Trifexis by is a Animal medication manufactured, distributed, or labeled by Elanco US Inc,. Drug facts, warnings, and ingredients follow.
TRIFEXIS (spinosad and milbemycin oxime) is available in five sizes for oral administration to dogs and puppies according to their weight. Each chewable flavored tablet is formulated to provide a minimum spinosad dose of 13.5 mg/lb (30 mg/kg) and a minimum milbemycin oxime dose of 0.2 mg/lb (0.5 mg/kg). Spinosad is a member of the spinosyns class of insecticides, which are non-antibacterial tetracyclic macrolides. Spinosad contains two major factors, spinosyn A and spinosyn D, derived from the naturally occurring bacterium, Saccharopolyspora spinosa. Spinosyn A and spinosyn D have the chemical compositions C41H65NO10 and C42H67NO10, respectively. Milbemycin oxime is a macrocyclic lactone anthelmintic, containing two major factors, A3 and A4 of milbemycin oxime. The approximate ratio of A3:A4 is 20:80. Milbemycin A4 5-oxime has the chemical composition of C32H45NO7 and milbemycin A3 5-oxime has the chemical composition of C31H43NO7.
TRIFEXIS is indicated for the prevention of heartworm disease (Dirofilaria immitis). TRIFEXIS kills fleas and is indicated for the prevention and treatment of flea infestations (Ctenocephalides felis), and the treatment and control of adult hookworm (Ancylostoma caninum), adult roundworm (Toxocara canis and Toxascaris leonina) and adult whipworm (Trichuris vulpis) infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.
TRIFEXIS is given orally, once a month at the minimum dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg) milbemycin oxime body weight. For heartworm prevention, give once monthly for at least 3 months after exposure to mosquitoes (see EFFECTIVENESS).
Body Weight | Spinosad | Milbemycin oxime | Tablets |
Per Tablet (mg) | Per Tablet (mg) | Administered | |
5 to 10 lbs | 140 | 2.3 | One |
10.1 to 20 lbs | 270 | 4.5 | One |
20.1 to 40 lbs | 560 | 9.3 | One |
40.1 to 60 lbs | 810 | 13.5 | One |
60.1 to 120 lbs | 1620 | 27 | One |
Over 120 lbs | Administer the appropriate combination of tablets |
Administer TRIFEXIS with food for maximum effectiveness. To ensure heartworm prevention, owners should observe the dog for one hour after dosing. If vomiting occurs within an hour of administration, redose with another full dose. If a dose is missed and a monthly interval between doses is exceeded, then immediate administration of TRIFEXIS with food and resumption of monthly dosing will minimize the opportunity for the development of adult heartworm infections and flea reinfestations.
TRIFEXIS should be administered at monthly intervals beginning within 1 month of the dog's first seasonal exposure and continuing until at least 3 months after the dog's last seasonal exposure to mosquitoes (see EFFECTIVENESS). TRIFEXIS may be administered year round without interruption. When replacing another heartworm preventative product, the first dose of TRIFEXIS should be given within a month of the last dose of the former medication.
Treatment with TRIFEXIS may begin at any time of the year, preferably starting one month before fleas become active and continuing monthly through the end of flea season. In areas where fleas are common year-round, monthly treatment with TRIFEXIS should continue the entire year without interruption.
To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea protection product.
TRIFEXIS also provides treatment and control of roundworms
(T. canis, T. leonina), hookworms (A. caninum) and whipworms (T. vulpis). Dogs may be exposed to and can become infected with roundworms, whipworms and hookworms throughout the year, regardless of season or climate. Clients should be advised of measures to be taken to prevent reinfection with intestinal parasites.
Not for human use. Keep this and all drugs out of the reach of children. Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, a component of TRIFEXIS (see ADVERSE REACTIONS).
Treatment with fewer than 3 monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention (see EFFECTIVENESS).
Prior to administration of TRIFEXIS, dogs should be tested for existing heartworm infection. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. TRIFEXIS is not effective against adult D. immitis. While the number of circulating microfilariae may decrease following treatment, TRIFEXIS is not indicated for microfilariae clearance (see ANIMAL SAFETY). Mild, transient hypersensitivity reactions manifested as labored respiration, vomiting, salivation and lethargy, have been noted in some dogs treated with milbemycin oxime carrying a high number of circulating microfilariae. These reactions are presumably caused by release of protein from dead or dying microfilariae.
