Climara Pro

Product NDC: 50419-491
11-digit product format: 504190491
Labeler code: 50419
Product ID: 50419-491_9f4e7765-d4e7-4f36-9530-8b4444587214
Type: HUMAN PRESCRIPTION DRUG
Nonproprietary name: Estradiol and Levonorgestrel
Dosage form: PATCH
Route: TRANSDERMAL
Labeler: Bayer HealthCare Pharmaceuticals Inc.
Application: NDA021258
Marketing category: NDA
Marketing start: 2003-11-21
Substance: ESTRADIOL; LEVONORGESTREL
Active strength: .045; .015 mg/d; mg/d
Pharmacologic classes: Estradiol Congeners [CS], Estrogen Receptor Agonists [MoA], Estrogen [EPC], Inhibit Ovum Fertilization [PE], Progesterone Congeners [CS], Progesterone Congeners [CS], Progestin [EPC], Progestin-containing Intrauterine System [EPC]
NDC exclude flag: No
Listing certified through: 2027-12-31
Current FDA listing: Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-product	Trade name	Ingredient	Strength	Dosage form / route	TE codes	RLD / RS	Approval date
N021258-001	CLIMARA PRO	ESTRADIOL; LEVONORGESTREL	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL		RLD, RS	2003-11-21

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Trade name	Strength	Dosage form / route	RLD / RS	Approval date	Source SHA-256
2026-02-19 14:30 UTC	2026-02	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`5bbf6a4d5a75…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`8072bd15b7f6…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`4b0b4de00fa7…`
2019-12-13 00:20 UTC	2019-12	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`74a2ff9319b5…`
2022-03-09 01:35 UTC	2022-03	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`bb7c543d1eb4…`
2021-12-28 21:50 UTC	2021-12	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`782e0a99824c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`87673890dc5c…`
2021-03-12 10:30 UTC	2021-03	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`5aa47cf7b7d7…`
2020-12-22 03:56 UTC	2020-12	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`8869cabd3fbd…`
2020-11-12 02:37 UTC	2020-11	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`c0c555d07b60…`
2019-12-14 00:12 UTC	2019-12	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`3f01610625f2…`
2019-09-15 20:21 UTC	2019-09	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`b00525d2431f…`
2019-07-19 19:46 UTC	2019-07	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`ea99ee380514…`
2024-03-16 18:09 UTC · 4 captures of this ZIP	2024-03	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`6a51e52b5d6a…`
2024-02-18 07:12 UTC	2024-02	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`1c564ffb4f44…`
2023-12-20 04:57 UTC	2023-12	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`ea1830bbd6c7…`
2023-11-28 05:40 UTC · 2 captures of this ZIP	2023-11	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`a72a2bbeb626…`
2023-10-25 00:34 UTC · 2 captures of this ZIP	2023-10	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`9b2671bbb829…`
2023-07-15 15:27 UTC · 2 captures of this ZIP	2023-07	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`a67488948f0b…`
2023-06-13 01:57 UTC · 3 captures of this ZIP	2023-06	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`3f0d92c62455…`
2023-05-13 08:27 UTC	2023-05	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`053a50430f4f…`
2023-01-26 05:58 UTC	2023-01	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`3bdfa0b2c4d7…`
2022-11-12 20:34 UTC · 5 captures of this ZIP	2022-11	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`3a93d1ddd44b…`
2022-10-28 04:53 UTC	2022-10	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`f41ea6bd6efb…`
2022-09-29 23:25 UTC	2022-09	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`e64feba35796…`
2022-07-09 03:26 UTC · 3 captures of this ZIP	2022-07	N021258-001	CLIMARA PRO	0.045MG/24HR;0.015MG/24HR	FILM, EXTENDED RELEASE / TRANSDERMAL	RLD, RS	2003-11-21	`cb3db0bc1861…`

Additional Listing Data#

Finished product: Yes
Brand name base: Climara Pro
Listing expiration: 2027-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
ESTRADIOL	.045 mg/d
LEVONORGESTREL	.015 mg/d

