MUCINEX® Rapid Clear® Day Night Caplet + Clear & Cool Nasal Spray Combo
- Manufacturer
- Reckitt Benckiser LLC
- Effective date
- 2026-05-13
- Label type
- HUMAN OTC DRUG LABEL
- Version
- 2
- Source
- full-release
- Hydrated at
- 2026-06-01 01:57:08
Label at a glance#
Contacts and useful links#
Label contents#
Full prescribing information#
OTC - ACTIVE INGREDIENT SECTION
DAY
Acetaminophen 325 mg
Guaifenesin 200 mg
NIGHT
Acetaminophen 325 mg
Dextromethorphan HBr 10 mg
Triprolidine HCl 1.25 mg
SPRAY
Oxymetazoline hydrochloride 0.05%
OTC - PURPOSE SECTION
DAY
Acetaminophen 325 mg ........ Pain reliever/
fever reducer
Guaifenesin 200 mg.................... Expectorant
NIGHT
Acetaminophen 325 mg ........ Pain reliever/fever reducer
Dextromethorphan HBr 10 mg................Cough suppressant
Triprolidine HCl 1.25 mg...................................Antihistamine
SPRAY
Oxymetazoline hydrochloride 0.05% - Nasal decongestant
INDICATIONS & USAGE SECTION
DAY
Uses
■ temporarily relieves these common cold and flu
symptoms:
■ minor aches and pains ■ headache
■ sore throat
■ helps loosen phlegm (mucus) and thin
bronchial secretions to rid the bronchial
passageways of bothersome mucus and make
coughs more productive
■ temporarily reduces fever
NIGHT
Uses
■ temporarily relieves these common cold and flu symptoms:
■ cough ■ minor aches and pains
■ sore throat ■ headache
■ runny nose ■ sneezing
■ itching of the nose or throat
■ itchy, watery eyes due to hay fever
■ temporarily reduces fever
■ controls cough to help you get to sleep
SPRAY
Uses
temporarily relieves nasal congestion due to:
- a cold
- hay fever or other upper respiratory allergies
- promotes nasal and sinus drainage
- temporarily relieves sinus congestion and pressure
- helps clear nasal passages; shrinks swollen membranes
WARNINGS SECTION
DAY
Warnings
Liver warning: This product contains acetaminophen.
Severe liver damage may occur if you take:
■ more than 12 caplets in 24 hours, which is
the maximum daily amount for this product
■ with other drugs containing acetaminophen
■ 3 or more alcoholic drinks daily while using
this product
Allergy alert: Acetaminophen may cause severe
skin reactions. Symptoms may include:
■ skin reddening ■ blisters ■ rash
If a skin reaction occurs, stop use and seek
medical help right away.
Sore throat warning: If sore throat is severe,
persists for more than 2 days, is accompanied
or followed by fever, headache, rash, nausea, or
vomiting, consult a doctor promptly.
Do not use
■ with any other drug containing acetaminophen
(prescription or nonprescription). If you are not
sure whether a drug contains acetaminophen,
ask a doctor or pharmacist.
Ask a doctor before use if you have
■ liver disease
■ persistent or chronic cough such as occurs
with smoking, asthma, chronic bronchitis, or
emphysema
■ cough that occurs with too much phlegm
(mucus)
Ask a doctor or pharmacist before use if you
are taking the blood thinning drug warfarin
When using this product do not use more
than directed
Stop use and ask a doctor if
■ pain or cough gets worse or lasts more than
7 days
■ fever gets worse or lasts more than 3 days
■ redness or swelling is present
■ new symptoms occur
■ cough comes back or occurs with rash or
headache that lasts. These could be signs of
a serious condition.
If pregnant or breast-feeding, ask a health
professional before use.
Overdose warning: Taking more than the
recommended dose (overdose) may cause liver
damage. In case of overdose, get medical help or
contact a Poison Control Center right away. Quick
medical attention is critical for adults as well as
for children even if you do not notice any signs or
symptoms.
NIGHT
Warnings
Liver warning: This product contains acetaminophen.
