FDA.reportPublic FDA data

Active Ingredients

Manufacturer
Guangzhou Senmai Biotechnology Co.,Ltd. | Dongguan Xiaogoubeige trading company Ltd.
Effective date
2026-08-03
Label type
HUMAN OTC DRUG LABEL
Version
1
Source
daily-update
Hydrated at
2026-08-07 01:01:12

Label at a glance#

Product456 Acne Relief Cream
Active ingredientSALICYLIC ACID, NIACINAMIDE, COPTIS CHINENSIS ROOT, CENTELLA ASIATICA ROOT
Label structure16 sections

Indications and uses

STEP 1: Clean the skin and keep it dry. STEP 2: Take an appropriate amount of this product and apply to the skin. STEP 3: Gently massage with your fingertips to promote absorption.

Label contents#

Full prescribing information#

Active Ingredients

OTC - ACTIVE INGREDIENT SECTION

SALICYLIC ACID ...... 0.76% ...... Anti-Acne
NIACINAMIDE ...... 2% ...... Fades Acne Scars
COPTIS CHINENSIS ROOT EXTRACT ...... 0.24% ......Soothe Acne
CENTELLA ASIATICA EXTRACT ...... 0.02% ......Soothe Acne

Purpose

OTC - PURPOSE SECTION

Acne treatment

Uses

INDICATIONS & USAGE SECTION

STEP 1: Clean the skin and keep it dry.
STEP 2: Take an appropriate amount of this product and apply to the skin.
STEP 3: Gently massage with your fingertips to promote absorption.

Warnings

WARNINGS SECTION

1.For external use only.2.Avoid contact with eyes.3.Keep out of reach of children.4.Discontinue use immediately if you experience any allergic reactions and consult a physician.

Do not use

OTC - DO NOT USE SECTION

on damaged or broken skin.

When using this product

OTC - WHEN USING SECTION

1. It is recommended to test the product behind the ear beforeuse. If discomfort is felt, do not use.
2. If it accidentally enters the eyes, rinse immediately with water.
3. Keep out of reach of children. Do not use for children under 3 years old.
4. Do not expose to direct sunlight and high temperatures.
5. This product contains salicylic acid.

Keep out of reach of children.

OTC - KEEP OUT OF REACH OF CHILDREN SECTION

If swallowed,get medical help or contact a Poison Control Center right away.

DOSAGE

DOSAGE & ADMINISTRATION SECTION

Approximately 0.01-0.02 oz each time.

Product Name

DESCRIPTION SECTION

456 Acne Relief Cream

Inactive Ingredients

INACTIVE INGREDIENT SECTION

WATER,
BUTYLENE GLYCOL,
GLYCERIN,
PHELLODENDRON AMURENSE BARK EXTRACT,
SALVIA MILTIORRHIZA EXTRACT,
LONICERA JAPONICA EXTRACT,
ASPALATHUS LINEARIS EXTRACT,
SOPHORA FLAVESCENS EXTRACT,
SCUTELLARIA BAICALENSIS ROOT EXTRACT,
1,2-HEXANEDIOL,
HYDROXYACETOPHENONE,
ZANTHOXYLUM BUNGEANUM FRUIT EXTRACT,
SOPHORA ANGUSTIFOLIA ROOT EXTRACT,
CAPSICUM FRUTESCENS FRUIT EXTRACT,
PIPER METHYSTICUM ROOT EXTRACT,
QUATERNIUM-73,
CETEARYL GLUCOSIDE,
SORBITAN OLIVATE,
CETEARYL ALCOHOL,
ACACIA SENEGAL GUM,
MALTODEXTRIN,
CHITOSAN,
CAPRYLIC/CAPRIC TRIGLYCERIDE,
DIMETHICONE,
SIMMONDSIA CHINENSIS (JOJOBA) SEED OIL,
GLYCERYL STEARATE,
PEG-100 STEARATE,
INOSITOL,
DIMETHYL SULFONE,
PHENOXYETHANOL,
ETHYLHEXYLGLYCERIN,
POLYACRYLAMIDE,
C13-14 ISOPARAFFIN,
LAURETH-7,
CARBOMER,
ARGININE,
ALLANTOIN,
MENTHOL,
XANTHAN GUM,
HYDROXYETHYLCELLULOSE,
MELALEUCA ALTERNIFOLIA (TEA TREE) LEAF OIL,
DISODIUM EDTA,
SODIUM HYALURONATE,
CERAMIDE NP,
TOCOPHEROL

Manufacturer

DESCRIPTION SECTION

Guangzhou Senmai Biotechnology Co.,Ltd.

