Application 205257

Type
ANDA
Sponsor
MYLAN

Application Products#

Product, Drug, Ingredient table
ProductDrugIngredientFormStrengthReference drugReference standard
001TRAMADOL HYDROCHLORIDETRAMADOL HYDROCHLORIDETABLET, EXTENDED RELEASE;ORAL100MGNoNo
002TRAMADOL HYDROCHLORIDETRAMADOL HYDROCHLORIDETABLET, EXTENDED RELEASE;ORAL200MGNoNo
003TRAMADOL HYDROCHLORIDETRAMADOL HYDROCHLORIDETABLET, EXTENDED RELEASE;ORAL300MGNoNo

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 3 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A205257-001TRAMADOL HYDROCHLORIDETRAMADOL HYDROCHLORIDE100MGTABLET, EXTENDED RELEASE / ORAL2015-12-22
A205257-002TRAMADOL HYDROCHLORIDETRAMADOL HYDROCHLORIDE200MGTABLET, EXTENDED RELEASE / ORAL2015-12-22
A205257-003TRAMADOL HYDROCHLORIDETRAMADOL HYDROCHLORIDE300MGTABLET, EXTENDED RELEASE / ORAL2015-12-22

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 4 · 123 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-02-19 14:30 UTC2026-02A205257-001TRAMADOL HYDROCHLORIDE100MGTABLET, EXTENDED RELEASE / ORAL2015-12-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02A205257-002TRAMADOL HYDROCHLORIDE200MGTABLET, EXTENDED RELEASE / ORAL2015-12-22011fe1cb6892…
2026-02-19 14:30 UTC2026-02A205257-003TRAMADOL HYDROCHLORIDE300MGTABLET, EXTENDED RELEASE / ORAL2015-12-22011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A205257-001TRAMADOL HYDROCHLORIDE100MGTABLET, EXTENDED RELEASE / ORAL2015-12-2231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A205257-002TRAMADOL HYDROCHLORIDE200MGTABLET, EXTENDED RELEASE / ORAL2015-12-2231067a03dcf5…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A205257-003TRAMADOL HYDROCHLORIDE300MGTABLET, EXTENDED RELEASE / ORAL2015-12-2231067a03dcf5…
2025-08-23 18:47 UTC2025-08A205257-001TRAMADOL HYDROCHLORIDE100MGTABLET, EXTENDED RELEASE / ORAL2015-12-226a471c1ec25d…
2025-08-23 18:47 UTC2025-08A205257-002TRAMADOL HYDROCHLORIDE200MGTABLET, EXTENDED RELEASE / ORAL2015-12-226a471c1ec25d…
2025-08-23 18:47 UTC2025-08A205257-003TRAMADOL HYDROCHLORIDE300MGTABLET, EXTENDED RELEASE / ORAL2015-12-226a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A205257-001TRAMADOL HYDROCHLORIDE100MGTABLET, EXTENDED RELEASE / ORAL2015-12-22fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A205257-002TRAMADOL HYDROCHLORIDE200MGTABLET, EXTENDED RELEASE / ORAL2015-12-22fd3edfee7708…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A205257-003TRAMADOL HYDROCHLORIDE300MGTABLET, EXTENDED RELEASE / ORAL2015-12-22fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A205257-001TRAMADOL HYDROCHLORIDE100MGTABLET, EXTENDED RELEASE / ORAL2015-12-22b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A205257-002TRAMADOL HYDROCHLORIDE200MGTABLET, EXTENDED RELEASE / ORAL2015-12-22b8a1b40f171c…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A205257-003TRAMADOL HYDROCHLORIDE300MGTABLET, EXTENDED RELEASE / ORAL2015-12-22b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A205257-001TRAMADOL HYDROCHLORIDE100MGTABLET, EXTENDED RELEASE / ORAL2015-12-2203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A205257-002TRAMADOL HYDROCHLORIDE200MGTABLET, EXTENDED RELEASE / ORAL2015-12-2203ed91905a0d…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A205257-003TRAMADOL HYDROCHLORIDE300MGTABLET, EXTENDED RELEASE / ORAL2015-12-2203ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A205257-001TRAMADOL HYDROCHLORIDE100MGTABLET, EXTENDED RELEASE / ORAL2015-12-222680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A205257-002TRAMADOL HYDROCHLORIDE200MGTABLET, EXTENDED RELEASE / ORAL2015-12-222680178bc6a6…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A205257-003TRAMADOL HYDROCHLORIDE300MGTABLET, EXTENDED RELEASE / ORAL2015-12-222680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A205257-001TRAMADOL HYDROCHLORIDE100MGTABLET, EXTENDED RELEASE / ORAL2015-12-225bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A205257-002TRAMADOL HYDROCHLORIDE200MGTABLET, EXTENDED RELEASE / ORAL2015-12-225bbf6a4d5a75…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A205257-003TRAMADOL HYDROCHLORIDE300MGTABLET, EXTENDED RELEASE / ORAL2015-12-225bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A205257-001TRAMADOL HYDROCHLORIDE100MGTABLET, EXTENDED RELEASE / ORAL2015-12-22d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A205257-002TRAMADOL HYDROCHLORIDE200MGTABLET, EXTENDED RELEASE / ORAL2015-12-22d8e5a09893c0…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A205257-003TRAMADOL HYDROCHLORIDE300MGTABLET, EXTENDED RELEASE / ORAL2015-12-22d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A205257-001TRAMADOL HYDROCHLORIDE100MGTABLET, EXTENDED RELEASE / ORAL2015-12-22d06236e962d9…
2024-10-29 15:01 UTC2024-10A205257-002TRAMADOL HYDROCHLORIDE200MGTABLET, EXTENDED RELEASE / ORAL2015-12-22d06236e962d9…
2024-10-29 15:01 UTC2024-10A205257-003TRAMADOL HYDROCHLORIDE300MGTABLET, EXTENDED RELEASE / ORAL2015-12-22d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A205257-001TRAMADOL HYDROCHLORIDE100MGTABLET, EXTENDED RELEASE / ORAL2015-12-2279d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A205257-002TRAMADOL HYDROCHLORIDE200MGTABLET, EXTENDED RELEASE / ORAL2015-12-2279d66fd596c7…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A205257-003TRAMADOL HYDROCHLORIDE300MGTABLET, EXTENDED RELEASE / ORAL2015-12-2279d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A205257-001TRAMADOL HYDROCHLORIDE100MGTABLET, EXTENDED RELEASE / ORAL2015-12-22301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A205257-002TRAMADOL HYDROCHLORIDE200MGTABLET, EXTENDED RELEASE / ORAL2015-12-22301d65b070ca…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A205257-003TRAMADOL HYDROCHLORIDE300MGTABLET, EXTENDED RELEASE / ORAL2015-12-22301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A205257-001TRAMADOL HYDROCHLORIDE100MGTABLET, EXTENDED RELEASE / ORAL2015-12-221e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A205257-002TRAMADOL HYDROCHLORIDE200MGTABLET, EXTENDED RELEASE / ORAL2015-12-221e350fbaab3a…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A205257-003TRAMADOL HYDROCHLORIDE300MGTABLET, EXTENDED RELEASE / ORAL2015-12-221e350fbaab3a…
2024-05-31 18:47 UTC2024-05A205257-001TRAMADOL HYDROCHLORIDE100MGTABLET, EXTENDED RELEASE / ORAL2015-12-228072bd15b7f6…

