Indications and uses
temporarily relieves common cold/flu symptoms: cough due to minor throat and bronchial irritation sore throat headache minor aches and pains fever runny nose and sneezing
Up and Up Cold Flu Relief Day Night
- Manufacturer
- Sixarp, LLC
- Effective date
- 2024-03-15
- Label type
- HUMAN OTC DRUG LABEL
- Version
- 1
- Source
- legacy-cache
- Hydrated at
- 2026-08-01 21:07:58
Label at a glance#
ProductUp and Up Cold Flu Relief Day Night
Active ingredientACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, DOXYLAMINE SUCCINATE, PHENYLEPHRINE HYDROCHLORIDE
Label structure17 sections
Dosage and administration
take only as directed – see Liver warning use dose cup do not exceed 4 doses per 24 hrs adults & children 12 yrs & over 30 mL (2 TBSP) every 6 hrs children 4 to under 12 yrs ask a doctor children under 4 yrs do not use when using other Daytime or Nighttime products, carefully read each label to insure correct dosing
Storage and handling
each 30 mL dose cup contains: sodium 39 mg store at 20-25°C (68-77°F)
Contacts and useful links#
Label contents#
Full prescribing information#
Active ingredients - Nighttime (in each 30 mL dose cup)
Acetaminophen 650 mg
Dextromethorphan HBr 30 mg
Doxylamine succinate 12.5 mg
Active ingredients - Daytime (in each 15 mL tablespoon)
Acetaminophen 325 mg
Dextromethorphan HBr 10 mg
Phenylephrine HCl 5 mg
Purpose - Nighttime
Pain reliever/fever reducer
Cough suppressant
Antihistamine
Purpose - Daytime
Pain reliever/fever reducer
Cough suppressant
Nasal decongestant
Uses - Nighttime
temporarily relieves common cold/flu symptoms:
- cough due to minor throat and bronchial irritation
- sore throat
- headache
- minor aches and pains
- fever
- runny nose and sneezing
Uses - Daytime
temporarily relieves common cold/flu symptoms:
- nasal congestion
- cough due to minor throat and bronchial irritation
- sore throat
- headache
- minor aches and pains
- fever
Warnings - Nighttime
Liver warning: This product contains acetaminophen. The maximum daily dose of this product is 4 doses (2,600 mg acetaminophen) in 24 hours. Severe liver damage may occur if you take
- more than 4,000 mg of acetaminophen in 24 hours
- with other drugs containing acetaminophen
- 3 or more alcoholic drinks every day while using this product
Sore throat warning: If sore throat is severe, lasts for more than 2 days, occurs with or is followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
Warnings - Daytime
Liver warning: This product contains acetaminophen. The maximum daily dose of this product is 4 doses (adult: 2,600 mg acetaminophen; child: 1,300 mg acetaminophen) in 24 hours. Severe liver damage may occur if
- adult takes more than 4,000 mg of acetaminophen in 24 hours
- child takes more than 5 doses in 24 hours, which is the maximum daily amount
- taken with other drugs containing acetaminophen
- adult has 3 or more alcoholic drinks every day while using this product
Sore throat warning: If sore throat is severe, lasts for more than 2 days, occurs with or is followed by fever, headache, rash, nausea, or vomiting, consult a doctor promptly.
Do not use - Nighttime
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
- to make a child sleepy
- if you have ever had an allergic reaction to this product or any of its ingredients
Do not use - Daytime
- with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist.
- if you are now taking a prescription monoamine oxidase inhibitor (MAOI) (certain drugs for depression, psychiatric, or emotional conditions, or Parkinson’s disease), or for 2 weeks after stopping the MAOI drug. If you do not know if your prescription drug contains an MAOI, ask a doctor or pharmacist before taking this product.
- if you have ever had an allergic reaction to this product or any of its ingredients
Ask a doctor before use if you have - Nighttime
- liver disease
- trouble urinating due to an enlarged prostate gland
- cough that occurs with too much phlegm (mucus)
- persistent or chronic cough as occurs with smoking, asthma, or emphysema
- a breathing problem such as emphysema or chronic bronchitis
- glaucoma
- a sodium-restricted diet
Ask a doctor before use if you have - Daytime
- liver disease
- heart disease
- thyroid disease
- diabetes
- high blood pressure
- trouble urinating due to an enlarged prostate gland
- cough that occurs with too much phlegm (mucus)
- persistent or chronic cough as occurs with smoking, asthma, or emphysema
Ask a doctor or pharmacist before use if you are - Nighttime
- taking sedatives or tranquilizers
- taking the blood thinning drug warfarin
Ask a doctor or pharmacist before use if you are - Daytime
taking the blood thinning drug warfarin
When using this product - Nighttime
- excitability may occur, especially in children
- marked drowsiness may occur
- avoid alcoholic drinks
- be careful when driving a motor vehicle or operating machinery
- alcohol, sedatives, and tranquilizers may increase drowsiness
When using this product - Daytime
do not use more than directed
Stop use and ask a doctor if - Nighttime
- pain or cough gets worse or lasts more than 7 days
- fever gets worse or lasts more than 3 days
- redness or swelling is present
- new symptoms occur
- cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition.
