ORKAMBI

Product NDC
51167-122
11-digit product format
511670122
Labeler code
51167
Product ID
51167-122_e746b83a-cec1-40ab-8dba-7d8c1781e8b1
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
lumacaftor and ivacaftor
Dosage form
GRANULE
Route
ORAL
Labeler
Vertex Pharmaceuticals Incorporated
Application
NDA211358
Marketing category
NDA
Marketing start
2022-09-02
Substance
IVACAFTOR; LUMACAFTOR
Active strength
94; 75 mg/1; mg/1
Pharmacologic classes
Chloride Channel Activation Potentiators [MoA], Cystic Fibrosis Transmembrane Conductance Regulator Potentiator [EPC], Cytochrome P450 2B6 Inducers [MoA], Cytochrome P450 2C19 Inducers [MoA], Cytochrome P450 2C8 Inducers [MoA], Cytochrome P450 2C8 Inhibitors [MoA], Cytochrome P450 2C9 Inducers [MoA], Cytochrome P450 2C9 Inhibitors [MoA], Cytochrome P450 2C9 Inhibitors [MoA], Cytochrome P450 3A Inducers [MoA], Cytochrome P450 3A Inhibitors [MoA], P-Glycoprotein Inducers [MoA], P-Glycoprotein Inhibitors [MoA], P-Glycoprotein Inhibitors [MoA]
NDC exclude flag
No
Listing certified through
2027-12-31
Current FDA listing
Yes

Additional Listing Data#

Finished product
Yes
Brand name base
ORKAMBI
Listing expiration
2027-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
LUMACAFTOR94 mg/1
IVACAFTOR75 mg/1

Harmonized Identifiers#

Field, Values table
FieldValues
Unii1Y740ILL1Z, EGP8L81APK
Rxcui1655928, 1655934, 1812468, 1812470, 2053509, 2053512, 2053517, 2053519, 2611458, 2611460

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
362d7abb-94e6-4c60-9a58-266894157713Product name120231023
3345c65e-7c51-4ee3-a410-af7ec8592f92Product name220231010
31b21435-431d-4752-a7c5-89c6a41c6338Product name420230626
816b97af-edc5-4060-aff1-b814bdbcad50Product name120190415
eaf14f5a-a483-45c2-b6bb-bda37f923e37Product name120180508
419aab54-5d5a-4146-9453-026d4a9991beProduct name220170525
1c108d2a-865b-9f48-5b3a-b52233297e1dProduct name220150417
89dac932-b90a-4410-9ab1-84c53e57de25Product name120150316
d723478e-ad4a-ec23-6bd7-cfe33e1e3840Product name120140508

FDA-Initiated Inactive NDC Indexing#

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
51167-122-01ORKAMBI56 in 1 CARTONGRANULE5624
51167-122-01ORKAMBI1 in 1 PACKETGRANULE124

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
51167-122-01EA - Each51167-122e57aaa38-ed43-4932-8e01-73ddd968e52f12022-10-06

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
IngredientTypeUNIIDailyMed labelSPL versionUploaded
ivacaftorACTIVE INGREDIENT1Y740ILL1ZORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
lumacaftorACTIVE INGREDIENTEGP8L81APKORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
ivacaftorACTIVE MOIETY1Y740ILL1ZORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
lumacaftorACTIVE MOIETYEGP8L81APKORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
AMMONIAINACTIVE INGREDIENT5138Q19F1XORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
CARMINIC ACIDINACTIVE INGREDIENTCID8Z8N95NORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
CELLULOSE, MICROCRYSTALLINEINACTIVE INGREDIENTOP1R32D61UORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
CROSCARMELLOSE SODIUMINACTIVE INGREDIENTM28OL1HH48ORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
FD&C Blue No. 1INACTIVE INGREDIENTH3R47K3TBDORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
FD&C Blue No. 2INACTIVE INGREDIENTL06K8R7DQKORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
FERROSOFERRIC OXIDEINACTIVE INGREDIENTXM0M87F357ORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
HYPROMELLOSE ACETATE SUCCINATE 06081224 (3 MM2/S)INACTIVE INGREDIENT6N003M473WORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
MAGNESIUM STEARATEINACTIVE INGREDIENT70097M6I30ORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
POLYETHYLENE GLYCOL 3350INACTIVE INGREDIENTG2M7P15E5PORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
POLYVINYL ALCOHOLINACTIVE INGREDIENT532B59J990ORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
POVIDONESINACTIVE INGREDIENTFZ989GH94EORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
PROPYLENE GLYCOLINACTIVE INGREDIENT6DC9Q167V3ORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
SHELLACINACTIVE INGREDIENT46N107B71OORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
SODIUM LAURYL SULFATEINACTIVE INGREDIENT368GB5141JORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
TALCINACTIVE INGREDIENT7SEV7J4R1UORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1
TITANIUM DIOXIDEINACTIVE INGREDIENT15FIX9V2JPORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED [VERTEX PHARMACEUTICALS INCORPORATED]1

