BIOFREEZE
- Product NDC
- 59316-102
- 11-digit product format
- 593160102
- Labeler code
- 59316
- Product ID
- 59316-102_51b44481-a7ad-8a46-e063-6294a90aefda
- Type
- HUMAN OTC DRUG
- Nonproprietary name
- MENTHOL
- Dosage form
- GEL
- Route
- TOPICAL
- Labeler
- Reckitt Benckiser LLC
- Application
- M017
- Marketing category
- OTC MONOGRAPH DRUG
- Marketing start
- 2012-01-03
- Substance
- MENTHOL, UNSPECIFIED FORM
- Active strength
- 40 mg/mL
- NDC exclude flag
- No
- Listing certified through
- 2027-12-31
- Current FDA listing
- Yes
NDC auxiliary status#
These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.
| Dataset | Scope | Product NDC | Package NDC | Code | Status | Reporting period | Source date |
|---|---|---|---|---|---|---|---|
| excluded package | package | 59316-102 | 59316-102-15 | D | Discontinued by firm | 2026-10-23 | |
| excluded package | package | 59316-102 | 59316-102-16 | D | Discontinued by firm | 2026-10-23 | |
| excluded package | package | 59316-102 | 59316-102-25 | D | Discontinued by firm | 2026-10-23 | |
| excluded package | package | 59316-102 | 59316-102-91 | D | Discontinued by firm | 2026-10-23 | |
| excluded package | package | 59316-102 | 59316-102-92 | D | Discontinued by firm | 2026-10-23 |
Observed NDC auxiliary status history#
This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.
| Captured / source date | Package NDC | Snapshot | Source SHA-256 |
|---|---|---|---|
| 2025-12-14 17:58 UTC · source 2025-12-05 | 59316-102-25 | d630ba8d3edf… | 732f749b63fb… |
| 2025-12-14 17:58 UTC · source 2025-12-05 | 59316-102-16 | d630ba8d3edf… | 732f749b63fb… |
| 2025-12-14 17:58 UTC · source 2025-12-05 | 59316-102-15 | d630ba8d3edf… | 732f749b63fb… |
| 2025-08-27 00:01 UTC · source 2025-08-26 | 59316-102-25 | f5e01cc5f278… | a2eaf40c39c3… |
| 2025-08-27 00:01 UTC · source 2025-08-26 | 59316-102-16 | f5e01cc5f278… | a2eaf40c39c3… |
| 2025-08-27 00:01 UTC · source 2025-08-26 | 59316-102-15 | f5e01cc5f278… | a2eaf40c39c3… |
| 2025-04-01 02:39 UTC · source 2025-03-31 | 59316-102-25 | 2ef7874e63bc… | 57b86245f4fa… |
| 2025-04-01 02:39 UTC · source 2025-03-31 | 59316-102-16 | 2ef7874e63bc… | 57b86245f4fa… |
| 2025-04-01 02:39 UTC · source 2025-03-31 | 59316-102-15 | 2ef7874e63bc… | 57b86245f4fa… |
| 2025-03-28 20:22 UTC · source 2025-03-28 | 59316-102-25 | a1b67e2a42f9… | c4cf2c586c0d… |
| 2025-03-28 20:22 UTC · source 2025-03-28 | 59316-102-16 | a1b67e2a42f9… | c4cf2c586c0d… |
