Application 207986

Type: NDA
Sponsor: OTONOMY INC

Application Products#

Product, Drug, Ingredient table
Product	Drug	Ingredient	Form	Strength	Reference drug	Reference standard
001	OTIPRIO	CIPROFLOXACIN	INJECTABLE, SUSPENSION;OTIC	6% (60MG/ML)	Yes	Yes

Source provenance: Browse the complete Orange Book source catalog · source snapshot 43.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-product	Trade name	Ingredient	Strength	Dosage form / route	TE codes	RLD / RS	Approval date
N207986-001	OTIPRIO	CIPROFLOXACIN	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC		RLD	2015-12-10

Orange Book patents#

Current patent rows page 1 of 1 · 8 matching rows.

Application-product, Patent, Expiration table
Application-product	Patent	Expiration	Use code	Coverage / status	Submission date
N207986-001	11369566	2029-04-21		Drug product	2022-07-14
N207986-001	9205048	2029-04-21	U-1793		2016-01-11
N207986-001	9603796	2029-04-21	U-2252	Drug substance, Drug product	2018-03-26
N207986-001	9233068	2029-12-11		Drug product	2016-02-05
N207986-001	8318817	2030-04-27	U-1792		2016-01-11
N207986-001	9220796	2035-07-01		Drug product	2016-01-11
N207986-001	11040004	2037-11-12	U-2252		2021-07-21
N207986-001	11246863	2038-11-27		Drug product	2022-03-11

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Product history page 1 of 2 · 43 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Trade name	Strength	Dosage form / route	RLD / RS	Approval date	Source SHA-256
2026-09-14 22:38:34	2026-08	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`84e616aacf4f…`
2026-08-18 06:07:40	2026-07	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`caaa826d4ba7…`
2026-02-19 14:30 UTC	2026-02	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`6a471c1ec25d…`
2025-03-22 03:13 UTC · 3 captures of this ZIP	2025-03	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`fd3edfee7708…`
2025-02-26 10:13 UTC · 3 captures of this ZIP	2025-02	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`b8a1b40f171c…`
2025-01-19 17:59 UTC · 7 captures of this ZIP	2025-01	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`03ed91905a0d…`
2024-12-13 21:23 UTC · 2 captures of this ZIP	2024-12	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`2680178bc6a6…`
2024-09-14 05:58 UTC · 2 captures of this ZIP	2024-09	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`5bbf6a4d5a75…`
2024-11-08 22:44 UTC · 3 captures of this ZIP	2024-11	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`d8e5a09893c0…`
2024-10-29 15:01 UTC	2024-10	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`d06236e962d9…`
2024-08-13 05:28 UTC · 3 captures of this ZIP	2024-08	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`79d66fd596c7…`
2024-07-13 05:37 UTC · 2 captures of this ZIP	2024-07	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`301d65b070ca…`
2024-06-18 03:08 UTC · 5 captures of this ZIP	2024-06	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`1e350fbaab3a…`
2024-05-31 18:47 UTC	2024-05	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`8072bd15b7f6…`
2022-06-29 02:47 UTC · 2 captures of this ZIP	2022-06	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD, RS	2015-12-10	`5c6f7cd8ea54…`
2022-04-08 23:34 UTC	2022-04	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD, RS	2015-12-10	`5d02ea3f76ae…`
2022-04-04 05:41 UTC	2022-04	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD, RS	2015-12-10	`4b0b4de00fa7…`
2019-12-13 00:20 UTC	2019-12	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD, RS	2015-12-10	`74a2ff9319b5…`
2022-03-09 01:35 UTC	2022-03	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD, RS	2015-12-10	`bb7c543d1eb4…`
2021-12-28 21:50 UTC	2021-12	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD, RS	2015-12-10	`782e0a99824c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD, RS	2015-12-10	`87673890dc5c…`
2021-03-12 10:30 UTC	2021-03	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD, RS	2015-12-10	`5aa47cf7b7d7…`
2020-12-22 03:56 UTC	2020-12	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD, RS	2015-12-10	`8869cabd3fbd…`
2020-11-12 02:37 UTC	2020-11	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD, RS	2015-12-10	`c0c555d07b60…`
2019-12-14 00:12 UTC	2019-12	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD, RS	2015-12-10	`3f01610625f2…`
2019-09-15 20:21 UTC	2019-09	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD, RS	2015-12-10	`b00525d2431f…`
2019-07-19 19:46 UTC	2019-07	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD, RS	2015-12-10	`ea99ee380514…`
2024-03-16 18:09 UTC · 4 captures of this ZIP	2024-03	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`6a51e52b5d6a…`
2024-02-18 07:12 UTC	2024-02	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`1c564ffb4f44…`
2023-12-20 04:57 UTC	2023-12	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`ea1830bbd6c7…`
2023-11-28 05:40 UTC · 2 captures of this ZIP	2023-11	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`a72a2bbeb626…`
2023-10-25 00:34 UTC · 2 captures of this ZIP	2023-10	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`9b2671bbb829…`
2023-07-15 15:27 UTC · 2 captures of this ZIP	2023-07	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`a67488948f0b…`
2023-06-13 01:57 UTC · 3 captures of this ZIP	2023-06	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`3f0d92c62455…`
2023-05-13 08:27 UTC	2023-05	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD	2015-12-10	`053a50430f4f…`
2023-01-26 05:58 UTC	2023-01	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD, RS	2015-12-10	`3bdfa0b2c4d7…`
2022-11-12 20:34 UTC · 5 captures of this ZIP	2022-11	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD, RS	2015-12-10	`3a93d1ddd44b…`
2022-10-28 04:53 UTC	2022-10	N207986-001	OTIPRIO	6% (60MG/ML)	INJECTABLE, SUSPENSION / OTIC	RLD, RS	2015-12-10	`f41ea6bd6efb…`

