Identity: CRISPR-Cas9 editing with or without homology dependent repair in heat-susceptible beef breeds to introduce mutations into at least one copy of the PRLR gene of Bos taurus chromosome 20 (NC_037347.1). The intended mutations generate a premature stop codon in the coding sequence resulting in a truncated PRLR protein and a SLICK coat phenotype.
Claim: Mutations causing PRLR protein truncation at or between amino acids 433 to 497 produce a SLICK coat phenotype that is reported to be linked to increased thermotolerance in Bos taurus species raised in sub-tropical environments.
Product Use: Founder animals are intended for production and sale of seed stock and/or embryos to enable the establishment of PRLR-SLICK thermotolerant beef herds that will be used as a food source. Due to the specific process used to produce these animals, they may have 2 or more genetically different sets of cells, and as a result the PRLR-SLICK thermotolerant phenotype may not be inherited by all first generation progeny.
| Package NDC | Product | Description | Form | Quantity | Strength | SPL version |
|---|---|---|---|---|---|---|
| 86086-006-01 | PRLR-SLICK Cattle | 1 [arb'U] in 1 NOT APPLICABLE | NOT APPLICABLE | 1 | 4 |
| NDC | Dashboard title | SPL version | Validation | Dashboard ZIP |
|---|---|---|---|---|
| 86086-006 | PRLR-SLICK CATTLE (PRLR GENE EDIT IN AT LEAST ONE COPY PRODUCING PROTEIN TRUNCATION AT OR BETWEEN AMINO ACIDS 433 TO 497) NOT APPLICABLE [RECOMBINETICS, INC.] | 4 | 1 package rows | 20240726_423a7b9c-9f78-4461-a2de-7e9ee34c12ee.zip |
Every source-derived product name is available through these pages.
| Product NDC | Package NDC |
|---|---|
| 86086-006 | 86086-006-01 |
Every source-derived ingredient row is available through these pages.
| Name | UNII | Kind |
|---|---|---|
| SLICK ALTERATION DISRUPTING BOS TAURUS G.(NC_037347.1) FS(39099129-39099368) IN EXON 9 OF PRLR GENE IN BOS TAURUS | B8K52Z76YK | ACTIM |
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