Observed Orange Book normalized TE history#

Normalized TE history page 1 of 2 · 41 observed states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTE codeOrderSource SHA-256
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A205257-001AB115c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A205257-002AB115c6f7cd8ea54…
2022-06-29 02:47 UTC · 2 captures of this ZIP2022-06A205257-003AB115c6f7cd8ea54…
2022-04-08 23:34 UTC2022-04A205257-001AB115d02ea3f76ae…
2022-04-08 23:34 UTC2022-04A205257-002AB115d02ea3f76ae…
2022-04-08 23:34 UTC2022-04A205257-003AB115d02ea3f76ae…
2022-04-04 05:41 UTC2022-04A205257-001AB114b0b4de00fa7…
2022-04-04 05:41 UTC2022-04A205257-002AB114b0b4de00fa7…
2022-04-04 05:41 UTC2022-04A205257-003AB114b0b4de00fa7…
2019-12-13 00:20 UTC2019-12A205257-001AB1174a2ff9319b5…
2019-12-13 00:20 UTC2019-12A205257-002AB1174a2ff9319b5…
2019-12-13 00:20 UTC2019-12A205257-003AB1174a2ff9319b5…
2022-03-09 01:35 UTC2022-03A205257-001AB11bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03A205257-002AB11bb7c543d1eb4…
2022-03-09 01:35 UTC2022-03A205257-003AB11bb7c543d1eb4…
2021-12-28 21:50 UTC2021-12A205257-001AB11782e0a99824c…
2021-12-28 21:50 UTC2021-12A205257-002AB11782e0a99824c…
2021-12-28 21:50 UTC2021-12A205257-003AB11782e0a99824c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A205257-001AB1187673890dc5c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A205257-002AB1187673890dc5c…
2021-05-05 16:15 UTC · 3 captures of this ZIP2021-05A205257-003AB1187673890dc5c…
2021-03-12 10:30 UTC2021-03A205257-001AB115aa47cf7b7d7…
2021-03-12 10:30 UTC2021-03A205257-002AB115aa47cf7b7d7…
2021-03-12 10:30 UTC2021-03A205257-003AB115aa47cf7b7d7…
2020-12-22 03:56 UTC2020-12A205257-001AB118869cabd3fbd…
2020-12-22 03:56 UTC2020-12A205257-002AB118869cabd3fbd…
2020-12-22 03:56 UTC2020-12A205257-003AB118869cabd3fbd…
2020-11-12 02:37 UTC2020-11A205257-001AB11c0c555d07b60…
2020-11-12 02:37 UTC2020-11A205257-002AB11c0c555d07b60…
2020-11-12 02:37 UTC2020-11A205257-003AB11c0c555d07b60…
2019-12-14 00:12 UTC2019-12A205257-001AB113f01610625f2…
2019-12-14 00:12 UTC2019-12A205257-002AB113f01610625f2…
2019-12-14 00:12 UTC2019-12A205257-003AB113f01610625f2…
2019-09-15 20:21 UTC2019-09A205257-001AB11b00525d2431f…
2019-09-15 20:21 UTC2019-09A205257-002AB11b00525d2431f…
2019-09-15 20:21 UTC2019-09A205257-003AB11b00525d2431f…
2019-07-19 19:46 UTC2019-07A205257-001AB11ea99ee380514…
2019-07-19 19:46 UTC2019-07A205257-002AB11ea99ee380514…
2019-07-19 19:46 UTC2019-07A205257-003AB11ea99ee380514…
2022-09-29 23:25 UTC2022-09A205257-001AB11e64feba35796…