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
4TI98Z838E	Internal UNII lookup
5W7SIA7YZW	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
402250	Internal RxNorm lookup
402252	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
184d3092-7fc6-4375-816b-1ab06bb99cfd	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
5bec24fd-caeb-8b32-1ff0-ca0dd1751379	Product name	2	20250618
3fcaf367-cbc2-4d1e-845e-e1ce4b0d86a6	Product name	2	20250616
4ca088c7-0c0e-114d-ffaa-d1b94f9eadc1	Product name	6	20250311
99d68ea7-fba4-0d7b-b5fa-468e21dd1cbf	Product name	2	20250204
8511fc19-172b-4e1f-90ec-2f09c85b16de	Product name	2	20250116
a1c50ef5-9c2c-d846-1ca1-70fabf2428e1	Product name	3	20240507
66263a7f-f64d-41c4-90f1-2cee106617cc	Product name	1	20240501
a0f93f28-4e91-4bb1-8dcb-5456fd4bfc50	Product name	3	20230718
76820076-f087-4073-b1d1-aa04b361335e	Product name	2	20220921
132e7bcf-ca42-94e4-3c78-c44ae7819a94	Product name	3	20220126
fa479cfe-0bd0-7366-d57a-92f3682e87c5	Product name	3	20210518
0a040ba8-1f34-4328-bb07-4f64503daaab	Product name	2	20210513
20e1a411-dba8-4afa-b9f9-1205d5b0bde9	Product name	3	20210513
833edb59-a012-45c2-aff5-2ed74b66fa59	Product name	1	20201207
5956a0e2-c373-452c-bdcf-c93d354432ef	Product name	1	20200714
ca306105-d51c-4821-9ec1-8eec753d073d	Product name	1	20200619
f4d31098-441e-52d3-27f1-49c829f8a3a1	Product name	5	20190703
d2c4820a-bb24-f61d-8cd0-dd0290a6bd4d	Product name	7	20190612
001f367b-fa14-49a0-865b-b395f2553601	Product name	2	20190611
f92411e4-13dd-7baf-106e-9b3fcf758c39	Product name	4	20190502
f713a022-3e1c-4035-bc91-62131bc80b42	Product name	2	20190125
3f090665-4687-4bb4-8790-8efb1930ee74	Product name	1	20180801
79d5025d-8129-440a-b861-6df2d2661609	Product name	3	20180607
d871c48c-6b0b-4203-b55d-72ead21ea7ad	Product name	5	20180419
12434b90-2738-45d5-9e1b-55001e853273	Product name	2	20171122
741e98f2-ac6c-4d80-9ca8-c663c171ba1d	Product name	1	20161121
7a549f52-8b99-472c-8b1d-3a70c53c9bf4	Product name	1	20160623
cc765024-f257-4c67-b780-c356aadd6980	Product name	3	20150902
3ca8d96e-517a-05ea-5690-f8e1d3726540	Product name	1	20140508
5a9b579b-8431-5b3a-2ba4-86556704f873	Product name	1	20140508
5f44c957-835a-ada0-662f-5b1071b7a68b	Product name	1	20140508
7d6c8f26-fe65-2465-c993-66dd6e1c1183	Product name	1	20140508
83cac4be-cfee-33c1-5b8e-bb83ae18bce4	Product name	1	20140508
c3f7be78-e6d7-47c9-c840-70c566e8d5c4	Product name	1	20140508
d03a75af-b11b-673b-268b-318050d0b3bd	Product name	1	20140508
d0cc7d42-77a7-b452-c6c3-a162fa11225f	Product name	1	20140508
d6b36b6b-65d6-a810-0fa7-61ddf1a96352	Product name	1	20140508
e5ccd419-1745-560a-1e25-c6e3941c710a	Product name	1	20140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	SPL version
50419-491-04	Climara Pro	7 d in 1 PATCH	PATCH	7	27
50419-491-04	Climara Pro	4 in 1 CARTON	PATCH	4	27
50419-491-73	Climara Pro	7 d in 1 PATCH	PATCH	7	27
50419-491-73	Climara Pro	1 in 1 CARTON	PATCH	1	27

