Application 205649

Type: NDA
Sponsor: ASTRAZENECA AB

Application Products#

Product, Drug, Ingredient table
Product	Drug	Ingredient	Form	Strength	Reference drug	Reference standard
001	XIGDUO XR	DAPAGLIFLOZIN; METFORMIN HYDROCHLORIDE	TABLET, EXTENDED RELEASE;ORAL	5MG;500MG	Yes	No
002	XIGDUO XR	DAPAGLIFLOZIN; METFORMIN HYDROCHLORIDE	TABLET, EXTENDED RELEASE;ORAL	5MG;1GM	Yes	No
003	XIGDUO XR	DAPAGLIFLOZIN; METFORMIN HYDROCHLORIDE	TABLET, EXTENDED RELEASE;ORAL	10MG;500MG	Yes	No
004	XIGDUO XR	DAPAGLIFLOZIN; METFORMIN HYDROCHLORIDE	TABLET, EXTENDED RELEASE;ORAL	10MG;1GM	Yes	Yes
005	XIGDUO XR	DAPAGLIFLOZIN; METFORMIN HYDROCHLORIDE	TABLET, EXTENDED RELEASE;ORAL	2.5MG;1GM	Yes	No

Source provenance: Browse the complete Orange Book source catalog · source snapshot 1.

Orange Book products#

Current product rows page 1 of 1 · 5 matching rows.

Application-product, Trade name, Ingredient table
Application-product	Trade name	Ingredient	Strength	Dosage form / route	TE codes	RLD / RS	Approval date
N205649-001	XIGDUO XR	DAPAGLIFLOZIN; METFORMIN HYDROCHLORIDE	5MG;500MG	TABLET, EXTENDED RELEASE / ORAL	AB	RLD	2014-10-29
N205649-002	XIGDUO XR	DAPAGLIFLOZIN; METFORMIN HYDROCHLORIDE	5MG;1GM	TABLET, EXTENDED RELEASE / ORAL	AB	RLD	2014-10-29
N205649-003	XIGDUO XR	DAPAGLIFLOZIN; METFORMIN HYDROCHLORIDE	10MG;500MG	TABLET, EXTENDED RELEASE / ORAL	AB	RLD	2014-10-29
N205649-004	XIGDUO XR	DAPAGLIFLOZIN; METFORMIN HYDROCHLORIDE	10MG;1GM	TABLET, EXTENDED RELEASE / ORAL	AB	RLD, RS	2014-10-29
N205649-005	XIGDUO XR	DAPAGLIFLOZIN; METFORMIN HYDROCHLORIDE	2.5MG;1GM	TABLET, EXTENDED RELEASE / ORAL	AB	RLD	2017-07-28

Therapeutic equivalence codes#

Current TE-code rows page 1 of 1 · 5 matching rows.

Application-product, TE code table
Application-product	TE code
N205649-001	AB
N205649-002	AB
N205649-003	AB
N205649-004	AB
N205649-005	AB

Orange Book patents#

Current patent rows page 1 of 1 · 50 matching rows.

