Naloxone Hydrochloride Nasal Spray

Naloxone hydrochloride 4 mg

Emergency treatment of opioid overdose

• to “revive” someone during an overdose from many  prescription pain medicationsor street drugs such as heroin
• this medicine can save a life

1 check

Step 1: CHECK if you suspect an overdose

• CHECKfor a suspected overdose: the person will not wake up or is very sleepy or not breathing well
• yell “Wake up!”
• shake the person gently
• if the person is not awake, go to Step 2

2 give

Step 2: GIVE 1st dose in the nose

• HOLDthe nasal spray device with your thumb on the bottom of the plunger
• INSERTthe nozzle into either NOSTRIL
• PRESSthe plunger firmly to give the 1st dose
• 1 nasal spray device contains 1 dose

3 call

Step 3: CALL 911

• CALL 911immediately after giving the 1st dose

step 4

Step 4: WATCH & GIVE

• WAIT2 to 3 minutes after the 1st dose to give the medicine time to work
• if the person wakes up: Go to Step 5
• if the person does not wake up:
• CONTINUE TO GIVEdoses every 2 to 3 minutes until the person wakes up
• it is safe to keep giving doses

5 stay

Step 5: STAY

• STAYuntil ambulance arrives: even if the person wakes up
• GIVEanother dose if the person becomes very sleepy again
• You may need to give all the doses in the pack

• store at room temperature or refrigerated, between 2°C to 25°C (36°F to 77°F)
• do not freeze
• avoid excessive heat above 40°C (104°F)
• protect from light
• this product is packaged in individually-sealed blisters. Do not use if the blister is open or torn, or if the device appears damaged.
  

benzalkonium chloride, disodium ethylenediaminetetraacetate, hydrochloric acid, purified water, and sodium chloride

Naloxone Hydrochloride Nasal Spray, 4 mg

Emergency Treatment of Opioid Overdose

Important:

• For use in the nose only
• Do not test nasal spray device before use
• 1 nasal spray device contains 1 dose of medicine
• Each device sprays 1 time only

hand

1

Step 1: CHECK if you suspect an overdose

• CHECK for a suspected overdose: the person will not wake up or is very sleepy or not breathing well
• yell “Wake up!”
• shake the person gently
• if the person is not awake, go to Step 2

1

Step 2: GIVE 1st dose in the nose

• HOLD the nasal spray device with your thumb on the bottom of the plunger
• INSERT the nozzle into either NOSTRIL
• PRESS the plunger firmly to give the 1st dose
• 1 nasal spray device contains 1 dose

1

Step 3: CALL 911

• CALL 911 immediately after giving the 1st dose

1

Step 4: WATCH & GIVE

• WAIT 2 to 3 minutes after the 1st dose to give the medicine time to work
• if the person wakes up: Go to Step 5
• if the person does not wake up:
• CONTINUE TO GIVE doses every 2 to 3 minutes until the person wakes up
• it is safe to keep giving doses

1

Step 5: STAY

• STAY until ambulance arrives: even if the person wakes up
• GIVE another dose if the person becomes very sleepy again
• You may need to give all the doses in the pack

For opioid emergencies, call 911.For questions or more information about Naloxone Hydrochloride Nasal Spray, contact

AvKARE at 1-855-361-3993.

Mfg. Rev. 03-2023-01 AV 05/23

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