DayQuil Severe Plus VapoCOOL Cold And Flu

Product NDC: 66715-9904
11-digit product format: 667159904
Labeler code: 66715
Product ID: 66715-9904_2969fd97-4d37-c1d4-e063-6394a90ab50e
Type: HUMAN OTC DRUG
Nonproprietary name: Acetaminophen, Dextromethorphan Hydrobromide, Guaifenesin, and Phenylephrine Hydrochloride
Dosage form: TABLET, COATED
Route: ORAL
Labeler: Lil' Drug Store Products, Inc.
Application: M012
Marketing category: OTC MONOGRAPH DRUG
Marketing start: 2019-05-01
Substance: ACETAMINOPHEN; DEXTROMETHORPHAN HYDROBROMIDE; GUAIFENESIN; PHENYLEPHRINE HYDROCHLORIDE
Active strength: 325; 10; 200; 5 mg/1; mg/1; mg/1; mg/1
Pharmacologic classes: Adrenergic alpha1-Agonists [MoA], Decreased Respiratory Secretion Viscosity [PE], Expectorant [EPC], Increased Respiratory Secretions [PE], Sigma-1 Agonist [EPC], Sigma-1 Receptor Agonists [MoA], Uncompetitive N-methyl-D-aspartate Receptor Antagonist [EPC], Uncompetitive NMDA Receptor Antagonists [MoA], alpha-1 Adrenergic Agonist [EPC]
NDC exclude flag: No
Listing certified through: 2026-12-31
Current FDA listing: Yes

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 2 matching rows.

Dataset, Scope, Product NDC table
Dataset	Scope	Product NDC	Package NDC	Code	Status	Reporting period	Source date
excluded package	package	66715-9904	66715-9904-3	D	Discontinued by firm		2026-10-23
excluded package	package	66715-9904	66715-9904-7	D	Discontinued by firm		2026-10-23

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 14 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Package NDC, Snapshot table
Captured / source date	Package NDC	Snapshot	Source SHA-256
2025-12-14 17:58 UTC · source 2025-12-05	66715-9904-7	`d630ba8d3edf…`	`732f749b63fb…`
2025-12-14 17:58 UTC · source 2025-12-05	66715-9904-3	`d630ba8d3edf…`	`732f749b63fb…`
2025-08-27 00:01 UTC · source 2025-08-26	66715-9904-7	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-08-27 00:01 UTC · source 2025-08-26	66715-9904-3	`f5e01cc5f278…`	`a2eaf40c39c3…`
2025-04-01 02:39 UTC · source 2025-03-31	66715-9904-7	`2ef7874e63bc…`	`57b86245f4fa…`
2025-03-28 20:22 UTC · source 2025-03-28	66715-9904-7	`a1b67e2a42f9…`	`c4cf2c586c0d…`
2025-03-22 03:12 UTC · source 2025-03-21	66715-9904-7	`cfe11265f3b6…`	`090c488252e2…`
2025-03-10 12:48 UTC · source 2025-03-10	66715-9904-7	`cdf11ea48f46…`	`ba0047e9e063…`
2025-02-02 03:52 UTC · source 2025-01-31	66715-9904-7	`302b2466d912…`	`e7b80fea0513…`
2025-01-20 13:05 UTC · source 2025-01-20	66715-9904-7	`ed331223b511…`	`672a5bd82f5f…`
2025-01-11 03:41 UTC · source 2025-01-10	66715-9904-7	`0efc9e666f02…`	`f202fb6c5f17…`
2024-11-09 02:27 UTC · source 2024-11-08	66715-9904-7	`ad56d346431e…`	`cc804d4bbf1e…`
2024-10-04 04:10 UTC · source 2024-10-03	66715-9904-7	`367a005e9d99…`	`383a685ebd0f…`
2024-07-10 04:00 UTC · source 2024-07-09	66715-9904-7	`557ba5c1ecfa…`	`9c80585c8c6e…`

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

Additional Listing Data#

Finished product: Yes
Brand name base: DayQuil Severe Plus VapoCOOL Cold And Flu
Listing expiration: 2026-12-31

Active Ingredients#

Ingredient, Strength table
Ingredient	Strength
ACETAMINOPHEN	325 mg/1
DEXTROMETHORPHAN HYDROBROMIDE	10 mg/1
GUAIFENESIN	200 mg/1
PHENYLEPHRINE HYDROCHLORIDE	5 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 4 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
9D2RTI9KYH	Internal UNII lookup
495W7451VQ	Internal UNII lookup
04JA59TNSJ	Internal UNII lookup
362O9ITL9D	Internal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
1110988	Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
Identifier	FDA.report destination
cfab9b80-0580-4482-b6e3-0aab875b5797	Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product concept	Relation	Version	Effective
4fe95224-f543-4dbb-9445-8cca122b48c8	Product name	1	20150609
e8718272-64cb-4436-969b-176c3067c8f4	Product name	1	20150609
106ff02a-57e1-4c4c-a307-fd582ff4e311	Product name	1	20150212

