CLINIQUE EVEN BETTER CLINICAL SERUM FOUNDATION BROAD SPECTRUM SPF 25

Product NDC: 49527-080
11-digit product format: 495270080
Labeler code: 49527
Product ID: 49527-080_0818396d-cc21-00ac-e063-6394a90a5d82
Type: HUMAN OTC DRUG
Nonproprietary name: TITANIUM DIOXIDE, ZINC OXIDE
Dosage form: LIQUID
Route: TOPICAL
Labeler: CLINIQUE LABORATORIES LLC
Application: M020
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2020-09-24
Substance: TITANIUM DIOXIDE; ZINC OXIDE
Active strength: 24; 59 mg/mL; mg/mL
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 1 matching rows.

Dataset, Scope, Product NDC table
Dataset	Scope	Product NDC	Package NDC	Code	Status	Reporting period	Source date
excluded package	package	49527-080	49527-080-03	D	Discontinued by firm		2026-10-12

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 27 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Dataset, Scope table
Captured / source date	Dataset	Scope	Package NDC	Code	Status	Archive	Snapshot	Source SHA-256
2025-12-14 17:58 UTC · source 2025-12-05	excluded package	package	49527-080-03	D	Discontinued by firm	excluded / ndc_excluded.zip	`d630ba8d3edf…`	`732f749b63fb…`
2025-08-27 00:01 UTC · source 2025-08-26	excluded package	package	49527-080-03	D	Discontinued by firm	excluded / ndc_excluded.zip	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-04-01 02:39 UTC · source 2025-03-31	excluded package	package	49527-080-03	D	Discontinued by firm	excluded / ndc_excluded.zip	`2ef7874e63bc…`	`57b86245f4fa…`
2025-03-28 20:22 UTC · source 2025-03-28	excluded package	package	49527-080-03	D	Discontinued by firm	excluded / ndc_excluded.zip	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-22 03:12 UTC · source 2025-03-21	excluded package	package	49527-080-03	D	Discontinued by firm	excluded / ndc_excluded.zip	`cfe11265f3b6…`	`090c488252e2…`
2025-03-10 12:48 UTC · source 2025-03-10	excluded package	package	49527-080-03	D	Discontinued by firm	excluded / ndc_excluded.zip	`cdf11ea48f46…`	`ba0047e9e063…`
2025-02-27 05:24 UTC · source 2025-02-26	unfinished product	product		UNFINISHED	Active or certified unfinished drug listing	unfinished / ndc_unfinished.zip	`f268b84574a6…`	`26285f5ac5df…`
2025-02-02 03:52 UTC · source 2025-01-31	excluded package	package	49527-080-03	D	Discontinued by firm	excluded / ndc_excluded.zip	`302b2466d912…`	`e7b80fea0513…`
2025-02-01 13:13 UTC · source 2025-01-31	unfinished product	product		UNFINISHED	Active or certified unfinished drug listing	unfinished / ndc_unfinished.zip	`f764e8902f78…`	`92046438deef…`
2025-01-20 13:05 UTC · source 2025-01-20	excluded package	package	49527-080-03	D	Discontinued by firm	excluded / ndc_excluded.zip	`ed331223b511…`	`672a5bd82f5f…`
2025-01-20 13:05 UTC · source 2025-01-17	unfinished product	product		UNFINISHED	Active or certified unfinished drug listing	unfinished / ndc_unfinished.zip	`68b1e3bced9e…`	`98a755eb8bc6…`
