Application 022059

Type: NDA
Sponsor: NOVARTIS

Application Products#

Product, Drug, Ingredient table
Product	Drug	Ingredient	Form	Strength	Reference drug	Reference standard
001	TYKERB	LAPATINIB DITOSYLATE	TABLET;ORAL	EQ 250MG BASE	Yes	Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-product	Trade name	Ingredient	Strength	Dosage form / route	TE codes	RLD / RS	Approval date
N022059-001	TYKERB	LAPATINIB DITOSYLATE	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-product	TE code
N022059-001	AB

Orange Book patents#

Current patent rows page 1 of 1 · 1 matching rows.

Application-product, Patent, Expiration table
Application-product	Patent	Expiration	Use code	Coverage / status	Submission date
N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 42 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Trade name	Strength	Dosage form / route	Product TE source text	RLD / RS	Approval date	Source SHA-256
2026-08-18 06:07:40	2026-07	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`caaa826d4ba7…`
2026-02-19 14:30 UTC	2026-02	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`5bbf6a4d5a75…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`8072bd15b7f6…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`4b0b4de00fa7…`
2019-12-13 00:20 UTC	2019-12	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL		RLD, RS	2007-03-13	`74a2ff9319b5…`
2022-03-09 01:35 UTC	2022-03	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`bb7c543d1eb4…`
2021-12-28 21:50 UTC	2021-12	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`782e0a99824c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`87673890dc5c…`
2021-03-12 10:30 UTC	2021-03	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`5aa47cf7b7d7…`
2020-12-22 03:56 UTC	2020-12	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`8869cabd3fbd…`
2020-11-12 02:37 UTC	2020-11	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`c0c555d07b60…`
2019-12-14 00:12 UTC	2019-12	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL		RLD, RS	2007-03-13	`3f01610625f2…`
2019-09-15 20:21 UTC	2019-09	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL		RLD, RS	2007-03-13	`b00525d2431f…`
2019-07-19 19:46 UTC	2019-07	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL		RLD, RS	2007-03-13	`ea99ee380514…`
2024-03-16 18:09 UTC · 4 captures of this ZIP	2024-03	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`6a51e52b5d6a…`
2024-02-18 07:12 UTC	2024-02	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`1c564ffb4f44…`
2023-12-20 04:57 UTC	2023-12	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`ea1830bbd6c7…`
2023-11-28 05:40 UTC · 2 captures of this ZIP	2023-11	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`a72a2bbeb626…`
2023-10-25 00:34 UTC · 2 captures of this ZIP	2023-10	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`9b2671bbb829…`
2023-07-15 15:27 UTC · 2 captures of this ZIP	2023-07	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`a67488948f0b…`
2023-06-13 01:57 UTC · 3 captures of this ZIP	2023-06	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`3f0d92c62455…`
2023-05-13 08:27 UTC	2023-05	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`053a50430f4f…`
2023-01-26 05:58 UTC	2023-01	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`3bdfa0b2c4d7…`
2022-11-12 20:34 UTC · 5 captures of this ZIP	2022-11	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`3a93d1ddd44b…`
2022-10-28 04:53 UTC	2022-10	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`f41ea6bd6efb…`
2022-09-29 23:25 UTC	2022-09	N022059-001	TYKERB	EQ 250MG BASE	TABLET / ORAL	AB	RLD, RS	2007-03-13	`e64feba35796…`