Observed Orange Book patent history#

Patent history page 1 of 8 · 311 observed states.

Captured, Edition, Application-product table
Captured	Edition	Application-product	Patent	Expiration	Use code	Coverage / status	Submission date	Source SHA-256
2026-09-14 22:38:34	2026-08	N207986-001	11369566	2029-04-21		Drug product	2022-07-14	`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N207986-001	9205048	2029-04-21	U-1793		2016-01-11	`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N207986-001	9603796	2029-04-21	U-2252	Drug substance, Drug product	2018-03-26	`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N207986-001	9233068	2029-12-11		Drug product	2016-02-05	`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N207986-001	8318817	2030-04-27	U-1792		2016-01-11	`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N207986-001	9220796	2035-07-01		Drug product	2016-01-11	`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N207986-001	11040004	2037-11-12	U-2252		2021-07-21	`84e616aacf4f…`
2026-09-14 22:38:34	2026-08	N207986-001	11246863	2038-11-27		Drug product	2022-03-11	`84e616aacf4f…`
2026-08-18 06:07:40	2026-07	N207986-001	11369566	2029-04-21		Drug product	2022-07-14	`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N207986-001	9205048	2029-04-21	U-1793		2016-01-11	`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N207986-001	9603796	2029-04-21	U-2252	Drug substance, Drug product	2018-03-26	`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N207986-001	9233068	2029-12-11		Drug product	2016-02-05	`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N207986-001	8318817	2030-04-27	U-1792		2016-01-11	`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N207986-001	9220796	2035-07-01		Drug product	2016-01-11	`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N207986-001	11040004	2037-11-12	U-2252		2021-07-21	`caaa826d4ba7…`
2026-08-18 06:07:40	2026-07	N207986-001	11246863	2038-11-27		Drug product	2022-03-11	`caaa826d4ba7…`
2026-02-19 14:30 UTC	2026-02	N207986-001	11369566	2029-04-21		Drug product	2022-07-14	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N207986-001	9205048	2029-04-21	U-1793		2016-01-11	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N207986-001	9603796	2029-04-21	U-2252	Drug substance, Drug product	2018-03-26	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N207986-001	9233068	2029-12-11		Drug product	2016-02-05	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N207986-001	8318817	2030-04-27	U-1792		2016-01-11	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N207986-001	9220796	2035-07-01		Drug product	2016-01-11	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N207986-001	11040004	2037-11-12	U-2252		2021-07-21	`011fe1cb6892…`
2026-02-19 14:30 UTC	2026-02	N207986-001	11246863	2038-11-27		Drug product	2022-03-11	`011fe1cb6892…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N207986-001	11369566	2029-04-21		Drug product	2022-07-14	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N207986-001	9205048	2029-04-21	U-1793		2016-01-11	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N207986-001	9603796	2029-04-21	U-2252	Drug substance, Drug product	2018-03-26	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N207986-001	9233068	2029-12-11		Drug product	2016-02-05	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N207986-001	8318817	2030-04-27	U-1792		2016-01-11	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N207986-001	9220796	2035-07-01		Drug product	2016-01-11	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N207986-001	11040004	2037-11-12	U-2252		2021-07-21	`31067a03dcf5…`
2025-12-14 10:44 UTC · 2 captures of this ZIP	2025-12	N207986-001	11246863	2038-11-27		Drug product	2022-03-11	`31067a03dcf5…`
2025-08-23 18:47 UTC	2025-08	N207986-001	11369566	2029-04-21		Drug product	2022-07-14	`6a471c1ec25d…`
2025-08-23 18:47 UTC	2025-08	N207986-001	9205048	2029-04-21	U-1793		2016-01-11	`6a471c1ec25d…`
2025-08-23 18:47 UTC	2025-08	N207986-001	9603796	2029-04-21	U-2252	Drug substance, Drug product	2018-03-26	`6a471c1ec25d…`
2025-08-23 18:47 UTC	2025-08	N207986-001	9233068	2029-12-11		Drug product	2016-02-05	`6a471c1ec25d…`
2025-08-23 18:47 UTC	2025-08	N207986-001	8318817	2030-04-27	U-1792		2016-01-11	`6a471c1ec25d…`
2025-08-23 18:47 UTC	2025-08	N207986-001	9220796	2035-07-01		Drug product	2016-01-11	`6a471c1ec25d…`
2025-08-23 18:47 UTC	2025-08	N207986-001	11040004	2037-11-12	U-2252		2021-07-21	`6a471c1ec25d…`
2025-08-23 18:47 UTC	2025-08	N207986-001	11246863	2038-11-27		Drug product	2022-03-11	`6a471c1ec25d…`