2025-01-11 03:41 UTC · source 2025-01-10	excluded package	package	49527-080-03	D	Discontinued by firm	excluded / ndc_excluded.zip	`0efc9e666f02…`	`f202fb6c5f17…`
2024-11-29 20:42 UTC · source 2024-11-29	unfinished product	product		UNFINISHED	Active or certified unfinished drug listing	unfinished / ndc_unfinished.zip	`05c55d027831…`	`ca05dca9dc4c…`
2024-11-29 20:42 UTC · source 2024-11-29	unfinished package	package	49527-080-00	UNFINISHED	Active or certified unfinished drug listing	unfinished / ndc_unfinished.zip	`05c55d027831…`	`ca05dca9dc4c…`
2024-11-09 02:36 UTC · source 2024-11-08	unfinished product	product		UNFINISHED	Active or certified unfinished drug listing	unfinished / ndc_unfinished.zip	`48b4f40e6753…`	`c7c7a00d2afa…`
2024-11-09 02:36 UTC · source 2024-11-08	unfinished package	package	49527-080-00	UNFINISHED	Active or certified unfinished drug listing	unfinished / ndc_unfinished.zip	`48b4f40e6753…`	`c7c7a00d2afa…`
2024-11-09 02:27 UTC · source 2024-11-08	excluded package	package	49527-080-03	D	Discontinued by firm	excluded / ndc_excluded.zip	`ad56d346431e…`	`cc804d4bbf1e…`
2024-10-09 02:27 UTC · source 2024-10-08	unfinished product	product		UNFINISHED	Active or certified unfinished drug listing	unfinished / ndc_unfinished.zip	`27f29a85d7e4…`	`1372111e901f…`
2024-10-09 02:27 UTC · source 2024-10-08	unfinished package	package	49527-080-00	UNFINISHED	Active or certified unfinished drug listing	unfinished / ndc_unfinished.zip	`27f29a85d7e4…`	`1372111e901f…`
2024-10-04 04:10 UTC · source 2024-10-03	excluded package	package	49527-080-03	D	Discontinued by firm	excluded / ndc_excluded.zip	`367a005e9d99…`	`383a685ebd0f…`
2024-07-10 04:00 UTC · source 2024-07-09	unfinished product	product		UNFINISHED	Active or certified unfinished drug listing	unfinished / ndc_unfinished.zip	`8d62ce987f31…`	`9fe9ef23e30d…`
2024-07-10 04:00 UTC · source 2024-07-09	unfinished package	package	49527-080-00	UNFINISHED	Active or certified unfinished drug listing	unfinished / ndc_unfinished.zip	`8d62ce987f31…`	`9fe9ef23e30d…`
2024-07-10 04:00 UTC · source 2024-07-09	excluded package	package	49527-080-03	D	Discontinued by firm	excluded / ndc_excluded.zip	`557ba5c1ecfa…`	`9c80585c8c6e…`
2024-05-28 21:11 UTC · source 2024-05-28	unfinished product	product		UNFINISHED	Active or certified unfinished drug listing	unfinished / ndc_unfinished.zip	`d1e113ab4d42…`	`063ee3eb0a1d…`
2024-05-28 21:11 UTC · source 2024-05-28	unfinished package	package	49527-080-00	UNFINISHED	Active or certified unfinished drug listing	unfinished / ndc_unfinished.zip	`d1e113ab4d42…`	`063ee3eb0a1d…`
2024-05-15 03:51 UTC · source 2024-05-14	unfinished product	product		UNFINISHED	Active or certified unfinished drug listing	unfinished / ndc_unfinished.zip	`50b4072663b7…`	`eae3003ed65e…`
2024-05-15 03:51 UTC · source 2024-05-14	unfinished package	package	49527-080-00	UNFINISHED	Active or certified unfinished drug listing	unfinished / ndc_unfinished.zip	`50b4072663b7…`	`eae3003ed65e…`

