Imodium

Product NDC
50580-134
11-digit product format
505800134
Labeler code
50580
Product ID
50580-134_3f73b325-ad6b-8e65-e063-6394a90a361e
Type
HUMAN OTC DRUG
Nonproprietary name
Loperamide Hydrochloride
Dosage form
SOLUTION
Route
ORAL
Labeler
Kenvue Brands LLC
Application
NDA019487
Marketing category
NDA
Marketing start
2004-07-01
Substance
LOPERAMIDE HYDROCHLORIDE
Active strength
1 mg/7.5mL
Pharmacologic classes
Opioid Agonist [EPC], Opioid Agonists [MoA]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N019487-001IMODIUM A-DLOPERAMIDE HYDROCHLORIDE1MG/5ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**SOLUTION / ORALRLD1988-03-01
N019487-002IMODIUM A-DLOPERAMIDE HYDROCHLORIDE1MG/7.5MLSOLUTION / ORALRLD, RS2004-07-08

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 84 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07N019487-001IMODIUM A-D1MG/5ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**SOLUTION / ORALRLD1988-03-01caaa826d4ba7…
2026-08-18 06:07:402026-07N019487-002IMODIUM A-D1MG/7.5MLSOLUTION / ORALRLD, RS2004-07-08caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD1988-03-01011fe1cb6892…
2026-02-19 14:30 UTC2026-02N019487-002IMODIUM A-D1MG/7.5MLSOLUTION / ORALRLD, RS2004-07-08011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD1988-03-0131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N019487-002IMODIUM A-D1MG/7.5MLSOLUTION / ORALRLD, RS2004-07-0831067a03dcf5…
2025-08-23 18:47 UTC2025-08N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD1988-03-016a471c1ec25d…
2025-08-23 18:47 UTC2025-08N019487-002IMODIUM A-D1MG/7.5MLSUSPENSION / ORALRLD, RS2004-07-086a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD, RS1988-03-01fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N019487-002IMODIUM A-D1MG/7.5MLSUSPENSION / ORALRLD, RS2004-07-08fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD, RS1988-03-01b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N019487-002IMODIUM A-D1MG/7.5MLSUSPENSION / ORALRLD, RS2004-07-08b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD, RS1988-03-0103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N019487-002IMODIUM A-D1MG/7.5MLSUSPENSION / ORALRLD, RS2004-07-0803ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD, RS1988-03-012680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N019487-002IMODIUM A-D1MG/7.5MLSUSPENSION / ORALRLD, RS2004-07-082680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD, RS1988-03-015bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N019487-002IMODIUM A-D1MG/7.5MLSUSPENSION / ORALRLD, RS2004-07-085bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD, RS1988-03-01d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N019487-002IMODIUM A-D1MG/7.5MLSUSPENSION / ORALRLD, RS2004-07-08d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD, RS1988-03-01d06236e962d9…
2024-10-29 15:01 UTC2024-10N019487-002IMODIUM A-D1MG/7.5MLSUSPENSION / ORALRLD, RS2004-07-08d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD, RS1988-03-0179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N019487-002IMODIUM A-D1MG/7.5MLSUSPENSION / ORALRLD, RS2004-07-0879d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD, RS1988-03-01301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N019487-002IMODIUM A-D1MG/7.5MLSUSPENSION / ORALRLD, RS2004-07-08301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD, RS1988-03-011e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N019487-002IMODIUM A-D1MG/7.5MLSUSPENSION / ORALRLD, RS2004-07-081e350fbaab3a…
2024-05-31 18:47 UTC2024-05N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD, RS1988-03-018072bd15b7f6…
2024-05-31 18:47 UTC2024-05N019487-002IMODIUM A-D1MG/7.5MLSUSPENSION / ORALRLD, RS2004-07-088072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD, RS1988-03-015c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N019487-002IMODIUM A-D1MG/7.5MLSUSPENSION / ORALRLD, RS2004-07-085c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD, RS1988-03-015d02ea3f76ae…
2022-04-08 23:34 UTC2022-04N019487-002IMODIUM A-D1MG/7.5MLSUSPENSION / ORALRLD, RS2004-07-085d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD, RS1988-03-014b0b4de00fa7…
2022-04-04 05:41 UTC2022-04N019487-002IMODIUM A-D1MG/7.5MLSUSPENSION / ORALRLD, RS2004-07-084b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD, RS1988-03-0174a2ff9319b5…
2019-12-13 00:20 UTC2019-12N019487-002IMODIUM A-D1MG/7.5MLSUSPENSION / ORALRLD, RS2004-07-0874a2ff9319b5…
2022-03-09 01:35 UTC2022-03N019487-001IMODIUM A-D1MG/5MLSOLUTION / ORALRLD, RS1988-03-01bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03N019487-002IMODIUM A-D1MG/7.5MLSUSPENSION / ORALRLD, RS2004-07-08bb7c543d1eb4…

