FDA.reportPublic FDA data

ESTRADIOL

Substance profile for UNII 4TI98Z838E, enriched with FDA NDC listings, DailyMed labels, legacy aliases, and open chemistry identifiers.

Chemical structure for ESTRADIOL
Structure render from PubChem CID 5757

Substance Identity#

UNII
4TI98Z838E
Preferred term
ESTRADIOL
Registry number
50-28-2
EC number
200-023-8
Ingredient type
INGREDIENT SUBSTANCE
Molecular formula
C18H24O2
Chemical structure for ESTRADIOL
Structure render from PubChem CID 5757

Chemical And Database Identifiers#

InChIKey
VOXZDWNPVJITMN-ZBRFXRBCSA-N
SMILES
C[C@]12CC[C@H]3[C@@H](CCC4=CC(O)=CC=C34)[C@@H]1CC[C@@H]2O
RxCUI
4083
PubChem
5757
NCIt
C478
INN ID
406

Open Chemistry Sources#

Source, Identifier, Link table
SourceIdentifierLink
PubChem Compound5757pubchem.ncbi.nlm.nih.gov/compound/5757
PubChem InChIKey SearchVOXZDWNPVJITMN-ZBRFXRBCSA-Npubchem.ncbi.nlm.nih.gov/#query=VOXZDWNPVJITMN-ZBRFXRBCSA-N
RxNorm4083mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=4083
NCI ThesaurusC478ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C478
FDA Substance Registration System4TI98Z838Eprecision.fda.gov/uniisearch/srs/unii/4TI98Z838E
European Community number200-023-8commonchemistry.cas.org/results?q=200-023-8

