Biofreeze Overnight Roll-on

Product NDC: 59316-207
11-digit product format: 593160207
Labeler code: 59316
Product ID: 59316-207_51e06d5e-11fe-5814-e063-6294a90a2736
Type: HUMAN OTC DRUG
Nonproprietary name: Menthol
Dosage form: GEL
Route: TOPICAL
Labeler: Reckitt Benckiser LLC
Application: M017
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2023-03-16
Substance: MENTHOL
Active strength: 40 mg/mL
NDC exclude flag: No
Listing certified through: 2027-12-31
Current FDA listing: Yes

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: Biofreeze Overnight Roll-on
Listing expiration: 2027-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
MENTHOL	40 mg/mL

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
L7T10EIP3A	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
415974	Internal RxNorm lookup
1111683	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
f67d7b7a-8922-73f6-e053-2995a90a2e80	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
6c13b22c-b3ba-4127-b768-0132dd5ab0d1	Product name	1	20230829

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	Strength	SPL version
59316-207-14	Biofreeze Roll-On and Overnight Roll-On	74 mL in 1 BOTTLE	GEL	74 mL	40 mg in 1mL	5
59316-207-14	Biofreeze Overnight Roll-on	74 mL in 1 BOTTLE	GEL	74		3

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDC	Billing unit	Product NDC	DailyMed indexing SPL	SPL version	Effective
59316-207-14	ML - Milliliter	59316-207	984f94ed-b81d-4470-a2af-d26d054baea7	1	2024-02-14

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
59316-207	BIOFREEZE OVERNIGHT ROLL-ON (MENTHOL) GEL [RB HEALTH (US) LLC]	2	Current NDC, 1 package rows	20241228_f67d7b7a-8922-73f6-e053-2995a90a2e80.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 99 of 152 · 3,029 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Hydrocortisone with aloe	HYDROCORTISONE	Encube Ethicals, Inc.	12a1774d-a97e-4787-b6b1-8e8cd40b7b70	2025-02-26	Warnings	Exact identifier application number: M017
Thera Plus Maximum Strength Feminine Anti-Itch	BENZOCAINE, RESORCINOL	FOURSTAR GROUP USA, INC.	0007e3ea-882b-4000-8e70-2bcec2c08613	2025-02-26	Warnings	Exact identifier application number: M017
Tattoo numbing cream	LIDOCAINE	BLOOMWELL GARDENS LLC	2ea9d34e-408d-f8d6-e063-6394a90a72a4	2025-02-26	Warnings	Exact identifier application number: M017
Icy Hot Pro No-Mess	CAMPHOR, MENTHOL	Chattem, Inc.	9e8fedf5-fb59-4531-b288-715f851ee05b	2025-02-26	Warnings	Exact identifier application number: M017
Family Wellness Max Strength 1 Hydrocortisone Cream	HYDROCORTISONE	Family Dollar Stores, Inc	bca5ac2c-45cd-44e3-98f1-317a04e44d7d	2025-02-25	Warnings	Exact identifier application number: M017
Tylenol Precise Nighttime Pain Relieving	CAMPHOR, MENTHOL	Kenvue Brands LLC	2ef4fe16-0820-6aad-e063-6294a90a8449	2025-02-25	Warnings	Exact identifier application number: M017
LidoPro Pain Relief	CAPSAICIN AND LIDOCAINE	Preferred Pharmaceuticals Inc.	c259ef92-5d07-4590-adf1-3a106333eee0	2025-02-21	Warnings	Exact identifier application number: M017
Cortizone 10 Ultra Soothing Itch Relief	HYDROCORTISONE	Chattem, Inc.	8a9e2d32-a65f-4253-8041-4146f4e3b738	2025-02-21	Warnings	Exact identifier application number: M017
AVCOO Pain Relief Roll On	MENTHOL	ADP Health Limited	420d8cdc-f47f-4d33-bf25-9033ff266c49	2025-02-19	Warnings	Exact identifier application number: M017
AVCOO Pain Relief	MENTHOL	ADP Health Limited	700ce2cf-749e-40be-91c3-850d9b2168ca	2025-02-19	Warnings	Exact identifier application number: M017
Sunburn Relief Gel	LIDOCAINE HCL	Jell Pharmaceuticals Pvt. Ltd	2e7c49de-5438-4858-e063-6294a90ad98c	2025-02-19	Warnings	Exact identifier application number: M017
VTROUY Tattoo Numbing Cream	TATTOO NUMBING CREAM	Guangzhou Zanming Trading Co., Ltd.	2e899851-b3cd-0758-e063-6294a90afea8	2025-02-19	Warnings	Exact identifier application number: M017
Pomada Dragon Pain Relief	MENTHOL, UNSPECIFIED FORM, CAMPHOR (SYNTHETIC), AND METHYL SALICYLATE	Genomma Lab USA	9d98f48b-6d88-4df9-9459-7cf7ba5de044	2025-02-19	Warnings	Exact identifier application number: M017
Pain Relieving Cream	HISTAMINE DIHYDROCHLORIDE	Mediapower, Inc. DBA Dr Newton's And Naturals	9eeea033-ae87-4d83-85d0-b8fa653a0806	2025-02-19	Warnings	Exact identifier application number: M017
Sure Complete Confidence Antiperspirant Deodorant Aerosol, Regular	ALUMINUM CHLOROHYDRATE	Sodalis USA, LLC	7839cf53-dbd2-4dbb-a309-1581d51f8adc	2025-02-18	Warnings	Exact identifier application number: M017
CANNA NUMB Roll On	LIDOCAINE HYDROCHLORIDE, MENTHOL	Cannanumb LLC	c1eb0348-3b0e-4f1c-a46b-1ff4aa165fb4	2025-02-17	Warnings	Exact identifier application number: M017
Vaporizing Chest Rub 4 oz.	CAMPHOR, EUCALYPTUS OIL, MENTHOL	Rejoice International Inc.	7173b141-123e-6cd4-e053-2a95a90a8600	2025-02-12	Warnings	Exact identifier application number: M017
Vaporizing Chest Rub 4 oz. 3 pk	CAMPHOR, EUCALYPTUS OIL, MENTHOL	Rejoice International Inc.	71c186a1-8283-2482-e053-2995a90acc1f	2025-02-12	Warnings	Exact identifier application number: M017
Roman Swipes	BENZOCAINE	Roman Health Ventures Inc.	7f0eac8c-7235-99d8-e053-2a91aa0a634e	2025-02-12	Warnings	Exact identifier application number: M017
SANAR NATURAL-ARNICA ROLL ON ARNICA PAIN RELIEVING WITH CAMPHOR	EVI LABS	EVI LABS	2df7658d-83d3-41ac-e063-6294a90ab1dd	2025-02-12	Warnings	Exact identifier application number: M017

