Application 019851

Type
NDA
Sponsor
US PHARMS HOLDINGS I

Application Products#

Product, Drug, Ingredient table
ProductDrugIngredientFormStrengthReference drugReference standard
001LOTENSINBENAZEPRIL HYDROCHLORIDETABLET;ORAL5MGYesNo
002LOTENSINBENAZEPRIL HYDROCHLORIDETABLET;ORAL10MGYesNo
003LOTENSINBENAZEPRIL HYDROCHLORIDETABLET;ORAL20MGYesNo
004LOTENSINBENAZEPRIL HYDROCHLORIDETABLET;ORAL40MGYesYes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 4 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
N019851-001LOTENSINBENAZEPRIL HYDROCHLORIDE5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**TABLET / ORALRLD1991-06-25
N019851-002LOTENSINBENAZEPRIL HYDROCHLORIDE10MGTABLET / ORALABRLD1991-06-25
N019851-003LOTENSINBENAZEPRIL HYDROCHLORIDE20MGTABLET / ORALABRLD1991-06-25
N019851-004LOTENSINBENAZEPRIL HYDROCHLORIDE40MGTABLET / ORALABRLD1991-06-25

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 3 matching rows.

Application-product, TE code table
Application-productTE code
N019851-002AB
N019851-003AB
N019851-004AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 5 · 168 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-08-18 06:07:402026-07N019851-001LOTENSIN5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**TABLET / ORALRLD1991-06-25caaa826d4ba7…
2026-08-18 06:07:402026-07N019851-002LOTENSIN10MGTABLET / ORALABRLD1991-06-25caaa826d4ba7…
2026-08-18 06:07:402026-07N019851-003LOTENSIN20MGTABLET / ORALABRLD1991-06-25caaa826d4ba7…
2026-08-18 06:07:402026-07N019851-004LOTENSIN40MGTABLET / ORALABRLD1991-06-25caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N019851-001LOTENSIN5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**TABLET / ORALRLD1991-06-25011fe1cb6892…
2026-02-19 14:30 UTC2026-02N019851-002LOTENSIN10MGTABLET / ORALABRLD1991-06-25011fe1cb6892…
2026-02-19 14:30 UTC2026-02N019851-003LOTENSIN20MGTABLET / ORALABRLD1991-06-25011fe1cb6892…
2026-02-19 14:30 UTC2026-02N019851-004LOTENSIN40MGTABLET / ORALABRLD1991-06-25011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N019851-001LOTENSIN5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**TABLET / ORALRLD1991-06-2531067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N019851-002LOTENSIN10MGTABLET / ORALABRLD1991-06-2531067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N019851-003LOTENSIN20MGTABLET / ORALABRLD1991-06-2531067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N019851-004LOTENSIN40MGTABLET / ORALABRLD1991-06-2531067a03dcf5…
2025-08-23 18:47 UTC2025-08N019851-001LOTENSIN5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**TABLET / ORALRLD1991-06-256a471c1ec25d…
2025-08-23 18:47 UTC2025-08N019851-002LOTENSIN10MGTABLET / ORALABRLD1991-06-256a471c1ec25d…
2025-08-23 18:47 UTC2025-08N019851-003LOTENSIN20MGTABLET / ORALABRLD1991-06-256a471c1ec25d…
2025-08-23 18:47 UTC2025-08N019851-004LOTENSIN40MGTABLET / ORALABRLD1991-06-256a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N019851-001LOTENSIN5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**TABLET / ORALRLD1991-06-25fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N019851-002LOTENSIN10MGTABLET / ORALABRLD1991-06-25fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N019851-003LOTENSIN20MGTABLET / ORALABRLD1991-06-25fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N019851-004LOTENSIN40MGTABLET / ORALABRLD1991-06-25fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N019851-001LOTENSIN5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**TABLET / ORALRLD1991-06-25b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N019851-002LOTENSIN10MGTABLET / ORALABRLD1991-06-25b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N019851-003LOTENSIN20MGTABLET / ORALABRLD1991-06-25b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N019851-004LOTENSIN40MGTABLET / ORALABRLD1991-06-25b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N019851-001LOTENSIN5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**TABLET / ORALRLD1991-06-2503ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N019851-002LOTENSIN10MGTABLET / ORALABRLD1991-06-2503ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N019851-003LOTENSIN20MGTABLET / ORALABRLD1991-06-2503ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N019851-004LOTENSIN40MGTABLET / ORALABRLD1991-06-2503ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N019851-001LOTENSIN5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**TABLET / ORALRLD1991-06-252680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N019851-002LOTENSIN10MGTABLET / ORALABRLD1991-06-252680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N019851-003LOTENSIN20MGTABLET / ORALABRLD1991-06-252680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N019851-004LOTENSIN40MGTABLET / ORALABRLD1991-06-252680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N019851-001LOTENSIN5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**TABLET / ORALRLD1991-06-255bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N019851-002LOTENSIN10MGTABLET / ORALABRLD1991-06-255bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N019851-003LOTENSIN20MGTABLET / ORALABRLD1991-06-255bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N019851-004LOTENSIN40MGTABLET / ORALABRLD1991-06-255bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N019851-001LOTENSIN5MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**TABLET / ORALRLD1991-06-25d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N019851-002LOTENSIN10MGTABLET / ORALABRLD1991-06-25d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N019851-003LOTENSIN20MGTABLET / ORALABRLD1991-06-25d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N019851-004LOTENSIN40MGTABLET / ORALABRLD1991-06-25d8e5a09893c0…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 4 · 139 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2026-08-18 06:07:402026-07N019851-002AB1caaa826d4ba7…
2026-08-18 06:07:402026-07N019851-003AB1caaa826d4ba7…
2026-08-18 06:07:402026-07N019851-004AB1caaa826d4ba7…
2026-02-19 14:30 UTC2026-02N019851-002AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02N019851-003AB1011fe1cb6892…
2026-02-19 14:30 UTC2026-02N019851-004AB1011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N019851-002AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N019851-003AB131067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12N019851-004AB131067a03dcf5…
2025-08-23 18:47 UTC2025-08N019851-002AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08N019851-003AB16a471c1ec25d…
2025-08-23 18:47 UTC2025-08N019851-004AB16a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N019851-002AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N019851-003AB1fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03N019851-004AB1fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N019851-002AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N019851-003AB1b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02N019851-004AB1b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N019851-002AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N019851-003AB103ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01N019851-004AB103ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N019851-002AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N019851-003AB12680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12N019851-004AB12680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N019851-002AB15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N019851-003AB15bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09N019851-004AB15bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N019851-002AB1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N019851-003AB1d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11N019851-004AB1d8e5a09893c0…
2024-10-29 15:01 UTC2024-10N019851-002AB1d06236e962d9…
2024-10-29 15:01 UTC2024-10N019851-003AB1d06236e962d9…
2024-10-29 15:01 UTC2024-10N019851-004AB1d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N019851-002AB179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N019851-003AB179d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08N019851-004AB179d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N019851-002AB1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N019851-003AB1301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07N019851-004AB1301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06N019851-002AB11e350fbaab3a…

