DayQuil Severe Plus VapoCOOL Cold And Flu

Product NDC: 66715-9904
11-digit product format: 667159904
Labeler code: 66715
Product ID: 66715-9904_2969fd97-4d37-c1d4-e063-6394a90ab50e
Type: HUMAN OTC DRUG
Nonproprietary name: Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, and Phenylephrine Hydrochloride
Dosage form: TABLET, COATED
Route: ORAL
Labeler: Lil' Drug Store Products, Inc.
Application: M012
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2019-05-01
Substance: ACETAMINOPHEN; DEXTROMETHORPHAN HYDROBROMIDE; GUAIFENESIN; PHENYLEPHRINE HYDROCHLORIDE
Active strength: 325; 10; 200; 5 mg/1; mg/1; mg/1; mg/1
Pharmacologic classes: Adrenergic alpha1-Agonists [MoA], Decreased Respiratory Secretion Viscosity [PE], Expectorant [EPC], Increased Respiratory Secretions [PE], Sigma-1 Agonist [EPC], Sigma-1 Receptor Agonists [MoA], Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC], Uncompetitive NMDA Receptor Antagonists [MoA], alpha-1 Adrenergic Agonist [EPC]
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 2 matching rows.

Dataset, Scope, Product NDC table
Dataset	Scope	Product NDC	Package NDC	Code	Status	Reporting period	Source date
excluded package	package	66715-9904	66715-9904-3	D	Discontinued by firm		2026-10-21
excluded package	package	66715-9904	66715-9904-7	D	Discontinued by firm		2026-10-21

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 14 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Package NDC, Snapshot table
Captured / source date	Package NDC	Snapshot	Source SHA-256
2025-12-14 17:58 UTC · source 2025-12-05	66715-9904-7	`d630ba8d3edf…`	`732f749b63fb…`
2025-12-14 17:58 UTC · source 2025-12-05	66715-9904-3	`d630ba8d3edf…`	`732f749b63fb…`
2025-08-27 00:01 UTC · source 2025-08-26	66715-9904-7	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-08-27 00:01 UTC · source 2025-08-26	66715-9904-3	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-04-01 02:39 UTC · source 2025-03-31	66715-9904-7	`2ef7874e63bc…`	`57b86245f4fa…`
2025-03-28 20:22 UTC · source 2025-03-28	66715-9904-7	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-22 03:12 UTC · source 2025-03-21	66715-9904-7	`cfe11265f3b6…`	`090c488252e2…`
2025-03-10 12:48 UTC · source 2025-03-10	66715-9904-7	`cdf11ea48f46…`	`ba0047e9e063…`
2025-02-02 03:52 UTC · source 2025-01-31	66715-9904-7	`302b2466d912…`	`e7b80fea0513…`
2025-01-20 13:05 UTC · source 2025-01-20	66715-9904-7	`ed331223b511…`	`672a5bd82f5f…`
2025-01-11 03:41 UTC · source 2025-01-10	66715-9904-7	`0efc9e666f02…`	`f202fb6c5f17…`
2024-11-09 02:27 UTC · source 2024-11-08	66715-9904-7	`ad56d346431e…`	`cc804d4bbf1e…`
2024-10-04 04:10 UTC · source 2024-10-03	66715-9904-7	`367a005e9d99…`	`383a685ebd0f…`
2024-07-10 04:00 UTC · source 2024-07-09	66715-9904-7	`557ba5c1ecfa…`	`9c80585c8c6e…`

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: DayQuil Severe Plus VapoCOOL Cold And Flu
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
ACETAMINOPHEN	325 mg/1
DEXTROMETHORPHAN HYDROBROMIDE	10 mg/1
GUAIFENESIN	200 mg/1
PHENYLEPHRINE HYDROCHLORIDE	5 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 4 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
9D2RTI9KYH	Internal UNII lookup
362O9ITL9D	Internal UNII lookup
04JA59TNSJ	Internal UNII lookup
495W7451VQ	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1110988	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
cfab9b80-0580-4482-b6e3-0aab875b5797	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
4fe95224-f543-4dbb-9445-8cca122b48c8	Product name	1	20150609
e8718272-64cb-4436-969b-176c3067c8f4	Product name	1	20150609
106ff02a-57e1-4c4c-a307-fd582ff4e311	Product name	1	20150212