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 3 of 5 · 92 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Tramadol HydrochlorideTRAMADOL HYDROCHLORIDEAurobindo Pharma Limitede5005d9e-91cb-4ff8-bcf2-b5ee70cf4f3f2025-11-03Boxed warning, Warnings, Adverse reactionsName fallback
brand name: Tramadol Hydrochloride
generic name: TRAMADOL HYDROCHLORIDE
Tramadol HydrochlorideTRAMADOL HYDROCHLORIDEPreferred Pharmaceuticals Inc.f558c59c-cbd4-4b17-9a3d-b014ad09bbb12025-10-13Boxed warning, Warnings, Adverse reactionsName fallback
brand name: Tramadol Hydrochloride
generic name: TRAMADOL HYDROCHLORIDE
TRAMADOL HYDROCHLORIDETRAMADOL HYDROCHLORIDEPreferred Pharmaceuticals, Inc.83367367-5654-4078-831a-69ade48bc7952025-10-01Boxed warning, Warnings, Adverse reactionsName fallback
brand name: TRAMADOL HYDROCHLORIDE
generic name: TRAMADOL HYDROCHLORIDE
tramadol hydrochlorideTRAMADOL HYDROCHLORIDEPreferred Pharmaceuticals Inc.05f8e06b-f3eb-4cb2-aee5-bd0b038841782025-10-01Boxed warning, Warnings, Adverse reactionsName fallback
brand name: tramadol hydrochloride
generic name: TRAMADOL HYDROCHLORIDE
TRAMADOL HYDROCHLORIDETRAMADOL HYDROCHLORIDEPreferred Pharmaceuticals, Inc.c30f6e9e-8014-40fc-9615-a6b8654137c12025-10-01Boxed warning, Warnings, Adverse reactionsName fallback
brand name: TRAMADOL HYDROCHLORIDE
generic name: TRAMADOL HYDROCHLORIDE
Tramadol HydrochlorideTRAMADOL HYDROCHLORIDEPreferred Pharmaceuticals Inc.84b12129-cf10-4a3e-889c-990ebabdece62025-10-01Boxed warning, Warnings, Adverse reactionsName fallback
brand name: Tramadol Hydrochloride
generic name: TRAMADOL HYDROCHLORIDE
tramadol hydrochlorideTRAMADOL HYDROCHLORIDEREMEDYREPACK INC.c6104e62-5b2c-41a1-afb3-00dcf267a3842025-09-30Boxed warning, Warnings, Adverse reactionsName fallback
brand name: tramadol hydrochloride
generic name: TRAMADOL HYDROCHLORIDE
Tramadol HydrochlorideTRAMADOL HYDROCHLORIDEPreferred Pharmaceuticals Inc.e6e275c3-1e16-4a00-b7fd-608ae6cbd5152025-09-29Boxed warning, Warnings, Adverse reactionsName fallback
brand name: Tramadol Hydrochloride
generic name: TRAMADOL HYDROCHLORIDE
Tramadol HydrochlorideTRAMADOL HYDROCHLORIDEBryant Ranch Prepack2bf66203-8b45-475d-9a70-4d7c8bdfe6b32025-09-26Boxed warning, Warnings, Adverse reactionsName fallback
brand name: Tramadol Hydrochloride
generic name: TRAMADOL HYDROCHLORIDE
TRAMADOL HYDROCHLORIDETRAMADOL HYDROCHLORIDEA-S Medication Solutionsc28c98ac-7e07-46a5-8f34-57c008308fba2025-09-05Boxed warning, Warnings, Adverse reactionsName fallback
brand name: TRAMADOL HYDROCHLORIDE
generic name: TRAMADOL HYDROCHLORIDE
Tramadol HydrochlorideTRAMADOL HYDROCHLORIDEAmerican Health Packagingf6f6069b-cc75-4b87-afa5-b83001b543e02025-08-27Boxed warning, Warnings, Adverse reactionsName fallback
brand name: Tramadol Hydrochloride
generic name: TRAMADOL HYDROCHLORIDE
Tramadol HydrochlorideTRAMADOL HYDROCHLORIDEAsclemed USA, Inc.6a60bd36-7dcc-49c3-b6de-b263fdaa312c2025-08-14Boxed warning, Warnings, Adverse reactionsName fallback
brand name: Tramadol Hydrochloride
generic name: TRAMADOL HYDROCHLORIDE
Tramadol HydrochlorideTRAMADOL HYDROCHLORIDECoupler LLC3135a131-5f2d-3775-e063-6394a90a43222025-03-25Boxed warning, Warnings, Adverse reactionsName fallback
brand name: Tramadol Hydrochloride
generic name: TRAMADOL HYDROCHLORIDE
TRAMADOL HYDROCHLORIDETRAMADOL HYDROCHLORIDECoupler LLC2f23ba6c-89d2-cc42-e063-6394a90aee0a2025-02-27Boxed warning, Warnings, Adverse reactionsName fallback
brand name: TRAMADOL HYDROCHLORIDE
generic name: TRAMADOL HYDROCHLORIDE
Tramadol HydrochlorideTRAMADOL HYDROCHLORIDEAdvanced Rx of Tennessee, LLC2e738ced-9cde-e776-e063-6294a90a7e332025-02-13Boxed warning, Warnings, Adverse reactionsName fallback
brand name: Tramadol Hydrochloride
generic name: TRAMADOL HYDROCHLORIDE
Tramadol HydrochlorideTRAMADOL HYDROCHLORIDEClinical Solutions Wholesale, LLC728157e2-d153-4ea0-81eb-36599dc7dfda2025-02-06Boxed warning, Warnings, Adverse reactionsName fallback
brand name: Tramadol Hydrochloride
generic name: TRAMADOL HYDROCHLORIDE
Tramadol HydrochlorideTRAMADOL HYDROCHLORIDENuCare Pharmaceuticals,Inc.5babcfcf-331b-5db9-e053-2a91aa0aaf892025-02-03Boxed warning, Warnings, Adverse reactionsName fallback
brand name: Tramadol Hydrochloride
generic name: TRAMADOL HYDROCHLORIDE
TRAMADOL HYDROCHLORIDETRAMADOL HYDROCHLORIDEDirectRxd5685c80-c84d-d0a1-e053-2995a90afc542025-01-21Warnings, Adverse reactionsName fallback
brand name: TRAMADOL HYDROCHLORIDE
generic name: TRAMADOL HYDROCHLORIDE
TRAMADOL HYDROCHLORIDETRAMADOL HYDROCHLORIDEDIRECT RXb3c702f7-0a8c-a52b-e053-2995a90a6df32025-01-17Boxed warning, Warnings, Adverse reactionsName fallback
brand name: TRAMADOL HYDROCHLORIDE
generic name: TRAMADOL HYDROCHLORIDE
tramadol hydrochlorideTRAMADOL HYDROCHLORIDENuCare Pharmaceuticals,Inc.1e79e1fa-3473-f4a7-e063-6294a90a95762025-01-14Boxed warning, Warnings, Adverse reactionsName fallback
brand name: tramadol hydrochloride
generic name: TRAMADOL HYDROCHLORIDE