Severe liver damage may occur if you take:
■ more than 8 caplets in 24 hours, which is the maximum
daily amount for this product
■ with other drugs containing acetaminophen
■ 3 or more alcoholic drinks daily while using this product
Allergy alert: Acetaminophen may cause severe skin
reactions. Symptoms may include:
■ skin reddening ■ blisters ■ rash
If a skin reaction occurs, stop use and seek medical help right
away.
Sore throat warning: If sore throat is severe, persists for
more than 2 days, is accompanied or followed by fever,
headache, rash, nausea, or vomiting, consult a doctor
promptly.
Do not use
■ with any other drug containing acetaminophen
(prescription or nonprescription). If you are not sure
whether a drug contains acetaminophen, ask a doctor or
pharmacist.
■ if you are now taking a prescription monoamine oxidase
inhibitor (MAOI) (certain drugs for depression, psychiatric,
or emotional conditions, or Parkinson’s disease), or for
2 weeks after stopping the MAOI drug. If you do not know
if your prescription drug contains an MAOI, ask a doctor or
pharmacist before taking this product.
Ask a doctor before use if you have
■ liver disease ■ glaucoma
■ trouble urinating due to an enlarged prostate gland
■ a breathing problem such as emphysema or chronic
bronchitis
■ persistent or chronic cough such as occurs with
smoking, asthma, or emphysema
■ cough that occurs with too much phlegm (mucus)
Ask a doctor or pharmacist before use if you are
■ taking the blood thinning drug warfarin
■ taking sedatives or tranquilizers
When using this product
■ do not use more than directed
■ excitability may occur, especially in children
■ marked drowsiness may occur
■ alcohol, sedatives, and tranquilizers may increase drowsiness
■ avoid alcoholic drinks
■ use caution when driving amotor vehicle or operatingmachinery
Stop use and ask a doctor if
■ pain or cough gets worse or lasts more than 7 days
■ fever gets worse or lasts more than 3 days
■ redness or swelling is present
■ new symptoms occur
■ cough comes back or occurs with rash or headache
that lasts. These could be signs of a serious condition.
Overdose warning: Taking more than the recommended
dose (overdose) may cause liver damage. In case of overdose,
get medical help or contact a Poison Control Center right
away. Quick medical attention is critical for adults as well as
for children even if you do not notice any signs or symptoms.
SPRAY
Ask a doctor before use if you have
heart disease
high blood pressure
thyroid disease
diabetes
difficulty in urination due to enlargement of the prostate gland
When using this product
do not exceed recommended dosage
do not use this product for more than 3 days. Use only as directed. Frequent or prolonged use may cause nasal congestion to recur or worsen
this product may cause temporary discomfort such as burning, stinging, sneezing, or an increase in nasal discharge
the use of this container by more than one person may spread infection
Stop use and ask a doctor ifsymptoms persist
If pregnant or breast-feeding,ask a health professional before use.
DOSAGE & ADMINISTRATION SECTION
DAY
Directions
■ do not take more than directed (see
Overdose warning)
■ do not take more than 12 caplets in any
24-hour period
■ adults and children 12 years of age and
over: take 2 caplets every 4 hours
■ children under 12 years of age: do not use
NIGHT
Directions
■ do not take more than directed (see Overdose warning)
■ do not take more than 8 caplets in any 24-hour period
■ adults and children 12 years of age and over: take
2 caplets every 4 hours
■ children under 12 years of age: do not use
SPRAY
adults and children 6 to under 12 years of age (with adult supervision): 2 or 3 sprays in each nostril, not more often than every 10 to 12 hours. Do not exceed 2 doses in any 24-hour period.
children under 6 years of age: consult a doctor.
Shake well before use.
To open, hold by the white grips then squeeze, push down
firmly and turn cap counterclockwise. Before using for the
first time, remove the protective cap from the tip and prime
metered pump by depressing firmly several times. To spray,
hold bottle with thumb at the base and nozzle between first
and second fingers. Without tilting head, insert nozzle into
nostril. Fully depress pump all the way down with a firm
even stroke and sniff deeply. Wipe nozzle clean after use.
