FDA.reportPublic FDA data

ESTRADIOL

Substance profile for UNII 4TI98Z838E, enriched with FDA NDC listings, DailyMed labels, legacy aliases, and open chemistry identifiers.

Chemical structure for ESTRADIOL
Structure render from PubChem CID 5757

Substance Identity#

UNII
4TI98Z838E
Preferred term
ESTRADIOL
Registry number
50-28-2
EC number
200-023-8
Ingredient type
INGREDIENT SUBSTANCE
Molecular formula
C18H24O2
Chemical structure for ESTRADIOL
Structure render from PubChem CID 5757

Chemical And Database Identifiers#

InChIKey
VOXZDWNPVJITMN-ZBRFXRBCSA-N
SMILES
C[C@]12CC[C@H]3[C@@H](CCC4=CC(O)=CC=C34)[C@@H]1CC[C@@H]2O
RxCUI
4083
PubChem
5757
NCIt
C478
INN ID
406

Open Chemistry Sources#

Source, Identifier, Link table
SourceIdentifierLink
PubChem Compound5757https://pubchem.ncbi.nlm.nih.gov/compound/5757
PubChem InChIKey SearchVOXZDWNPVJITMN-ZBRFXRBCSA-Nhttps://pubchem.ncbi.nlm.nih.gov/#query=VOXZDWNPVJITMN-ZBRFXRBCSA-N
RxNorm4083https://mor.nlm.nih.gov/RxNav/search?searchBy=RXCUI&searchTerm=4083
NCI ThesaurusC478https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C478
FDA Substance Registration System4TI98Z838Ehttps://precision.fda.gov/uniisearch/srs/unii/4TI98Z838E
European Community number200-023-8https://commonchemistry.cas.org/results?q=200-023-8