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDC	Billing unit	Product NDC	DailyMed indexing SPL	SPL version	Effective
50419-491-04	EA - Each	50419-491	c130464b-016b-40c7-8a63-69cebbb5ee5a	1	2012-07-24

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	DailyMed label	SPL version
ESTRADIOL	ACTIVE INGREDIENT	4TI98Z838E	CLIMARA PRO (ESTRADIOL AND LEVONORGESTREL) PATCH [BAYER HEALTHCARE PHARMACEUTICALS INC.]	7
LEVONORGESTREL	ACTIVE INGREDIENT	5W7SIA7YZW	CLIMARA PRO (ESTRADIOL AND LEVONORGESTREL) PATCH [BAYER HEALTHCARE PHARMACEUTICALS INC.]	7
ESTRADIOL	ACTIVE MOIETY	4TI98Z838E	CLIMARA PRO (ESTRADIOL AND LEVONORGESTREL) PATCH [BAYER HEALTHCARE PHARMACEUTICALS INC.]	7
LEVONORGESTREL	ACTIVE MOIETY	5W7SIA7YZW	CLIMARA PRO (ESTRADIOL AND LEVONORGESTREL) PATCH [BAYER HEALTHCARE PHARMACEUTICALS INC.]	7
ESTRADIOL	ACTIVE INGREDIENT	4TI98Z838E	CLIMARA PRO (ESTRADIOL AND LEVONORGESTREL) PATCH [PHYSICIANS TOTAL CARE, INC.]	1
LEVONORGESTREL	ACTIVE INGREDIENT	5W7SIA7YZW	CLIMARA PRO (ESTRADIOL AND LEVONORGESTREL) PATCH [PHYSICIANS TOTAL CARE, INC.]	1
ESTRADIOL	ACTIVE MOIETY	4TI98Z838E	CLIMARA PRO (ESTRADIOL AND LEVONORGESTREL) PATCH [PHYSICIANS TOTAL CARE, INC.]	1
LEVONORGESTREL	ACTIVE MOIETY	5W7SIA7YZW	CLIMARA PRO (ESTRADIOL AND LEVONORGESTREL) PATCH [PHYSICIANS TOTAL CARE, INC.]	1
POVIDONE	INACTIVE INGREDIENT	FZ989GH94E	CLIMARA PRO (ESTRADIOL AND LEVONORGESTREL) PATCH [PHYSICIANS TOTAL CARE, INC.]	1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
50419-491	CLIMARA PRO (ESTRADIOL AND LEVONORGESTREL) PATCH [BAYER HEALTHCARE PHARMACEUTICALS INC.]	19	Current NDC, Legacy NDC, 4 package rows	20241115_184d3092-7fc6-4375-816b-1ab06bb99cfd.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Climara Pro	ESTRADIOL AND LEVONORGESTREL	Bayer HealthCare Pharmaceuticals Inc.	184d3092-7fc6-4375-816b-1ab06bb99cfd	2026-03-26	Boxed warning, Warnings, Adverse reactions	Exact identifier application applno (NDA): 021258 application number: NDA021258 ndc (product): 50419-491

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
4TI98Z838E	ESTRADIOL	50-28-2	ESTRADIOL
5W7SIA7YZW	LEVONORGESTREL	797-63-7	LEVONORGESTREL