DailyMed Socrata Ingredients#

Type, DailyMed label, SPL version table
TypeDailyMed labelSPL version
ACTIVE INGREDIENTESTRADIOL1
ACTIVE MOIETYESTRADIOL1
ACTIVE INGREDIENTEstradiol Tablets USP1
ACTIVE MOIETYEstradiol Tablets USP1
ACTIVE MOIETYEstradiol Tablets USP1000
ACTIVE INGREDIENTEstradiol Tablets USP1000
ACTIVE INGREDIENTEstradiol Tablets USP3
ACTIVE MOIETYEstradiol Tablets USP3
ACTIVE INGREDIENTThese highlights do not include all the information needed to use EVAMIST safely and effectively. See full prescribing information for EVAMIST. EVAMIST (estradiol transdermal spray) Initial U.S. Approval: 197512
ACTIVE MOIETYThese highlights do not include all the information needed to use EVAMIST safely and effectively. See full prescribing information for EVAMIST. EVAMIST (estradiol transdermal spray) Initial U.S. Approval: 197512
ACTIVE MOIETYESTRADIOL TABLETS, USP1
ACTIVE INGREDIENTESTRADIOL TABLETS, USP1
ACTIVE MOIETY0e8341f1-8089-46ff-b142-1fb04209029d1
ACTIVE INGREDIENT0e8341f1-8089-46ff-b142-1fb04209029d1
ACTIVE INGREDIENTEstradiol/Norethindrone Acetate Tablets1
ACTIVE MOIETYEstradiol/Norethindrone Acetate Tablets1
ACTIVE MOIETYZovia 1/35E-28 Zovia 1/50E-28 (Ethynodiol Diacetate and Ethinyl Estradiol Tablets USP) Revised: August 2006 Rx only1
ACTIVE INGREDIENTThese highlights do not include all the information needed to use Vagifem safely and effectively. See full prescribing information for Vagifem. Vagifem ® (estradiol vaginal tablets) Initial U.S. Approval: 19992
ACTIVE MOIETYThese highlights do not include all the information needed to use Vagifem safely and effectively. See full prescribing information for Vagifem. Vagifem ® (estradiol vaginal tablets) Initial U.S. Approval: 19992
ACTIVE INGREDIENTVivelle-Dot1
ACTIVE MOIETYVivelle-Dot1
ACTIVE MOIETY7abf2fff-f612-4842-9d1d-375af93f42591
ACTIVE INGREDIENTProBLEN Estrogen and Progesterone1
ACTIVE MOIETYProBLEN Estrogen and Progesterone1
ACTIVE INGREDIENTProBLEN Estrogen & Progesterone1
ACTIVE MOIETYProBLEN Estrogen & Progesterone1
ACTIVE INGREDIENTESTRADIOL TABLETS, USP1
ACTIVE MOIETYESTRADIOL TABLETS, USP1
ACTIVE MOIETYThese highlights do not include all the information needed to use Evamist safely and effectively. See full prescribing information for Evamist. Evamist (estradiol transdermal spray) Initial U.S. Approval: 19751
ACTIVE INGREDIENTThese highlights do not include all the information needed to use Evamist safely and effectively. See full prescribing information for Evamist. Evamist (estradiol transdermal spray) Initial U.S. Approval: 19751
ACTIVE INGREDIENT37f3094c-f02d-4a9c-8e30-2c4752bc62ed2
ACTIVE MOIETY37f3094c-f02d-4a9c-8e30-2c4752bc62ed2
ACTIVE MOIETY86b90d68-bfb6-47f6-aa5b-a6642391ff131
ACTIVE MOIETY396686ba-ab8d-4223-80e7-9c4f7ddb78522
ACTIVE INGREDIENT396686ba-ab8d-4223-80e7-9c4f7ddb78522