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
IngredientTypeUNIIDailyMed labelSPL versionUploaded
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL1
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL1
ESTRADIOLACTIVE MOIETY4TI98Z838EEstradiol Tablets USP1
ESTRADIOLACTIVE INGREDIENT4TI98Z838EEstradiol Tablets USP1
ESTRADIOLACTIVE INGREDIENT4TI98Z838EEstradiol Tablets USP3
ESTRADIOLACTIVE MOIETY4TI98Z838EEstradiol Tablets USP3
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL TABLETS, USP1
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL TABLETS, USP1
ESTRADIOLACTIVE MOIETY4TI98Z838E0e8341f1-8089-46ff-b142-1fb04209029d1
ESTRADIOLACTIVE INGREDIENT4TI98Z838E0e8341f1-8089-46ff-b142-1fb04209029d1
EstradiolACTIVE INGREDIENT4TI98Z838EEstradiol/Norethindrone Acetate Tablets1
EstradiolACTIVE MOIETY4TI98Z838EEstradiol/Norethindrone Acetate Tablets1
ESTRADIOLACTIVE MOIETY4TI98Z838EZovia 1/35E-28 Zovia 1/50E-28 (Ethynodiol Diacetate and Ethinyl Estradiol Tablets USP) Revised: August 2006 Rx only1
ESTRADIOLACTIVE MOIETY4TI98Z838EThese highlights do not include all the information needed to use Vagifem safely and effectively. See full prescribing information for Vagifem. Vagifem ® (estradiol vaginal tablets) Initial U.S. Approval: 19992
ESTRADIOLACTIVE INGREDIENT4TI98Z838EThese highlights do not include all the information needed to use Vagifem safely and effectively. See full prescribing information for Vagifem. Vagifem ® (estradiol vaginal tablets) Initial U.S. Approval: 19992
ESTRADIOLACTIVE INGREDIENT4TI98Z838EVivelle-Dot1
ESTRADIOLACTIVE MOIETY4TI98Z838EVivelle-Dot1
ESTRADIOLACTIVE MOIETY4TI98Z838E7abf2fff-f612-4842-9d1d-375af93f42591
ESTRADIOLACTIVE MOIETY4TI98Z838EProBLEN Estrogen and Progesterone1
ESTRADIOLACTIVE INGREDIENT4TI98Z838EProBLEN Estrogen and Progesterone1
ESTRADIOLACTIVE INGREDIENT4TI98Z838EProBLEN Estrogen & Progesterone1
ESTRADIOLACTIVE MOIETY4TI98Z838EProBLEN Estrogen & Progesterone1
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL TABLETS, USP1
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL TABLETS, USP1
ESTRADIOLACTIVE MOIETY4TI98Z838EThese highlights do not include all the information needed to use Evamist safely and effectively. See full prescribing information for Evamist. Evamist (estradiol transdermal spray) Initial U.S. Approval: 19751
ESTRADIOLACTIVE INGREDIENT4TI98Z838EThese highlights do not include all the information needed to use Evamist safely and effectively. See full prescribing information for Evamist. Evamist (estradiol transdermal spray) Initial U.S. Approval: 19751
ESTRADIOLACTIVE MOIETY4TI98Z838E37f3094c-f02d-4a9c-8e30-2c4752bc62ed2
ESTRADIOLACTIVE INGREDIENT4TI98Z838E37f3094c-f02d-4a9c-8e30-2c4752bc62ed2
ESTRADIOLACTIVE MOIETY4TI98Z838E86b90d68-bfb6-47f6-aa5b-a6642391ff131
ESTRADIOLACTIVE MOIETY4TI98Z838E396686ba-ab8d-4223-80e7-9c4f7ddb78522
ESTRADIOLACTIVE INGREDIENT4TI98Z838E396686ba-ab8d-4223-80e7-9c4f7ddb78522
estradiolACTIVE MOIETY4TI98Z838EEstradiol (Estradiol) tablet2
EstradiolACTIVE INGREDIENT4TI98Z838EEstradiol (Estradiol) tablet2
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRING ® (estradiol vaginal ring)1
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRING ® (estradiol vaginal ring)1
ESTRADIOLACTIVE INGREDIENT4TI98Z838EDivigel ® (estradiol gel) 0.1%2
ESTRADIOLACTIVE MOIETY4TI98Z838EDivigel ® (estradiol gel) 0.1%2
ESTRADIOLACTIVE INGREDIENT4TI98Z838EClimara Pro1
