Application 021990

Type: NDA
Sponsor: NOVARTIS

Application Products#

Product, Drug, Ingredient table
Product	Drug	Ingredient	Form	Strength	Reference drug	Reference standard
002	EXFORGE	AMLODIPINE BESYLATE; VALSARTAN	TABLET;ORAL	EQ 5MG BASE;160MG	Yes	No
003	EXFORGE	AMLODIPINE BESYLATE; VALSARTAN	TABLET;ORAL	EQ 10MG BASE;160MG	Yes	Yes
004	EXFORGE	AMLODIPINE BESYLATE; VALSARTAN	TABLET;ORAL	EQ 5MG BASE;320MG	Yes	No
005	EXFORGE	AMLODIPINE BESYLATE; VALSARTAN	TABLET;ORAL	EQ 10MG BASE;320MG	Yes	Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 43.

Orange Book products#

Current product rows page 1 of 1 · 4 matching rows.

Application-product, Trade name, Ingredient table
Application-product	Trade name	Ingredient	Strength	Dosage form / route	TE codes	RLD / RS	Approval date
N021990-002	EXFORGE	AMLODIPINE BESYLATE; VALSARTAN	EQ 5MG BASE;160MG	TABLET / ORAL	AB	RLD	2007-06-20
N021990-003	EXFORGE	AMLODIPINE BESYLATE; VALSARTAN	EQ 10MG BASE;160MG	TABLET / ORAL	AB	RLD, RS	2007-06-20
N021990-004	EXFORGE	AMLODIPINE BESYLATE; VALSARTAN	EQ 5MG BASE;320MG	TABLET / ORAL	AB	RLD	2007-06-20
N021990-005	EXFORGE	AMLODIPINE BESYLATE; VALSARTAN	EQ 10MG BASE;320MG	TABLET / ORAL	AB	RLD, RS	2007-06-20

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 4 matching rows.

Application-product, TE code table
Application-product	TE code
N021990-002	AB
N021990-003	AB
N021990-004	AB
N021990-005	AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 5 · 172 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Trade name	Strength	Dosage form / route	Product TE source text	RLD / RS	Approval date	Source SHA-256
2026-09-14 22:38:34	2026-08	N021990-002	EXFORGE	EQ 5MG BASE;160MG	TABLET / ORAL	AB	RLD	2007-06-20	`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N021990-003	EXFORGE	EQ 10MG BASE;160MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N021990-004	EXFORGE	EQ 5MG BASE;320MG	TABLET / ORAL	AB	RLD	2007-06-20	`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N021990-005	EXFORGE	EQ 10MG BASE;320MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`84e616aacf4f…`
2026-08-18 06:07:40	2026-07	N021990-002	EXFORGE	EQ 5MG BASE;160MG	TABLET / ORAL	AB	RLD	2007-06-20	`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N021990-003	EXFORGE	EQ 10MG BASE;160MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N021990-004	EXFORGE	EQ 5MG BASE;320MG	TABLET / ORAL	AB	RLD	2007-06-20	`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N021990-005	EXFORGE	EQ 10MG BASE;320MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`caaa826d4ba7…`
2026-02-19 14:30 UTC	2026-02	N021990-002	EXFORGE	EQ 5MG BASE;160MG	TABLET / ORAL	AB	RLD	2007-06-20	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N021990-003	EXFORGE	EQ 10MG BASE;160MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N021990-004	EXFORGE	EQ 5MG BASE;320MG	TABLET / ORAL	AB	RLD	2007-06-20	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N021990-005	EXFORGE	EQ 10MG BASE;320MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021990-002	EXFORGE	EQ 5MG BASE;160MG	TABLET / ORAL	AB	RLD	2007-06-20	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021990-003	EXFORGE	EQ 10MG BASE;160MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021990-004	EXFORGE	EQ 5MG BASE;320MG	TABLET / ORAL	AB	RLD	2007-06-20	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N021990-005	EXFORGE	EQ 10MG BASE;320MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	N021990-002	EXFORGE	EQ 5MG BASE;160MG	TABLET / ORAL	AB	RLD	2007-06-20	`6a471c1ec25d…`
2025-08-23 18:47 UTC	2025-08	N021990-003	EXFORGE	EQ 10MG BASE;160MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`6a471c1ec25d…`
2025-08-23 18:47 UTC	2025-08	N021990-004	EXFORGE	EQ 5MG BASE;320MG	TABLET / ORAL	AB	RLD	2007-06-20	`6a471c1ec25d…`
2025-08-23 18:47 UTC	2025-08	N021990-005	EXFORGE	EQ 10MG BASE;320MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N021990-002	EXFORGE	EQ 5MG BASE;160MG	TABLET / ORAL	AB	RLD	2007-06-20	`fd3edfee7708…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N021990-003	EXFORGE	EQ 10MG BASE;160MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`fd3edfee7708…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N021990-004	EXFORGE	EQ 5MG BASE;320MG	TABLET / ORAL	AB	RLD	2007-06-20	`fd3edfee7708…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N021990-005	EXFORGE	EQ 10MG BASE;320MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N021990-002	EXFORGE	EQ 5MG BASE;160MG	TABLET / ORAL	AB	RLD	2007-06-20	`b8a1b40f171c…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N021990-003	EXFORGE	EQ 10MG BASE;160MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`b8a1b40f171c…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N021990-004	EXFORGE	EQ 5MG BASE;320MG	TABLET / ORAL	AB	RLD	2007-06-20	`b8a1b40f171c…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N021990-005	EXFORGE	EQ 10MG BASE;320MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N021990-002	EXFORGE	EQ 5MG BASE;160MG	TABLET / ORAL	AB	RLD	2007-06-20	`03ed91905a0d…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N021990-003	EXFORGE	EQ 10MG BASE;160MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`03ed91905a0d…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N021990-004	EXFORGE	EQ 5MG BASE;320MG	TABLET / ORAL	AB	RLD	2007-06-20	`03ed91905a0d…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N021990-005	EXFORGE	EQ 10MG BASE;320MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N021990-002	EXFORGE	EQ 5MG BASE;160MG	TABLET / ORAL	AB	RLD	2007-06-20	`2680178bc6a6…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N021990-003	EXFORGE	EQ 10MG BASE;160MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`2680178bc6a6…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N021990-004	EXFORGE	EQ 5MG BASE;320MG	TABLET / ORAL	AB	RLD	2007-06-20	`2680178bc6a6…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N021990-005	EXFORGE	EQ 10MG BASE;320MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N021990-002	EXFORGE	EQ 5MG BASE;160MG	TABLET / ORAL	AB	RLD	2007-06-20	`5bbf6a4d5a75…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N021990-003	EXFORGE	EQ 10MG BASE;160MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`5bbf6a4d5a75…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N021990-004	EXFORGE	EQ 5MG BASE;320MG	TABLET / ORAL	AB	RLD	2007-06-20	`5bbf6a4d5a75…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N021990-005	EXFORGE	EQ 10MG BASE;320MG	TABLET / ORAL	AB	RLD, RS	2007-06-20	`5bbf6a4d5a75…`