Use with caution in breeding females (see ANIMAL SAFETY). The safe use of TRIFEXIS in breeding males has not been evaluated.
Use with caution in dogs with pre-existing epilepsy (see ADVERSE REACTIONS).
Puppies less than 14 weeks of age may experience a higher rate of vomiting (see ANIMAL SAFETY).
In a well-controlled US field study, which included a total of 352 dogs (176 treated with TRIFEXIS and 176 treated with an active control), no serious adverse reactions were attributed to administration of TRIFEXIS. All reactions were regarded as mild.
Over the 180-day study period, all observations of potential adverse reactions were recorded. Reactions that occurred at an incidence >1% (average monthly rate) within any of the 6 months of observation are presented in the following table. The most frequently reported adverse reaction in dogs in the TRIFEXIS group was vomiting.
an=176 dogs |
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Adverse Reaction | TRIFEXIS Chewable | Active Control |
Tabletsa | Tabletsa | |
Vomiting | 6.13 | 3.08 |
Pruritus | 4.00 | 4.91 |
Lethargy | 2.63 | 1.54 |
Diarrhea | 2.25 | 1.54 |
Dermatitis | 1.47 | 1.45 |
Skin Reddening | 1.37 | 1.26 |
Decreased appetite | 1.27 | 1.35 |
Pinnal Reddening | 1.18 | 0.87 |
In the US field study, one dog administered TRIFEXIS experienced a single mild seizure 2 ½ hours after receiving the second monthly dose. The dog remained enrolled and received four additional monthly doses after the event and completed the study without further incident.
Following concomitant extra-label use of ivermectin with spinosad alone, a component of TRIFEXIS, some dogs have experienced the following clinical signs: trembling/twitching, salivation/drooling, seizures, ataxia, mydriasis, blindness and disorientation. Spinosad alone has been shown to be safe when administered concurrently with heartworm preventatives at label directions.
In US and European field studies, no dogs experienced seizures when dosed with spinosad alone at the therapeutic dose range of 13.5-27.3 mg/lb (30-60 mg/kg), including 4 dogs with pre-existing epilepsy. Four epileptic dogs that received higher than the maximum recommended dose of 27.3 mg/lb (60 mg/kg) experienced at least one seizure within the week following the second dose of spinosad, but no seizures following the first and third doses. The cause of the seizures observed in the field studies could not be determined.
For technical assistance or to report suspected adverse drug events, contact Elanco US Inc. at 1-888-545-5973. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/AnimalVeterinary/SafetyHealth
The primary target of action of spinosad, a component of TRIFEXIS, is an activation of nicotinic acetylcholine receptors (nAChRs) in insects. Spinosad does not interact with known insecticidal binding sites of other nicotinic or GABAergic insecticides such as neonicotinoids, fiproles, milbemycins, avermectins and cyclodienes. Insects treated with spinosad show involuntary muscle contractions and tremors resulting from activation of motor neurons. Prolonged spinosad-induced hyperexcitation results in prostration, paralysis and flea death. The selective toxicity of spinosad between insects and vertebrates may be conferred by the differential sensitivity of the insect versus vertebrate nAChRs.
Milbemycin oxime, a component of TRIFEXIS, acts by binding to glutamate-gated chloride ion channels in invertebrate nerve and muscle cells. Increased permeability by the cell membrane to chloride ions causes hyperpolarization of affected cells and subsequent paralysis and death of the intended parasites. Milbemycin oxime may also act by disrupting the transmission of invertebrate neurotransmitters, notably gamma amino butyric acid (GABA).
In a well-controlled laboratory study, TRIFEXIS was 100% effective against induced heartworm infections when administered for
3 consecutive monthly doses. Two consecutive monthly doses did not provide 100% effectiveness against heartworm infection. In another well-controlled laboratory study, a single dose of TRIFEXIS was 100% effective against induced heartworm infections.
In a well-controlled six-month US field study conducted with TRIFEXIS, no dogs were positive for heartworm infection as determined by heartworm antigen testing performed at the end of the study and again three months later.