Observed Orange Book exclusivity history#

Captured, Edition, Application-product table
Captured	Edition	Application-product	Exclusivity code	Expiration	Source SHA-256
2019-12-13 00:20 UTC	2019-12	N207986-001	I-770	2021-03-02	`74a2ff9319b5…`
2021-12-28 21:50 UTC	2021-12	N207986-001	I-770	2021-03-02	`782e0a99824c…`
2021-05-05 16:15 UTC · 3 captures of this ZIP	2021-05	N207986-001	I-770	2021-03-02	`87673890dc5c…`
2021-03-12 10:30 UTC	2021-03	N207986-001	I-770	2021-03-02	`5aa47cf7b7d7…`
2020-12-22 03:56 UTC	2020-12	N207986-001	I-770	2021-03-02	`8869cabd3fbd…`
2020-11-12 02:37 UTC	2020-11	N207986-001	I-770	2021-03-02	`c0c555d07b60…`
2019-12-14 00:12 UTC	2019-12	N207986-001	I-770	2021-03-02	`3f01610625f2…`
2019-09-15 20:21 UTC	2019-09	N207986-001	I-770	2021-03-02	`b00525d2431f…`
2019-07-19 19:46 UTC	2019-07	N207986-001	I-770	2021-03-02	`ea99ee380514…`