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDC	Product	Description	Form	Quantity	SPL version
66715-9904-2	DayQuil Severe Plus VapoCOOL Cold And Flu	2 in 1 POUCH	TABLET, COATED	2	8
66715-9904-2	DayQuil Severe Plus VapoCOOL Cold And Flu	2 in 1 CARTON	TABLET, COATED	2	8
66715-9904-3	DayQuil Severe Plus VapoCOOL Cold And Flu	2 in 1 POUCH	TABLET, COATED	2	8
66715-9904-3	DayQuil Severe Plus VapoCOOL Cold And Flu	3 in 1 CARTON	TABLET, COATED	3	8
66715-9904-7	DayQuil Severe Plus VapoCOOL Cold And Flu	20 in 1 CARTON	TABLET, COATED	20	8
66715-9904-7	DayQuil Severe Plus VapoCOOL Cold And Flu	2 in 1 POUCH	TABLET, COATED	2	8

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDC	Dashboard title	SPL version	Validation	Dashboard ZIP
66715-9904	DAYQUIL SEVERE PLUS VAPOCOOL COLD AND FLU, CVP HEALTH (ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, AND PHENYLEPHRINE HYDROCHLORIDE) TABLET, COATED DAYQUIL SEVERE PLUS VAPOCOOL COLD AND FLU, TRAVEL BASIX (ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, AND PHENYLEPHRINE HYDROCHLORIDE) TABLET, COATED DAYQUIL SEVERE PLUS VAPOCOOL COLD AND FLU (ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, GUAIFENESIN, AND PHENYLEPHRINE HYDROCHLORIDE) TABLET, COATED [LIL' DRUG STORE PRODUCTS, INC.]	8	Current NDC, Legacy NDC, 6 package rows	20241218_cfab9b80-0580-4482-b6e3-0aab875b5797.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 78 of 178 · 3,551 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Vaporizing Rub	CAMPHOR, EUCALYPTUS OIL AND MENTHOL	ALAINA HEALTHCARE PRIVATE LIMITED	4c6a7ac0-be76-42b0-9a08-b287e70a3460	2025-12-09	Warnings	Exact identifier application number: M012
24-7 Life BY 7-ELEVEN Nighttime Cold and Flu	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, DOXYLAMINE SUCCINATE SOLUTION	Lil' Drug Store products, Inc.	277363f4-1c00-ddb7-e063-6294a90a4677	2025-12-09	Warnings	Exact identifier application number: M012
Daytime Cold and Flu Relief, 24-7 Life BY 7-Eleven	ACETAMINOPHEN, DEXTROMETHORPHAN HBR, PHENYLEPHRINE HCL SOLUTION	Lil' Drug Store Products, Inc.	2771d699-3f70-4318-e063-6394a90a89cc	2025-12-09	Warnings	Exact identifier application number: M012
Allergy Relief	DIPHENHYDRAMINE HYDROCHLORIDE	Shield Pharmaceuticals Corp	3d243264-5cd8-47da-9f5e-cfcfc8d1fa4b	2025-12-09	Warnings	Exact identifier application number: M012
Circle K Nighttime Cold and Flu	ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, AND DOXYLAMINE SUCCINATE	Lil' Drug Store Products, Inc	9a32bc6d-0499-48fa-a6ad-702c8a28bf5f	2025-12-09	Warnings	Exact identifier application number: M012
Allergy Relief	DIPHENHYDRAMINE HYDROCHLORIDE	Shield Pharmaceuticals Corp	5015a380-a229-4eff-8e31-528065c6ed64	2025-12-09	Warnings	Exact identifier application number: M012
Allergy Relief	DIPHENHYDRAMINE HYDROCHLORIDE	Harris Teeter	caf59320-5b48-4533-bda9-7b03a2fde0b5	2025-12-09	Warnings	Exact identifier application number: M012
Sinus Severe	ACETAMINOPHEN, GUAIFENESIN, AND PHENYLEPHRINE HYDROCHLORIDE	STRATEGIC SOURCING SERVICES LLC	30d41dc3-e2ef-4cad-b63c-d634bc749aa1	2025-12-09	Warnings	Exact identifier application number: M012
Walgreens Childrens Chest Rub	CAMPHOR, EUCALYPTUS OIL, MENTHOL	Walgreen Company	327a7226-84b9-26d7-e063-6394a90a99b9	2025-12-09	Warnings	Exact identifier application number: M012
Mucus Relief DM	DEXTROMETHORPHAN HBR AND GUAIFENESIN	Meijer Distribution Inc	8ed5b802-a26e-45b4-a696-bc64dbac4733	2025-12-09	Warnings	Exact identifier application number: M012
dg health cold plus flu relief	ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, PHENYLEPHRINE HYDROCHLORIDE	Dolgencorp, LLC	ff4a2f0a-d638-4ed2-8e05-2a52afbc4909	2025-12-09	Warnings	Exact identifier application number: M012
Daytime Cold and Flu	ACETAMINOPHEN DEXTROMETHORPHAN HBR PHENYLEPHRINE HCL	QUALITY CHOICE (Chain Drug Marketing Association)	24894484-b834-4b2f-b365-c95b5e30d8bf	2025-12-09	Warnings	Exact identifier application number: M012
Nighttime Cold and Flu Relief	ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, DOXYLAMINE SUCCINATE	Family Dollar (FAMILY WELLNESS)	2c431220-c61b-4ad5-9ad2-58ccaee2d1c3	2025-12-09	Warnings	Exact identifier application number: M012
Sinus PE Congestion Daytime Nighttime	DIPHENHYDRAMINE HCL, PHENYLEPHRINE HCL	Meijer Distribution, Inc.	9da77306-5098-4c79-845c-97ead849c84a	2025-12-08	Warnings	Exact identifier application number: M012
Nighttime Cold and Flu Relief	ACETAMINOPHEN DEXTROMETHORPHAN HBR DOXYLAMINE SUCCINATE	QUALITY CHOICE (Chain Drug Marketing Association)	fdd0dadc-5313-4f6e-aef5-ca853efe5c4d	2025-12-08	Warnings	Exact identifier application number: M012
Mucolyte	GUAIFENESIN	Rising Pharma Holdings, Inc.	e4091aaf-44e3-4701-9986-aff248a2f1b8	2025-12-08	Warnings	Exact identifier application number: M012
Mucolyte DM	GUAIFENESIN, DEXTROMETHORPHAN HBR	Rising Pharma Holdings, Inc.	c913d27d-bc00-4ace-9a5f-c55522e1cd1d	2025-12-08	Warnings	Exact identifier application number: M012
honey lemon cough drops	MENTHOL	American Sales	47f504d5-3ec5-5227-e054-00144ff88e88	2025-12-07	Warnings	Exact identifier application number: M012
Sugar Free Menthol Cough Drops	MENTHOL	American Sales	4893ac0a-7769-5657-e054-00144ff8d46c	2025-12-07	Warnings	Exact identifier application number: M012
Cherry cough drop	MENTHOL	American Sales	45e891ea-2f2a-31b7-e054-00144ff88e88	2025-12-07	Warnings	Exact identifier application number: M012

