NOVARTIS FDA Approval NDA 209884

NDA 209884

NOVARTIS

FDA Drug Application

Application #209884

Documents

Label2019-03-27
Medication Guide2019-03-27
Letter2019-03-27
Review2019-05-03
Letter2020-07-31
Label2020-09-03
Medication Guide2020-09-04
Letter2021-01-26
Label2021-01-26
Medication Guide2021-01-26
Letter2021-08-25
Letter2021-09-14
Label2021-10-15
Letter2022-03-02
Label2022-03-02
Medication Guide2022-03-02
Letter2022-06-14
Label2022-06-15
Medication Guide2022-06-15
Letter2022-06-22
Label2022-06-27
Medication Guide2022-06-28

Application Sponsors

NDA 209884NOVARTIS

Marketing Status

Prescription001
Prescription002
Prescription003

Application Products

001TABLET;ORALEQ 0.25MG BASE1MAYZENTSIPONIMOD FUMARIC ACID
002TABLET;ORALEQ 2MG BASE1MAYZENTSIPONIMOD FUMARIC ACID
003TABLET;ORALEQ 1MG BASE1MAYZENTSIPONIMOD FUMARIC ACID

FDA Submissions

TYPE 1; Type 1 - New Molecular EntityORIG1AP2019-03-26PRIORITY
LABELING; LabelingSUPPL2TA2020-07-30STANDARD
LABELING; LabelingSUPPL3AP2021-01-23STANDARD
LABELING; LabelingSUPPL5AP2021-09-10STANDARD
S; SupplementSUPPL6AP2021-08-24STANDARD
EFFICACY; EfficacySUPPL7AP2022-03-01STANDARD
LABELING; LabelingSUPPL10AP2022-06-10STANDARD
LABELING; LabelingSUPPL11AP2022-06-21STANDARD

Submissions Property Types

ORIG1Null15
SUPPL2Null15
SUPPL3Null7
SUPPL5Null15
SUPPL7Null6
SUPPL10Null15
SUPPL11Null15

CDER Filings

NOVARTIS
cder:Array
(
    [0] => Array
        (
            [ApplNo] => 209884
            [companyName] => NOVARTIS
            [docInserts] => ["Medication Guide","https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2022\/209884Orig1s011lbl.pdf#page=23"]
            [products] => [{"drugName":"MAYZENT","activeIngredients":"SIPONIMOD FUMARIC ACID","strength":"EQ 0.25MG BASE","dosageForm":"TABLET;ORAL","marketingStatus":"Prescription","te":"None","rld":"Yes","rs":"No"},{"drugName":"MAYZENT","activeIngredients":"SIPONIMOD FUMARIC ACID","strength":"EQ 2MG BASE","dosageForm":"TABLET;ORAL","marketingStatus":"Prescription","te":"None","rld":"Yes","rs":"Yes"},{"drugName":"MAYZENT","activeIngredients":"SIPONIMOD FUMARIC ACID","strength":"EQ 1MG BASE","dosageForm":"TABLET;ORAL","marketingStatus":"Prescription","te":"None","rld":"Yes","rs":"No"}]
            [labels] => [{"actionDate":"06\/21\/2022","submission":"SUPPL-11","supplementCategories":"Labeling-Container\/Carton Labels","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2022\\\/209884Orig1s011lbl.pdf\"}]","notes":""},{"actionDate":"06\/10\/2022","submission":"SUPPL-10","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2022\\\/209884s010lbl.pdf\"}]","notes":""},{"actionDate":"03\/01\/2022","submission":"SUPPL-7","supplementCategories":"Efficacy-Labeling Change With Clinical Data","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2022\\\/209884s007lbl.pdf\"}]","notes":""},{"actionDate":"08\/24\/2021","submission":"SUPPL-6","supplementCategories":"Supplement","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2021\\\/209884Orig1s006Lbledt.pdf\"}]","notes":""},{"actionDate":"01\/23\/2021","submission":"SUPPL-3","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2021\\\/209884s003lbl.pdf\"}]","notes":""},{"actionDate":"07\/31\/2020","submission":"SUPPL-2","supplementCategories":"Labeling-Container\/Carton Labels","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2020\\\/209884s002lbl.pdf\"}]","notes":""},{"actionDate":"07\/31\/2020","submission":"SUPPL-2","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2020\\\/209884s002lbl.pdf\"}]","notes":""},{"actionDate":"03\/26\/2019","submission":"ORIG-1","supplementCategories":"Approval","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2019\\\/209884s000lbl.pdf\"}]","notes":""}]
            [originalApprovals] => [{"actionDate":"03\/26\/2019","submission":"ORIG-1","actionType":"Approval","submissionClassification":"Type 1 - New Molecular Entity","reviewPriority":"PRIORITY","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2019\\\/209884s000lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2019\\\/209884Orig1s000ltr.pdf\"},{\"name\":\"Review\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/nda\\\/2019\\\/209884Orig1s000TOC.cfm\"}]","notes":">"}]
            [supplements] => [{"actionDate":"06\/21\/2022","submission":"SUPPL-11","supplementCategories":"Labeling-Container\/Carton Labels","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2022\\\/209884Orig1s011lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2022\\\/209884Orig1s011ltr.pdf\"}]","notes":">"},{"actionDate":"06\/10\/2022","submission":"SUPPL-10","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2022\\\/209884s010lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2022\\\/209884Orig1s010ltr.pdf\"}]","notes":">"},{"actionDate":"03\/01\/2022","submission":"SUPPL-7","supplementCategories":"Efficacy-Labeling Change With Clinical Data","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2022\\\/209884s007lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2022\\\/209884Orig1s007ltr.pdf\"}]","notes":">"},{"actionDate":"08\/24\/2021","submission":"SUPPL-6","supplementCategories":"","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2021\\\/209884Orig1s006Lbledt.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2021\\\/209884Orig1s006CorrectedLtr.pdf\"}]","notes":">"},{"actionDate":"09\/10\/2021","submission":"SUPPL-5","supplementCategories":"Labeling-Container\/Carton Labels","inserts":"[{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2021\\\/209884Orig1s005ltr.pdf\"}]","notes":"> Label is not available on this site."},{"actionDate":"01\/23\/2021","submission":"SUPPL-3","supplementCategories":"Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2021\\\/209884s003lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2021\\\/209884Orig1s003ltr.pdf\"}]","notes":">"},{"actionDate":"07\/31\/2020","submission":"SUPPL-2","supplementCategories":"Labeling-Container\/Carton Labels, Labeling-Package Insert","inserts":"[{\"name\":\"Label (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/label\\\/2020\\\/209884s002lbl.pdf\"},{\"name\":\"Letter (PDF)\",\"url\":\"https:\\\/\\\/www.accessdata.fda.gov\\\/drugsatfda_docs\\\/appletter\\\/2020\\\/209884Orig1s002ltr.pdf\"}]","notes":">"}]
            [actionDate] => 2022-06-21
        )

)

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