Ibuprofen

Product NDC
58657-680
Requested package NDC
58657-680-01
11-digit product format
586570680
Labeler code
58657
Product ID
58657-680_9d53122c-b5f8-1472-e053-2a95a90a971c
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
Ibuprofen
Dosage form
TABLET
Route
ORAL
Labeler
Method Pharmaceuticals, LLC
Application
ANDA202413
Marketing category
ANDA
Marketing start
2017-04-15
Marketing end
0000-00-00
Substance
IBUPROFEN
Active strength
400 mg/1
Pharmacologic classes
Cyclooxygenase Inhibitors [MoA],Anti-Inflammatory Agents, Non-Steroidal [CS],Nonsteroidal Anti-inflammatory Drug [EPC]
NDC exclude flag
No
Listing certified through
2021-12-31
Current FDA listing
Historical FDA.report record

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 1 matching rows.

Dataset, Scope, Product NDC table
DatasetScopeProduct NDCPackage NDCCodeStatusReporting periodSource date
excluded packagepackage58657-68058657-680-01DDiscontinued by firm2026-10-12

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 12 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Snapshot, Source SHA-256 table
Captured / source dateSnapshotSource SHA-256
2025-12-14 17:58 UTC · source 2025-12-05d630ba8d3edf…732f749b63fb…
2025-08-27 00:01 UTC · source 2025-08-26f5e01cc5f278…a2eaf40c39c3…
2025-04-01 02:39 UTC · source 2025-03-312ef7874e63bc…57b86245f4fa…
2025-03-28 20:22 UTC · source 2025-03-28a1b67e2a42f9…c4cf2c586c0d…
2025-03-22 03:12 UTC · source 2025-03-21cfe11265f3b6…090c488252e2…
2025-03-10 12:48 UTC · source 2025-03-10cdf11ea48f46…ba0047e9e063…
2025-02-02 03:52 UTC · source 2025-01-31302b2466d912…e7b80fea0513…
2025-01-20 13:05 UTC · source 2025-01-20ed331223b511…672a5bd82f5f…
2025-01-11 03:41 UTC · source 2025-01-100efc9e666f02…f202fb6c5f17…
2024-11-09 02:27 UTC · source 2024-11-08ad56d346431e…cc804d4bbf1e…
2024-10-04 04:10 UTC · source 2024-10-03367a005e9d99…383a685ebd0f…
2024-07-10 04:00 UTC · source 2024-07-09557ba5c1ecfa…9c80585c8c6e…

Source provenance: Browse the complete Orange Book source catalog · source snapshot 43.

Orange Book products#

Current product rows page 1 of 1 · 4 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A202413-001IBUPROFENIBUPROFEN400MGTABLET / ORALAB2016-11-23
A202413-002IBUPROFENIBUPROFEN600MGTABLET / ORALAB2016-11-23
A202413-003IBUPROFENIBUPROFEN800MGTABLET / ORALAB2016-11-23
A202413-004IBUPROFENIBUPROFEN300MGTABLET / ORAL2024-07-05

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 3 matching rows.