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
LotensinBENAZEPRIL HYDROCHLORIDEValidus Pharmaceuticals LLC2abb091b-a53e-46b0-9b84-e5ee8f2bdd8e2025-09-30Boxed warning, Warnings, Adverse reactionsExact identifier
application applno (NDA): 019851
application number: NDA019851
ndc (product): 30698-448
ndc (product): 30698-449
ndc (product): 30698-450

NDC Listings For This Application#

NDC listings for this application page 1 of 1 · 9 matching rows.

NDC, Name, Nonproprietary name table
NDCNameNonproprietary nameLabelerMarketing categoryStatus
30698-448Lotensinbenazepril hydrochlorideValidus Pharmaceuticals LLCNDACurrent
30698-448Lotensinbenazepril hydrochlorideValidus Pharmaceuticals LLCNDACurrent
30698-448Lotensinbenazepril hydrochlorideValidus Pharmaceuticals LLCNDACurrent
30698-449Lotensinbenazepril hydrochlorideValidus Pharmaceuticals LLCNDACurrent
30698-449Lotensinbenazepril hydrochlorideValidus Pharmaceuticals LLCNDACurrent
30698-449Lotensinbenazepril hydrochlorideValidus Pharmaceuticals LLCNDACurrent
30698-450Lotensinbenazepril hydrochlorideValidus Pharmaceuticals LLCNDACurrent
30698-450Lotensinbenazepril hydrochlorideValidus Pharmaceuticals LLCNDACurrent
30698-450Lotensinbenazepril hydrochlorideValidus Pharmaceuticals LLCNDACurrent

Documents#

Document, Submission type, Date table
DocumentSubmission typeDate
57433SUPPL2019-02-04
57159SUPPL2019-01-09
49266SUPPL2017-08-07
49252SUPPL2017-08-07
34035SUPPL2015-07-24
11780SUPPL2015-07-24
19759SUPPL2015-07-23
1712SUPPL2015-07-23
34034SUPPL2015-01-30
19758SUPPL2015-01-27
34033SUPPL2014-12-16
19757SUPPL2014-12-15
34032SUPPL2012-09-25
34030SUPPL2012-05-22
19755SUPPL2012-05-21
19756SUPPL2012-02-06
34031SUPPL2012-01-23
11779SUPPL2011-06-16
1711SUPPL2011-06-16
1710SUPPL2010-01-07
34029SUPPL2009-11-16
19754SUPPL2009-01-26
1709SUPPL2008-06-02
1708SUPPL2007-02-12
44037ORIG2006-06-09
11778SUPPL2004-04-05
1706SUPPL2004-03-03
1707SUPPL2003-11-05
51783ORIG1900-01-01
51782ORIG1900-01-01
51781ORIG1900-01-01
51780ORIG1900-01-01
51779ORIG1900-01-01