| 2025-03-28 20:22 UTC · source 2025-03-28 | 59316-102-15 | a1b67e2a42f9… | c4cf2c586c0d… |
| 2025-03-22 03:12 UTC · source 2025-03-21 | 59316-102-25 | cfe11265f3b6… | 090c488252e2… |
| 2025-03-22 03:12 UTC · source 2025-03-21 | 59316-102-16 | cfe11265f3b6… | 090c488252e2… |
| 2025-03-22 03:12 UTC · source 2025-03-21 | 59316-102-15 | cfe11265f3b6… | 090c488252e2… |
| 2025-03-10 12:48 UTC · source 2025-03-10 | 59316-102-25 | cdf11ea48f46… | ba0047e9e063… |
| 2025-03-10 12:48 UTC · source 2025-03-10 | 59316-102-16 | cdf11ea48f46… | ba0047e9e063… |
| 2025-03-10 12:48 UTC · source 2025-03-10 | 59316-102-15 | cdf11ea48f46… | ba0047e9e063… |
| 2025-02-02 03:52 UTC · source 2025-01-31 | 59316-102-25 | 302b2466d912… | e7b80fea0513… |
| 2025-02-02 03:52 UTC · source 2025-01-31 | 59316-102-16 | 302b2466d912… | e7b80fea0513… |
| 2025-02-02 03:52 UTC · source 2025-01-31 | 59316-102-15 | 302b2466d912… | e7b80fea0513… |
| 2025-01-20 13:05 UTC · source 2025-01-20 | 59316-102-25 | ed331223b511… | 672a5bd82f5f… |
| 2025-01-20 13:05 UTC · source 2025-01-20 | 59316-102-16 | ed331223b511… | 672a5bd82f5f… |
| 2025-01-20 13:05 UTC · source 2025-01-20 | 59316-102-15 | ed331223b511… | 672a5bd82f5f… |
| 2025-01-11 03:41 UTC · source 2025-01-10 | 59316-102-25 | 0efc9e666f02… | f202fb6c5f17… |
| 2025-01-11 03:41 UTC · source 2025-01-10 | 59316-102-16 | 0efc9e666f02… | f202fb6c5f17… |
| 2025-01-11 03:41 UTC · source 2025-01-10 | 59316-102-15 | 0efc9e666f02… | f202fb6c5f17… |
| 2024-11-09 02:27 UTC · source 2024-11-08 | 59316-102-25 | ad56d346431e… | cc804d4bbf1e… |
| 2024-11-09 02:27 UTC · source 2024-11-08 | 59316-102-16 | ad56d346431e… | cc804d4bbf1e… |
| 2024-11-09 02:27 UTC · source 2024-11-08 | 59316-102-15 | ad56d346431e… | cc804d4bbf1e… |
| 2024-10-04 04:10 UTC · source 2024-10-03 | 59316-102-25 | 367a005e9d99… | 383a685ebd0f… |
| 2024-10-04 04:10 UTC · source 2024-10-03 | 59316-102-16 | 367a005e9d99… | 383a685ebd0f… |
| 2024-10-04 04:10 UTC · source 2024-10-03 | 59316-102-15 | 367a005e9d99… | 383a685ebd0f… |
| 2024-07-10 04:00 UTC · source 2024-07-09 | 59316-102-25 | 557ba5c1ecfa… | 9c80585c8c6e… |
| 2024-07-10 04:00 UTC · source 2024-07-09 | 59316-102-16 | 557ba5c1ecfa… | 9c80585c8c6e… |
| 2024-07-10 04:00 UTC · source 2024-07-09 | 59316-102-15 | 557ba5c1ecfa… | 9c80585c8c6e… |
Reported adverse events (FAERS/openFDA)#
Adverse event summaries are temporarily unavailable. Other product information remains available.