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
Captured	Edition	Application-product	TE code	Order	Source SHA-256
2026-08-18 06:07:40	2026-07	N022059-001	AB	1	`caaa826d4ba7…`
2026-02-19 14:30 UTC	2026-02	N022059-001	AB	1	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N022059-001	AB	1	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	N022059-001	AB	1	`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N022059-001	AB	1	`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N022059-001	AB	1	`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N022059-001	AB	1	`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N022059-001	AB	1	`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N022059-001	AB	1	`5bbf6a4d5a75…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N022059-001	AB	1	`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	N022059-001	AB	1	`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N022059-001	AB	1	`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N022059-001	AB	1	`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N022059-001	AB	1	`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	N022059-001	AB	1	`8072bd15b7f6…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N022059-001	AB	1	`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	N022059-001	AB	1	`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	N022059-001	AB	1	`4b0b4de00fa7…`
2022-03-09 01:35 UTC	2022-03	N022059-001	AB	1	`bb7c543d1eb4…`
2021-12-28 21:50 UTC	2021-12	N022059-001	AB	1	`782e0a99824c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N022059-001	AB	1	`87673890dc5c…`
2021-03-12 10:30 UTC	2021-03	N022059-001	AB	1	`5aa47cf7b7d7…`
2020-12-22 03:56 UTC	2020-12	N022059-001	AB	1	`8869cabd3fbd…`
2020-11-12 02:37 UTC	2020-11	N022059-001	AB	1	`c0c555d07b60…`
2024-03-16 18:09 UTC · 4 captures of this ZIP	2024-03	N022059-001	AB	1	`6a51e52b5d6a…`
2024-02-18 07:12 UTC	2024-02	N022059-001	AB	1	`1c564ffb4f44…`
2023-12-20 04:57 UTC	2023-12	N022059-001	AB	1	`ea1830bbd6c7…`
2023-11-28 05:40 UTC · 2 captures of this ZIP	2023-11	N022059-001	AB	1	`a72a2bbeb626…`
2023-10-25 00:34 UTC · 2 captures of this ZIP	2023-10	N022059-001	AB	1	`9b2671bbb829…`
2023-07-15 15:27 UTC · 2 captures of this ZIP	2023-07	N022059-001	AB	1	`a67488948f0b…`
2023-06-13 01:57 UTC · 3 captures of this ZIP	2023-06	N022059-001	AB	1	`3f0d92c62455…`
2023-05-13 08:27 UTC	2023-05	N022059-001	AB	1	`053a50430f4f…`
2023-01-26 05:58 UTC	2023-01	N022059-001	AB	1	`3bdfa0b2c4d7…`
2022-11-12 20:34 UTC · 5 captures of this ZIP	2022-11	N022059-001	AB	1	`3a93d1ddd44b…`
2022-10-28 04:53 UTC	2022-10	N022059-001	AB	1	`f41ea6bd6efb…`
2022-09-29 23:25 UTC	2022-09	N022059-001	AB	1	`e64feba35796…`
2022-07-09 03:26 UTC · 3 captures of this ZIP	2022-07	N022059-001	AB	1	`cb3db0bc1861…`
2026-07-26 02:55 UTC · 3 captures of this ZIP	2026-06	N022059-001	AB	1	`a50c72e98297…`

Observed Orange Book patent history#

Patent history page 1 of 2 · 75 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Patent	Expiration	Use code	Coverage / status	Submission date	Source SHA-256
2026-08-18 06:07:40	2026-07	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`caaa826d4ba7…`
2026-02-19 14:30 UTC	2026-02	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`5bbf6a4d5a75…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`8072bd15b7f6…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`4b0b4de00fa7…`
2019-12-13 00:20 UTC	2019-12	N022059-001	6727256	2019-01-08	U-800	Drug substance, Drug product		`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N022059-001	6727256	2019-01-08	U-1429	Drug substance, Drug product		`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N022059-001	8513262	2019-01-08		Drug substance, Drug product	2013-09-20	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N022059-001	6713485	2020-09-29	U-800	Drug substance, Drug product		`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N022059-001	6713485	2020-09-29	U-1429	Drug substance, Drug product		`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N022059-001	7157466	2021-11-19		Drug substance, Drug product	2013-10-24	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`74a2ff9319b5…`
2022-03-09 01:35 UTC	2022-03	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`bb7c543d1eb4…`
2021-12-28 21:50 UTC	2021-12	N022059-001	7157466	2021-11-19		Drug substance, Drug product	2013-10-24	`782e0a99824c…`
2021-12-28 21:50 UTC	2021-12	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`782e0a99824c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N022059-001	7157466	2021-11-19		Drug substance, Drug product	2013-10-24	`87673890dc5c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`87673890dc5c…`
2021-03-12 10:30 UTC	2021-03	N022059-001	7157466	2021-11-19		Drug substance, Drug product	2013-10-24	`5aa47cf7b7d7…`
2021-03-12 10:30 UTC	2021-03	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`5aa47cf7b7d7…`
2020-12-22 03:56 UTC	2020-12	N022059-001	6713485	2020-09-29	U-1429	Drug substance, Drug product		`8869cabd3fbd…`
2020-12-22 03:56 UTC	2020-12	N022059-001	6713485	2020-09-29	U-800	Drug substance, Drug product		`8869cabd3fbd…`
2020-12-22 03:56 UTC	2020-12	N022059-001	7157466	2021-11-19		Drug substance, Drug product	2013-10-24	`8869cabd3fbd…`
2020-12-22 03:56 UTC	2020-12	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`8869cabd3fbd…`
2020-11-12 02:37 UTC	2020-11	N022059-001	6713485	2020-09-29	U-800	Drug substance, Drug product		`c0c555d07b60…`
2020-11-12 02:37 UTC	2020-11	N022059-001	6713485	2020-09-29	U-1429	Drug substance, Drug product		`c0c555d07b60…`
2020-11-12 02:37 UTC	2020-11	N022059-001	7157466	2021-11-19		Drug substance, Drug product	2013-10-24	`c0c555d07b60…`
2020-11-12 02:37 UTC	2020-11	N022059-001	8821927	2029-09-18		Drug substance, Drug product	2014-10-03	`c0c555d07b60…`

