Application 022465

Type: NDA
Sponsor: NOVARTIS

Application Products#

Product, Drug, Ingredient table
Product	Drug	Ingredient	Form	Strength	Reference drug	Reference standard
001	VOTRIENT	PAZOPANIB HYDROCHLORIDE	TABLET;ORAL	EQ 200MG BASE	Yes	Yes
002	VOTRIENT	PAZOPANIB HYDROCHLORIDE	TABLET;ORAL	EQ 400MG BASE	Yes	No

Source provenance: Browse the complete Orange Book source catalog · source snapshot 42.

Orange Book products#

Current product rows page 1 of 1 · 2 matching rows.

Application-product, Trade name, Ingredient table
Application-product	Trade name	Ingredient	Strength	Dosage form / route	TE codes	RLD / RS	Approval date
N022465-001	VOTRIENT	PAZOPANIB HYDROCHLORIDE	EQ 200MG BASE	TABLET / ORAL	AB	RLD, RS	2009-10-19
N022465-002	VOTRIENT	PAZOPANIB HYDROCHLORIDE	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 1 matching rows.

Application-product, TE code table
Application-product	TE code
N022465-001	AB

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 3 · 84 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Trade name	Strength	Dosage form / route	Product TE source text	RLD / RS	Approval date	Source SHA-256
2026-08-18 06:07:40	2026-07	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL	AB	RLD, RS	2009-10-19	`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N022465-002	VOTRIENT	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19	`caaa826d4ba7…`
2026-02-19 14:30 UTC	2026-02	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL	AB	RLD, RS	2009-10-19	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N022465-002	VOTRIENT	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL	AB	RLD, RS	2009-10-19	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N022465-002	VOTRIENT	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL	AB	RLD, RS	2009-10-19	`6a471c1ec25d…`
2025-08-23 18:47 UTC	2025-08	N022465-002	VOTRIENT	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19	`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL	AB	RLD, RS	2009-10-19	`fd3edfee7708…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N022465-002	VOTRIENT	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19	`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL	AB	RLD, RS	2009-10-19	`b8a1b40f171c…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N022465-002	VOTRIENT	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19	`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL	AB	RLD, RS	2009-10-19	`03ed91905a0d…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N022465-002	VOTRIENT	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19	`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL	AB	RLD, RS	2009-10-19	`2680178bc6a6…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N022465-002	VOTRIENT	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19	`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL	AB	RLD, RS	2009-10-19	`5bbf6a4d5a75…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N022465-002	VOTRIENT	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19	`5bbf6a4d5a75…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL	AB	RLD, RS	2009-10-19	`d8e5a09893c0…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N022465-002	VOTRIENT	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19	`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL	AB	RLD, RS	2009-10-19	`d06236e962d9…`
2024-10-29 15:01 UTC	2024-10	N022465-002	VOTRIENT	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19	`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL	AB	RLD, RS	2009-10-19	`79d66fd596c7…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N022465-002	VOTRIENT	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19	`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL	AB	RLD, RS	2009-10-19	`301d65b070ca…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N022465-002	VOTRIENT	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19	`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL	AB	RLD, RS	2009-10-19	`1e350fbaab3a…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N022465-002	VOTRIENT	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19	`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL	AB	RLD, RS	2009-10-19	`8072bd15b7f6…`
2024-05-31 18:47 UTC	2024-05	N022465-002	VOTRIENT	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19	`8072bd15b7f6…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL		RLD, RS	2009-10-19	`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N022465-002	VOTRIENT	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19	`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL		RLD, RS	2009-10-19	`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N022465-002	VOTRIENT	EQ 400MG BASE	TABLET / ORAL		RLD	2009-10-19	`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL		RLD, RS	2009-10-19	`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N022465-002	VOTRIENT	EQ 400MG BASE	TABLET / ORAL		RLD	2009-10-19	`4b0b4de00fa7…`
2019-12-13 00:20 UTC	2019-12	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL		RLD, RS	2009-10-19	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N022465-002	VOTRIENT	EQ 400MG BASE	TABLET / ORAL			2009-10-19	`74a2ff9319b5…`
2022-03-09 01:35 UTC	2022-03	N022465-001	VOTRIENT	EQ 200MG BASE	TABLET / ORAL		RLD, RS	2009-10-19	`bb7c543d1eb4…`
2022-03-09 01:35 UTC	2022-03	N022465-002	VOTRIENT	EQ 400MG BASE Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET / ORAL		RLD	2009-10-19	`bb7c543d1eb4…`

