Naloxone Hydrochloride Nasal Spray

Naloxone hydrochloride 4 mg

Emergency treatment of opioid overdose

• to “revive” someone during an overdose from many prescription pain medications or street drugs such as heroin
• this medicine can save a life

1

Step 1: CHECK if you suspect an overdose

• CHECK for a suspected overdose: the person will not wake up or is very sleepy or not breathing well
• yell “Wake up!”
• shake the person gently
• if the person is not awake, go to Step 2

2

Step 2: GIVE 1st dose in the nose

• HOLD the nasal spray device with your thumb on the bottom of the plunger
• INSERT the nozzle into either NOSTRIL
• PRESS the plunger firmly to give the 1st dose
• 1 nasal spray device contains 1 dose

3

Step 3: CALL 911

• CALL 911 immediately after giving the 1st dose

Step 4: WATCH & GIVE

• WAIT 2 to 3 minutes after the 1st dose to give the medicine time to work
• if the person wakes up: Go to Step 5
• if the person does not wake up:
• CONTINUE TO GIVE doses every 2 to 3 minutes until the person wakes up
• it is safe to keep giving doses

5

Step 5: STAY

• STAY until ambulance arrives: even if the person wakes up
• GIVE another dose if the person becomes very sleepy again
• You may need to give all the doses in the pack

• store at room temperature or refrigerated, between 2°C to 25°C (36°F to 77°F)
• do not freeze
• avoid excessive heat above 40°C (104°F)
• protect from light
• this product is packaged in individually-sealed blisters. Do not use if the blister is open or torn, or if the device appears damaged.

benzalkonium chloride, disodium ethylenediaminetetraacetate, hydrochloric acid, purified water, and sodium chloride

1-877-835-5472 (Mon-Fri, 9AM-5PM EST)

 Naloxone Hydrochloride Nasal Spray, 4 mg

Emergency Treatment of Opioid Overdose

Important:

• For use in the nose only
• Do not test nasal spray device before use
• 1 nasal spray device contains 1 dose of medicine
• Each device sprays 1 time only

Step 1: CHECK if you suspect an overdose:

• CHECK for a suspected overdose: the person will not wake up
  or is very sleepy or not breathing well
• yell “Wake up!”
• shake the person gently
• if the person is not awake, go to Step 2

Step 2: GIVE 1^st dose in the nose

• HOLD the nasal spray device with your thumb on the bottom
  of the plunger
• INSERT the nozzle into either NOSTRIL
• PRESS the plunger firmly to give the 1^st dose
• 1 nasal spray device contains 1 dose

Step 3: CALL 911

• CALL 911 immediately after giving the 1^st dose

Step 4: WATCH AND GIVE

• WAIT 2 to 3 minutes after the 1^st dose to give the medicine time to work
• if the person wakes up: Go to Step 5
• if the person does not wake up:
  • CONTINUE TO GIVE doses every 2 to 3 minutes until the person
    wakes up
  • it is safe to keep giving doses

Step 5: STAY

• STAY until ambulance arrives: even if the person wakes up
• GIVE another dose if the person becomes very sleepy again
• You may need to give all the doses in the pack

For opioid emergencies, call 911.For questions or more information about Naloxone Hydrochloride Nasal Spray, contact Amneal Pharmaceuticals at 1-877-835-5472.

Rev. 07-2023-04