NDC Listings For This Application#

NDC listings for this application page 1 of 1 · 16 matching rows.

NDC, Name, Nonproprietary name table
NDCNameNonproprietary nameLabelerMarketing categoryStatus
0378-4152Tramadol Hydrochloridetramadol hydrochlorideMylan Pharmaceuticals Inc.ANDACurrent
0378-4152Tramadol Hydrochloridetramadol hydrochlorideMylan Pharmaceuticals Inc.ANDACurrent
0378-4152Tramadol Hydrochloridetramadol hydrochlorideMylan Pharmaceuticals Inc.ANDACurrent
0378-4152Tramadol Hydrochloridetramadol hydrochlorideMylan Pharmaceuticals Inc.ANDACurrent
0378-4152Tramadol Hydrochloridetramadol hydrochlorideMylan Pharmaceuticals Inc.ANDACurrent
0378-4153Tramadol Hydrochloridetramadol hydrochlorideMylan Pharmaceuticals Inc.ANDACurrent
0378-4153Tramadol Hydrochloridetramadol hydrochlorideMylan Pharmaceuticals Inc.ANDACurrent
0378-4153Tramadol Hydrochloridetramadol hydrochlorideMylan Pharmaceuticals Inc.ANDACurrent
0378-4153Tramadol Hydrochloridetramadol hydrochlorideMylan Pharmaceuticals Inc.ANDACurrent
0378-4153Tramadol Hydrochloridetramadol hydrochlorideMylan Pharmaceuticals Inc.ANDACurrent
0378-4154Tramadol Hydrochloridetramadol hydrochlorideMylan Pharmaceuticals Inc.ANDACurrent
0378-4154Tramadol Hydrochloridetramadol hydrochlorideMylan Pharmaceuticals Inc.ANDACurrent
0378-4154Tramadol Hydrochloridetramadol hydrochlorideMylan Pharmaceuticals Inc.ANDACurrent
0378-4154Tramadol Hydrochloridetramadol hydrochlorideMylan Pharmaceuticals Inc.ANDACurrent
0378-4154Tramadol Hydrochloridetramadol hydrochlorideMylan Pharmaceuticals Inc.ANDACurrent
68788-7284Tramadol Hydrochloridetramadol hydrochloridePreferred Pharmaceuticals Inc.ANDACurrent

Documents#

Document, Submission type, Date table
DocumentSubmission typeDate
76124ORIG 2023-11-03