Application-product, Patent, Expiration table
Application-product	Patent	Expiration	Use code	Coverage / status	Submission date
N205649-001	6515117	2025-10-04	U-493	Drug substance, Drug product	2014-11-24
N205649-001	6515117*PED	2026-04-04		Pediatric extension
N205649-001	8501698	2027-06-20	U-493	Drug product	2014-11-24
N205649-001	8501698*PED	2027-12-20		Pediatric extension
N205649-001	7919598	2029-12-16		Drug substance	2014-11-24
N205649-001	8685934	2030-05-26	U-1522		2014-11-24
N205649-001	7919598*PED	2030-06-16		Pediatric extension
N205649-001	9616028	2030-11-12		Drug product	2017-08-30
N205649-001	8685934*PED	2030-11-26		Pediatric extension
N205649-001	9616028*PED	2031-05-12		Pediatric extension
N205649-002	6515117	2025-10-04	U-493	Drug substance, Drug product	2014-11-24
N205649-002	6515117*PED	2026-04-04		Pediatric extension
N205649-002	8501698	2027-06-20	U-493	Drug product	2014-11-24
N205649-002	8501698*PED	2027-12-20		Pediatric extension
N205649-002	7919598	2029-12-16		Drug substance	2014-11-24
N205649-002	8685934	2030-05-26	U-1522		2014-11-24
N205649-002	7919598*PED	2030-06-16		Pediatric extension
N205649-002	9616028	2030-11-12		Drug product	2017-08-30
N205649-002	8685934*PED	2030-11-26		Pediatric extension
N205649-002	9616028*PED	2031-05-12		Pediatric extension
N205649-003	6515117	2025-10-04	U-493	Drug substance, Drug product	2014-11-24
N205649-003	6515117*PED	2026-04-04		Pediatric extension
N205649-003	8501698	2027-06-20	U-493	Drug product	2014-11-24
N205649-003	8501698*PED	2027-12-20		Pediatric extension
N205649-003	7919598	2029-12-16		Drug substance	2014-11-24
N205649-003	8685934	2030-05-26	U-1522		2014-11-24
N205649-003	7919598*PED	2030-06-16		Pediatric extension
N205649-003	9616028	2030-11-12		Drug product	2017-08-30
N205649-003	8685934*PED	2030-11-26		Pediatric extension
N205649-003	9616028*PED	2031-05-12		Pediatric extension
N205649-004	6515117	2025-10-04	U-493	Drug substance, Drug product	2014-11-24
N205649-004	6515117*PED	2026-04-04		Pediatric extension
N205649-004	8501698	2027-06-20	U-493	Drug product	2014-11-24
N205649-004	8501698*PED	2027-12-20		Pediatric extension
N205649-004	7919598	2029-12-16		Drug substance	2014-11-24
N205649-004	8685934	2030-05-26	U-1522		2014-11-24
N205649-004	7919598*PED	2030-06-16		Pediatric extension
N205649-004	9616028	2030-11-12		Drug product	2017-08-30
N205649-004	8685934*PED	2030-11-26		Pediatric extension
N205649-004	9616028*PED	2031-05-12		Pediatric extension
N205649-005	6515117	2025-10-04	U-493	Drug substance, Drug product	2014-11-24
N205649-005	6515117*PED	2026-04-04		Pediatric extension
N205649-005	8501698	2027-06-20	U-493	Drug product	2017-08-30
N205649-005	8501698*PED	2027-12-20		Pediatric extension
N205649-005	7919598	2029-12-16		Drug substance	2017-08-30
N205649-005	8685934	2030-05-26	U-1522		2017-08-30
N205649-005	7919598*PED	2030-06-16		Pediatric extension
N205649-005	9616028	2030-11-12		Drug product	2017-08-30
N205649-005	8685934*PED	2030-11-26		Pediatric extension
N205649-005	9616028*PED	2031-05-12		Pediatric extension

Orange Book exclusivity#

Current exclusivity rows page 1 of 1 · 10 matching rows.

Application-product, Exclusivity code, Expiration table
Application-product	Exclusivity code	Expiration
N205649-001	NPP	2027-06-12
N205649-001	PED	2027-12-12
N205649-002	NPP	2027-06-12
N205649-002	PED	2027-12-12
N205649-003	NPP	2027-06-12
N205649-003	PED	2027-12-12
N205649-004	NPP	2027-06-12
N205649-004	PED	2027-12-12
N205649-005	NPP	2027-06-12
N205649-005	PED	2027-12-12