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 4 of 4 · 76 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
ciprofloxacin	CIPROFLOXACIN	NuCare Pharmaceuticals,Inc.	641729a3-6dd3-3a2f-e053-2991aa0a015e	2024-06-06	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: CIPROFLOXACIN
ciprofloxacin	CIPROFLOXACIN	NuCare Pharmaceuticals,Inc.	5bab9397-b9f3-d309-e053-2991aa0a6612	2024-06-04	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: CIPROFLOXACIN
ciprofloxacin	CIPROFLOXACIN	Leading Pharma, LLC	545527e7-05c7-4dbf-ab32-b3fa463d55b0	2024-05-10	Warnings, Adverse reactions	Name fallback generic name: CIPROFLOXACIN
Ciprofloxacin	CIPROFLOXACIN	Bryant Ranch Prepack	4f600112-168a-4a58-9914-7c01f71894da	2024-05-02	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: CIPROFLOXACIN
Ciprofloxacin	CIPROFLOXACIN	Bryant Ranch Prepack	a57066d7-dc2c-d2d0-b003-d9143fcca1c5	2024-04-04	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: CIPROFLOXACIN
ciprofloxacin	CIPROFLOXACIN	A-S Medication Solutions	6971a958-08f0-4712-bf5f-47fe4f76b863	2023-11-13	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: CIPROFLOXACIN
ciprofloxacin	CIPROFLOXACIN	Asclemed USA, Inc.	86c2ba30-9372-4e70-88a2-e6e1da07fa92	2023-09-02	Warnings, Adverse reactions	Name fallback generic name: CIPROFLOXACIN
Ciprofloxacin	CIPROFLOXACIN	Proficient Rx LP	6b5fe0aa-c74f-42f3-a84a-1cb16009aa80	2023-01-01	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: CIPROFLOXACIN
ciprofloxacin	CIPROFLOXACIN	PharmPak, Inc.	e2902d14-16bb-46a9-a45a-4f1f9b0ecf4a	2022-10-09	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: CIPROFLOXACIN
ciprofloxacin	CIPROFLOXACIN	PharmPak, Inc.	6a70db6c-ae68-49e5-8a4a-b5cd1d4840bd	2022-10-09	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: CIPROFLOXACIN
Ciprofloxacin	CIPROFLOXACIN	Sagent Pharmaceuticals	7049f870-6741-4a67-8033-398c36126a06	2022-09-19	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: CIPROFLOXACIN
ciprofloxacin	CIPROFLOXACIN	Proficient Rx LP	fbcd32c0-bcfd-4cc7-8e81-6612bc0cfc45	2022-06-01	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: CIPROFLOXACIN
ciprofloxacin	CIPROFLOXACIN	Proficient Rx LP	05b2836d-cd3d-4d7f-970c-66ec2d788667	2022-05-02	Warnings, Adverse reactions	Name fallback generic name: CIPROFLOXACIN
Ciprofloxacin	CIPROFLOXACIN	Asclemed USA, Inc.	1bb1d26e-fad0-4338-8948-3f095d5817a6	2022-03-08	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: CIPROFLOXACIN
ciprofloxacin	CIPROFLOXACIN	Proficient Rx LP	4af3894a-8945-4b2d-bdf6-a83bbd415b89	2020-02-01	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: CIPROFLOXACIN
Ciprofloxacin	CIPROFLOXACIN	Aphena Pharma Solutions - Tennessee, LLC	c7bc0d20-526c-48ea-b23a-cea9eb7080ff	2018-07-09	Boxed warning, Warnings, Adverse reactions	Name fallback generic name: CIPROFLOXACIN

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.

NDC Listings For This Application#

NDC listings for this application page 1 of 1 · 7 matching rows.

NDC, Name, Nonproprietary name table
NDC	Name	Nonproprietary name	Labeler	Marketing category	Status
0268-8200	OTIPRIO	OTIPRIO	ALK-Abello, Inc.	NDA	Current
0268-8200	OTIPRIO	OTIPRIO	ALK-Abello, Inc.	NDA	Current
69251-201	Otiprio	ciprofloxacin	Otonomy, Inc.	NDA	Current
69251-201	Otiprio	ciprofloxacin	Otonomy, Inc.	NDA	Current
69251-201	Otiprio	ciprofloxacin	Otonomy, Inc.	NDA	Current
69251-201	Otiprio	ciprofloxacin	Otonomy, Inc.	NDA	Current
69251-201	Otiprio	ciprofloxacin	Otonomy, Inc.	NDA	Current

Documents#

Document, Submission type, Date table
Document	Submission type	Date
53009	SUPPL	2018-03-15
52820	SUPPL	2018-03-06
44968	ORIG	2016-02-19
43540	ORIG	2016-02-19
40607	SUPPL	2016-02-18
32873	SUPPL	2016-01-28
40606	ORIG	2015-12-15
10639	ORIG	2015-12-14
52576	ORIG	1900-01-01
52575	ORIG	1900-01-01
52574	ORIG	1900-01-01
52573	ORIG	1900-01-01