ACTIVE MOIETYEstradiol (Estradiol) tablet2
ACTIVE INGREDIENTEstradiol (Estradiol) tablet2
ACTIVE MOIETYESTRING ® (estradiol vaginal ring)1
ACTIVE INGREDIENTESTRING ® (estradiol vaginal ring)1
ACTIVE INGREDIENTDivigel ® (estradiol gel) 0.1%2
ACTIVE MOIETYDivigel ® (estradiol gel) 0.1%2
ACTIVE INGREDIENTClimara Pro1
ACTIVE MOIETYClimara Pro1
ACTIVE MOIETYANGELIQ TABLETS (Drospirenone and Estradiol) 0.5 mg/1 mg1
ACTIVE INGREDIENTANGELIQ TABLETS (Drospirenone and Estradiol) 0.5 mg/1 mg1
ACTIVE MOIETYCESIA ® (desogestrel/ethinyl estradiol) Tablets1
ACTIVE INGREDIENTESTRADIOL TABLET [LAKE ERIE MEDICAL & SURGICAL SUPPLY DBA QUALITY CARE PRODUCTS LLC]3657
ACTIVE MOIETYESTRADIOL TABLET [LAKE ERIE MEDICAL & SURGICAL SUPPLY DBA QUALITY CARE PRODUCTS LLC]3657
ACTIVE INGREDIENTESTRADIOL TABLET [BRYANT RANCH PREPACK]1002
ACTIVE MOIETYESTRADIOL TABLET [BRYANT RANCH PREPACK]1002
ACTIVE MOIETYESTRADIOL TABLET [BRYANT RANCH PREPACK]1002
ACTIVE INGREDIENTESTRADIOL TABLET [BRYANT RANCH PREPACK]1002
ACTIVE INGREDIENTESTRADIOL TABLET [BRYANT RANCH PREPACK]1000
ACTIVE MOIETYESTRADIOL TABLET [BRYANT RANCH PREPACK]1000
ACTIVE MOIETYESTROGEL (ESTRADIOL) GEL, METERED [ASCEND THERAPEUTICS US, LLC]26
ACTIVE INGREDIENTESTROGEL (ESTRADIOL) GEL, METERED [ASCEND THERAPEUTICS US, LLC]26
ACTIVE MOIETYESTRING (ESTRADIOL) RING [PHARMACIA AND UPJOHN COMPANY]11
ACTIVE INGREDIENTESTRING (ESTRADIOL) RING [PHARMACIA AND UPJOHN COMPANY]11
ACTIVE MOIETYACTIVELLA (ESTRADIOL AND NORETHINDRONE ACETATE) TABLET, FILM COATED [NOVO NORDISK]10
ACTIVE INGREDIENTACTIVELLA (ESTRADIOL AND NORETHINDRONE ACETATE) TABLET, FILM COATED [NOVO NORDISK]10
ACTIVE MOIETYVAGIFEM (ESTRADIOL) TABLET, FILM COATED [NOVO NORDISK]10
ACTIVE INGREDIENTVAGIFEM (ESTRADIOL) TABLET, FILM COATED [NOVO NORDISK]10
ACTIVE MOIETYESTRADIOL PATCH [MYLAN PHARMACEUTICALS INC.]9
ACTIVE INGREDIENTESTRADIOL PATCH [MYLAN PHARMACEUTICALS INC.]9
ACTIVE MOIETYNATAZIA (ESTRADIOL VALERATE AND ESTRADIOL VALERATE/DIENOGEST) KIT [BAYER HEALTHCARE PHARMACEUTICALS INC.]9
ACTIVE MOIETYCLIMARA (ESTRADIOL) PATCH [BAYER HEALTHCARE PHARMACEUTICALS INC.]8
ACTIVE INGREDIENTCLIMARA (ESTRADIOL) PATCH [BAYER HEALTHCARE PHARMACEUTICALS INC.]8
ACTIVE MOIETYDELESTROGEN (ESTRADIOL VALERATE) INJECTION [PAR PHARMACEUTICAL INC.]8
ACTIVE INGREDIENTALORA (ESTRADIOL TRANSDERMAL SYSTEM) PATCH [ACTAVIS PHARMA, INC.]7
ACTIVE MOIETYALORA (ESTRADIOL TRANSDERMAL SYSTEM) PATCH [ACTAVIS PHARMA, INC.]7
ACTIVE MOIETYANGELIQ (DROSPIRENONE AND ESTRADIOL) TABLET, FILM COATED [BAYER HEALTHCARE PHARMACEUTICALS INC.]7
ACTIVE INGREDIENTANGELIQ (DROSPIRENONE AND ESTRADIOL) TABLET, FILM COATED [BAYER HEALTHCARE PHARMACEUTICALS INC.]7
ACTIVE MOIETYCLIMARA PRO (ESTRADIOL AND LEVONORGESTREL) PATCH [BAYER HEALTHCARE PHARMACEUTICALS INC.]7