Application-product, TE code table
Application-productTE code
A202413-001AB
A202413-002AB
A202413-003AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 4 · 143 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-09-14 22:38:342026-08A202413-001IBUPROFEN400MGTABLET / ORALAB2016-11-2384e616aacf4f…
2026-09-14 22:38:342026-08A202413-002IBUPROFEN600MGTABLET / ORALAB2016-11-2384e616aacf4f…
2026-09-14 22:38:342026-08A202413-003IBUPROFEN800MGTABLET / ORALAB2016-11-2384e616aacf4f…
2026-09-14 22:38:342026-08A202413-004IBUPROFEN300MGTABLET / ORAL2024-07-0584e616aacf4f…
2026-08-18 06:07:402026-07A202413-001IBUPROFEN400MGTABLET / ORALAB2016-11-23caaa826d4ba7…
2026-08-18 06:07:402026-07A202413-002IBUPROFEN600MGTABLET / ORALAB2016-11-23caaa826d4ba7…
2026-08-18 06:07:402026-07A202413-003IBUPROFEN800MGTABLET / ORALAB2016-11-23caaa826d4ba7…
2026-08-18 06:07:402026-07A202413-004IBUPROFEN300MGTABLET / ORAL2024-07-05caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A202413-001IBUPROFEN400MGTABLET / ORALAB2016-11-23011fe1cb6892…
2026-02-19 14:30 UTC2026-02A202413-002IBUPROFEN600MGTABLET / ORALAB2016-11-23011fe1cb6892…
2026-02-19 14:30 UTC2026-02A202413-003IBUPROFEN800MGTABLET / ORALAB2016-11-23011fe1cb6892…
2026-02-19 14:30 UTC2026-02A202413-004IBUPROFEN300MGTABLET / ORAL2024-07-05011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A202413-001IBUPROFEN400MGTABLET / ORALAB2016-11-2331067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A202413-002IBUPROFEN600MGTABLET / ORALAB2016-11-2331067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A202413-003IBUPROFEN800MGTABLET / ORALAB2016-11-2331067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A202413-004IBUPROFEN300MGTABLET / ORAL2024-07-0531067a03dcf5…
2025-08-23 18:47 UTC2025-08A202413-001IBUPROFEN400MGTABLET / ORALAB2016-11-236a471c1ec25d…
2025-08-23 18:47 UTC2025-08A202413-002IBUPROFEN600MGTABLET / ORALAB2016-11-236a471c1ec25d…
2025-08-23 18:47 UTC2025-08A202413-003IBUPROFEN800MGTABLET / ORALAB2016-11-236a471c1ec25d…
2025-08-23 18:47 UTC2025-08A202413-004IBUPROFEN300MGTABLET / ORAL2024-07-056a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A202413-001IBUPROFEN400MGTABLET / ORALAB2016-11-23fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A202413-002IBUPROFEN600MGTABLET / ORALAB2016-11-23fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A202413-003IBUPROFEN800MGTABLET / ORALAB2016-11-23fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A202413-004IBUPROFEN300MGTABLET / ORAL2024-07-05fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A202413-001IBUPROFEN400MGTABLET / ORALAB2016-11-23b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A202413-002IBUPROFEN600MGTABLET / ORALAB2016-11-23b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A202413-003IBUPROFEN800MGTABLET / ORALAB2016-11-23b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A202413-004IBUPROFEN300MGTABLET / ORAL2024-07-05b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A202413-001IBUPROFEN400MGTABLET / ORALAB2016-11-2303ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A202413-002IBUPROFEN600MGTABLET / ORALAB2016-11-2303ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A202413-003IBUPROFEN800MGTABLET / ORALAB2016-11-2303ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A202413-004IBUPROFEN300MGTABLET / ORAL2024-07-0503ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A202413-001IBUPROFEN400MGTABLET / ORALAB2016-11-232680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A202413-002IBUPROFEN600MGTABLET / ORALAB2016-11-232680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A202413-003IBUPROFEN800MGTABLET / ORALAB2016-11-232680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A202413-004IBUPROFEN300MGTABLET / ORAL2024-07-052680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A202413-001IBUPROFEN400MGTABLET / ORALAB2016-11-235bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A202413-002IBUPROFEN600MGTABLET / ORALAB2016-11-235bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A202413-003IBUPROFEN800MGTABLET / ORALAB2016-11-235bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A202413-004IBUPROFEN300MGTABLET / ORAL2024-07-055bbf6a4d5a75…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 4 · 129 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-09-14 22:38:342026-08A202413-001AB184e616aacf4f…
2026-09-14 22:38:342026-08A202413-002AB184e616aacf4f…
2026-09-14 22:38:342026-08A202413-003AB184e616aacf4f…
2026-08-18 06:07:402026-07A202413-001AB1caaa826d4ba7…
2026-08-18 06:07:402026-07A202413-002AB1caaa826d4ba7…
2026-08-18 06:07:402026-07A202413-003AB1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A202413-001AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A202413-002AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02A202413-003AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A202413-001AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A202413-002AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A202413-003AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08A202413-001AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A202413-002AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08A202413-003AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A202413-001AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A202413-002AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A202413-003AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A202413-001AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A202413-002AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A202413-003AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A202413-001AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A202413-002AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A202413-003AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A202413-001AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A202413-002AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A202413-003AB12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A202413-001AB15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A202413-002AB15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A202413-003AB15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A202413-001AB1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A202413-002AB1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A202413-003AB1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A202413-001AB1d06236e962d9…
2024-10-29 15:01 UTC2024-10A202413-002AB1d06236e962d9…
2024-10-29 15:01 UTC2024-10A202413-003AB1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A202413-001AB179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A202413-002AB179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A202413-003AB179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A202413-001AB1301d65b070ca…