Additional Listing Data#

Finished product
Yes
Brand name base
Imodium
Brand name suffix
A-D
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
LOPERAMIDE HYDROCHLORIDE1 mg/7.5mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
77TI35393CInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1250685Internal RxNorm lookup
1250693Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
76a976d5-8bee-4158-a94d-7fbfc5544fd4Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
10f838ef-a72b-645d-80f8-e2255205c3b1Product name620240805

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
50580-134-04ImodiumA-D120 mL in 1 BOTTLESOLUTION12010
50580-134-08ImodiumA-D240 mL in 1 BOTTLESOLUTION24010
50580-134-44ImodiumA-D120 mL in 1 BOTTLESOLUTION12010

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
50580-134-04ML - Milliliter50580-134bfdfb816-6cb3-44da-8e3a-011ee1011bfe12012-07-24
50580-134-08ML - Milliliter50580-1340dd4bb36-574a-42f4-90f0-a567f747976a12012-07-24
50580-134-44ML - Milliliter50580-13487ed0291-7636-44f0-88c9-325ba3d85b8412012-07-24

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
IngredientTypeUNIIDailyMed labelSPL versionUploaded
Loperamide HydrochlorideACTIVE INGREDIENT77TI35393CIMODIUM A-D (LOPERAMIDE HYDROCHLORIDE) SOLUTION [JOHNSON & JOHNSON CONSUMER INC., MCNEIL CONSUMER HEALTHCARE DIVISION]3
LoperamideACTIVE MOIETY6X9OC3H4IIIMODIUM A-D (LOPERAMIDE HYDROCHLORIDE) SOLUTION [JOHNSON & JOHNSON CONSUMER INC., MCNEIL CONSUMER HEALTHCARE DIVISION]3
anhydrous citric acidINACTIVE INGREDIENTXF417D3PSLIMODIUM A-D (LOPERAMIDE HYDROCHLORIDE) SOLUTION [JOHNSON & JOHNSON CONSUMER INC., MCNEIL CONSUMER HEALTHCARE DIVISION]3
carboxymethylcellulose sodium, unspecified formINACTIVE INGREDIENTK679OBS311IMODIUM A-D (LOPERAMIDE HYDROCHLORIDE) SOLUTION [JOHNSON & JOHNSON CONSUMER INC., MCNEIL CONSUMER HEALTHCARE DIVISION]3
cellulose, microcrystallineINACTIVE INGREDIENTOP1R32D61UIMODIUM A-D (LOPERAMIDE HYDROCHLORIDE) SOLUTION [JOHNSON & JOHNSON CONSUMER INC., MCNEIL CONSUMER HEALTHCARE DIVISION]3
D&C yellow no. 10INACTIVE INGREDIENT35SW5USQ3GIMODIUM A-D (LOPERAMIDE HYDROCHLORIDE) SOLUTION [JOHNSON & JOHNSON CONSUMER INC., MCNEIL CONSUMER HEALTHCARE DIVISION]3
FD&C blue no. 1INACTIVE INGREDIENTH3R47K3TBDIMODIUM A-D (LOPERAMIDE HYDROCHLORIDE) SOLUTION [JOHNSON & JOHNSON CONSUMER INC., MCNEIL CONSUMER HEALTHCARE DIVISION]3
glycerinINACTIVE INGREDIENTPDC6A3C0OXIMODIUM A-D (LOPERAMIDE HYDROCHLORIDE) SOLUTION [JOHNSON & JOHNSON CONSUMER INC., MCNEIL CONSUMER HEALTHCARE DIVISION]3
propylene glycolINACTIVE INGREDIENT6DC9Q167V3IMODIUM A-D (LOPERAMIDE HYDROCHLORIDE) SOLUTION [JOHNSON & JOHNSON CONSUMER INC., MCNEIL CONSUMER HEALTHCARE DIVISION]3
sodium benzoateINACTIVE INGREDIENTOJ245FE5EUIMODIUM A-D (LOPERAMIDE HYDROCHLORIDE) SOLUTION [JOHNSON & JOHNSON CONSUMER INC., MCNEIL CONSUMER HEALTHCARE DIVISION]3
sucraloseINACTIVE INGREDIENT96K6UQ3ZD4IMODIUM A-D (LOPERAMIDE HYDROCHLORIDE) SOLUTION [JOHNSON & JOHNSON CONSUMER INC., MCNEIL CONSUMER HEALTHCARE DIVISION]3
titanium dioxideINACTIVE INGREDIENT15FIX9V2JPIMODIUM A-D (LOPERAMIDE HYDROCHLORIDE) SOLUTION [JOHNSON & JOHNSON CONSUMER INC., MCNEIL CONSUMER HEALTHCARE DIVISION]3
waterINACTIVE INGREDIENT059QF0KO0RIMODIUM A-D (LOPERAMIDE HYDROCHLORIDE) SOLUTION [JOHNSON & JOHNSON CONSUMER INC., MCNEIL CONSUMER HEALTHCARE DIVISION]3
xanthan gumINACTIVE INGREDIENTTTV12P4NEEIMODIUM A-D (LOPERAMIDE HYDROCHLORIDE) SOLUTION [JOHNSON & JOHNSON CONSUMER INC., MCNEIL CONSUMER HEALTHCARE DIVISION]3