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1111683	BIOFREEZE 4 % Topical Gel	PSN	4d3dcb8f-2075-6bbc-e063-6394a90a4992	5
415974	menthol 4 % Topical Gel	PSN	4d3dcb8f-2075-6bbc-e063-6394a90a4992	5
1111683	menthol 0.04 MG/MG Topical Gel [Biofreeze]	SBD	4d3dcb8f-2075-6bbc-e063-6394a90a4992	5
415974	menthol 0.04 MG/MG Topical Gel	SCD	4d3dcb8f-2075-6bbc-e063-6394a90a4992	5
1111683	Biofreeze 0.04 MG/MG Topical Gel	SY	4d3dcb8f-2075-6bbc-e063-6394a90a4992	5
1111683	Biofreeze 4 % Topical Gel	SY	4d3dcb8f-2075-6bbc-e063-6394a90a4992	5
415974	menthol 4 % Topical Gel	SY	4d3dcb8f-2075-6bbc-e063-6394a90a4992	5
1111683	BIOFREEZE 4 % Topical Gel	PSN	f67d7b7a-8922-73f6-e053-2995a90a2e80	3
415974	menthol 4 % Topical Gel	PSN	f67d7b7a-8922-73f6-e053-2995a90a2e80	3
1111683	menthol 0.04 MG/MG Topical Gel [Biofreeze]	SBD	f67d7b7a-8922-73f6-e053-2995a90a2e80	3
415974	menthol 0.04 MG/MG Topical Gel	SCD	f67d7b7a-8922-73f6-e053-2995a90a2e80	3
1111683	Biofreeze 0.04 MG/MG Topical Gel	SY	f67d7b7a-8922-73f6-e053-2995a90a2e80	3
1111683	Biofreeze 4 % Topical Gel	SY	f67d7b7a-8922-73f6-e053-2995a90a2e80	3
415974	menthol 4 % Topical Gel	SY	f67d7b7a-8922-73f6-e053-2995a90a2e80	3

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Sample	Exclude flag	Status
59316-207-14	59316020714	74 mL in 1 BOTTLE (59316-207-14)	74 ml	2023-03-16	No	No	Current

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
BioFreeze Day & Overnight Roll-On	Reckitt Benckiser LLC	2026-05-15	HUMAN OTC DRUG LABEL	5
BiOFREEZE ® Overnight Roll-on	Reckitt Benckiser LLC	2026-05-15	HUMAN OTC DRUG LABEL	3