ACNE RELIEF CALMING TREATMENT AND HYDRATOR
- Manufacturer
- NV Perricone LLC
- Effective date
- 2022-02-10
- Label type
- HUMAN OTC DRUG LABEL
- Version
- 2
- Source
- full-release
- Hydrated at
- 2026-05-31 23:48:11
Label at a glance#
Contacts and useful links#
Label contents#
Full prescribing information#
SPL UNCLASSIFIED SECTION
Drug Facts
OTC - ACTIVE INGREDIENT SECTION
Active Ingredient
Salicylic Acid 0.5%
OTC - PURPOSE SECTION
Purpose
Acne Treatment
INDICATIONS & USAGE SECTION
Use
■ For the treatment of acne.
WARNINGS SECTION
Warnings
■ For external use only.
■ When Using This Product Skin irritation and dryness are
more likely to occur if you use another topical acne medication
at the same time.
■ If irritation occurs, only use one topical acne medication at a time.
■ Keep out of reach of children. If swallowed, get medical
help or contact a Poison Control Center right away.
DOSAGE & ADMINISTRATION SECTION
Directions
■ Shake well. Apply a thin, even layer to skin in the morning.
For best results, use after cleansing with ACNE RELIEF
Gentle & Soothing Cleanser.
■ Clean the skin thoroughly before applying this product.
■ Cover the entire affected area with a thin layer one to three
times daily.
■ Because excessive drying of the skin may occur, start with
one application daily, then gradually increase to two or three
times daily if needed or as directed by a doctor.
■ If bothersome dryness or peeling occurs, reduce application
to once a day or every other day.
■ Sensitivity Test for a New User Apply product sparingly
to one or two small affected areas during the first 3 days.
If no discomfort occurs, follow the directions stated above.
INACTIVE INGREDIENT SECTION
Inactive Ingredients Water/Aqua/Eau, SD Alcohol 40-B,
Glycerin, C12-15 Alkyl Lactate, PVP, Dimethicone, Polysor-
bate 20, Citrulline, Squalane, Lactic Acid, Succinic Acid, Poly-
acrylamide, Dimethicone/Vinyl Dimethicone Crosspolymer,
C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Sodium Benzo-
atr, Potassium Sorbate
OTC - QUESTIONS SECTION
Questions 1-888-823-7837
Product Package
ACNE RELIEF
Calming Treatment
& Hydrator
Nourishes, hydrates & visibly
reduces redness
STEP 2
DAY
Perricone MD
ACNE RELIEF
90 DAY SUPPLY
Lactic & Succinic Acids,
Citrulline, Squalane
℮ 59 mL / 2 fl oz
KEY INGREDIENTS
Lactic & Succinic Acids: Attack
Acne-Causing Bacteria These
short-chain fatty acids help quickly
shrink blemishes by working
alongside salicylic acid to attack
acne-causing bacteria for a healthier
skin microbiome. They also
provide gentle yet effective ex-
foliation for smoother, more even=
looking skin.
Citrulline: Fight Irritation &
Visibly Reduce Redness First
discovered in watermelon, this
alpha-amino acid visibly calms
skin for a clearer, more even-
looking complexion. Nourishing
& soothing, it is an ideal way to
counteract the irritating effects
of anti-acne ingredients.
Squalane: Hydrate & Nourish
Found naturally in the human
body & derived from olive oil,
squalane hydrates without making
skin look or feel greasy. This lightweight
hydration is ideal for oil
& acne-prone skin as it helps
maintain optimal hydration without
clogging pores or causing
blemishes.
Perricone MD ACNE RELIEF
Prebiotic Acne Therapy is a
simple, comprehensive system
that works with your surface
skin’s natural microbiome to
safely, gently & effectively treat
& prevent the most troublesome
acne, while restoring &
maintaining a healthy skin
balance, for clearer, blemish-
free skin. This powerful 2-step
regimen is clinically proven to
be non-irritating & will not
strip or over-dry skin.
The Calming Treatment &
Hydrator is Step 2 in your day or
morning regimen, after cleans-
ing, The lightweight lotion
glides onto skin to gently kill
acne-causing bacteria, while
nourishing with essential hy-
dration. Lactic & succinic acids
support a healthy surface skin
microbiome for a clearer, more
radiant complexion, while citrul-
line & squalane fight irritation,
nourish, hydrate, soothe & vis-
ibly reduce redness.