Additional Listing Data#
- Finished product
- Yes
- Brand name base
- BIOFREEZE
- Listing expiration
- 2027-12-31
Active Ingredients#
| Ingredient | Strength |
|---|---|
| MENTHOL, UNSPECIFIED FORM | 40 mg/mL |
Harmonized UNII identifiers#
| Identifier | FDA.report destination |
|---|---|
| L7T10EIP3A | Internal UNII lookup |
Harmonized RxCUI identifiers#
Harmonized SPL set identifiers#
| Identifier | FDA.report destination |
|---|---|
| 83d5c2f2-2413-4d28-83b2-0808d0917b4d | Available on FDA.report |
DailyMed Package Descriptions#
| Package NDC | Product | Description | Form | Quantity | Strength | SPL version |
|---|---|---|---|---|---|---|
| 59316-102-10 | BIOFREEZE | 5 mL in 1 BOTTLE | GEL | 5 | 35 | |
| 59316-102-11 | BIOFREEZE | 3 mL in 1 BOTTLE | GEL | 3 | 35 | |
| 59316-102-12 | BIOFREEZE | 89 mL in 1 BOTTLE | GEL | 89 | 35 | |
| 59316-102-15 | BIOFREEZE | 89 mL in 1 BOTTLE, WITH APPLICATOR | GEL | 89 | 35 | |
| 59316-102-16 | BIOFREEZE | 89 mL in 1 BOTTLE, WITH APPLICATOR | GEL | 89 | 35 | |
| 59316-102-20 | BIOFREEZE | 118 mL in 1 BOTTLE | GEL | 118 | 35 | |
| 59316-102-25 | BIOFREEZE | 118 mL in 1 BOTTLE, WITH APPLICATOR | GEL | 118 | 35 | |
| 59316-102-28 | BIOFREEZE | 237 mL in 1 BOTTLE | GEL | 237 | 35 | |
| 59316-102-30 | BIOFREEZE | 473 mL in 1 BOTTLE | GEL | 473 | 35 | |
| 59316-102-40 | BIOFREEZE | 946 mL in 1 BOTTLE | GEL | 946 | 35 | |
| 59316-102-50 | BIOFREEZE | 3785 mL in 1 CONTAINER | GEL | 3785 | 35 | |
| 59316-102-80 | BIOFREEZE | 44 mL in 1 TUBE | GEL | 44 | 35 | |
| 59316-102-90 | BIOFREEZE | 100 in 1 CARTON | GEL | 100 | 35 | |
| 59316-102-91 | BIOFREEZE | 10 in 1 CARTON | GEL | 10 | 35 | |
| 59316-102-92 | BIOFREEZE | 16 in 1 CARTON | GEL | 16 | 35 | |
| 59316-102-98 | BIOFREEZE | 30 mL in 1 BOTTLE | GEL | 30 | 35 | |
| 59316-102-80 | Biofreeze | 44 mL in 1 TUBE | GEL | 44 | 1 |
DailyMed Billing Units#
| Package NDC | Billing unit | Product NDC | DailyMed indexing SPL | SPL version | Effective |
|---|---|---|---|---|---|
| 59316-102-12 | ML - Milliliter | 59316-102 | 8c11b8a5-4f02-41bf-88b6-e4af8c4214f8 | 1 | 2018-09-05 |
| 59316-102-20 | ML - Milliliter | 59316-102 | 63342204-7fd4-4732-9ec3-4df580a6e6ce | 1 | 2015-06-09 |
| 59316-102-28 | ML - Milliliter | 59316-102 | e8471990-bf89-42b8-8a43-721055ce7645 | 1 | 2018-09-05 |
| 59316-102-30 | ML - Milliliter | 59316-102 | 8537e275-8662-4f2c-ae52-44981681af99 | 1 | 2024-08-12 |
| 59316-102-40 | ML - Milliliter | 59316-102 | 030b1aca-eae8-43da-9839-6522c8c985ac | 1 | 2024-08-12 |
| 59316-102-50 | ML - Milliliter | 59316-102 | 35b2fa59-5fb2-4779-a89d-b84cda167825 | 1 | 2024-08-12 |
| 59316-102-80 | ML - Milliliter | 59316-102 | 39ef3edc-90e7-4701-bbcc-add710ddea6d | 1 | 2024-08-12 |
DailyMed Socrata Ingredients#
DailyMed Dashboard NDC Coverage#
| NDC | Dashboard title | SPL version | Validation | Dashboard ZIP |
|---|---|---|---|---|