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
402252	Climara Pro 0.045/0.015 MG/Day Weekly Transdermal System	PSN	184d3092-7fc6-4375-816b-1ab06bb99cfd	27
402250	estradiol 0.045 MG / levonorgestrel 0.015 MG/Day Weekly Transdermal System	PSN	184d3092-7fc6-4375-816b-1ab06bb99cfd	27
402252	168 HR estradiol 0.00188 MG/HR / levonorgestrel 0.000625 MG/HR Transdermal System [Climara Pro]	SBD	184d3092-7fc6-4375-816b-1ab06bb99cfd	27
402250	168 HR estradiol 0.00188 MG/HR / levonorgestrel 0.000625 MG/HR Transdermal System	SCD	184d3092-7fc6-4375-816b-1ab06bb99cfd	27
402252	Climara Pro (estradiol 0.045 MG / levonorgestrel 0.015 MG) per 24HR Weekly Transdermal Patch	SY	184d3092-7fc6-4375-816b-1ab06bb99cfd	27
402252	Climara Pro 0.045/0.015 MG/Day Weekly Transdermal System	SY	184d3092-7fc6-4375-816b-1ab06bb99cfd	27
402250	estradiol 0.00188 MG / levonorgestrel 0.000625 MG/HR Weekly Transdermal Patch	SY	184d3092-7fc6-4375-816b-1ab06bb99cfd	27
402250	estradiol 0.045 MG / levonorgestrel 0.015 MG/Day Weekly Transdermal System	SY	184d3092-7fc6-4375-816b-1ab06bb99cfd	27
402250	estradiol 45 MCG / levonorgestrel 15 MCG/Day Weekly Transdermal Patch	SY	184d3092-7fc6-4375-816b-1ab06bb99cfd	27
402252	Climara Pro 0.045/0.015 MG/Day Weekly Transdermal System	PSN	eabc0fb3-da2a-482f-83a7-99b1e823a150	1
402250	estradiol 0.045 MG / levonorgestrel 0.015 MG/Day Weekly Transdermal System	PSN	eabc0fb3-da2a-482f-83a7-99b1e823a150	1
402252	168 HR estradiol 0.00188 MG/HR / levonorgestrel 0.000625 MG/HR Transdermal System [Climara Pro]	SBD	eabc0fb3-da2a-482f-83a7-99b1e823a150	1
402250	168 HR estradiol 0.00188 MG/HR / levonorgestrel 0.000625 MG/HR Transdermal System	SCD	eabc0fb3-da2a-482f-83a7-99b1e823a150	1
402252	Climara Pro (estradiol 0.045 MG / levonorgestrel 0.015 MG) per 24HR Weekly Transdermal Patch	SY	eabc0fb3-da2a-482f-83a7-99b1e823a150	1
402252	Climara Pro 0.045/0.015 MG/Day Weekly Transdermal System	SY	eabc0fb3-da2a-482f-83a7-99b1e823a150	1
402250	estradiol 0.00188 MG / levonorgestrel 0.000625 MG/HR Weekly Transdermal Patch	SY	eabc0fb3-da2a-482f-83a7-99b1e823a150	1
402250	estradiol 0.045 MG / levonorgestrel 0.015 MG/Day Weekly Transdermal System	SY	eabc0fb3-da2a-482f-83a7-99b1e823a150	1
402250	estradiol 45 MCG / levonorgestrel 15 MCG/Day Weekly Transdermal Patch	SY	eabc0fb3-da2a-482f-83a7-99b1e823a150	1

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
50419-491-04	50419049104	4 PATCH in 1 CARTON (50419-491-04) / 7 d in 1 PATCH	4 patch	2013-11-21	0000-00-00	No	No	Current
50419-491-73	50419049173	1 PATCH in 1 CARTON (50419-491-73) / 7 d in 1 PATCH	1 patch	2017-04-12	0000-00-00	No	No	Current

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
Climara Pro - Bayer HealthCare Pharmaceuticals Inc. \| Kindeva Drug Delivery L.P. \| Sixarp, LLC	Bayer HealthCare Pharmaceuticals Inc. \| Kindeva Drug Delivery L.P. \| Sixarp, LLC	2026-03-26	HUMAN PRESCRIPTION DRUG LABEL	27
Climara Pro	Physicians Total Care, Inc.	2009-06-03	HUMAN PRESCRIPTION DRUG LABEL	1