Address

DESCRIPTION SECTION

Floor 1-4,Building A,Guanger Smart Industrial Park,No.2 Qianyi East Road, Shiling Town,Huadu District,Guangzhou,Guangdong,CN(China)

Capacity

DESCRIPTION SECTION

50ml/1.69fl.oz

Shelf Life

DESCRIPTION SECTION

Shelf Life ·3 Years

Place of Origin

DESCRIPTION SECTION

Made in PRC

PACKAGE LABEL.PRINCIPAL DISPLAY PANEL

labellabel

Products#

Every source-derived product name is available through these pages.

DailyMed product names page 1 of 2 · 51 matching rows.

NDC Codes#

Product NDC, Package NDC table
Product NDCPackage NDC
84509-11184509-111-01

Ingredients#

Every source-derived ingredient row is available through these pages.

DailyMed ingredient rows page 1 of 2 · 49 matching rows.

Name, UNII, Kind table
NameUNIIKind
SALICYLIC ACIDO414PZ4LPZACTIB
NIACINAMIDE25X51I8RD4ACTIB
COPTIS CHINENSIS ROOTCXS4LJR7ELACTIB
CENTELLA ASIATICA ROOT8MXU1P42J0ACTIB
WATER059QF0KO0RIACT
GLYCERINPDC6A3C0OXIACT
BUTYLENE GLYCOL3XUS85K0RAIACT
PHELLODENDRON AMURENSE BARKPBG27B754GIACT
SALVIA MILTIORRHIZA ROOT1693AM5SBNIACT
LONICERA JAPONICA FLOWER4465L2WS4YIACT
ASPALATHUS LINEARIS LEAFH7UGK1GJCUIACT
SOPHORA FLAVESCENS ROOTIYR6K8KQ5KIACT
SCUTELLARIA BAICALENSIS ROOT7J95K7ID2SIACT
HYDROXYACETOPHENONEG1L3HT4CMHIACT
ZANTHOXYLUM BUNGEANUM FRUIT3CIP16A418IACT
SOPHORA FLAVESCENS WHOLEX8KX602M5LIACT
CAPSICUM FRUTESCENS FRUITJ1M3NA843LIACT
PIPER METHYSTICUM ROOTBOW48C81XPIACT
QUATERNIUM-735X73DDS97AIACT
SORBITAN OLIVATEMDL271E3GRIACT
CETEARYL ALCOHOL2DMT128M1SIACT
MALTODEXTRIN7CVR7L4A2DIACT
ACACIA SENEGAL GUM5C5403N26OIACT
CHITOSAN OLIGOSACCHARIDE23R93M6Y64IACT
CAPRYLIC/CAPRIC TRIGLYCERIDEC9H2L21V7UIACT
DIMETHICONE92RU3N3Y1OIACT
SIMMONDSIA CHINENSIS (JOJOBA) SEED OIL724GKU717MIACT
GLYCERYL STEARATE230OU9XXE4IACT
PEG-100 STEARATEYD01N1999RIACT
INOSITOL4L6452S749IACT
DIMETHYL SULFONE9H4PO4Z4FTIACT
PHENOXYETHANOLHIE492ZZ3TIACT
ETHYLHEXYLGLYCERIN147D247K3PIACT
POLYACRYLAMIDE (CROSSLINKED; 0.01-0.2 MOLE PERCENT BISACRYLAMIDE)RHA9LWJ494IACT
C13-14 ISOPARAFFINE4F12ROE70IACT
ARGININE94ZLA3W45FIACT
ALLANTOIN344S277G0ZIACT
MENTHOLL7T10EIP3AIACT
CARBOMER0A5MM307FCIACT
1,2-HEXANEDIOLTR046Y3K1GIACT

Source Document#

Source XML

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
456 Acne Relief CreamNIACINAMIDE,SALICYLIC ACID,CENTELLA ASIATICA ROOT,COPTIS CHINENSIS ROOTGuangzhou Senmai Biotechnology Co.,Ltd.5830fd36-0613-1980-e063-6294a90adfb72026-08-03WarningsExact identifier
ndc (package): 84509-111-01
ndc (product): 84509-111
ndc11 (package): 84509011101
spl id: 5830fd36-0614-1980-e063-6294a90adfb7
spl set id: 5830fd36-0613-1980-e063-6294a90adfb7

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.