Akovaz

Product NDC
76014-005
Requested package NDC
76014-005-25
11-digit product format
760140005
Labeler code
76014
Product ID
76014-005_26f0bc51-fbc5-4d99-9972-6344f51f64a6
Type
HUMAN PRESCRIPTION DRUG
Nonproprietary name
ephedrine sulfate
Dosage form
INJECTION
Route
INTRAVENOUS
Labeler
Avadel Legacy Pharmaceuticals, LLC
Application
NDA208289
Marketing category
NDA
Marketing start
2016-08-01
Marketing end
2023-09-30
Substance
EPHEDRINE SULFATE
Active strength
50 mg/mL
Pharmacologic classes
alpha-Adrenergic Agonist [EPC],Adrenergic alpha-Agonists [MoA],beta-Adrenergic Agonist [EPC],Adrenergic beta-Agonists [MoA],Norepinephrine Releasing Agent [EPC],Increased Norepinephrine Activity [PE]
NDC exclude flag
No
Listing certified through
0000-00-00
Current FDA listing
Historical FDA.report record

NDC auxiliary status#

These records are reproduced from FDA’s unfinished, excluded, and compounder listings. They describe what appeared in the source files; a missing record does not establish a regulatory status. View all current auxiliary records, including entries without an NDC. · View the auxiliary file history.

Current NDC status page 1 of 1 · 1 matching rows.

Dataset, Scope, Product NDC table
DatasetScopeProduct NDCPackage NDCCodeStatusReporting periodSource date
excluded packagepackage76014-00576014-005-25DDiscontinued by firm2026-08-10

Observed NDC auxiliary status history#

This history shows the information present in each captured FDA auxiliary file. It is not a continuous regulatory timeline, and a missing record does not establish a status.

Historic NDC status page 1 of 1 · 12 matching rows.

View current auxiliary records. · View the auxiliary file history.

Captured / source date, Snapshot, Source SHA-256 table
Captured / source dateSnapshotSource SHA-256
2025-12-14 17:58 UTC · source 2025-12-05d630ba8d3edf…732f749b63fb…
2025-08-27 00:01 UTC · source 2025-08-26f5e01cc5f278…a2eaf40c39c3…
2025-04-01 02:39 UTC · source 2025-03-312ef7874e63bc…57b86245f4fa…
2025-03-28 20:22 UTC · source 2025-03-28a1b67e2a42f9…c4cf2c586c0d…
2025-03-22 03:12 UTC · source 2025-03-21cfe11265f3b6…090c488252e2…
2025-03-10 12:48 UTC · source 2025-03-10cdf11ea48f46…ba0047e9e063…
2025-02-02 03:52 UTC · source 2025-01-31302b2466d912…e7b80fea0513…
2025-01-20 13:05 UTC · source 2025-01-20ed331223b511…672a5bd82f5f…
2025-01-11 03:41 UTC · source 2025-01-100efc9e666f02…f202fb6c5f17…
2024-11-09 02:27 UTC · source 2024-11-08ad56d346431e…cc804d4bbf1e…
2024-10-04 04:10 UTC · source 2024-10-03367a005e9d99…383a685ebd0f…
2024-07-10 04:00 UTC · source 2024-07-09557ba5c1ecfa…9c80585c8c6e…

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N208289-001AKOVAZEPHEDRINE SULFATE50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-29
N208289-002AKOVAZEPHEDRINE SULFATE25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSAP3RLD, RS2021-08-02

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 2 matching rows.

Application-product, TE code table
Application-productTE code
N208289-001AP
N208289-002AP3

