation Dashboard ZIP 41226-370 HEADACHE RELIEF (ACETAMINOPHEN, ASPIRIN AND CAFFEINE) TABLET, COATED [KROGER COMPANY] 3 Current NDC, Legacy NDC, 4 package rows 20250216_bbed29a1-3c52-3531-e053-2995a90a686c.zip
openFDA label cross-check# OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
Matched openFDA labels page 74 of 180 · 3,583 matching rows.
DailyMed RxNorm Mappings# Packages# Package NDC, 11-digit format, Description table Package NDC 11-digit format Description Units Marketing start Marketing end Sample Exclude flag Status 41226-370-01 41226037001 1 BOTTLE in 1 CARTON (41226-370-01) / 100 TABLET, COATED in 1 BOTTLE 1 bottle 2021-04-10 0000-00-00 No No Current 41226-370-42 41226037042 1 BOTTLE in 1 CARTON (41226-370-42) / 24 TABLET, COATED in 1 BOTTLE 1 bottle 2021-04-10 0000-00-00 No No Current