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
51167-122ORKAMBI (LUMACAFTOR AND IVACAFTOR) TABLET, FILM COATED ORKAMBI (LUMACAFTOR AND IVACAFTOR) GRANULE [VERTEX PHARMACEUTICALS INCORPORATED]21Current NDC, Legacy NDC, 2 package rows20241222_3fc1c40e-cfac-47a1-9e1a-61ead3570600.zip

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
2053509ivacaftor 125 MG / lumacaftor 100 MG Oral GranulesPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053517ivacaftor 188 MG / lumacaftor 150 MG Oral GranulesPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
2611458ivacaftor 94 MG / lumacaftor 75 MG Oral GranulesPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
1812468lumacaftor 100 MG / ivacaftor 125 MG Oral TabletPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
1655928lumacaftor 200 MG / ivacaftor 125 MG Oral TabletPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053512ORKAMBI 100 MG / 125 MG Oral GranulesPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
1812470ORKAMBI 100 MG / 125 MG Oral TabletPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053519ORKAMBI 150 MG / 188 MG Oral GranulesPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
1655934ORKAMBI 200 MG / 125 MG Oral TabletPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
2611460ORKAMBI 94 MG / 75 MG Oral GranulesPSN3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053512ivacaftor 125 MG / lumacaftor 100 MG Oral Granules [ORKAMBI]SBD3fc1c40e-cfac-47a1-9e1a-61ead357060024
1812470ivacaftor 125 MG / lumacaftor 100 MG Oral Tablet [ORKAMBI]SBD3fc1c40e-cfac-47a1-9e1a-61ead357060024
1655934ivacaftor 125 MG / lumacaftor 200 MG Oral Tablet [ORKAMBI]SBD3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053519ivacaftor 188 MG / lumacaftor 150 MG Oral Granules [ORKAMBI]SBD3fc1c40e-cfac-47a1-9e1a-61ead357060024
2611460ivacaftor 94 MG / lumacaftor 75 MG Oral Granules [ORKAMBI]SBD3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053509ivacaftor 125 MG / lumacaftor 100 MG Oral GranulesSCD3fc1c40e-cfac-47a1-9e1a-61ead357060024
1812468ivacaftor 125 MG / lumacaftor 100 MG Oral TabletSCD3fc1c40e-cfac-47a1-9e1a-61ead357060024
1655928ivacaftor 125 MG / lumacaftor 200 MG Oral TabletSCD3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053517ivacaftor 188 MG / lumacaftor 150 MG Oral GranulesSCD3fc1c40e-cfac-47a1-9e1a-61ead357060024
2611458ivacaftor 94 MG / lumacaftor 75 MG Oral GranulesSCD3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053512ORKAMBI (ivacaftor 125 MG / lumacaftor 100 MG) Oral GranulesSY3fc1c40e-cfac-47a1-9e1a-61ead357060024
2053519ORKAMBI (ivacaftor 188 MG / lumacaftor 150 MG) Oral GranulesSY3fc1c40e-cfac-47a1-9e1a-61ead357060024
2611460ORKAMBI (ivacaftor 94 MG / lumacaftor 75 MG) Oral GranulesSY3fc1c40e-cfac-47a1-9e1a-61ead357060024
1812470ORKAMBI (lumacaftor 100 MG / ivacaftor 125 MG) Oral TabletSY3fc1c40e-cfac-47a1-9e1a-61ead357060024
1655934ORKAMBI (lumacaftor 200 MG / ivacaftor 125 MG) Oral TabletSY3fc1c40e-cfac-47a1-9e1a-61ead357060024

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
51167-122-015116701220156 PACKET in 1 CARTON (51167-122-01) / 1 GRANULE in 1 PACKET56 packet2022-09-020000-00-00NoNoCurrent