In a well-controlled laboratory study, TRIFEXIS demonstrated 100% effectiveness on the first day following treatment and 100% effectiveness on Day 30. In a well-controlled laboratory study, spinosad, a component of TRIFEXIS, began to kill fleas 30 minutes after administration and demonstrated 100% effectiveness within 4 hours. Spinosad, a component of TRIFEXIS, kills fleas before they can lay eggs. If a severe environmental infestation exists, fleas may persist for a period of time after dose administration due to the emergence of adult fleas from pupae already in the environment. In field studies conducted in households with existing flea infestations of varying severity, flea reductions of 98.0% to 99.8% were observed over the course of 3 monthly treatments with spinosad alone. Dogs with signs of flea allergy dermatitis showed improvement in erythema, papules, scaling, alopecia, dermatitis/pyodermatitis and pruritus as a direct result of eliminating the fleas.
In well-controlled laboratory studies, TRIFEXIS was ≥ 90% effective in removing naturally and experimentally induced adult roundworm, whipworm and hookworm infections.
TRIFEXIS is a flavored chewable tablet. In a field study of client-owned dogs where 175 dogs were each offered TRIFEXIS once a month for 6 months, dogs voluntarily consumed 54% of the doses when offered plain as if a treat, and 33% of the doses when offered in or on food. The remaining 13% of doses were administered like other tablet medications.
TRIFEXIS was tested in pure and mixed breeds of healthy dogs in well-controlled clinical and laboratory studies. No dogs were withdrawn from the field studies due to treatment-related adverse reactions.
In a margin of safety study, TRIFEXIS was administered orally to 8-week-old Beagle puppies at doses of 1, 3, and 5 times the upper half of the therapeutic dose band, every 28 days for 6 dosing periods. Vomiting was seen in all groups including control animals with similar frequency. Adverse reactions seen during the course of the study were salivation, tremors, decreased activity, coughing and vocalization.
Body weights were similar between control and treated groups throughout the study. Treatment with TRIFEXIS was not associated with any clinically significant hematology, clinical chemistry or gross necropsy changes. One 5X dog had minimal glomerular lipidosis observed microscopically. The clinical relevance of this finding is unknown.
Plasma spinosyn A, spinosyn D, milbemycin A3 5-oxime and milbemycin A4 5-oxime concentrations increased throughout the study. At each dosing period, plasma spinosyn A and spinosyn D concentrations were greater than proportional across the dose range 1 to 5X. Plasma milbemycin A4 5-oxime concentrations appeared to be dose proportional across range 1 to 5X by the end of the study. Plasma concentrations of spinosad and milbemycin oxime indicate that expected systemic exposures were achieved throughout the study.
In an avermectin-sensitive Collie dog study, TRIFEXIS was administered orally at 1, 3, and 5 times the upper half of the recommended therapeutic dose band every 28 days. No signs of avermectin sensitivity were observed after administration of TRIFEXIS during the study period to avermectin-sensitive Collie dogs. The adverse reactions observed in the treatment groups were vomiting and diarrhea. Body weights in all treatment groups were comparable to the control group. Hematology and clinical chemistry parameters showed no clinically significant changes from study start to end, and all dogs were considered healthy throughout the study.
In a heartworm positive safety study, TRIFEXIS was administered orally at 1, 3, and 5 times the upper half of the therapeutic dose band to Beagle dogs with adult heartworm infections and circulating microfilariae, every 28 days for 3 treatments. Vomiting was observed in one dog in the 1X group, in three dogs in the 3X group, and in one dog in the 5X group. All but one incident of vomiting was observed on the treatment day during the first treatment cycle. The vomiting was mild and self-limiting. Hypersensitivity reactions were not observed in any of the treatment groups. Microfilariae counts decreased with treatment.