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
50580-134IMODIUM A-D (LOPERAMIDE HYDROCHLORIDE) SOLUTION [KENVUE BRANDS LLC]9Current NDC, Legacy NDC, 3 package rows20241103_76a976d5-8bee-4158-a94d-7fbfc5544fd4.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Imodium A-DLOPERAMIDE HYDROCHLORIDEKenvue Brands LLC76a976d5-8bee-4158-a94d-7fbfc5544fd42025-09-23WarningsExact identifier
application applno (NDA): 019487
application number: NDA019487
ndc (product): 50580-134

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1250693Imodium A-D 1 MG in 7.5 mL Oral SuspensionPSN76a976d5-8bee-4158-a94d-7fbfc5544fd410
1250685loperamide HCl 1 MG in 7.5 mL Oral SuspensionPSN76a976d5-8bee-4158-a94d-7fbfc5544fd410
1250693loperamide hydrochloride 0.133 MG/ML Oral Suspension [Imodium]SBD76a976d5-8bee-4158-a94d-7fbfc5544fd410
1250685loperamide hydrochloride 0.133 MG/ML Oral SuspensionSCD76a976d5-8bee-4158-a94d-7fbfc5544fd410
1250693Imodium 0.133 MG/ML Oral SuspensionSY76a976d5-8bee-4158-a94d-7fbfc5544fd410
1250693Imodium A-D 1 MG per 7.5 ML Oral SuspensionSY76a976d5-8bee-4158-a94d-7fbfc5544fd410
1250685loperamide HCl 1 MG per 7.5 ML Oral SolutionSY76a976d5-8bee-4158-a94d-7fbfc5544fd410
1250685loperamide hydrochloride 1 MG per 7.5 ML Oral SuspensionSY76a976d5-8bee-4158-a94d-7fbfc5544fd410

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
50580-134-0450580013404120 mL in 1 BOTTLE (50580-134-04) 120 ml2004-07-010000-00-00NoNoCurrent
50580-134-0850580013408240 mL in 1 BOTTLE (50580-134-08) 240 ml2004-07-010000-00-00NoNoCurrent
50580-134-4450580013444120 mL in 1 BOTTLE (50580-134-44) 120 ml2004-07-010000-00-00NoNoCurrent