Observed Orange Book normalized TE history#

Normalized TE history page 2 of 5 · 172 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	TE code	Order	Source SHA-256
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N021990-002	AB	1	`d8e5a09893c0…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N021990-003	AB	1	`d8e5a09893c0…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N021990-004	AB	1	`d8e5a09893c0…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N021990-005	AB	1	`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	N021990-002	AB	1	`d06236e962d9…`
2024-10-29 15:01 UTC	2024-10	N021990-003	AB	1	`d06236e962d9…`
2024-10-29 15:01 UTC	2024-10	N021990-004	AB	1	`d06236e962d9…`
2024-10-29 15:01 UTC	2024-10	N021990-005	AB	1	`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N021990-002	AB	1	`79d66fd596c7…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N021990-003	AB	1	`79d66fd596c7…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N021990-004	AB	1	`79d66fd596c7…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N021990-005	AB	1	`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N021990-002	AB	1	`301d65b070ca…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N021990-003	AB	1	`301d65b070ca…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N021990-004	AB	1	`301d65b070ca…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N021990-005	AB	1	`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N021990-002	AB	1	`1e350fbaab3a…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N021990-003	AB	1	`1e350fbaab3a…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N021990-004	AB	1	`1e350fbaab3a…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N021990-005	AB	1	`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	N021990-002	AB	1	`8072bd15b7f6…`
2024-05-31 18:47 UTC	2024-05	N021990-003	AB	1	`8072bd15b7f6…`
2024-05-31 18:47 UTC	2024-05	N021990-004	AB	1	`8072bd15b7f6…`
2024-05-31 18:47 UTC	2024-05	N021990-005	AB	1	`8072bd15b7f6…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021990-002	AB	1	`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021990-003	AB	1	`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021990-004	AB	1	`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N021990-005	AB	1	`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	N021990-002	AB	1	`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021990-003	AB	1	`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021990-004	AB	1	`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N021990-005	AB	1	`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	N021990-002	AB	1	`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021990-003	AB	1	`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021990-004	AB	1	`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N021990-005	AB	1	`4b0b4de00fa7…`
2019-12-13 00:20 UTC	2019-12	N021990-002	AB	1	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N021990-003	AB	1	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N021990-004	AB	1	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N021990-005	AB	1	`74a2ff9319b5…`