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Trade name	Strength	Dosage form / route	Product TE source text	RLD / RS	Approval date	Source SHA-256
2026-08-01 22:54:32	2026-06	N205649-001	XIGDUO XR	5MG;500MG	TABLET, EXTENDED RELEASE / ORAL	AB	RLD	2014-10-29	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-002	XIGDUO XR	5MG;1GM	TABLET, EXTENDED RELEASE / ORAL	AB	RLD	2014-10-29	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-003	XIGDUO XR	10MG;500MG	TABLET, EXTENDED RELEASE / ORAL	AB	RLD	2014-10-29	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-004	XIGDUO XR	10MG;1GM	TABLET, EXTENDED RELEASE / ORAL	AB	RLD, RS	2014-10-29	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-005	XIGDUO XR	2.5MG;1GM	TABLET, EXTENDED RELEASE / ORAL	AB	RLD	2017-07-28	`a50c72e98297…`

Observed Orange Book normalized TE history#

Captured, Edition, Application-product table
Captured	Edition	Application-product	TE code	Order	Source SHA-256
2026-08-01 22:54:32	2026-06	N205649-001	AB	1	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-002	AB	1	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-003	AB	1	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-004	AB	1	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-005	AB	1	`a50c72e98297…`

Observed Orange Book patent history#

Patent history page 1 of 2 · 50 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Patent	Expiration	Use code	Coverage / status	Submission date	Source SHA-256
2026-08-01 22:54:32	2026-06	N205649-001	6515117	2025-10-04	U-493	Drug substance, Drug product	2014-11-24	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-001	6515117*PED	2026-04-04		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-001	8501698	2027-06-20	U-493	Drug product	2014-11-24	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-001	8501698*PED	2027-12-20		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-001	7919598	2029-12-16		Drug substance	2014-11-24	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-001	8685934	2030-05-26	U-1522		2014-11-24	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-001	7919598*PED	2030-06-16		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-001	9616028	2030-11-12		Drug product	2017-08-30	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-001	8685934*PED	2030-11-26		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-001	9616028*PED	2031-05-12		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-002	6515117	2025-10-04	U-493	Drug substance, Drug product	2014-11-24	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-002	6515117*PED	2026-04-04		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-002	8501698	2027-06-20	U-493	Drug product	2014-11-24	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-002	8501698*PED	2027-12-20		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-002	7919598	2029-12-16		Drug substance	2014-11-24	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-002	8685934	2030-05-26	U-1522		2014-11-24	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-002	7919598*PED	2030-06-16		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-002	9616028	2030-11-12		Drug product	2017-08-30	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-002	8685934*PED	2030-11-26		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-002	9616028*PED	2031-05-12		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-003	6515117	2025-10-04	U-493	Drug substance, Drug product	2014-11-24	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-003	6515117*PED	2026-04-04		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-003	8501698	2027-06-20	U-493	Drug product	2014-11-24	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-003	8501698*PED	2027-12-20		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-003	7919598	2029-12-16		Drug substance	2014-11-24	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-003	8685934	2030-05-26	U-1522		2014-11-24	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-003	7919598*PED	2030-06-16		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-003	9616028	2030-11-12		Drug product	2017-08-30	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-003	8685934*PED	2030-11-26		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-003	9616028*PED	2031-05-12		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-004	6515117	2025-10-04	U-493	Drug substance, Drug product	2014-11-24	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-004	6515117*PED	2026-04-04		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-004	8501698	2027-06-20	U-493	Drug product	2014-11-24	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-004	8501698*PED	2027-12-20		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-004	7919598	2029-12-16		Drug substance	2014-11-24	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-004	8685934	2030-05-26	U-1522		2014-11-24	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-004	7919598*PED	2030-06-16		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-004	9616028	2030-11-12		Drug product	2017-08-30	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-004	8685934*PED	2030-11-26		Pediatric extension		`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-004	9616028*PED	2031-05-12		Pediatric extension		`a50c72e98297…`

Observed Orange Book exclusivity history#

Captured, Edition, Application-product table
Captured	Edition	Application-product	Exclusivity code	Expiration	Source SHA-256
2026-08-01 22:54:32	2026-06	N205649-001	NPP	2027-06-12	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-001	PED	2027-12-12	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-002	NPP	2027-06-12	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-002	PED	2027-12-12	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-003	NPP	2027-06-12	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-003	PED	2027-12-12	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-004	NPP	2027-06-12	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-004	PED	2027-12-12	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-005	NPP	2027-06-12	`a50c72e98297…`
2026-08-01 22:54:32	2026-06	N205649-005	PED	2027-12-12	`a50c72e98297…`

openFDA label cross-check#

Cross-check layer: openFDA label JSON enriches search and identifies hydration gaps. The DailyMed Structured Product Label remains the canonical label presentation on FDA.report. Every label matching the complete exact-identifier union is deduplicated and paginated below.