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: CLINIQUE EVEN BETTER CLINICAL SERUM FOUNDATION BROAD SPECTRUM SPF 25
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
TITANIUM DIOXIDE	24 mg/mL
ZINC OXIDE	59 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
15FIX9V2JP	Internal UNII lookup
SOI2LOH54Z	Internal UNII lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
884abba1-891d-4c3c-b203-38a5a8a57756	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
7dea7767-9f52-b60a-5435-33cb9cc28bae	Product name	4	20250124
6338270f-96cb-0ecb-6fbb-0a9bc78001f4	Product name	7	20250116
0ca83774-3f79-b837-5d6f-c210102f3bc8	Product name	6	20250114
cb89b86a-369e-4204-8910-ae797c503af3	Product name	1	20230706
41b814f3-0166-1c53-c9ef-a0794c7daf9d	Product name	3	20221110
a590be26-846c-8659-a5a1-fb25907965dc	Product name	2	20221110
2dc76302-91c0-4c35-ad78-99adfb049c4b	Product name	1	20200603
d4880ace-a516-8c47-8dfd-73a4ba5887d7	Product name	2	20180830
7cda52fc-125f-421c-8fea-bc1974370c49	Product name	2	20180703
e6065d4b-5ae1-476f-a40e-f2851cbb5d2b	Product name	2	20180221
f212291f-05fe-9603-fc7e-bd73e38ce1e6	Product name	2	20161129
182f9ab4-4ab5-c449-200f-87ce2ce8e550	Product name	2	20151105
0ca1d589-929b-4b33-bc5b-1d84abdafa6a	Product name	1	20150324
fc363c46-397b-4476-ac0f-70e43e8e4592	Product name	1	20150324
332e86c3-7875-ca6e-f934-2206d2b31996	Product name	1	20140508
56625fcc-aa34-9d30-d0e9-1c1beb37ea21	Product name	1	20140508
7dfac40f-a405-cd2e-7c06-3059ec0e1092	Product name	1	20140508
96c2be53-8e44-452d-56a2-d255b2f1af2d	Product name	1	20140508
bf8bd5f7-495f-4022-2780-7ded7ea7ea44	Product name	1	20140508
d223c173-c39b-d764-47d4-d671d3088815	Product name	1	20140508
e01133ad-4dcd-c7f3-454b-2ff569ee160a	Product name	1	20140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	SPL version
49527-080-01	CLINIQUE EVEN BETTER CLINICAL SERUM FOUNDATION BROAD SPECTRUM SPF 25	30 mL in 1 BOTTLE	LIQUID	30	13
49527-080-01	CLINIQUE EVEN BETTER CLINICAL SERUM FOUNDATION BROAD SPECTRUM SPF 25	1 in 1 CARTON	LIQUID	1	13
49527-080-02	CLINIQUE EVEN BETTER CLINICAL SERUM FOUNDATION BROAD SPECTRUM SPF 25	1 in 1 CARTON	LIQUID	1	13
49527-080-02	CLINIQUE EVEN BETTER CLINICAL SERUM FOUNDATION BROAD SPECTRUM SPF 25	5 mL in 1 TUBE	LIQUID	5	13
49527-080-03	CLINIQUE EVEN BETTER CLINICAL SERUM FOUNDATION BROAD SPECTRUM SPF 25	0.2 mL in 1 PACKET	LIQUID	0.2	13