| 59316-102 | BIOFREEZE (MENTHOL) GEL [RB HEALTH (US) LLC] | 34 | Current NDC, Legacy NDC, 16 package rows | 20231114_83d5c2f2-2413-4d28-83b2-0808d0917b4d.zip |
| 59316-102 | BIOFREEZE (MENTHOL) GEL [PERFORMANCE HEALTH, LLC] | 1 | Current NDC, Legacy NDC, 1 package rows | 20181108_f0c4d165-a242-4fb5-b2de-d64a825a29e9.zip |
openFDA label cross-check#
OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
| Brand | Generic | Manufacturer | SPL set ID | Effective date | Available safety fields | Join |
|---|---|---|---|---|---|---|
| Coralite Capsaicin Heat Patch 2ct | CAPSAICIN | United Exchange Corp. | 4128b1ac-f540-2611-e063-6294a90ac98b | 2025-10-08 | Warnings | M017 |
| Ombre Men overtime wipes | BENZOCAINE | Sambria Pharmaceuticals, LLC | 405f23ca-99c1-4db4-aba1-2fd7f93f55ee | 2025-10-07 | Warnings | M017 |
| Pain free IV | LIDOCAINE | Sambria Pharmaceuticals, LLC | 7aa4cb20-d452-417f-afdb-307df754ed75 | 2025-10-07 | Warnings | M017 |
| HYDROCORTISONE | HYDROCORTISONE | CVS PHARMACY, INC | b3bdff5e-37fe-442a-a370-7b19799ea781 | 2025-10-07 | Warnings | M017 |
| HealthWise Pain Relief Patch | MENTHOL, METHYL SALICYLATE | Veridian Healthcare | b65932fd-ee9f-4fa2-b842-01e0f54133c9 | 2025-10-07 | Warnings | M017 |
| AREX SINSIN PAS | CAMPHOR, MENTHA OIL, MENTHOL, METHYL SALICYLATE, ZINC OXIDE | Sinsin Pharmaceutical Co., Ltd. | 2013ea44-e2ea-4b36-bddb-7f64163284b6 | 2025-10-07 | Warnings | M017 |
| SINSINPAS LIDOCAINE PAIN RELIEVING | LIDOCAINE | Sinsin Pharmaceutical Co., Ltd. | 82c0a036-8750-5b3d-e053-2a91aa0a1815 | 2025-10-07 | Warnings | M017 |
| SINSIN MULPAS | L-MENTHOL, METHYL SALICYLATE, DL-CAMPHOR, CHLORPHENIRAMINE MALEATE, THYMOL | Sinsin Pharmaceutical Co., Ltd. | 81baffcb-c08e-4616-e053-2a91aa0aaf15 | 2025-10-07 | Warnings | M017 |
| Arex Sinsin Pas | CAMPHOR, MENTHA OIL, MENTHOL, METHYL SALICYLATE, ZINC OXIDE | Sinsin Pharmaceutical Co., Ltd. | a851854a-5dfe-4bd5-95f6-67c3f13f1187 | 2025-10-07 | Warnings | M017 |
| Sinsinpas Arex Flex Gel Pain Relieving Patch | L-MENTHOL | Sinsin Pharmaceutical Co., Ltd. | 1758ef9b-4fac-4066-e063-6394a90a8cc3 | 2025-10-07 | Warnings | M017 |
| SINSINPAS CORN REMOVER | SALICYLIC ACID | Sinsin Pharmaceutical Co., Ltd. | e2771dfc-ee57-553f-e053-2a95a90af281 | 2025-10-07 | Warnings | M017 |
| Feminine Anti-Itch Creme | BENZOCAINE, RESORCINOL | Quality Choice (CHAIN DRUG MARKETING ASSOCIATION) | aa6cc963-dc60-5222-e053-2995a90acaf6 | 2025-10-06 | Warnings | M017 |
| TheraCare 2% Diphenhydramine Anti-Itch Cream | DIPHENHYDRAMINE HYDROCHLORIDE AND ZINC ACETATE | Veridian Healthcare | 5999b677-63dd-49c6-b5b8-7b3c117ecc5c | 2025-10-06 | Warnings | M017 |
| HealthWise Pain Relief | MENTHOL | Veridian Healthcare | 06be5331-7a1e-4ab3-9f17-2d350bd4b890 | 2025-10-02 | Warnings | M017 |
| equate Burn Relief | LIDOCAINE HYDROCHLORIDE | Walmart Inc | a90cbd92-80a5-4463-8152-b83165121a6f | 2025-10-02 | Warnings | M017 |