In a reproductive safety study, TRIFEXIS was administered orally to female dogs at 1 and 3 times the upper half of the therapeutic dose band every 28 days prior to mating, during gestation and during a six-week lactation period. Dogs with confirmed fetal heartbeats on ultrasound examination were evaluated for reproductive safety. One 3X and one 1X group female did not become pregnant. No treatment-related adverse reactions or signs of avermectin toxicosis were noted for adult females. Adult females in the 3X group lost weight during the 6-week pre-mating period, while control group females gained weight during that time. The body weights of the treated groups were comparable to the control group during gestation and post-parturition phases of the study. Gestation length, litter average body weight, litter size, stillborn pups, pup survival and the proportion of pups with malformations were comparable between treated and control dam groups. Malformations in the 1X group included a pup with cleft palate and a littermate with anophthalmia, fused single nares, misshapen palate, hydrocephalus, omphalocele and malpositioned testes; a pup with a malformation of the anterior tip of the urinary bladder and umbilical blood vessel; and a pup with patent ductus arteriosus (PDA). Malformations in the 3X group included three littermates with PDA. Malformations in the control group included a pup with a malformed sternum and a pup with PDA and a malpositioned superior vena cava. Clinical findings in pups of the treated groups were comparable to the control group except for one 1X group pup that was smaller and less coordinated than its littermates and had tremors when excited. The relationship between spinosad and milbemycin oxime treatment and the 1X and 3X dogs that did not become pregnant, the specific pup malformations and the unthrifty 1X group pup are unknown. The incidence of cleft palate is not unexpected based on the historical data collected at the breeding site.
In a margin of safety study with spinosad alone, 6-week old Beagle puppies were administered average doses of 1.5, 4.4, and 7.4 times the maximum recommended dose at 28-day intervals over a 6-month period. Vomiting was observed across all treatments, including controls, and was observed at an increased rate at elevated doses. Vomiting most often occurred 1 hour following administration and decreased over time and stabilized when puppies reached 14 weeks of age.
TRIFEXIS is available in five tablet sizes. Each tablet size is available in color-coded packages of 6 tablets.
5-10 lbs (140 mg spinosad and 2.3 mg milbemycin oxime)
10.1-20 lbs (270 mg spinosad and 4.5 mg milbemycin oxime)
20.1-40 lbs (560 mg spinosad and 9.3 mg milbemycin oxime)
40.1-60 lbs (810 mg spinosad and 13.5 mg milbemycin oxime)
60.1-120 lbs (1620 mg spinosad and 27 mg milbemycin oxime)
NADA 141-321, Approved by the FDA
Manufactured for:
Elanco US Inc.
Greenfield, IN 46140
www.trifexis.com
Elanco, Trifexis and the diagonal bar are trademarks owned or licensed by Eli Lilly and Company, its subsidiaries or affiliates.
NDC: 58198-4332-6
NDC: 58198-4333-6
NDC: 58198-4334-6
NDC: 58198-4335-6
NDC: 58198-4336-6
CA4332
CA4333
CA4334
CA4335
CA4336
Trifexis™
(spinosad + milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and
older and 5 lbs of body weight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH A Meal
FOR DOGS 5-10 lbs
6 CHEWABLE TABLETS
140 mg spinosad/2.3 mg milbemycin oxime
Elanco™
Trifexis™
(spinosad + milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and
older and 5 lbs of body weight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH A Meal
FOR DOGS 5-10 lbs
6 CHEWABLE TABLETS
140 mg spinosad/2.3 mg milbemycin oxime
Elanco™
Trifexis™
(spinosad + milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and
older and 5 lbs of body weight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH A Meal
FOR DOGS 10.1-20 lbs
6 CHEWABLE TABLETS
270 mg spinosad/4.5 mg milbemycin oxime
Elanco™
Trifexis™
(spinosad + milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and
older and 5 lbs of body weight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH A Meal
FOR DOGS 10.1-20 lbs
6 CHEWABLE TABLETS
270 mg spinosad/4.5 mg milbemycin oxime
Elanco™
Trifexis™
(spinosad + milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and
older and 5 lbs of body weight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH A Meal
FOR DOGS 20.1-40 lbs
6 CHEWABLE TABLETS
560 mg spinosad/9.3 mg milbemycin oxime
Elanco™
Trifexis™
(spinosad + milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and
older and 5 lbs of body weight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH A Meal
FOR DOGS 20.1-40 lbs
6 CHEWABLE TABLETS
560 mg spinosad/9.3 mg milbemycin oxime
Elanco™
Trifexis™
(spinosad + milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and
older and 5 lbs of body weight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH A Meal
FOR DOGS 40.1-60 lbs
6 CHEWABLE TABLETS
810 mg spinosad/13.5 mg milbemycin oxime
Elanco™
Trifexis™
(spinosad + milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and
older and 5 lbs of body weight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH A Meal
FOR DOGS 40.1-60 lbs
6 CHEWABLE TABLETS
810 mg spinosad/13.5 mg milbemycin oxime
Elanco™
Trifexis™
(spinosad + milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and
older and 5 lbs of body weight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH A Meal
FOR DOGS 60.1-120 lbs
6 CHEWABLE TABLETS
1620 mg spinosad/27 mg milbemycin oxime
Elanco™
Trifexis™
(spinosad + milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or on the order of a licensed veterinarian.
