SUPPRELIN

Product NDC
67979-002
11-digit product format
679790002
Labeler code
67979
Product ID
67979-002_917e915f-4793-48bf-84c3-50272421616f
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
histrelin acetate
Dosage form
IMPLANT
Route
SUBCUTANEOUS
Labeler
Endo USA, Inc.
Application
NDA022058
Marketing category
NDA
Marketing start
2007-05-31
Substance
HISTRELIN ACETATE
Active strength
50 mg/1
Pharmacologic classes
Gonadotropin Releasing Hormone Receptor Agonist [EPC], Gonadotropin Releasing Hormone Receptor Agonists [MoA]
NDC exclude flag
No
Listing certified through
2026-12-31
Current FDA listing
Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N022058-001SUPPRELIN LAHISTRELIN ACETATE50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03

Orange Book patents#

Current patent rows page 1 of 1 · 1 matching rows.

Application-product, Patent, Expiration table
Application-productPatentExpirationUse codeCoverage / statusSubmission date
N022058-00180626522026-06-16U-1197

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-0331067a03dcf5…
2025-08-23 18:47 UTC2025-08N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-036a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-0303ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-032680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-035bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-0379d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-031e350fbaab3a…
2024-05-31 18:47 UTC2024-05N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-038072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-035c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-035d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-034b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-0374a2ff9319b5…
2022-03-09 01:35 UTC2022-03N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-0387673890dc5c…
2021-03-12 10:30 UTC2021-03N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-035aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-038869cabd3fbd…
2020-11-12 02:37 UTC2020-11N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03c0c555d07b60…
2019-12-14 00:12 UTC2019-12N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-033f01610625f2…
2019-09-15 20:21 UTC2019-09N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03b00525d2431f…
2019-07-19 19:46 UTC2019-07N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-036a51e52b5d6a…
2024-02-18 07:12 UTC2024-02N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-031c564ffb4f44…
2023-12-20 04:57 UTC2023-12N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-039b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-033f0d92c62455…
2023-05-13 08:27 UTC2023-05N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03053a50430f4f…
2023-01-26 05:58 UTC2023-01N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-033bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-033a93d1ddd44b…
2022-10-28 04:53 UTC2022-10N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07N022058-001SUPPRELIN LA50MGIMPLANT / SUBCUTANEOUSRLD, RS2007-05-03cb3db0bc1861…

Observed Orange Book patent history#

Patent history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productPatentExpirationUse codeCoverage / statusSubmission dateSource SHA-256
2026-02-19 14:30 UTC2026-02N022058-00180626522026-06-16U-1197011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N022058-00180626522026-06-16U-119731067a03dcf5…
2025-08-23 18:47 UTC2025-08N022058-00180626522026-06-16U-11976a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N022058-00180626522026-06-16U-1197fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N022058-00180626522026-06-16U-1197b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N022058-00180626522026-06-16U-119703ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N022058-00180626522026-06-16U-11972680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N022058-00180626522026-06-16U-11975bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N022058-00180626522026-06-16U-1197d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N022058-00180626522026-06-16U-1197d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N022058-00180626522026-06-16U-119779d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N022058-00180626522026-06-16U-1197301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N022058-00180626522026-06-16U-11971e350fbaab3a…
2024-05-31 18:47 UTC2024-05N022058-00180626522026-06-16U-11978072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N022058-00180626522026-06-16U-11975c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N022058-00180626522026-06-16U-11975d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N022058-00180626522026-06-16U-11974b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N022058-00180626522026-06-16U-119774a2ff9319b5…
2022-03-09 01:35 UTC2022-03N022058-00180626522026-06-16U-1197bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N022058-00180626522026-06-16U-1197782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N022058-00180626522026-06-16U-119787673890dc5c…
2021-03-12 10:30 UTC2021-03N022058-00180626522026-06-16U-11975aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12N022058-00180626522026-06-16U-11978869cabd3fbd…
2020-11-12 02:37 UTC2020-11N022058-00180626522026-06-16U-1197c0c555d07b60…
2019-12-14 00:12 UTC2019-12N022058-00180626522026-06-16U-11973f01610625f2…
2019-09-15 20:21 UTC2019-09N022058-00180626522026-06-16U-1197b00525d2431f…
2019-07-19 19:46 UTC2019-07N022058-00180626522026-06-16U-1197ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03N022058-00180626522026-06-16U-11976a51e52b5d6a…
2024-02-18 07:12 UTC2024-02N022058-00180626522026-06-16U-11971c564ffb4f44…
2023-12-20 04:57 UTC2023-12N022058-00180626522026-06-16U-1197ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N022058-00180626522026-06-16U-1197a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N022058-00180626522026-06-16U-11979b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07N022058-00180626522026-06-16U-1197a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06N022058-00180626522026-06-16U-11973f0d92c62455…
2023-05-13 08:27 UTC2023-05N022058-00180626522026-06-16U-1197053a50430f4f…
2023-01-26 05:58 UTC2023-01N022058-00180626522026-06-16U-11973bdfa0b2c4d7…
2022-11-12 20:34 UTC · 5 captures of this ZIP2022-11N022058-00180626522026-06-16U-11973a93d1ddd44b…
2022-10-28 04:53 UTC2022-10N022058-00180626522026-06-16U-1197f41ea6bd6efb…
2022-09-29 23:25 UTC2022-09N022058-00180626522026-06-16U-1197e64feba35796…
2022-07-09 03:26 UTC · 3 captures of this ZIP2022-07N022058-00180626522026-06-16U-1197cb3db0bc1861…