To close, turn cap clockwise.
DO NOT DISCARD CAP.
OTHER SAFETY INFORMATION
DAY/NIGHT/SPRAY
Other information
■ store at 20-25°C (68-77°F)
INACTIVE INGREDIENT SECTION
DAY
Inactive ingredients
croscarmellose sodium, FD&C red no. 40
aluminum lake, FD&C yellow no. 6 aluminum
lake, magnesium stearate, microcrystalline
cellulose, polyethylene glycol, polyvinyl
alcohol, povidone, talc, titanium dioxide
NIGHT
Inactive ingredients
croscarmellose sodium, crospovidone, hypromellose,
microcrystalline cellulose, polyethylene glycol,
polysorbate 80, povidone, titanium dioxide
SPRAY
benzalkonium chloride,
benzododecinium chloride,
camphor
OTC - QUESTIONS SECTION
Questions? 1-866-MUCINEX
(1-866-682-4639)
OTC - KEEP OUT OF REACH OF CHILDREN SECTION
Keep out of reach of children.
If pregnant or breast-feeding,ask a health professional before use.
PACKAGE LABEL.PRINCIPAL DISPLAY PANEL
DailyMed RxNorm Mappings#
| RxCUI | RxNorm string | TTY | SPL version |
|---|---|---|---|
| 2549034 | acetaminophen 325 MG / dextromethorphan HBr 10 MG / triprolidine HCl 1.25 MG Oral Tablet | PSN | 2 |
| 602617 | acetaminophen 325 MG / guaiFENesin 200 MG Oral Tablet | PSN | 2 |
| 1000990 | oxymetazoline HCl 0.05 % Nasal Spray | PSN | 2 |
| 2549034 | acetaminophen 325 MG / dextromethorphan hydrobromide 10 MG / triprolidine hydrochloride 1.25 MG Oral Tablet | SCD | 2 |
| 602617 | acetaminophen 325 MG / guaifenesin 200 MG Oral Tablet | SCD | 2 |
| 1000990 | oxymetazoline hydrochloride 0.5 MG/ML Nasal Spray | SCD | 2 |
| 2549034 | APAP 325 MG / dextromethorphan hydrobromide 10 MG / triprolidine hydrochloride 1.25 MG Oral Tablet | SY | 2 |
| 602617 | APAP 325 MG / guaifenesin 200 MG Oral Tablet | SY | 2 |
| 1000990 | oxymetazoline hydrochloride 0.05 % Nasal Spray | SY | 2 |
DailyMed Pharmacologic Classes#
| Class | Version | Type | Effective |
|---|---|---|---|
| DEXTROMETHORPHAN Pharmacologic Class Indexing | 2 | Indexing - Pharmacologic Class | 20180813 |
| GUAIFENESIN Pharmacologic Class Indexing | 1 | Indexing - Pharmacologic Class | 20211129 |
| OXYMETAZOLINE Pharmacologic Class Indexing | 2 | Indexing - Pharmacologic Class | 20180813 |
Product Linked Resources#
| Resource | Code type | Value | Equivalent identifiers | Source image |
|---|---|---|---|---|
| Barcode | EAN-13 | 0363824999517 | GTIN-13: 0363824999517 EAN-13: 0363824999517 GTIN-12: 363824999517 UPC-A: 363824999517 GTIN storage (14 digits): 00363824999517 | 72854-213 front label.jpg |
DailyMed Product Concepts#
DailyMed Package Descriptions#
| Package NDC | Product | Description | Form | Quantity | Strength | SPL version |
|---|---|---|---|---|---|---|
| 72854-213-03 | MUCINEX Rapid Clear Day Night and Clear and Cool Nasal | 1 in 1 CARTON | KIT | 1 | 2 | |
| 72854-213-03 | MUCINEX Rapid Clear Day Night and Clear and Cool Nasal | 1 in 1 KIT | KIT | 1 | 2 |
DailyMed Billing Units#
| Package NDC | Billing unit | Product NDC | DailyMed indexing SPL | SPL version | Effective |
|---|---|---|---|---|---|
| 63824-129-17 | ML - Milliliter | 63824-129 | b2305dd6-0eb3-4c18-a9b1-70e28c613033 | 1 | 2019-11-12 |
Products#
Every source-derived product name is available through these pages.