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
Captured	Edition	Application-product	TE code	Order	Source SHA-256
2026-08-18 06:07:40	2026-07	N022465-001	AB	1	`caaa826d4ba7…`
2026-02-19 14:30 UTC	2026-02	N022465-001	AB	1	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N022465-001	AB	1	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	N022465-001	AB	1	`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N022465-001	AB	1	`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N022465-001	AB	1	`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N022465-001	AB	1	`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N022465-001	AB	1	`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N022465-001	AB	1	`5bbf6a4d5a75…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N022465-001	AB	1	`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	N022465-001	AB	1	`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N022465-001	AB	1	`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N022465-001	AB	1	`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N022465-001	AB	1	`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	N022465-001	AB	1	`8072bd15b7f6…`
2024-03-16 18:09 UTC · 4 captures of this ZIP	2024-03	N022465-001	AB	1	`6a51e52b5d6a…`
2024-02-18 07:12 UTC	2024-02	N022465-001	AB	1	`1c564ffb4f44…`
2023-12-20 04:57 UTC	2023-12	N022465-001	AB	1	`ea1830bbd6c7…`
2023-11-28 05:40 UTC · 2 captures of this ZIP	2023-11	N022465-001	AB	1	`a72a2bbeb626…`
2026-07-26 02:55 UTC · 3 captures of this ZIP	2026-06	N022465-001	AB	1	`a50c72e98297…`