Additional Listing Data#

Finished product
Yes
Brand name base
SUPPRELIN
Brand name suffix
LA
Listing expiration
2026-12-31

Active Ingredients#

Ingredient, Strength table
IngredientStrength
HISTRELIN ACETATE50 mg/1

Harmonized UNII identifiers#

UNII identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
QMG7HLD1ZEInternal UNII lookup

Harmonized RxCUI identifiers#

RxCUI identifiers page 1 of 1 · 2 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
1294641Internal RxNorm lookup
1740437Internal RxNorm lookup

Harmonized SPL set identifiers#

SPL set identifiers page 1 of 1 · 1 matching rows.

Identifier, FDA.report destination table
IdentifierFDA.report destination
d8fb000e-3cc9-4803-b71d-2cc597661977Available on FDA.report

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
77e9eb99-9c92-7584-f2ea-26b00d25ea66Product name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
67979-002-01SUPPRELINLA1 in 1 VIAL, GLASSIMPLANT138
67979-002-01SUPPRELINLA1 in 1 CARTONIMPLANT138

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
67979-002-01EA - Each67979-002599fb662-151c-4eeb-9814-6a0f6540357c12012-07-24

DailyMed Socrata Ingredients#

DailyMed Dashboard NDC Coverage#

NDC, Dashboard title, SPL version table
NDCDashboard titleSPL versionValidationDashboard ZIP
67979-002SUPPRELIN LA (HISTRELIN ACETATE) IMPLANT [ENDO USA, INC.]36Current NDC, Legacy NDC, 2 package rows20240425_d8fb000e-3cc9-4803-b71d-2cc597661977.zip

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
SUPPRELIN LAHISTRELIN ACETATEEndo USA, Inc.d8fb000e-3cc9-4803-b71d-2cc5976619772025-09-25Warnings, Adverse reactionsExact identifier
application applno (NDA): 022058
application number: NDA022058
ndc (product): 67979-002

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYDailyMedSPL version
1740437histrelin acetate 50 MG (65 MCG per 24HR) Subcutaneous Drug ImplantPSNd8fb000e-3cc9-4803-b71d-2cc59766197738
1294641Supprelin LA 50 MG (65 MCG per 24HR) Subcutaneous Drug ImplantPSNd8fb000e-3cc9-4803-b71d-2cc59766197738
1294641histrelin acetate 0.00271 MG/HR Drug Implant [Supprelin]SBDd8fb000e-3cc9-4803-b71d-2cc59766197738
1740437histrelin acetate 0.00271 MG/HR Drug ImplantSCDd8fb000e-3cc9-4803-b71d-2cc59766197738
1740437histrelin acetate 50 MG (65 MCG per 24 HR) Drug ImplantSYd8fb000e-3cc9-4803-b71d-2cc59766197738
1294641Supprelin 50 MG (65 MCG per 24 HR) Drug ImplantSYd8fb000e-3cc9-4803-b71d-2cc59766197738

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionMarketing startMarketing endSampleExclude flagStatus
67979-002-01679790002011 VIAL, GLASS in 1 CARTON (67979-002-01) / 1 IMPLANT in 1 VIAL, GLASS2007-05-310000-00-00NoNoCurrent