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
49527-080	CLINIQUE EVEN BETTER CLINICAL SERUM FOUNDATION BROAD SPECTRUM SPF 25 (TITANIUM DIOXIDE, ZINC OXIDE) LIQUID [CLINIQUE LABORATORIES LLC]	13	Current NDC, Legacy NDC, 5 package rows	20231020_884abba1-891d-4c3c-b203-38a5a8a57756.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 48 of 357 · 7,139 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Simple Mineral Sunscreen SPF 50	ZINC OXIDE	Simple Sunscreen LLC	c38cb4fa-8b8d-4c2d-9c32-301e120db1a1	2026-04-06	Warnings	Exact identifier application number: M020
Badger SPF 50 Adventure Sport Mineral Sunscreen Cream	ZINC OXIDE	W.S. Badger Company, Inc.	2a96c423-f4ad-0f07-e063-6394a90a39f8	2026-04-06	Warnings	Exact identifier application number: M020
Sheer Touch Sunscreen SPF 55	AVOBENZONE, HOMOSALATE, OCTISALATE	Amazon.com Services LLC	03fce792-bcbb-4848-bc87-8913ecbe0786	2026-04-06	Warnings, Adverse reactions	Exact identifier application number: M020
Sport Sunscreen SPF 30	AVOBENZONE, HOMOSALATE, OCTISALATE	Amazon.com Services LLC	8937705d-b745-4b8c-bf9b-89e64a1e52b1	2026-04-06	Warnings, Adverse reactions	Exact identifier application number: M020
Avebonzone, Homosalate, Octisalate	AVEBONZONE, HOMOSALATE, OCTISALATE	Amazon.com Services LLC	4ab6773f-00e1-897a-e063-6294a90ab0b8	2026-04-06	Warnings, Adverse reactions	Exact identifier application number: M020
Principal Secret Revolutionary Anti-Aging Broad Spectrum SPF 15	AVOBENZONE, OCTINOXATE, OCTISALATE, AND OCTOCRYLENE	Guthy-Renker LLC	eb1a9b67-b9e2-41f8-bc6d-df94b6a33ab8	2026-04-06	Warnings	Exact identifier application number: M020
TIRTIR HYDRO UV SHIELD SUNSCREEN SPF50 BROAD SPECTRUM	HOMOSALATE, AVOBENZONE, OCTISALATE, OCTOCRYLENE	TIRTIR USA Inc.	4ec04105-e54f-a82e-e063-6394a90a6c5a	2026-04-05	Warnings	Exact identifier application number: M020
PRVWORA Ultra Defense Sunscreen	AVOBENZONE, OCTINOXATE, OCTISALATE, OCTOCRYLENE	Cellarkbio Inc.	50cf1d88-3e7e-47b7-816a-3d579bde0a6a	2026-04-04	Warnings	Exact identifier application number: M020
EltaMD UV Shield SPF45	ZINC OXIDE AND OCTINOXATE SUNSCREEN	CP Skin Health Group, Inc.	7c49f971-d425-4be9-a665-5cd218b7f945	2026-04-03	Warnings	Exact identifier application number: M020
Jack Black	AVOBENZONE/HOMOSALATE/OCTISALATE/PETROLATUM	Jack Black L.L.C.	4baade5c-e759-d98f-e063-6394a90aa056	2026-04-03	Warnings	Exact identifier application number: M020
Vacation SPF 30 ClassicSpray	AVOBENZONE, OCTISALATE, OCTOCRYLENE	Vacation Inc.	da43d71d-733b-5700-e053-2a95a90a5dca	2026-04-03	Warnings	Exact identifier application number: M020
Warriors Crown Sentinel Zinc Defense Sunscreen SPF 30	ZINC OXIDE	Allure Labs	4e93e64a-97ab-e0a5-e063-6294a90ad950	2026-04-03	Warnings	Exact identifier application number: M020
Pro-Collagen Marine Broad Spectrum SPF 30	AVOBENZONE, OCTINOXATE, AND OCTOCRYLENE	ELEMIS Limited	3321281e-612b-4305-bf6d-bfab02c65ffb	2026-04-03	Warnings	Exact identifier application number: M020
EltaMD Skincare UV AOX Elements SPF50 Tinted	TITANIUM DIOXIDE, ZINC OXIDE SUNSCREEN	CP Skin Health Group, Inc	2c74209d-9b88-4c32-ad42-cd6de16c1fef	2026-04-03	Warnings	Exact identifier application number: M020
EltaMD UV Restore Tinted	TITANIUM DIOXIDE AND ZINC OXIDE SUNSCREEN	CP Skin Health Group, Inc	4fc18856-01b3-43ed-9e1b-b4394e31aa3c	2026-04-03	Warnings	Exact identifier application number: M020
Sunscreen for baby SPF50plus	OCTOCRYLENE,ETHYLHEXYL METHOXYCINNAMATE,TITANIUM DIOXIDE,ETHYLHEXYL SALICYLATE	Guangzhou Senmai Biotechnology Co., Ltd.	1cb7fbca-0874-ae53-e063-6294a90ab42a	2026-04-02	Warnings	Exact identifier application number: M020
TiZO3	TITANIUM DIOXIDE, ZINC OXIDE	Fallien Cosmeceuticals, LTD	4e7bdec2-abcc-0267-e063-6394a90ae47a	2026-04-02	Warnings	Exact identifier application number: M020
TIZO PHOTOCEUTICAL AM REPLENISH - TINTED	ZINC OXIDE	Fallien Cosmeceuticals, LTD	4e7c4702-5707-6c3e-e063-6394a90a05fd	2026-04-02	Warnings	Exact identifier application number: M020
Ilia Sun Serum Mineral Sunscreen SPF 50 Light Medium	ZINC OXIDE	Ilia, Inc.	4e7cc73c-d6c9-ecb0-e063-6394a90a922c	2026-04-02	Warnings	Exact identifier application number: M020
EltaMD UV Restore	TITANIUM DIOXIDE, ZINC OXIDE SUNSCREEN	CP Skin Health Group, Inc	17b47994-82d6-4f9d-8249-bdb55106c9b3	2026-04-02	Warnings	Exact identifier application number: M020

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
15FIX9V2JP	TITANIUM DIOXIDE	13463-67-7	TITANIUM DIOXIDE
SOI2LOH54Z	ZINC OXIDE	1314-13-2	ZINC OXIDE

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
49527-080-01	49527008001	1 BOTTLE in 1 CARTON (49527-080-01) / 30 mL in 1 BOTTLE	1 bottle	2020-09-24	0000-00-00	No	No	Current
49527-080-02	49527008002	1 TUBE in 1 CARTON (49527-080-02) / 5 mL in 1 TUBE	1 tube	2022-06-06	0000-00-00	No	No	Current
49527-080-03	49527008003	.2 mL in 1 PACKET (49527-080-03)		2022-11-30	0000-00-00	Yes	No	Current

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
CLINIQUE EVEN BETTER CLINICAL SERUM FOUNDATION BROAD SPECTRUM SPF 25	CLINIQUE LABORATORIES LLC \| Estee Lauder Companies Inc. \| Estee Lauder Cosmetics Ltd.	2023-10-19	HUMAN OTC DRUG LABEL	13