Observed Orange Book exclusivity history#

Captured, Edition, Application-product table
Captured	Edition	Application-product	Exclusivity code	Expiration	Source SHA-256
2019-12-13 00:20 UTC	2019-12	N022059-001	M-235	2021-12-06	`74a2ff9319b5…`
2021-12-28 21:50 UTC	2021-12	N022059-001	M-235	2021-12-06	`782e0a99824c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N022059-001	M-235	2021-12-06	`87673890dc5c…`
2021-03-12 10:30 UTC	2021-03	N022059-001	M-235	2021-12-06	`5aa47cf7b7d7…`
2020-12-22 03:56 UTC	2020-12	N022059-001	M-235	2021-12-06	`8869cabd3fbd…`
2020-11-12 02:37 UTC	2020-11	N022059-001	M-235	2021-12-06	`c0c555d07b60…`
2019-12-14 00:12 UTC	2019-12	N022059-001	M-235	2021-12-06	`3f01610625f2…`
2019-09-15 20:21 UTC	2019-09	N022059-001	M-235	2021-12-06	`b00525d2431f…`
2019-07-19 19:46 UTC	2019-07	N022059-001	M-235	2021-12-06	`ea99ee380514…`

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
TYKERB	LAPATINIB	Novartis Pharmaceuticals Corporation	eee37f88-ec6a-4c30-b8aa-e2c71f93088c	2026-01-27	Boxed warning, Warnings, Adverse reactions	Exact identifier application applno (NDA): 022059 application number: NDA022059 ndc (product): 0078-0671

NDC Listings For This Application#

NDC listings for this application page 1 of 1 · 5 matching rows.

NDC, Name, Nonproprietary name table
NDC	Name	Nonproprietary name	Labeler	Marketing category	Status
0078-0671	TYKERB	lapatinib	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0671	TYKERB	lapatinib	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0671	TYKERB	lapatinib	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0671	TYKERB	lapatinib	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0671	TYKERB	lapatinib	Novartis Pharmaceuticals Corporation	NDA	Current

Documents#

Document, Submission type, Date table
Document	Submission type	Date
70628	SUPPL	2022-03-28
70623	SUPPL	2022-03-28
64841	SUPPL	2020-10-06
60093	SUPPL	2019-09-24
56658	SUPPL	2018-12-07
56657	SUPPL	2018-12-07
56642	SUPPL	2018-12-07
56641	SUPPL	2018-12-07
47973	SUPPL	2017-04-12
47890	SUPPL	2017-04-05
29180	SUPPL	2015-04-02
38169	SUPPL	2015-04-01
16868	SUPPL	2015-01-05
29181	SUPPL	2014-12-30
38168	SUPPL	2013-10-22
38167	SUPPL	2013-10-22
29178	SUPPL	2013-10-22
29177	SUPPL	2013-10-22
16867	SUPPL	2013-06-25
16866	SUPPL	2013-06-25
29179	SUPPL	2013-06-24
29176	SUPPL	2013-06-24
29175	SUPPL	2012-02-21
38166	SUPPL	2012-02-17
29174	SUPPL	2011-08-15
29173	SUPPL	2011-08-15
38165	SUPPL	2011-08-12
16865	SUPPL	2011-08-12
6793	SUPPL	2010-03-09
6792	SUPPL	2010-03-09
6794	SUPPL	2010-02-05
38164	SUPPL	2010-02-01
16864	SUPPL	2010-02-01
16862	SUPPL	2010-02-01
29172	SUPPL	2008-07-10
16863	SUPPL	2008-07-09
29171	SUPPL	2007-08-22
38163	SUPPL	2007-08-21
42404	ORIG	2007-05-09
16861	SUPPL	2007-05-01
6791	SUPPL	2007-05-01
29170	ORIG	2007-03-15
38162	ORIG	2007-03-13