ACTIVE INGREDIENTCLIMARA PRO (ESTRADIOL AND LEVONORGESTREL) PATCH [BAYER HEALTHCARE PHARMACEUTICALS INC.]7
ACTIVE INGREDIENTDIVIGEL (ESTRADIOL) GEL [UPSHER-SMITH LABORATORIES, INC.]7
ACTIVE MOIETYDIVIGEL (ESTRADIOL) GEL [UPSHER-SMITH LABORATORIES, INC.]7
ACTIVE MOIETYFEMRING (ESTRADIOL ACETATE) RING [WARNER CHILCOTT (US), LLC]7
ACTIVE INGREDIENTCOMBIPATCH (ESTRADIOL AND NORETHINDRONE ACETATE) PATCH, EXTENDED RELEASE [NOVARTIS PHARMACEUTICALS CORPORATION]6
ACTIVE MOIETYCOMBIPATCH (ESTRADIOL AND NORETHINDRONE ACETATE) PATCH, EXTENDED RELEASE [NOVARTIS PHARMACEUTICALS CORPORATION]6
ACTIVE MOIETYELESTRIN (ESTRADIOL) GEL [JAZZ PHARMACEUTICALS COMMERCIAL CORP.]6
ACTIVE INGREDIENTELESTRIN (ESTRADIOL) GEL [JAZZ PHARMACEUTICALS COMMERCIAL CORP.]6
ACTIVE MOIETYESTRACE (ESTRADIOL) CREAM [WARNER CHILCOTT (US), LLC]6
ACTIVE INGREDIENTESTRACE (ESTRADIOL) CREAM [WARNER CHILCOTT (US), LLC]6
ACTIVE MOIETYHGH VITALITY (AGNUS CASTUS, AMBRA GRISEA, CONIUM MACULATUM, APIOLUM, ESTRADIOL, ESTRIOL, FOLLICULINUM, L-DOPA, MELATONIN, TESTOSTERONE, ALPHA-LIPOICUM ACIDUM, ADENOSINUM TRIPHOSPHORICUM DINATRUM, COENZYME A, UBIDECARENONUM, NADIDUM, SARCOLACTICUM ACIDUM, BARYTA CARBONICA, SELENIUM METALLICUM, FUNICULUS UMBILICALIS SUIS, GLANDULA SUPRARENALIS SUIS, HEPAR SUIS, HYPOTHALAMUS (SUIS), LYMPH NODE(SUIS), MEDULLA OSSIS SUIS, OOPHORINUM (SUIS), ORCHITINUM (SUIS), PANCREAS SUIS, SPLEEN (SUIS)) LIQUID [DESERET BIOLOGICALS, INC.]6
ACTIVE INGREDIENTHGH VITALITY (AGNUS CASTUS, AMBRA GRISEA, CONIUM MACULATUM, APIOLUM, ESTRADIOL, ESTRIOL, FOLLICULINUM, L-DOPA, MELATONIN, TESTOSTERONE, ALPHA-LIPOICUM ACIDUM, ADENOSINUM TRIPHOSPHORICUM DINATRUM, COENZYME A, UBIDECARENONUM, NADIDUM, SARCOLACTICUM ACIDUM, BARYTA CARBONICA, SELENIUM METALLICUM, FUNICULUS UMBILICALIS SUIS, GLANDULA SUPRARENALIS SUIS, HEPAR SUIS, HYPOTHALAMUS (SUIS), LYMPH NODE(SUIS), MEDULLA OSSIS SUIS, OOPHORINUM (SUIS), ORCHITINUM (SUIS), PANCREAS SUIS, SPLEEN (SUIS)) LIQUID [DESERET BIOLOGICALS, INC.]6
ACTIVE MOIETYESTRADIOL TABLET [AMNEAL PHARMACEUTICALS OF NEW YORK, LLC]5
ACTIVE INGREDIENTESTRADIOL TABLET [AMNEAL PHARMACEUTICALS OF NEW YORK, LLC]5
ACTIVE INGREDIENTESTRADIOL TABLET [MYLAN PHARMACEUTICALS INC.]5
ACTIVE MOIETYESTRADIOL TABLET [MYLAN PHARMACEUTICALS INC.]5
ACTIVE INGREDIENTMENOSTAR (ESTRADIOL) PATCH [BAYER HEALTHCARE PHARMACEUTICALS INC.]5
ACTIVE MOIETYMENOSTAR (ESTRADIOL) PATCH [BAYER HEALTHCARE PHARMACEUTICALS INC.]5
ACTIVE MOIETYPREFEST (ESTRADIOL/NORGESTIMATE) KIT [TEVA WOMEN'S HEALTH, INC.]5
ACTIVE INGREDIENTPREFEST (ESTRADIOL/NORGESTIMATE) KIT [TEVA WOMEN'S HEALTH, INC.]5
ACTIVE MOIETYSRONYX (LEVONORGESTREL AND ETHINYL ESTRADIOL) KIT [WATSON PHARMA, INC.]5
ACTIVE INGREDIENTVIVELLE-DOT (ESTRADIOL) PATCH, EXTENDED RELEASE [NOVARTIS PHARMACEUTICALS CORPORATION]5