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	SPL version
66715-9904-2	DayQuil Severe Plus VapoCOOL Cold And Flu	2 in 1 POUCH	TABLET, COATED	2	8
66715-9904-2	DayQuil Severe Plus VapoCOOL Cold And Flu	2 in 1 CARTON	TABLET, COATED	2	8
66715-9904-3	DayQuil Severe Plus VapoCOOL Cold And Flu	2 in 1 POUCH	TABLET, COATED	2	8
66715-9904-3	DayQuil Severe Plus VapoCOOL Cold And Flu	3 in 1 CARTON	TABLET, COATED	3	8
66715-9904-7	DayQuil Severe Plus VapoCOOL Cold And Flu	20 in 1 CARTON	TABLET, COATED	20	8
66715-9904-7	DayQuil Severe Plus VapoCOOL Cold And Flu	2 in 1 POUCH	TABLET, COATED	2	8

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
66715-9904	DAYQUIL SEVERE PLUS VAPOCOOL COLD AND FLU, CVP HEALTH (ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, AND PHENYLEPHRINE HYDROCHLORIDE) TABLET, COATED DAYQUIL SEVERE PLUS VAPOCOOL COLD AND FLU, TRAVEL BASIX (ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, AND PHENYLEPHRINE HYDROCHLORIDE) TABLET, COATED DAYQUIL SEVERE PLUS VAPOCOOL COLD AND FLU (ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, AND PHENYLEPHRINE HYDROCHLORIDE) TABLET, COATED [LIL' DRUG STORE PRODUCTS, INC.]	8	Current NDC, Legacy NDC, 6 package rows	20241218_cfab9b80-0580-4482-b6e3-0aab875b5797.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 61 of 178 · 3,551 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Berkley and Jensen Tussin DM Max	DEXTROMETHORPHAN HBR, GUAIFENESIN	BJWC	c15b97a8-968f-4d38-905e-863e9fd16ce6	2026-01-06	Warnings	Exact identifier application number: M012
Complete Allergy Medicine	DIPHENHYDRAMINE HCL	Salado Sales, Inc.	c0f5c8ca-b187-40bf-9245-6a29f1c32c97	2026-01-06	Warnings	Exact identifier application number: M012
Allergy Multi-Symptom	ACETAMINOPHEN, CHLORPHENIRAMINE MALEATE, PHENYLEPHRINE HCL	Cardinal Health 110, LLC. DBA Leader	c5776b1e-9f72-4a6a-9961-8ac8e05b3249	2026-01-06	Warnings	Exact identifier application number: M012
Severe Congestion and Cough	DEXTROMETHORPHAN HBR, GUAIFENESIN, PHENYLEPHRINE HCL	Family Dollar Services Inc	b9215a5e-3be8-44fd-9189-50dab760869c	2026-01-06	Warnings	Exact identifier application number: M012
Night Time Cold and Flu Relief	ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, DOXYLAMINE SUCCINATE	Major Pharmaceuticals	f81efbf4-204b-45be-ae32-910d9e4ae4aa	2026-01-06	Warnings	Exact identifier application number: M012
SINUS AND NASAL DECONGESTANT	PSEUDOEPHEDRINE HYDROCHLORIDE	CVS WOONSOCKET PRESCRIPTION CENTER, INCORPORATED	d7646859-f996-46cd-a0b9-56b860f60901	2026-01-05	Warnings	Exact identifier application number: M012
HyVee Cough Drops Honey Lemon	MENTHOL	HY-VEE, INC	47a71cdf-856d-9ecd-e063-6294a90a70c6	2026-01-05	Warnings	Exact identifier application number: M012
Guaifenesin	GUAIFENESIN	Oncor Pharmaceuticals	fd35036c-b722-48a3-85fd-60471beb6e74	2026-01-05	Warnings	Exact identifier application number: M012
Diphenhydramine HCl	DIPHENHYDRAMINE HCL	NuCare Pharmaceuticals,Inc.	3c323dc8-f734-b44c-e063-6394a90a6184	2026-01-05	Warnings	Exact identifier application number: M012
Congestion and Cough Childrens	DEXTROMETHORPHAN HBR, GUAIFENESIN, PHENYLEPHRINE HCL	CVS PHARMACY	f43d97b1-aeb9-4ca5-8909-b28e7bf764f5	2026-01-05	Warnings	Exact identifier application number: M012
Daytime Nighttime Cold Flu Relief	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE, PHENYLEPHRINE HCL	WinCo Foods, LLC	6bd2b8fd-2023-413b-8988-a47d2058dc85	2026-01-05	Warnings	Exact identifier application number: M012
Daytime Cold and Flu	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, PHENYLEPHRINE HCL	WinCo Foods, LLC	4c1046df-53a6-4219-83ac-bbf5cf4db9c8	2026-01-05	Warnings	Exact identifier application number: M012
Night Time Cold and Flu Relief Multi Symptom	ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, DOXYLAMINE SUCCINATE	P & L Development, LLC	80323208-9ba5-432b-a8a0-0c0b51e67145	2026-01-05	Warnings	Exact identifier application number: M012
Sinus Pressure and Pain PE Maximum Strength	ACETAMINOPHEN AND PHENYLEPHRINE HCL	Rite Aid Corporation	347868e4-0182-4e16-895c-ec269895c57c	2026-01-02	Warnings	Exact identifier application number: M012
HyVee Cough Drops Cherry	MENTHOL	Xiamen Kang Zhongyuan Biotechnology Co., Ltd.	c5b11a9c-6d93-4772-93c2-1ef5c5647016	2026-01-02	Warnings	Exact identifier application number: M012
HyVee Cough Drops Honey Lemon	MENTHOL	Xiamen Kang Zhongyuan Biotechnology Co., Ltd.	fae96736-1453-42fe-8158-cde770b23165	2026-01-02	Warnings	Exact identifier application number: M012
HyVee Cough Drops Menthol	MENTHOL	Xiamen Kang Zhongyuan Biotechnology Co., Ltd.	8cac1229-8e8e-4d8c-9f18-c2cd0f6f50bd	2026-01-02	Warnings	Exact identifier application number: M012
Reliable-1 Tussin	GUAIFENESIN	RELIABLE 1 LABORATORIES LLC	2a33ff82-49df-7aaa-e063-6294a90a1281	2026-01-02	Warnings	Exact identifier application number: M012
Tussin DMMax	DEXTROMETHORPHAN HBR, GUAIFENESIN	RELIABLE 1 LABORATORIES LLC	c4bb2e12-e0f6-4cbf-ad24-cfad9326f7fa	2026-01-02	Warnings	Exact identifier application number: M012
Severe Sinus Pain and Congestion Daytime	ACETAMINOPHEN, GUAIFENESIN, PHENYLEPHRINE HCL	CVS Pharmacy	4af347ce-9745-4a5e-8ce9-e7c97a0a6cc7	2026-01-02	Warnings	Exact identifier application number: M012