Matched openFDA labels page 1 of 1 · 2 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
dapagliflozin and metformin hydrochloride	DAPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE	Prasco Laboratories	eaf135b6-e378-4f62-a1e7-db45e23668c7	2024-12-20	Boxed warning, Warnings, Adverse reactions	Exact identifier application applno (NDA): 205649 application number: NDA205649
XIGDUO XR	DAPAGLIFLOZIN AND METFORMIN HYDROCHLORIDE	AstraZeneca Pharmaceuticals LP	ac8a0f7b-9f69-4495-abbc-3a47cd75a859	2024-12-20	Boxed warning, Warnings, Adverse reactions	Exact identifier application applno (NDA): 205649 application number: NDA205649 ndc (product): 0310-6260 ndc (product): 0310-6225 ndc (product): 0310-6270 ndc (product): 0310-6250 ndc (product): 0310-6280

NDC Listings For This Application#

NDC listings for this application page 1 of 1 · 45 matching rows.

NDC, Name, Nonproprietary name table
NDC	Name	Nonproprietary name	Labeler	Marketing category	Status
0310-6225	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6225	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6225	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6225	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6225	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6225	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6225	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6225	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6225	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6250	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6250	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6250	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6250	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6250	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6250	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6250	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6250	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6250	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6260	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6260	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6260	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6260	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6260	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6260	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6260	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6260	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6260	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6270	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6270	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6270	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6270	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6270	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6270	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6270	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6270	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6270	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6280	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6280	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6280	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6280	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6280	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6280	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6280	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6280	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current
0310-6280	XIGDUO	dapagliflozin and metformin hydrochloride	AstraZeneca Pharmaceuticals LP	NDA	Current

Documents#

Document, Submission type, Date table
Document	Submission type	Date
80707	SUPPL	2024-12-26
80700	SUPPL	2024-12-23
80699	SUPPL	2024-12-23
78791	SUPPL	2024-06-13
78790	SUPPL	2024-06-13
75426	SUPPL	2023-09-13
75413	SUPPL	2023-09-13
72372	SUPPL	2022-10-17
72371	SUPPL	2022-10-17
72328	SUPPL	2022-10-14
70761	SUPPL	2022-04-14
70760	SUPPL	2022-04-14
70752	SUPPL	2022-04-12
70102	SUPPL	2022-02-07
70101	SUPPL	2022-02-07
70092	SUPPL	2022-02-04
61775	SUPPL	2020-02-04
61772	SUPPL	2020-02-04
61771	SUPPL	2020-02-04
61689	SUPPL	2020-01-27
61684	SUPPL	2020-01-27
61683	SUPPL	2020-01-27
61661	SUPPL	2020-01-27
60617	SUPPL	2019-10-22
60601	SUPPL	2019-10-21
60600	SUPPL	2019-10-21
57821	SUPPL	2019-02-27
57802	SUPPL	2019-02-25
56195	SUPPL	2018-10-30
56147	SUPPL	2018-10-29
52234	SUPPL	2018-02-01
47461	SUPPL	2017-03-03
47393	SUPPL	2017-03-02
45093	SUPPL	2016-08-22
45051	SUPPL	2016-08-17
40493	SUPPL	2016-06-17
32701	SUPPL	2016-06-16
40492	SUPPL	2015-12-08
32700	SUPPL	2015-12-07
43498	ORIG	2015-04-06
24500	ORIG	2015-04-06
40491	ORIG	2014-11-04
10486	ORIG	2014-10-31