Observed Orange Book patent history#

Captured, Edition, Application-product table
Captured	Edition	Application-product	Patent	Expiration	Coverage / status	Source SHA-256
2019-12-13 00:20 UTC	2019-12	N021990-002	6395728	2019-07-08	Drug product	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N021990-003	6395728	2019-07-08	Drug product	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N021990-004	6395728	2019-07-08	Drug product	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N021990-005	6395728	2019-07-08	Drug product	`74a2ff9319b5…`
2019-12-14 00:12 UTC	2019-12	N021990-002	6395728	2019-07-08	Drug product	`3f01610625f2…`
2019-12-14 00:12 UTC	2019-12	N021990-003	6395728	2019-07-08	Drug product	`3f01610625f2…`
2019-12-14 00:12 UTC	2019-12	N021990-004	6395728	2019-07-08	Drug product	`3f01610625f2…`
2019-12-14 00:12 UTC	2019-12	N021990-005	6395728	2019-07-08	Drug product	`3f01610625f2…`
2019-09-15 20:21 UTC	2019-09	N021990-002	6395728	2019-07-08	Drug product	`b00525d2431f…`
2019-09-15 20:21 UTC	2019-09	N021990-003	6395728	2019-07-08	Drug product	`b00525d2431f…`
2019-09-15 20:21 UTC	2019-09	N021990-004	6395728	2019-07-08	Drug product	`b00525d2431f…`
2019-09-15 20:21 UTC	2019-09	N021990-005	6395728	2019-07-08	Drug product	`b00525d2431f…`
2019-07-19 19:46 UTC	2019-07	N021990-002	6395728	2019-07-08	Drug product	`ea99ee380514…`
2019-07-19 19:46 UTC	2019-07	N021990-003	6395728	2019-07-08	Drug product	`ea99ee380514…`
2019-07-19 19:46 UTC	2019-07	N021990-004	6395728	2019-07-08	Drug product	`ea99ee380514…`
2019-07-19 19:46 UTC	2019-07	N021990-005	6395728	2019-07-08	Drug product	`ea99ee380514…`

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
Exforge	AMLODIPINE BESYLATE AND VALSARTAN	Novartis Pharmaceuticals Corporation	d0caec89-96ec-411d-a933-63eda74a6da7	2026-02-17	Boxed warning, Warnings, Adverse reactions	Exact identifier application applno (NDA): 021990 application number: NDA021990 ndc (product): 0078-0489 ndc (product): 0078-0488 ndc (product): 0078-0490 ndc (product): 0078-0491

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

NDC Listings For This Application#

NDC listings for this application page 1 of 1 · 37 matching rows.

NDC, Name, Nonproprietary name table
NDC	Name	Nonproprietary name	Labeler	Marketing category	Status
0078-0488	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0488	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0488	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0488	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0488	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0488	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0488	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0488	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0489	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0489	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0489	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0489	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0489	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0489	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0489	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0489	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0490	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0490	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0490	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0490	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0490	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0490	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0490	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0490	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0491	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0491	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0491	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0491	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0491	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0491	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0491	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0491	Exforge	amlodipine besylate and valsartan	Novartis Pharmaceuticals Corporation	NDA	Current
0781-5615	AMLODIPINE AND VALSARTAN	amlodipine besylate and valsartan	Sandoz Inc	NDA AUTHORIZED GENERIC	Current
0781-5628	AMLODIPINE AND VALSARTAN	amlodipine besylate and valsartan	Sandoz Inc	NDA AUTHORIZED GENERIC	Current
0781-5639	AMLODIPINE AND VALSARTAN	amlodipine besylate and valsartan	Sandoz Inc	NDA AUTHORIZED GENERIC	Current
0781-5643	AMLODIPINE AND VALSARTAN	amlodipine besylate and valsartan	Sandoz Inc	NDA AUTHORIZED GENERIC	Current
50090-2471	AMLODIPINE AND VALSARTAN	amlodipine besylate and valsartan	A-S Medication Solutions	NDA AUTHORIZED GENERIC	Current

Documents#

Document, Submission type, Date table
Document	Submission type	Date
73304	SUPPL	2023-01-27
67008	SUPPL	2021-04-08
59064	SUPPL	2019-06-13
59059	SUPPL	2019-06-13
48427	SUPPL	2017-05-17
16702	SUPPL	2015-07-30
6606	SUPPL	2015-07-30
16701	SUPPL	2014-09-26
6605	SUPPL	2014-09-25
38011	SUPPL	2014-03-19
28992	SUPPL	2014-03-19
6604	SUPPL	2014-03-19
16700	SUPPL	2012-12-10
28991	SUPPL	2012-11-29
28990	SUPPL	2012-10-02
38010	SUPPL	2012-10-01
38009	SUPPL	2012-01-30
6603	SUPPL	2012-01-20
28989	SUPPL	2011-12-14
16699	SUPPL	2011-12-13
6602	SUPPL	2011-11-02
38008	SUPPL	2011-10-31
16698	SUPPL	2011-06-07
28988	SUPPL	2011-06-03
6601	SUPPL	2010-04-05
38007	SUPPL	2010-04-04
42370	ORIG	2008-10-03
6600	SUPPL	2008-07-25
38006	SUPPL	2008-07-24
6599	ORIG	2007-07-05
38005	ORIG	2007-06-25
6598	ORIG	2007-01-08