ESTRADIOLACTIVE MOIETY4TI98Z838EClimara Pro1
ESTRADIOLACTIVE MOIETY4TI98Z838EANGELIQ TABLETS (Drospirenone and Estradiol) 0.5 mg/1 mg1
ESTRADIOLACTIVE INGREDIENT4TI98Z838EANGELIQ TABLETS (Drospirenone and Estradiol) 0.5 mg/1 mg1
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL TABLET [LAKE ERIE MEDICAL & SURGICAL SUPPLY DBA QUALITY CARE PRODUCTS LLC]3657
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL TABLET [LAKE ERIE MEDICAL & SURGICAL SUPPLY DBA QUALITY CARE PRODUCTS LLC]3657
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL TABLET [BRYANT RANCH PREPACK]1002
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL TABLET [BRYANT RANCH PREPACK]1002
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL TABLET [BRYANT RANCH PREPACK]1002
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL TABLET [BRYANT RANCH PREPACK]1002
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL TABLET [BRYANT RANCH PREPACK]1000
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL TABLET [BRYANT RANCH PREPACK]1000
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL TABLET [BRYANT RANCH PREPACK]1000
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL TABLET [BRYANT RANCH PREPACK]1000
ESTRADIOLACTIVE MOIETY4TI98Z838EESTROGEL (ESTRADIOL) GEL, METERED [ASCEND THERAPEUTICS US, LLC]26
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTROGEL (ESTRADIOL) GEL, METERED [ASCEND THERAPEUTICS US, LLC]26
estradiolACTIVE INGREDIENT4TI98Z838EEVAMIST (ESTRADIOL) SPRAY, METERED [THER-RX CORPORATION]12
estradiolACTIVE MOIETY4TI98Z838EEVAMIST (ESTRADIOL) SPRAY, METERED [THER-RX CORPORATION]12
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRING (ESTRADIOL) RING [PHARMACIA AND UPJOHN COMPANY]11
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRING (ESTRADIOL) RING [PHARMACIA AND UPJOHN COMPANY]11
ESTRADIOLACTIVE INGREDIENT4TI98Z838EACTIVELLA (ESTRADIOL AND NORETHINDRONE ACETATE) TABLET, FILM COATED [NOVO NORDISK]10
ESTRADIOLACTIVE MOIETY4TI98Z838EACTIVELLA (ESTRADIOL AND NORETHINDRONE ACETATE) TABLET, FILM COATED [NOVO NORDISK]10
ESTRADIOLACTIVE INGREDIENT4TI98Z838EVAGIFEM (ESTRADIOL) TABLET, FILM COATED [NOVO NORDISK]10
ESTRADIOLACTIVE MOIETY4TI98Z838EVAGIFEM (ESTRADIOL) TABLET, FILM COATED [NOVO NORDISK]10
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL PATCH [MYLAN PHARMACEUTICALS INC.]9
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL PATCH [MYLAN PHARMACEUTICALS INC.]9
ESTRADIOLACTIVE MOIETY4TI98Z838ENATAZIA (ESTRADIOL VALERATE AND ESTRADIOL VALERATE/DIENOGEST) KIT [BAYER HEALTHCARE PHARMACEUTICALS INC.]9
ESTRADIOLACTIVE INGREDIENT4TI98Z838ECLIMARA (ESTRADIOL) PATCH [BAYER HEALTHCARE PHARMACEUTICALS INC.]8
ESTRADIOLACTIVE MOIETY4TI98Z838ECLIMARA (ESTRADIOL) PATCH [BAYER HEALTHCARE PHARMACEUTICALS INC.]8
estradiolACTIVE MOIETY4TI98Z838EDELESTROGEN (ESTRADIOL VALERATE) INJECTION [PAR PHARMACEUTICAL INC.]8
ESTRADIOLACTIVE MOIETY4TI98Z838EALORA (ESTRADIOL TRANSDERMAL SYSTEM) PATCH [ACTAVIS PHARMA, INC.]7
ESTRADIOLACTIVE INGREDIENT4TI98Z838EALORA (ESTRADIOL TRANSDERMAL SYSTEM) PATCH [ACTAVIS PHARMA, INC.]7
ESTRADIOLACTIVE INGREDIENT4TI98Z838EANGELIQ (DROSPIRENONE AND ESTRADIOL) TABLET, FILM COATED [BAYER HEALTHCARE PHARMACEUTICALS INC.]7
ESTRADIOLACTIVE MOIETY4TI98Z838EANGELIQ (DROSPIRENONE AND ESTRADIOL) TABLET, FILM COATED [BAYER HEALTHCARE PHARMACEUTICALS INC.]7
ESTRADIOLACTIVE MOIETY4TI98Z838ECLIMARA PRO (ESTRADIOL AND LEVONORGESTREL) PATCH [BAYER HEALTHCARE PHARMACEUTICALS INC.]7