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
58657-680-01EA - Each58657-68017122841-8e6c-44b3-b449-23c4c706a32112017-05-04
58657-680-50EA - Each58657-680357e6dc7-708d-4c8f-b1ca-1e110035e8aa12017-05-04

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 2 of 3 · 45 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
IbuprofenIBUPROFENRedpharm Drug44f609dd-c868-493f-e063-6294a90a71382025-12-02Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENA-S Medication Solutions71b5b2a2-397e-4dcb-b0c7-ef08df4337e02025-11-26Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENA-S Medication Solutions47711610-6577-4805-a2ce-cf9b7cbfa8122025-11-26Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENAdvanced Rx of Tennessee, LLC41351cc0-5ec6-2f4d-e063-6294a90a733a2025-10-15Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENCoupler LLC410f7320-4caa-8f88-e063-6394a90acf932025-10-13Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENPreferred Pharmaceuticals Inc.a85080d7-50b4-461b-9d77-d6fbab971c032025-10-13Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENPHOENIX RX LLC3b17587e-b609-42a9-e063-6294a90ab1f82025-08-01Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENSOLA Pharmaceuticals, LLC44fb0842-c34e-477e-96df-350cd5d6800e2025-07-20Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENAphena Pharma Solutions - Tennessee, LLC388e68dc-1822-f375-e063-6294a90a3d412025-06-27Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENNuCare Pharmaceuticals, Inc.2c3f8149-9b77-54cd-e063-6394a90a847e2025-05-21Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENNuCare Pharmaceuticals, Inc.3520deb7-5e45-3d0f-e063-6394a90ab44b2025-05-14Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENAphena Pharma Solutions - Tennessee, LLC34673d3b-41cd-f4c9-e063-6394a90a85102025-05-05Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENAphena Pharma Solutions - Tennessee, LLC3467b45b-c432-2923-e063-6394a90a10442025-05-05Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENBrisk Pharmaceuticals2dcbe4bb-fb24-e827-e063-6394a90acf9f2025-02-10Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENA-S Medication Solutions2d0c2d35-c212-4daa-b2c4-b407ca0b16ad2024-10-21Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENA-S Medication Solutions2b470e48-c23c-4f5c-916a-d38d8518896b2024-10-21Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENA-S Medication Solutionsdf0e55d0-617c-4084-984f-ece2f640e7152024-10-11Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENA-S Medication Solutionsb0917020-f0ec-4d07-8fbf-c1eb909f466b2024-10-10Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENA-S Medication Solutionsb365be3a-91ad-46bf-a949-103c81f2359a2024-10-10Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413
IbuprofenIBUPROFENWestminster Pharmaceuticals, LLCeeb8312f-7fd9-4c4f-8264-a7e63ff1aa9d2024-10-10Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (ANDA): 202413
application number: ANDA202413

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
58657-680-0158657068001100 TABLET in 1 BOTTLE (58657-680-01) 100 tablet2017-04-150000-00-00NoNoCurrent