Observed Orange Book patent history#

Patent history page 1 of 3 · 84 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Patent	Expiration	Coverage / status	Source SHA-256
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N022465-001	7105530	2023-10-19	Drug substance, Drug product	`5c6f7cd8ea54…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N022465-002	7105530	2023-10-19	Drug substance, Drug product	`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	N022465-001	7105530	2023-10-19	Drug substance, Drug product	`5d02ea3f76ae…`
2022-04-08 23:34 UTC	2022-04	N022465-002	7105530	2023-10-19	Drug substance, Drug product	`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	N022465-001	7105530	2023-10-19	Drug substance, Drug product	`4b0b4de00fa7…`
2022-04-04 05:41 UTC	2022-04	N022465-002	7105530	2023-10-19	Drug substance, Drug product	`4b0b4de00fa7…`
2019-12-13 00:20 UTC	2019-12	N022465-001	7262203	2021-12-19	Drug substance, Drug product	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N022465-001	8114885	2021-12-19	Drug substance, Drug product	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N022465-001	7105530	2023-10-19	Drug substance, Drug product	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N022465-002	7262203	2021-12-19	Drug substance, Drug product	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N022465-002	8114885	2021-12-19	Drug substance, Drug product	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N022465-002	7105530	2023-10-19	Drug substance, Drug product	`74a2ff9319b5…`
2022-03-09 01:35 UTC	2022-03	N022465-001	7105530	2023-10-19	Drug substance, Drug product	`bb7c543d1eb4…`
2022-03-09 01:35 UTC	2022-03	N022465-002	7105530	2023-10-19	Drug substance, Drug product	`bb7c543d1eb4…`
2021-12-28 21:50 UTC	2021-12	N022465-001	7262203	2021-12-19	Drug substance, Drug product	`782e0a99824c…`
2021-12-28 21:50 UTC	2021-12	N022465-001	8114885	2021-12-19	Drug substance, Drug product	`782e0a99824c…`
2021-12-28 21:50 UTC	2021-12	N022465-001	7105530	2023-10-19	Drug substance, Drug product	`782e0a99824c…`
2021-12-28 21:50 UTC	2021-12	N022465-002	7262203	2021-12-19	Drug substance, Drug product	`782e0a99824c…`
2021-12-28 21:50 UTC	2021-12	N022465-002	8114885	2021-12-19	Drug substance, Drug product	`782e0a99824c…`
2021-12-28 21:50 UTC	2021-12	N022465-002	7105530	2023-10-19	Drug substance, Drug product	`782e0a99824c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N022465-001	7262203	2021-12-19	Drug substance, Drug product	`87673890dc5c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N022465-001	8114885	2021-12-19	Drug substance, Drug product	`87673890dc5c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N022465-001	7105530	2023-10-19	Drug substance, Drug product	`87673890dc5c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N022465-002	7262203	2021-12-19	Drug substance, Drug product	`87673890dc5c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N022465-002	8114885	2021-12-19	Drug substance, Drug product	`87673890dc5c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N022465-002	7105530	2023-10-19	Drug substance, Drug product	`87673890dc5c…`
2021-03-12 10:30 UTC	2021-03	N022465-001	7262203	2021-12-19	Drug substance, Drug product	`5aa47cf7b7d7…`
2021-03-12 10:30 UTC	2021-03	N022465-001	8114885	2021-12-19	Drug substance, Drug product	`5aa47cf7b7d7…`
2021-03-12 10:30 UTC	2021-03	N022465-001	7105530	2023-10-19	Drug substance, Drug product	`5aa47cf7b7d7…`
2021-03-12 10:30 UTC	2021-03	N022465-002	7262203	2021-12-19	Drug substance, Drug product	`5aa47cf7b7d7…`
2021-03-12 10:30 UTC	2021-03	N022465-002	8114885	2021-12-19	Drug substance, Drug product	`5aa47cf7b7d7…`
2021-03-12 10:30 UTC	2021-03	N022465-002	7105530	2023-10-19	Drug substance, Drug product	`5aa47cf7b7d7…`
2020-12-22 03:56 UTC	2020-12	N022465-001	7262203	2021-12-19	Drug substance, Drug product	`8869cabd3fbd…`
2020-12-22 03:56 UTC	2020-12	N022465-001	8114885	2021-12-19	Drug substance, Drug product	`8869cabd3fbd…`
2020-12-22 03:56 UTC	2020-12	N022465-001	7105530	2023-10-19	Drug substance, Drug product	`8869cabd3fbd…`
2020-12-22 03:56 UTC	2020-12	N022465-002	7262203	2021-12-19	Drug substance, Drug product	`8869cabd3fbd…`
2020-12-22 03:56 UTC	2020-12	N022465-002	8114885	2021-12-19	Drug substance, Drug product	`8869cabd3fbd…`
2020-12-22 03:56 UTC	2020-12	N022465-002	7105530	2023-10-19	Drug substance, Drug product	`8869cabd3fbd…`
2020-11-12 02:37 UTC	2020-11	N022465-001	7262203	2021-12-19	Drug substance, Drug product	`c0c555d07b60…`
2020-11-12 02:37 UTC	2020-11	N022465-001	8114885	2021-12-19	Drug substance, Drug product	`c0c555d07b60…`

Observed Orange Book exclusivity history#

Captured, Edition, Application-product table
Captured	Edition	Application-product	Exclusivity code	Expiration	Source SHA-256
2019-12-13 00:20 UTC	2019-12	N022465-001	ODE-23	2019-04-26	`74a2ff9319b5…`
2019-12-13 00:20 UTC	2019-12	N022465-002	ODE-23	2019-04-26	`74a2ff9319b5…`
2019-12-14 00:12 UTC	2019-12	N022465-001	ODE-23	2019-04-26	`3f01610625f2…`
2019-12-14 00:12 UTC	2019-12	N022465-002	ODE-23	2019-04-26	`3f01610625f2…`
2019-09-15 20:21 UTC	2019-09	N022465-001	ODE-23	2019-04-26	`b00525d2431f…`
2019-09-15 20:21 UTC	2019-09	N022465-002	ODE-23	2019-04-26	`b00525d2431f…`
2019-07-19 19:46 UTC	2019-07	N022465-001	ODE-23	2019-04-26	`ea99ee380514…`
2019-07-19 19:46 UTC	2019-07	N022465-002	ODE-23	2019-04-26	`ea99ee380514…`

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
VOTRIENT	PAZOPANIB HYDROCHLORIDE	Novartis Pharmaceuticals Corporation	eeaaaf38-fb86-4d9f-a19d-0f61daac2fd7	2025-12-16	Boxed warning, Warnings, Adverse reactions	Exact identifier application applno (NDA): 022465 application number: NDA022465 ndc (product): 0078-1077

NDC Listings For This Application#

NDC listings for this application page 1 of 1 · 11 matching rows.