UNII, Preferred term, Registry number table
UNII	Preferred term	Registry number	Matched term
362O9ITL9D	ACETAMINOPHEN	103-90-2	ACETAMINOPHEN
9D2RTI9KYH	DEXTROMETHORPHAN HYDROBROMIDE	6700-34-1	DEXTROMETHORPHAN HYDROBROMIDE
495W7451VQ	GUAIFENESIN	93-14-1	GUAIFENESIN
04JA59TNSJ	PHENYLEPHRINE HYDROCHLORIDE	61-76-7	PHENYLEPHRINE HYDROCHLORIDE

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUI	RxNorm string	TTY	DailyMed	SPL version
1110988	acetaminophen 325 MG / dextromethorphan HBr 10 MG / guaiFENesin 200 MG / phenylephrine HCl 5 MG Oral Tablet	PSN	cfab9b80-0580-4482-b6e3-0aab875b5797	8
1110988	acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / guaifenesin 200 MG / phenylephrine hydrochloride 5 MG Oral Tablet	SCD	cfab9b80-0580-4482-b6e3-0aab875b5797	8
1110988	APAP 325 MG / dextromethorphan hydrobromide 10 MG / guaifenesin 200 MG / phenylephrine hydrochloride 5 MG Oral Tablet	SY	cfab9b80-0580-4482-b6e3-0aab875b5797	8

Packages#

Package NDC, 11-digit format, Description table
Package NDC	11-digit format	Description	Units	Marketing start	Marketing end	Sample	Exclude flag	Status
66715-9904-2	66715990402	2 POUCH in 1 CARTON (66715-9904-2) / 2 TABLET, COATED in 1 POUCH	2 pouch	2019-05-01	0000-00-00	No	No	Current
66715-9904-3	66715990403	3 POUCH in 1 CARTON (66715-9904-3) > 2 TABLET, COATED in 1 POUCH	3 pouch	2019-05-01	0000-00-00	No	No	Current
66715-9904-7	66715990407	20 POUCH in 1 CARTON (66715-9904-7) > 2 TABLET, COATED in 1 POUCH	20 pouch	2019-05-01	0000-00-00	No	No	Current

Title, Manufacturer, Effective date table
Title	Manufacturer	Effective date	Type	Version
DayQuil™ Severe+ VapoCOOL™ Cold & Flu	Lil' Drug Store Products, Inc.	2024-12-16	HUMAN OTC DRUG LABEL	8