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 74 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-29011fe1cb6892…
2026-02-19 14:30 UTC2026-02N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSAP3RLD, RS2021-08-02011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-2931067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSAP3RLD, RS2021-08-0231067a03dcf5…
2025-08-23 18:47 UTC2025-08N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-296a471c1ec25d…
2025-08-23 18:47 UTC2025-08N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSAP3RLD, RS2021-08-026a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-29fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2021-08-02fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-29b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2021-08-02b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-2903ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2021-08-0203ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-292680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2021-08-022680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-295bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSRLD, RS2021-08-025bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-29d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2021-08-02d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-29d06236e962d9…
2024-10-29 15:01 UTC2024-10N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSRLD, RS2021-08-02d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-2979d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSRLD, RS2021-08-0279d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-29301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSRLD, RS2021-08-02301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-291e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSRLD, RS2021-08-021e350fbaab3a…
2024-05-31 18:47 UTC2024-05N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-298072bd15b7f6…
2024-05-31 18:47 UTC2024-05N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSRLD, RS2021-08-028072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-295c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSRLD, RS2021-08-025c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-295d02ea3f76ae…
2022-04-08 23:34 UTC2022-04N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSRLD, RS2021-08-025d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-294b0b4de00fa7…
2022-04-04 05:41 UTC2022-04N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSRLD, RS2021-08-024b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-2974a2ff9319b5…
2022-03-09 01:35 UTC2022-03N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-29bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSRLD, RS2021-08-02bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-29782e0a99824c…
2021-12-28 21:50 UTC2021-12N208289-002AKOVAZ25MG/5ML (5MG/ML)SOLUTION / INTRAVENOUSRLD, RS2021-08-02782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N208289-001AKOVAZ50MG/ML (50MG/ML)SOLUTION / INTRAVENOUSAPRLD, RS2016-04-2987673890dc5c…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 50 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-02-19 14:30 UTC2026-02N208289-001AP1011fe1cb6892…
2026-02-19 14:30 UTC2026-02N208289-002AP31011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N208289-001AP131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N208289-002AP3131067a03dcf5…
2025-08-23 18:47 UTC2025-08N208289-001AP16a471c1ec25d…
2025-08-23 18:47 UTC2025-08N208289-002AP316a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N208289-001AP1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N208289-002AP1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N208289-001AP1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N208289-002AP1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N208289-001AP103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N208289-002AP103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N208289-001AP12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N208289-002AP12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N208289-001AP15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N208289-001AP1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N208289-002AP1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N208289-001AP1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N208289-001AP179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N208289-001AP1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N208289-001AP11e350fbaab3a…
2024-05-31 18:47 UTC2024-05N208289-001AP18072bd15b7f6…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06N208289-001AP15c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04N208289-001AP15d02ea3f76ae…
2022-04-04 05:41 UTC2022-04N208289-001AP14b0b4de00fa7…
2019-12-13 00:20 UTC2019-12N208289-001AP174a2ff9319b5…
2022-03-09 01:35 UTC2022-03N208289-001AP1bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12N208289-001AP1782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05N208289-001AP187673890dc5c…
2021-03-12 10:30 UTC2021-03N208289-001AP15aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12N208289-001AP18869cabd3fbd…
2020-11-12 02:37 UTC2020-11N208289-001AP1c0c555d07b60…
2019-12-14 00:12 UTC2019-12N208289-001AP13f01610625f2…
2019-09-15 20:21 UTC2019-09N208289-001AP1b00525d2431f…
2019-07-19 19:46 UTC2019-07N208289-001AP1ea99ee380514…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03N208289-001AP16a51e52b5d6a…
2024-02-18 07:12 UTC2024-02N208289-001AP11c564ffb4f44…
2023-12-20 04:57 UTC2023-12N208289-001AP1ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11N208289-001AP1a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10N208289-001AP19b2671bbb829…

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
76014-005-25ML - Milliliter76014-0057ea61651-c238-420b-8f20-b18f4c127f7012016-06-14
76014-005-30ML - Milliliter76014-0059b613ebe-444f-4cc2-8c8c-2aa9793257a912017-12-14

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
AkovazEPHEDRINE SULFATEExela Pharma Sciences, LLCe92f3eda-33eb-4b34-9e8b-db8d32a5dbd92020-11-27Warnings, Adverse reactionsExact identifier
application applno (NDA): 208289
application number: NDA208289

Packages#

Package NDC, 11-digit format, Description table
Package NDC11-digit formatDescriptionMarketing startMarketing endSampleExclude flagStatus
76014-005-257601400052525 VIAL, SINGLE-DOSE in 1 CARTON (76014-005-25) > 1 mL in 1 VIAL, SINGLE-DOSE (76014-005-30) 2016-08-012023-09-30NoNoCurrent