Dist. By: NV Perricone LLC, San Francisco,
CA 94111. Made in USA of foreign and
domestic components. 651196
1 888 823 7837
perriconemd.com
Expiration &
Lot Code area
Outer Box
Bottle
rege
DailyMed RxNorm Mappings#
DailyMed Product Concepts#
| Product concept | Relation | Version | Effective |
|---|---|---|---|
| f52be47f-7aa7-46c0-b1fa-50c18dd50206 | Product name | 1 | 20201029 |
| 444b3e50-f226-46ef-bfca-2e7035d140cd | Product name | 1 | 20190611 |
| 7cda52fc-125f-421c-8fea-bc1974370c49 | Product name | 2 | 20180703 |
| 597b1cfd-7b31-5048-62be-ca5cd740da2f | Product name | 1 | 20140508 |
| ec2149b3-5c6d-5344-f757-c86411073075 | Product name | 1 | 20140508 |
FDA-Initiated Inactive NDC Indexing#
| NDC | Effective | Action | Document | Indexing SPL | Related label |
|---|---|---|---|---|---|
| 45634-102-01 | 2024-01-30 | C162847 | 48780-1 | ba0f9c33-5033-a910-e053-dadaa90a0b85 | ACNE RELIEF CALMING TREATMENT & HYDRATOR STEP 2 - DAY |
| 45634-102-01 | 2022-02-10 | C162847 | 48780-1 | ba0f9c33-5033-a910-e053-dadaa90a0b85 | ACNE RELIEF CALMING TREATMENT & HYDRATOR STEP 2 - DAY |
| 45634-102-01 | 2021-01-29 | C162847 | 48780-1 | ba0f9c33-5033-a910-e053-dadaa90a0b85 | ACNE RELIEF CALMING TREATMENT & HYDRATOR STEP 2 - DAY |
DailyMed Package Descriptions#
| Package NDC | Product | Description | Form | Quantity | Strength | SPL version |
|---|---|---|---|---|---|---|
| 45634-102-01 | ACNE RELIEF CALMING TREATMENT AND HYDRATOR | 59 mL in 1 BOTTLE, DROPPER | LOTION | 59 | 2 | |
| 45634-102-01 | ACNE RELIEF CALMING TREATMENT AND HYDRATOR | 1 in 1 PACKAGE | LOTION | 1 | 2 |
DailyMed Dashboard NDC Coverage#
Products#
Every source-derived product name is available through these pages.
- ACNE RELIEF CALMING TREATMENT AND HYDRATOR
- Salicylic Acid Acne Treatment
- SALICYLIC ACID
- WATER
- ALCOHOL
- GLYCERIN
- C12-15 ALKYL LACTATE
- POVIDONE, UNSPECIFIED
- DIMETHICONE
- POLYSORBATE 20
- CITRULLINE
- SQUALANE
- LACTIC ACID
- SUCCINIC ACID
- POLYACRYLAMIDE (10000 MW)
- DIMETHICONE/VINYL DIMETHICONE CROSSPOLYMER (HARD PARTICLE)
- C13-14 ISOPARAFFIN
- LAURETH-7
- PHENOXYETHANOL
- SODIUM BENZOATE
- POTASSIUM SORBATE
NDC Codes#
| Product NDC | Package NDC |
|---|---|
| 45634-102 | 45634-102-01 |
Ingredients#
Every source-derived ingredient row is available through these pages.
Source Document#
openFDA label cross-check#
OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.
| Brand | Generic | Manufacturer | SPL set ID | Effective date | Available safety fields | Join |
|---|---|---|---|---|---|---|
| 2462ceb9-4c70-4f9b-afc2-a81e352f4b2f | 68ca7c59-afa4-4260-bc15-a7ebac372d1f | 2022-02-10 | Warnings | 2462ceb9-4c70-4f9b-afc2-a81e352f4b2f 68ca7c59-afa4-4260-bc15-a7ebac372d1f |
Reported adverse events (FAERS/openFDA)#
Adverse event summaries are temporarily unavailable. Other product information remains available.

