Zyvox

Product NDC
66298-4992
11-digit product format
662984992
Labeler code
66298
Product ID
66298-4992_74f6ba39-466c-c32b-e053-2991aa0a665c
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
LINEZOLID
Dosage form
INJECTION, SOLUTION
Route
INTRAVENOUS
Labeler
Fresenius Kabi Norge As
Application
NDA021131
Marketing category
NDA
Marketing start
2018-06-05
Marketing end
0000-00-00
Substance
LINEZOLID
Active strength
600 mg/300mL
Pharmacologic classes
Oxazolidinone Antibacterial [EPC],Oxazolidinones [CS]
NDC exclude flag
No
Listing certified through
2020-12-31
Current FDA listing
Historical FDA.report record

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 2 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Dataset, Scope table
Captured / source dateDatasetScopeProduct NDCPackage NDCCodeStatusReporting periodArchiveSnapshotSource SHA-256
2021-12-27 23:28 UTC · source 2021-12-27excluded productproduct66298-4992EExcluded after deficient or non-compliant submission was not correctedexcluded / ndc_excluded.zip8dfbde2a14a4…c9ff85d89658…
2021-12-27 23:28 UTC · source 2021-12-27excluded packagepackage66298-499266298-4992-1EExcluded after deficient or non-compliant submission was not correctedexcluded / ndc_excluded.zip8dfbde2a14a4…c9ff85d89658…

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 3 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N021131-001ZYVOXLINEZOLID200MG/100ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD2000-04-18
N021131-002ZYVOXLINEZOLID400MG/200ML (2MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**SOLUTION / INTRAVENOUSRLD2000-04-18
N021131-003ZYVOXLINEZOLID600MG/300ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2000-04-18

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 2 matching rows.

Application-product, TE code table
Application-productTE code
N021131-001AP
N021131-003AP

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 4 · 123 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02N021131-001ZYVOX200MG/100ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD2000-04-18011fe1cb6892…
2026-02-19 14:30 UTC2026-02N021131-002ZYVOX400MG/200ML (2MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**SOLUTION / INTRAVENOUSRLD2000-04-18011fe1cb6892…
2026-02-19 14:30 UTC2026-02N021131-003ZYVOX600MG/300ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2000-04-18011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021131-001ZYVOX200MG/100ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD2000-04-1831067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021131-002ZYVOX400MG/200ML (2MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**SOLUTION / INTRAVENOUSRLD2000-04-1831067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021131-003ZYVOX600MG/300ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2000-04-1831067a03dcf5…
2025-08-23 18:47 UTC2025-08N021131-001ZYVOX200MG/100ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD2000-04-186a471c1ec25d…
2025-08-23 18:47 UTC2025-08N021131-002ZYVOX400MG/200ML (2MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**SOLUTION / INTRAVENOUSRLD2000-04-186a471c1ec25d…
2025-08-23 18:47 UTC2025-08N021131-003ZYVOX600MG/300ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2000-04-186a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021131-001ZYVOX200MG/100ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD2000-04-18fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021131-002ZYVOX400MG/200ML (2MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**SOLUTION / INTRAVENOUSRLD2000-04-18fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021131-003ZYVOX600MG/300ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2000-04-18fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021131-001ZYVOX200MG/100ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD2000-04-18b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021131-002ZYVOX400MG/200ML (2MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**SOLUTION / INTRAVENOUSRLD2000-04-18b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021131-003ZYVOX600MG/300ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2000-04-18b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021131-001ZYVOX200MG/100ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD2000-04-1803ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021131-002ZYVOX400MG/200ML (2MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**SOLUTION / INTRAVENOUSRLD2000-04-1803ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021131-003ZYVOX600MG/300ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2000-04-1803ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021131-001ZYVOX200MG/100ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD2000-04-182680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021131-002ZYVOX400MG/200ML (2MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**SOLUTION / INTRAVENOUSRLD2000-04-182680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021131-003ZYVOX600MG/300ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2000-04-182680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021131-001ZYVOX200MG/100ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD2000-04-185bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021131-002ZYVOX400MG/200ML (2MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**SOLUTION / INTRAVENOUSRLD2000-04-185bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021131-003ZYVOX600MG/300ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2000-04-185bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021131-001ZYVOX200MG/100ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD2000-04-18d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021131-002ZYVOX400MG/200ML (2MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**SOLUTION / INTRAVENOUSRLD2000-04-18d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021131-003ZYVOX600MG/300ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2000-04-18d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N021131-001ZYVOX200MG/100ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD2000-04-18d06236e962d9…
2024-10-29 15:01 UTC2024-10N021131-002ZYVOX400MG/200ML (2MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**SOLUTION / INTRAVENOUSRLD2000-04-18d06236e962d9…
2024-10-29 15:01 UTC2024-10N021131-003ZYVOX600MG/300ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2000-04-18d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N021131-001ZYVOX200MG/100ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD2000-04-1879d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N021131-002ZYVOX400MG/200ML (2MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**SOLUTION / INTRAVENOUSRLD2000-04-1879d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N021131-003ZYVOX600MG/300ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2000-04-1879d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N021131-001ZYVOX200MG/100ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD2000-04-18301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N021131-002ZYVOX400MG/200ML (2MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**SOLUTION / INTRAVENOUSRLD2000-04-18301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N021131-003ZYVOX600MG/300ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2000-04-18301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N021131-001ZYVOX200MG/100ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD2000-04-181e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N021131-002ZYVOX400MG/200ML (2MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**SOLUTION / INTRAVENOUSRLD2000-04-181e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N021131-003ZYVOX600MG/300ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2000-04-181e350fbaab3a…
2024-05-31 18:47 UTC2024-05N021131-001ZYVOX200MG/100ML (2MG/ML)SOLUTION / INTRAVENOUSAPRLD2000-04-188072bd15b7f6…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 3 · 82 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02N021131-001AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02N021131-003AP1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021131-001AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N021131-003AP131067a03dcf5…
2025-08-23 18:47 UTC2025-08N021131-001AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08N021131-003AP16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021131-001AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N021131-003AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021131-001AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N021131-003AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021131-001AP103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N021131-003AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021131-001AP12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N021131-003AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021131-001AP15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N021131-003AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021131-001AP1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N021131-003AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N021131-001AP1d06236e962d9…
2024-10-29 15:01 UTC2024-10N021131-003AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N021131-001AP179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N021131-003AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N021131-001AP1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N021131-003AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N021131-001AP11e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N021131-003AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05N021131-001AP18072bd15b7f6…
2024-05-31 18:47 UTC2024-05N021131-003AP18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N021131-001AP15c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N021131-003AP15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N021131-001AP15d02ea3f76ae…
2022-04-08 23:34 UTC2022-04N021131-003AP15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N021131-001AP14b0b4de00fa7…
2022-04-04 05:41 UTC2022-04N021131-003AP14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N021131-001AP174a2ff9319b5…
2019-12-13 00:20 UTC2019-12N021131-003AP174a2ff9319b5…
2022-03-09 01:35 UTC2022-03N021131-001AP1bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03N021131-003AP1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N021131-001AP1782e0a99824c…
2021-12-28 21:50 UTC2021-12N021131-003AP1782e0a99824c…