Stop use and ask a doctor if - Daytime
- you get nervous, dizzy or sleepless
- pain, nasal congestion or cough gets worse or lasts more than 5 days (children) or 7 days (adults)
- fever gets worse or lasts more than 3 days
- redness or swelling is present
- new symptoms occur
- cough comes back or occurs with rash or headache that lasts. These could be signs of a serious condition
If pregnant or breast-feeding,
ask a health professional before use.
Keep out of reach of children.
In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222) Quick medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.
Directions - Nighttime
- take only as directed – see Liver warning
- use dose cup
- do not exceed 4 doses per 24 hrs
adults & children 12 yrs & over | 30 mL (2 TBSP) every 6 hrs |
children 4 to under 12 yrs | ask a doctor |
children under 4 yrs | do not use |
- when using other Daytime or Nighttime products, carefully read each label to insure correct dosing
Directions - Daytime
- take only as directed – see Liver warning
- use dose cup
- do not exceed 4 doses per 24 hrs
adults & children 12 yrs & over | 30 mL (2 TBSP) every 4 hrs |
children 6 to under 12 yrs | 15 mL (1 TBSP) every 4 hrs |
children 4 to under 6 yrs | ask a doctor |
children under 4 yrs | do not use |
- when using other Daytime or Nighttime products, carefully read each label to insure correct dosing
Other information - Nighttime
- each 30 mL dose cup contains: sodium 39 mg
- store at 20-25°C (68-77°F)
Other information - Daytime
- each tablespoon contains: sodium 7 mg
- store at 20-25°C (68-77°F)
Inactive ingredients - Nighttime
alcohol, anhydrous citric acid, FD&C blue no. 1, FD&C red no. 40, flavor, high fructose corn syrup, polyethylene glycol, propylene glycol, purified water, saccharin sodium, sodium citrate
Inactive Ingredients - Daytime
butylated hydroxyanisole, edetate disodium, FD&C yellow no. 6, flavor, glycerin, menthol, monobasic sodium phosphate, polyethylene glycol, propylene glycol, purified water, saccharin sodium, sucrose, xanthan gum
Questions?
Call 1-800-910-6874
Principal Display Panel - Daytime
Compare to active ingredients in Vicks® DayQuil® Cold & Flu
cold/flu relief
multi-symptom
day / non-drowsy
pain reliever/fever reducer, cough suppressant, nasal decongestant
acetaminophen – aches/fever
dextromethorphan HBr – cough
phenylephrine HCl – nasal congestion
alcohol free, antihistamine free
DAY
original flavor
Principal Display Panel - Nighttime
Compare to active ingredients in Vicks® NyQuil® Cold & Flu
cold/flu relief
multi-symptom
night
antihistamine, cough suppressant, fever reducer/pain reliever
acetaminophen – aches/fever/sore throat
dextromethorphan HBr – cough
doxylamine succinate – sneezing, runny nose
does not contain pseudoephedrine
ALCOHOL 10%
NIGHT
cherry flavor
TWO – 12 FL OZ (355 mL), TOTAL 24 FL OZ (1.5 pt) (710 mL)
Products#
Every source-derived product name is available through these pages.
- Up and Up Cold Flu Relief Day Night
- Acetaminophen, Dextromethorphan HBr, Doxylamine succinate, Phenylephrine HCl
- Up and Up Cold and Flu Relief
- acetaminophen, dextromethorphan hbr, doxylamine succinate
- ALCOHOL
- ANHYDROUS CITRIC ACID
- FD&C BLUE NO. 1
- FD&C RED NO. 40
- HIGH FRUCTOSE CORN SYRUP
- POLYETHYLENE GLYCOL
- PROPYLENE GLYCOL
- WATER
- SACCHARIN SODIUM
- SODIUM CITRATE
- ACETAMINOPHEN
- DEXTROMETHORPHAN HYDROBROMIDE
- DEXTROMETHORPHAN
- DOXYLAMINE SUCCINATE
- DOXYLAMINE
- Up and Up Cold Flu Relief
- acetaminophen, dextromethorphan hbr, phenylephrine hcl
- BUTYLATED HYDROXYANISOLE
- EDETATE DISODIUM
- FD&C YELLOW NO. 6
- GLYCERIN
- SODIUM PHOSPHATE, MONOBASIC, ANHYDROUS
- SUCROSE
- XANTHAN GUM
- MENTHOL
- PHENYLEPHRINE HYDROCHLORIDE
- PHENYLEPHRINE
NDC Codes#
| Product NDC | Package NDC |
|---|---|
| 59368-005 | 59368-005-01 |
Ingredients#
Every source-derived ingredient row is available through these pages.
Source Document#
openFDA label cross-check#
OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
| Brand | Generic | Manufacturer | SPL set ID | Effective date | Available safety fields | Join |
|---|---|---|---|---|---|---|
| 13b9077c-25ef-4d42-e063-6294a90a375a | 13b8f480-d1a9-d70c-e063-6394a90ab4f4 | 2024-03-15 | Warnings | 13b9077c-25ef-4d42-e063-6294a90a375a 13b8f480-d1a9-d70c-e063-6394a90ab4f4 |
Reported adverse events (FAERS/openFDA)#
Adverse event summaries are temporarily unavailable. Other product information remains available.