ACTIVE MOIETYVIVELLE-DOT (ESTRADIOL) PATCH, EXTENDED RELEASE [NOVARTIS PHARMACEUTICALS CORPORATION]5
ACTIVE INGREDIENTESTRADIOL PATCH [MYLAN PHARMACEUTICALS INC.]4
ACTIVE MOIETYESTRADIOL PATCH [MYLAN PHARMACEUTICALS INC.]4
ACTIVE INGREDIENTESTRADIOL TABLET [BARR LABORATORIES INC.]4
ACTIVE MOIETYESTRADIOL TABLET [BARR LABORATORIES INC.]4
ACTIVE INGREDIENTESTRADIOL TABLET [PD-RX PHARMACEUTICALS, INC.]4
ACTIVE MOIETYESTRADIOL TABLET [PD-RX PHARMACEUTICALS, INC.]4
ACTIVE MOIETYESTRADIOL TABLET [PREFERRED PHARMACEUTICALS, INC.]4
ACTIVE INGREDIENTESTRADIOL TABLET [PREFERRED PHARMACEUTICALS, INC.]4
ACTIVE INGREDIENTHGH VITALITY (AGNUS CASTUS, AMBRA GRISEA, CONIUM MACULATUM, APIOLUM, ESTRADIOL, ESTRIOL, FOLLICULINUM, L DOPA, MELATONIN, TESTOSTERONE, ALPHA-LIPOICUM ACIDUM, ATP, COENZYME A, COQ10, NADIDUM, SARCOLACTICUM ACIDUM, BARYTA CARBONICA, SELENIUM METALLICUM, FUNICULUS UMBILICALIS SUIS, GLANDULA SUPRARENALIS SUIS, HEPAR SUIS, HYPOTHALAMUS (SUIS), LYMPH (SUIS) MEDULLA OSSIS SUIS, OOPHORINUM (SUIS), ORCHITINUM (SUIS), PANCREAS SUIS, SPLEEN (SUIS), HUMAN GROWTH HORMONE, MORGAN PURE) LIQUID [DESERET BIOLOGICALS, INC.]4
ACTIVE MOIETYHGH VITALITY (AGNUS CASTUS, AMBRA GRISEA, CONIUM MACULATUM, APIOLUM, ESTRADIOL, ESTRIOL, FOLLICULINUM, L DOPA, MELATONIN, TESTOSTERONE, ALPHA-LIPOICUM ACIDUM, ATP, COENZYME A, COQ10, NADIDUM, SARCOLACTICUM ACIDUM, BARYTA CARBONICA, SELENIUM METALLICUM, FUNICULUS UMBILICALIS SUIS, GLANDULA SUPRARENALIS SUIS, HEPAR SUIS, HYPOTHALAMUS (SUIS), LYMPH (SUIS) MEDULLA OSSIS SUIS, OOPHORINUM (SUIS), ORCHITINUM (SUIS), PANCREAS SUIS, SPLEEN (SUIS), HUMAN GROWTH HORMONE, MORGAN PURE) LIQUID [DESERET BIOLOGICALS, INC.]4
ACTIVE MOIETYLOPREEZA (ESTRADIOL/NORETHINDRONE ACETATE) TABLET, FILM COATED [AMNEAL PHARMACEUTICALS OF NEW YORK, LLC]4
ACTIVE INGREDIENTLOPREEZA (ESTRADIOL/NORETHINDRONE ACETATE) TABLET, FILM COATED [AMNEAL PHARMACEUTICALS OF NEW YORK, LLC]4
ACTIVE INGREDIENTMINIVELLE (ESTRADIOL) FILM, EXTENDED RELEASE [NOVEN THERAPEUTICS, LLC]4
ACTIVE MOIETYMINIVELLE (ESTRADIOL) FILM, EXTENDED RELEASE [NOVEN THERAPEUTICS, LLC]4
ACTIVE MOIETYDEPO-ESTRADIOL (ESTRADIOL CYPIONATE) INJECTION [PHARMACIA AND UPJOHN COMPANY]3
ACTIVE MOIETYESTRACE (ESTRADIOL) TABLET [WARNER CHILCOTT (US), LLC]3
ACTIVE INGREDIENTESTRACE (ESTRADIOL) TABLET [WARNER CHILCOTT (US), LLC]3
ACTIVE INGREDIENTESTRADERM (ESTRADIOL) PATCH, EXTENDED RELEASE [NOVARTIS PHARMACEUTICALS CORPORATION]3
ACTIVE MOIETYESTRADERM (ESTRADIOL) PATCH, EXTENDED RELEASE [NOVARTIS PHARMACEUTICALS CORPORATION]3
ACTIVE INGREDIENTESTRADIOL (ESTRADIOL) TABLET [PD-RX PHARMACEUTICALS, INC.]3
ACTIVE MOIETYESTRADIOL (ESTRADIOL) TABLET [PD-RX PHARMACEUTICALS, INC.]3
ACTIVE MOIETYESTRADIOL TABLET [CARDINAL HEALTH]3
ACTIVE INGREDIENTESTRADIOL TABLET [CARDINAL HEALTH]3
ACTIVE MOIETYESTRADIOL TRANSDERMAL SYSTEM (ESTRADIOL) PATCH [ALVOGEN, INC.]3