Observed Orange Book patent history#

Patent history page 1 of 2 · 54 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productPatentExpirationUse codeCoverage / statusSubmission dateSource SHA-256
2019-12-13 00:20 UTC2019-12N021131-00165593052021-01-29Drug substance74a2ff9319b5…
2019-12-13 00:20 UTC2019-12N021131-0016559305*PED2021-07-29Pediatric extension74a2ff9319b5…
2019-12-13 00:20 UTC2019-12N021131-00265593052021-01-29Drug substance2003-08-1474a2ff9319b5…
2019-12-13 00:20 UTC2019-12N021131-0026559305*PED2021-07-29Pediatric extension74a2ff9319b5…
2019-12-13 00:20 UTC2019-12N021131-00365593052021-01-29Drug substance2003-08-1474a2ff9319b5…
2019-12-13 00:20 UTC2019-12N021131-0036559305*PED2021-07-29Pediatric extension74a2ff9319b5…
2021-12-28 21:50 UTC2021-12N021131-00165593052021-01-29Drug substance782e0a99824c…
2021-12-28 21:50 UTC2021-12N021131-0016559305*PED2021-07-29Pediatric extension782e0a99824c…
2021-12-28 21:50 UTC2021-12N021131-00265593052021-01-29Drug substance2003-08-14782e0a99824c…
2021-12-28 21:50 UTC2021-12N021131-0026559305*PED2021-07-29Pediatric extension782e0a99824c…
2021-12-28 21:50 UTC2021-12N021131-00365593052021-01-29Drug substance2003-08-14782e0a99824c…
2021-12-28 21:50 UTC2021-12N021131-0036559305*PED2021-07-29Pediatric extension782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N021131-00165593052021-01-29Drug substance87673890dc5c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N021131-0016559305*PED2021-07-29Pediatric extension87673890dc5c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N021131-00265593052021-01-29Drug substance2003-08-1487673890dc5c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N021131-0026559305*PED2021-07-29Pediatric extension87673890dc5c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N021131-00365593052021-01-29Drug substance2003-08-1487673890dc5c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N021131-0036559305*PED2021-07-29Pediatric extension87673890dc5c…
2021-03-12 10:30 UTC2021-03N021131-00165593052021-01-29Drug substance5aa47cf7b7d7…
2021-03-12 10:30 UTC2021-03N021131-0016559305*PED2021-07-29Pediatric extension5aa47cf7b7d7…
2021-03-12 10:30 UTC2021-03N021131-00265593052021-01-29Drug substance2003-08-145aa47cf7b7d7…
2021-03-12 10:30 UTC2021-03N021131-0026559305*PED2021-07-29Pediatric extension5aa47cf7b7d7…
2021-03-12 10:30 UTC2021-03N021131-00365593052021-01-29Drug substance2003-08-145aa47cf7b7d7…
2021-03-12 10:30 UTC2021-03N021131-0036559305*PED2021-07-29Pediatric extension5aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12N021131-00165593052021-01-29Drug substance8869cabd3fbd…
2020-12-22 03:56 UTC2020-12N021131-0016559305*PED2021-07-29Pediatric extension8869cabd3fbd…
2020-12-22 03:56 UTC2020-12N021131-00265593052021-01-29Drug substance2003-08-148869cabd3fbd…
2020-12-22 03:56 UTC2020-12N021131-0026559305*PED2021-07-29Pediatric extension8869cabd3fbd…
2020-12-22 03:56 UTC2020-12N021131-00365593052021-01-29Drug substance2003-08-148869cabd3fbd…
2020-12-22 03:56 UTC2020-12N021131-0036559305*PED2021-07-29Pediatric extension8869cabd3fbd…
2020-11-12 02:37 UTC2020-11N021131-00165593052021-01-29Drug substancec0c555d07b60…
2020-11-12 02:37 UTC2020-11N021131-0016559305*PED2021-07-29Pediatric extensionc0c555d07b60…
2020-11-12 02:37 UTC2020-11N021131-00265593052021-01-29Drug substance2003-08-14c0c555d07b60…
2020-11-12 02:37 UTC2020-11N021131-0026559305*PED2021-07-29Pediatric extensionc0c555d07b60…
2020-11-12 02:37 UTC2020-11N021131-00365593052021-01-29Drug substance2003-08-14c0c555d07b60…
2020-11-12 02:37 UTC2020-11N021131-0036559305*PED2021-07-29Pediatric extensionc0c555d07b60…
2019-12-14 00:12 UTC2019-12N021131-00165593052021-01-29Drug substance3f01610625f2…
2019-12-14 00:12 UTC2019-12N021131-0016559305*PED2021-07-29Pediatric extension3f01610625f2…
2019-12-14 00:12 UTC2019-12N021131-00265593052021-01-29Drug substance2003-08-143f01610625f2…
2019-12-14 00:12 UTC2019-12N021131-0026559305*PED2021-07-29Pediatric extension3f01610625f2…

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 5 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
ZyvoxLINEZOLIDPharmacia & Upjohn Company LLC3e5e9975-6f36-42e4-ab46-0e75dda835922026-07-09Warnings, Adverse reactionsExact identifier
application applno (NDA): 021131
application number: NDA021131
ZyvoxLINEZOLIDPharmacia & Upjohn Company LLC6e70e63b-bfd5-478d-a8ee-8ba22c9efabd2026-06-23Warnings, Adverse reactionsExact identifier
application applno (NDA): 021131
application number: NDA021131
ZyvoxLINEZOLIDHp Halden Pharma ASb0c75e79-bf29-4f1d-a45d-ae28398a52d92024-05-28Warnings, Adverse reactionsExact identifier
application applno (NDA): 021131
application number: NDA021131
ZyvoxLINEZOLIDHp Halden Pharma ASce57225b-4580-442b-8c48-8045297cbb502024-05-28Warnings, Adverse reactionsExact identifier
application applno (NDA): 021131
application number: NDA021131
ZyvoxLINEZOLIDHp Halden Pharma ASefe6818c-b798-4d1d-8196-6447a305ad712024-05-28Warnings, Adverse reactionsExact identifier
application applno (NDA): 021131
application number: NDA021131

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionUnitsMarketing startMarketing endSampleExclude flagStatus
66298-4992-166298499201300 mL in 1 BAG (66298-4992-1) 300 ml2018-06-050000-00-00NoNoCurrent