ESTRADIOLACTIVE INGREDIENT4TI98Z838ECLIMARA PRO (ESTRADIOL AND LEVONORGESTREL) PATCH [BAYER HEALTHCARE PHARMACEUTICALS INC.]7
EstradiolACTIVE INGREDIENT4TI98Z838EDIVIGEL (ESTRADIOL) GEL [UPSHER-SMITH LABORATORIES, INC.]7
EstradiolACTIVE MOIETY4TI98Z838EDIVIGEL (ESTRADIOL) GEL [UPSHER-SMITH LABORATORIES, INC.]7
ESTRADIOLACTIVE MOIETY4TI98Z838EFEMRING (ESTRADIOL ACETATE) RING [WARNER CHILCOTT (US), LLC]7
ESTRADIOLACTIVE MOIETY4TI98Z838ECOMBIPATCH (ESTRADIOL AND NORETHINDRONE ACETATE) PATCH, EXTENDED RELEASE [NOVARTIS PHARMACEUTICALS CORPORATION]6
ESTRADIOLACTIVE INGREDIENT4TI98Z838ECOMBIPATCH (ESTRADIOL AND NORETHINDRONE ACETATE) PATCH, EXTENDED RELEASE [NOVARTIS PHARMACEUTICALS CORPORATION]6
ESTRADIOLACTIVE INGREDIENT4TI98Z838EELESTRIN (ESTRADIOL) GEL [JAZZ PHARMACEUTICALS COMMERCIAL CORP.]6
ESTRADIOLACTIVE MOIETY4TI98Z838EELESTRIN (ESTRADIOL) GEL [JAZZ PHARMACEUTICALS COMMERCIAL CORP.]6
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRACE (ESTRADIOL) CREAM [WARNER CHILCOTT (US), LLC]6
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRACE (ESTRADIOL) CREAM [WARNER CHILCOTT (US), LLC]6
ESTRADIOLACTIVE MOIETY4TI98Z838EHGH VITALITY (AGNUS CASTUS, AMBRA GRISEA, CONIUM MACULATUM, APIOLUM, ESTRADIOL, ESTRIOL, FOLLICULINUM, L-DOPA, MELATONIN, TESTOSTERONE, ALPHA-LIPOICUM ACIDUM, ADENOSINUM TRIPHOSPHORICUM DINATRUM, COENZYME A, UBIDECARENONUM, NADIDUM, SARCOLACTICUM ACIDUM, BARYTA CARBONICA, SELENIUM METALLICUM, FUNICULUS UMBILICALIS SUIS, GLANDULA SUPRARENALIS SUIS, HEPAR SUIS, HYPOTHALAMUS (SUIS), LYMPH NODE(SUIS), MEDULLA OSSIS SUIS, OOPHORINUM (SUIS), ORCHITINUM (SUIS), PANCREAS SUIS, SPLEEN (SUIS)) LIQUID [DESERET BIOLOGICALS, INC.]6
ESTRADIOLACTIVE INGREDIENT4TI98Z838EHGH VITALITY (AGNUS CASTUS, AMBRA GRISEA, CONIUM MACULATUM, APIOLUM, ESTRADIOL, ESTRIOL, FOLLICULINUM, L-DOPA, MELATONIN, TESTOSTERONE, ALPHA-LIPOICUM ACIDUM, ADENOSINUM TRIPHOSPHORICUM DINATRUM, COENZYME A, UBIDECARENONUM, NADIDUM, SARCOLACTICUM ACIDUM, BARYTA CARBONICA, SELENIUM METALLICUM, FUNICULUS UMBILICALIS SUIS, GLANDULA SUPRARENALIS SUIS, HEPAR SUIS, HYPOTHALAMUS (SUIS), LYMPH NODE(SUIS), MEDULLA OSSIS SUIS, OOPHORINUM (SUIS), ORCHITINUM (SUIS), PANCREAS SUIS, SPLEEN (SUIS)) LIQUID [DESERET BIOLOGICALS, INC.]6
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL TABLET [AMNEAL PHARMACEUTICALS OF NEW YORK, LLC]5
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL TABLET [AMNEAL PHARMACEUTICALS OF NEW YORK, LLC]5
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL TABLET [MYLAN PHARMACEUTICALS INC.]5
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL TABLET [MYLAN PHARMACEUTICALS INC.]5
ESTRADIOLACTIVE INGREDIENT4TI98Z838EMENOSTAR (ESTRADIOL) PATCH [BAYER HEALTHCARE PHARMACEUTICALS INC.]5
ESTRADIOLACTIVE MOIETY4TI98Z838EMENOSTAR (ESTRADIOL) PATCH [BAYER HEALTHCARE PHARMACEUTICALS INC.]5
ESTRADIOLACTIVE MOIETY4TI98Z838EPREFEST (ESTRADIOL/NORGESTIMATE) KIT [TEVA WOMEN'S HEALTH, INC.]5
ESTRADIOLACTIVE INGREDIENT4TI98Z838EPREFEST (ESTRADIOL/NORGESTIMATE) KIT [TEVA WOMEN'S HEALTH, INC.]5
ESTRADIOLACTIVE MOIETY4TI98Z838ESRONYX (LEVONORGESTREL AND ETHINYL ESTRADIOL) KIT [WATSON PHARMA, INC.]5
ESTRADIOLACTIVE MOIETY4TI98Z838EVIVELLE-DOT (ESTRADIOL) PATCH, EXTENDED RELEASE [NOVARTIS PHARMACEUTICALS CORPORATION]5
ESTRADIOLACTIVE INGREDIENT4TI98Z838EVIVELLE-DOT (ESTRADIOL) PATCH, EXTENDED RELEASE [NOVARTIS PHARMACEUTICALS CORPORATION]5