| AsperFlex HOT | CAMPHOR, MENTHOL, METHYL SALICYLATE | Akron Pharma Inc. | a6cb0656-8866-44ff-b40c-73655ff68721 | 2025-10-02 | Warnings | M017 |
| AsperFlex Original Maximum Strength | MENTHOL | Akron Pharma Inc. | d766c61e-c48b-4aff-97b0-678159479e03 | 2025-10-02 | Warnings | M017 |
| HealthWise Feminine Anti-Itch Cream | BENZOCAINE, RESORCINOL | Veridian Healthcare | 1f9110da-f448-8e20-e063-6294a90a4275 | 2025-10-02 | Warnings | M017 |
| PROSTAT FIRST AID Burn Ease, 0.9g | LIDOCAINE | ProStat First Aid LLC | dc704403-e2aa-47f7-a7f4-f6afe1547ca8 | 2025-10-01 | Warnings | M017 |
| PROSTAT FIRST AID Burn Ease, 0.9g | LIDOCAINE | ProStat First Aid LLC | e02558a9-fe2b-4f28-9fd3-7308f859d759 | 2025-10-01 | Warnings | M017 |
DailyMed RxNorm Mappings#
Packages#
| Package NDC | 11-digit format | Description | Units | Marketing start | Marketing end | Sample | Exclude flag | Status |
|---|---|---|---|---|---|---|---|---|
| 59316-102-10 | 59316010210 | 5 mL in 1 BOTTLE (59316-102-10) | 5 ml | 2012-01-03 | 0000-00-00 | No | No | Current |
| 59316-102-11 | 59316010211 | 3 mL in 1 BOTTLE (59316-102-11) | 3 ml | 2012-01-03 | 0000-00-00 | No | No | Current |
| 59316-102-12 | 59316010212 | 89 mL in 1 BOTTLE (59316-102-12) | 89 ml | 2016-09-19 | 0000-00-00 | No | No | Current |
| 59316-102-15 | 59316010215 | 89 mL in 1 BOTTLE, WITH APPLICATOR | 89 ml | Historical | ||||
| 59316-102-16 | 59316010216 | 89 mL in 1 BOTTLE, WITH APPLICATOR | 89 ml | Historical | ||||
| 59316-102-20 | 59316010220 | 118 mL in 1 BOTTLE (59316-102-20) | 118 ml | 2012-01-03 | 0000-00-00 | No | No | Current |
| 59316-102-25 | 59316010225 | 118 mL in 1 BOTTLE, WITH APPLICATOR (59316-102-25) | 118 ml | 2012-01-03 | 2021-12-31 | No | No | Current |
| 59316-102-28 | 59316010228 | 237 mL in 1 BOTTLE (59316-102-28) | 237 ml | 2016-09-19 | 0000-00-00 | No | No | Current |
| 59316-102-30 | 59316010230 | 473 mL in 1 BOTTLE (59316-102-30) | 473 ml | 2012-01-03 | 0000-00-00 | No | No | Current |
| 59316-102-40 | 59316010240 | 946 mL in 1 BOTTLE (59316-102-40) | 946 ml | 2012-01-03 | 0000-00-00 | No | No | Current |
| 59316-102-50 | 59316010250 | 3785 mL in 1 CONTAINER (59316-102-50) | 3785 ml | 2012-01-03 | 0000-00-00 | No | No | Current |
| 59316-102-80 | 59316010280 | 44 mL in 1 TUBE (59316-102-80) | 44 ml | 2018-11-02 | 0000-00-00 | No | No | Current |
| 59316-102-90 | 59316010290 | 100 BOTTLE in 1 CARTON (59316-102-90) / 5 mL in 1 BOTTLE (59316-102-10) | 100 bottle | 2012-01-03 | 0000-00-00 | No | No | Current |
| 59316-102-91 | 59316010291 | 10 BOTTLE in 1 CARTON (59316-102-91) > 3 mL in 1 BOTTLE (59316-102-11) | 10 bottle | 2012-01-03 | 0000-00-00 | No | No | Current |
| 59316-102-92 | 59316010292 | 16 BOTTLE in 1 CARTON (59316-102-92) > 3 mL in 1 BOTTLE (59316-102-11) | 16 bottle | 2012-01-03 | 0000-00-00 | No | No | Current |
| 59316-102-98 | 59316010298 | 30 mL in 1 BOTTLE (59316-102-98) | 30 ml | 2012-01-03 | 0000-00-00 | No | No | Current |