- MUCINEX Rapid Clear Day Night and Clear and Cool Nasal
- Acetaminophen, Guaifenesin, Dextromethorphan Hydrobromide, Triprolidine Hydrochloride, and Oxymetazoline hydrochloride
- Maximum Strength Mucinex Sinus-Max Pressure, Pain and Cough
- Acetaminophen, Guaifenesin
- FD&C RED NO. 40 ALUMINUM LAKE
- FD&C YELLOW NO. 6 ALUMINUM LAKE
- POLYETHYLENE GLYCOL, UNSPECIFIED
- TITANIUM DIOXIDE
- POLYVINYL ALCOHOL
- POVIDONE
- CROSCARMELLOSE SODIUM
- GUAIFENESIN
- TALC
- ACETAMINOPHEN
- MAGNESIUM STEARATE
- MICROCRYSTALLINE CELLULOSE
- Mucinex Nightshift Sinus Maximum Strength
- Acetaminophen, Dextromethorphan Hydrobromide, and Triprolidine Hydrochloride
- TRIPROLIDINE HYDROCHLORIDE
- TRIPROLIDINE
- CROSPOVIDONE, UNSPECIFIED
- POLYSORBATE 80
- DEXTROMETHORPHAN HYDROBROMIDE
- DEXTROMETHORPHAN
- HYPROMELLOSE, UNSPECIFIED
- MUCINEX SINUS-MAX SEVERE NASAL CONGESTION RELIEF CLEAR and COOL NASAL
- Oxymetazoline Hydrochloride
- BENZODODECINIUM CHLORIDE
- CAMPHOR (NATURAL)
- BENZALKONIUM CHLORIDE
- OXYMETAZOLINE
NDC Codes#
| Product NDC | Package NDC |
|---|---|
| 72854-213 | 72854-213-03 |
| 72854-208 | |
| 72854-209 | |
| 63824-129 |
Ingredients#
Every source-derived ingredient row is available through these pages.
Source Document#
openFDA label cross-check#
OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
| Brand | Generic | Manufacturer | SPL set ID | Effective date | Available safety fields | Join |
|---|---|---|---|---|---|---|
| MUCINEX Rapid Clear Day Night and Clear and Cool Nasal | ACETAMINOPHEN, GUAIFENESIN, DEXTROMETHORPHAN HYDROBROMIDE, TRIPROLIDINE HYDROCHLORIDE, AND OXYMETAZOLINE HYDROCHLORIDE | Reckitt Benckiser LLC | 37dcb0ed-df56-1bec-e063-6394a90a695e | 2026-05-13 | Warnings | 72854-213-03 72854-213 72854021303 51b4c3a0-ce93-6ac8-e063-6394a90a2d96 37dcb0ed-df56-1bec-e063-6394a90a695e |
| MUCINEX SINUS-MAX SEVERE NASAL CONGESTION RELIEF CLEAR and COOL NASAL | OXYMETAZOLINE HYDROCHLORIDE | Reckitt Benckiser LLC | 5a397466-8721-4060-a178-5ebfd7069cc9 | 2026-05-13 | Warnings | 63824-129 |
| Maximum Strength Mucinex Sinus-Max Pressure, Pain and Cough | ACETAMINOPHEN, GUAIFENESIN | Reckitt Benckiser LLC | 350764de-7801-b24e-e063-6394a90ab3c3 | 2026-05-13 | Warnings | 72854-208 |
| Mucinex Nightshift Sinus Maximum Strength | ACETAMINOPHEN, DEXTROMETHORPHAN HYDROBROMIDE, AND TRIPROLIDINE HYDROCHLORIDE | RB Health (US) LLC | 35322238-d498-1a52-e063-6394a90ac9c4 | 2025-05-15 | Warnings | 72854-209 |
Reported adverse events (FAERS/openFDA)#
Adverse event summaries are temporarily unavailable. Other product information remains available.