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL PATCH [MYLAN PHARMACEUTICALS INC.]4
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL PATCH [MYLAN PHARMACEUTICALS INC.]4
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL TABLET [BARR LABORATORIES INC.]4
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL TABLET [BARR LABORATORIES INC.]4
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL TABLET [PD-RX PHARMACEUTICALS, INC.]4
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL TABLET [PD-RX PHARMACEUTICALS, INC.]4
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL TABLET [PREFERRED PHARMACEUTICALS, INC.]4
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL TABLET [PREFERRED PHARMACEUTICALS, INC.]4
ESTRADIOLACTIVE INGREDIENT4TI98Z838EHGH VITALITY (AGNUS CASTUS, AMBRA GRISEA, CONIUM MACULATUM, APIOLUM, ESTRADIOL, ESTRIOL, FOLLICULINUM, L DOPA, MELATONIN, TESTOSTERONE, ALPHA-LIPOICUM ACIDUM, ATP, COENZYME A, COQ10, NADIDUM, SARCOLACTICUM ACIDUM, BARYTA CARBONICA, SELENIUM METALLICUM, FUNICULUS UMBILICALIS SUIS, GLANDULA SUPRARENALIS SUIS, HEPAR SUIS, HYPOTHALAMUS (SUIS), LYMPH (SUIS) MEDULLA OSSIS SUIS, OOPHORINUM (SUIS), ORCHITINUM (SUIS), PANCREAS SUIS, SPLEEN (SUIS), HUMAN GROWTH HORMONE, MORGAN PURE) LIQUID [DESERET BIOLOGICALS, INC.]4
ESTRADIOLACTIVE MOIETY4TI98Z838EHGH VITALITY (AGNUS CASTUS, AMBRA GRISEA, CONIUM MACULATUM, APIOLUM, ESTRADIOL, ESTRIOL, FOLLICULINUM, L DOPA, MELATONIN, TESTOSTERONE, ALPHA-LIPOICUM ACIDUM, ATP, COENZYME A, COQ10, NADIDUM, SARCOLACTICUM ACIDUM, BARYTA CARBONICA, SELENIUM METALLICUM, FUNICULUS UMBILICALIS SUIS, GLANDULA SUPRARENALIS SUIS, HEPAR SUIS, HYPOTHALAMUS (SUIS), LYMPH (SUIS) MEDULLA OSSIS SUIS, OOPHORINUM (SUIS), ORCHITINUM (SUIS), PANCREAS SUIS, SPLEEN (SUIS), HUMAN GROWTH HORMONE, MORGAN PURE) LIQUID [DESERET BIOLOGICALS, INC.]4
ESTRADIOLACTIVE INGREDIENT4TI98Z838ELOPREEZA (ESTRADIOL/NORETHINDRONE ACETATE) TABLET, FILM COATED [AMNEAL PHARMACEUTICALS OF NEW YORK, LLC]4
ESTRADIOLACTIVE MOIETY4TI98Z838ELOPREEZA (ESTRADIOL/NORETHINDRONE ACETATE) TABLET, FILM COATED [AMNEAL PHARMACEUTICALS OF NEW YORK, LLC]4
ESTRADIOLACTIVE INGREDIENT4TI98Z838EMINIVELLE (ESTRADIOL) FILM, EXTENDED RELEASE [NOVEN THERAPEUTICS, LLC]4
ESTRADIOLACTIVE MOIETY4TI98Z838EMINIVELLE (ESTRADIOL) FILM, EXTENDED RELEASE [NOVEN THERAPEUTICS, LLC]4
ESTRADIOLACTIVE MOIETY4TI98Z838EDEPO-ESTRADIOL (ESTRADIOL CYPIONATE) INJECTION [PHARMACIA AND UPJOHN COMPANY]3
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRACE (ESTRADIOL) TABLET [WARNER CHILCOTT (US), LLC]3
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRACE (ESTRADIOL) TABLET [WARNER CHILCOTT (US), LLC]3
estradiolACTIVE MOIETY4TI98Z838EESTRADERM (ESTRADIOL) PATCH, EXTENDED RELEASE [NOVARTIS PHARMACEUTICALS CORPORATION]3
estradiolACTIVE INGREDIENT4TI98Z838EESTRADERM (ESTRADIOL) PATCH, EXTENDED RELEASE [NOVARTIS PHARMACEUTICALS CORPORATION]3
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL (ESTRADIOL) TABLET [PD-RX PHARMACEUTICALS, INC.]3
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL (ESTRADIOL) TABLET [PD-RX PHARMACEUTICALS, INC.]3
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL TABLET [CARDINAL HEALTH]3
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL TABLET [CARDINAL HEALTH]3
ESTRADIOLACTIVE MOIETY4TI98Z838EESTRADIOL TRANSDERMAL SYSTEM (ESTRADIOL) PATCH [ALVOGEN, INC.]3
ESTRADIOLACTIVE INGREDIENT4TI98Z838EESTRADIOL TRANSDERMAL SYSTEM (ESTRADIOL) PATCH [ALVOGEN, INC.]3