NDC, Name, Nonproprietary name table
NDC	Name	Nonproprietary name	Labeler	Marketing category	Status
0078-0670	VOTRIENT	pazopanib hydrochloride	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0670	VOTRIENT	pazopanib hydrochloride	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0670	VOTRIENT	pazopanib hydrochloride	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0670	VOTRIENT	pazopanib hydrochloride	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0670	VOTRIENT	pazopanib hydrochloride	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0670	VOTRIENT	pazopanib hydrochloride	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0670	VOTRIENT	pazopanib hydrochloride	Novartis Pharmaceuticals Corporation	NDA	Current
0078-0670	VOTRIENT	pazopanib hydrochloride	Novartis Pharmaceuticals Corporation	NDA	Current
0078-1077	VOTRIENT	pazopanib hydrochloride	Novartis Pharmaceuticals Corporation	NDA	Current
0078-1077	VOTRIENT	pazopanib hydrochloride	Novartis Pharmaceuticals Corporation	NDA	Current
0078-1077	VOTRIENT	pazopanib hydrochloride	Novartis Pharmaceuticals Corporation	NDA	Current

Documents#

Document, Submission type, Date table
Document	Submission type	Date
77316	SUPPL	2024-01-26
77313	SUPPL	2024-01-26
77312	SUPPL	2024-01-26
70233	SUPPL	2022-02-23
70185	SUPPL	2022-02-18
68816	SUPPL	2021-09-30
68815	SUPPL	2021-09-30
68814	SUPPL	2021-09-30
68733	SUPPL	2021-09-23
68732	SUPPL	2021-09-23
64294	SUPPL	2020-08-18
64293	SUPPL	2020-08-18
64292	SUPPL	2020-08-18
64058	SUPPL	2020-07-23
64057	SUPPL	2020-07-23
63974	SUPPL	2020-07-20
63467	SUPPL	2020-06-09
63466	SUPPL	2020-06-09
63408	SUPPL	2020-06-03
48646	SUPPL	2017-06-05
48645	SUPPL	2017-06-05
48623	SUPPL	2017-06-01
48622	SUPPL	2017-06-01
48621	SUPPL	2017-06-01
48620	SUPPL	2017-06-01
45038	SUPPL	2016-08-05
45002	SUPPL	2016-08-05
29757	SUPPL	2016-05-24
17615	SUPPL	2016-05-23
17614	SUPPL	2015-10-06
29756	SUPPL	2015-09-24
38741	SUPPL	2015-04-02
7431	SUPPL	2015-04-02
17613	SUPPL	2015-04-01
17612	SUPPL	2014-11-20
7430	SUPPL	2014-11-20
29755	SUPPL	2014-06-05
38740	SUPPL	2014-06-04
7429	SUPPL	2013-12-18
38739	SUPPL	2013-12-03
29754	SUPPL	2013-08-16
29753	SUPPL	2013-08-16
7428	SUPPL	2013-08-16
38738	SUPPL	2013-08-15
17611	SUPPL	2013-08-15
17610	SUPPL	2013-08-15
38737	SUPPL	2012-11-16
7427	SUPPL	2012-11-16
29752	SUPPL	2012-05-02
7425	SUPPL	2012-05-02
17609	SUPPL	2012-04-27
17607	SUPPL	2012-04-27
7426	SUPPL	2012-03-26
17608	SUPPL	2012-03-23
38736	SUPPL	2012-01-23
7424	SUPPL	2012-01-17
38735	SUPPL	2011-10-25
17606	SUPPL	2011-10-25
7422	SUPPL	2011-10-25
7421	SUPPL	2011-10-25
7423	SUPPL	2011-04-22
38734	SUPPL	2010-05-07
7420	SUPPL	2010-05-03
24315	ORIG	2010-01-22
22028	ORIG	2010-01-22
7419	ORIG	2009-11-03
17605	ORIG	2009-10-20