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
362O9ITL9D	ACETAMINOPHEN	103-90-2	ACETAMINOPHEN
9D2RTI9KYH	DEXTROMETHORPHAN HYDROBROMIDE	6700-34-1	DEXTROMETHORPHAN HYDROBROMIDE
495W7451VQ	GUAIFENESIN	93-14-1	GUAIFENESIN
04JA59TNSJ	PHENYLEPHRINE HYDROCHLORIDE	61-76-7	PHENYLEPHRINE HYDROCHLORIDE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1110988	acetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG / phenylephrine HCl 5 MG Oral Tablet	PSN	cfab9b80-0580-4482-b6e3-0aab875b5797	8
1110988	acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / guaifenesin 200 MG / phenylephrine hydrochloride 5 MG Oral Tablet	SCD	cfab9b80-0580-4482-b6e3-0aab875b5797	8
1110988	APAP 325 MG / dextromethorphan hydrobromide 10 MG / guaifenesin 200 MG / phenylephrine hydrochloride 5 MG Oral Tablet	SY	cfab9b80-0580-4482-b6e3-0aab875b5797	8

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
66715-9904-2	66715990402	2 POUCH in 1 CARTON (66715-9904-2) / 2 TABLET, COATED in 1 POUCH	2 pouch	2019-05-01	0000-00-00	No	No	Current
66715-9904-3	66715990403	3 POUCH in 1 CARTON (66715-9904-3) > 2 TABLET, COATED in 1 POUCH	3 pouch	2019-05-01	0000-00-00	No	No	Current
66715-9904-7	66715990407	20 POUCH in 1 CARTON (66715-9904-7) > 2 TABLET, COATED in 1 POUCH	20 pouch	2019-05-01	0000-00-00	No	No	Current

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
DayQuil™ Severe+ VapoCOOL™ Cold & Flu	Lil' Drug Store Products, Inc.	2024-12-16	HUMAN OTC DRUG LABEL	8