Prevents HEARTWORM Disease
Kills FLEAS & Prevents Infestations
Treats and Controls INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and
older and 5 lbs of body weight or greater
STARTS Killing Fleas in 30 mins.
MONTHLY Use
GIVE WITH A Meal
FOR DOGS 60.1-120 lbs
6 CHEWABLE TABLETS
1620 mg spinosad/27 mg milbemycin oxime
Elanco™
Trifexis™
(spinosad + milbemycin oxime)
Prevents
HEARTWORM Disease
Kills
FLEAS & Prevents Infestations
Treats and Controls
INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
Contains 5 puppy kits
For use in dogs and puppies 8 weeks of age and older, and
5 pounds of body weight or greater.
FOR DOGS 5-10 LBS 140mg spinosad/2.3mg milbemycin oxime
Starts Killing
Fleas in 30 mins.
MONTHLY
Use
GIVE WITH
A Meal
Elanco™
Trifexis™
(spinosad + milbemycin oxime)
Congratulations
on your new puppy
Prevents
HEARTWORM Disease
Kills
FLEAS & Prevents Infestations
Treats and Controls
INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
ONE TABLET
For use in dogs and puppies 8 weeks of age and older, and
5 pounds of body weight or greater.
FOR DOGS 5-10 LBS 140mg spinosad/2.3mg milbemycin oxime
Starts Killing
Fleas in 30 mins.
MONTHLY
Use
GIVE WITH
A Meal
Elanco™
Trifexis™
(spinosad + milbemycin oxime)
Prevents
HEARTWORM Disease
Kills
FLEAS & Prevents Infestations
Treats and Controls
INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
Contains 5 puppy kits
For use in dogs and puppies 8 weeks of age and older, and
5 pounds of body weight or greater.
FOR DOGS 10.1-20 LBS 270mg spinosad/4.5mg milbemycin oxime
Starts Killing
Fleas in 30 mins.
MONTHLY
Use
GIVE WITH
A Meal
Elanco™
Trifexis™
(spinosad + milbemycin oxime)
Congratulations
on your new puppy
Prevents
HEARTWORM Disease
Kills
FLEAS & Prevents Infestations
Treats and Controls
INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
ONE TABLET
For use in dogs and puppies 8 weeks of age and older, and
5 pounds of body weight or greater.
FOR DOGS 10.1-20 LBS 270mg spinosad/4.5mg milbemycin oxime
Starts Killing
Fleas in 30 mins.
MONTHLY
Use
GIVE WITH
A Meal
Elanco™
Trifexis™
(spinosad + milbemycin oxime)
CAUTION: Federal (USA) law restricts this drug to use by or on
the order of a licensed veterinarian.
PROTECTION POWER PACK
Prevents
HEARTWORM Disease
Kills
FLEAS & Prevents Infestations
Treats and Controls
INTESTINAL WORMS
Adult Hookworm, Roundworm, and Whipworm
For use in dogs and puppies 8 weeks of age and older
and 5 lbs of body weight or greater
Starts Killing
Fleas in 30 mins.
MONTHLY
Use
GIVE WITH
A Meal
Contains 12 doses
Elanco™
Trifexis™
(spinosad + milbemycin oxime)
For Trifexis refills visit your veterinarian
For use in dogs and puppies 8 weeks of age and
older and 5 lbs of body weight or greater.
Prevents
HEARTWORM Disease
Kills
FLEAS & Prevents Infestations
Treats and Controls
INTESTINAL WORMS
Hookworm, Roundworm, and Whipworm
TRIFEXIS
spinosad and milbemycin oxime tablet |
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TRIFEXIS
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TRIFEXIS
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TRIFEXIS
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TRIFEXIS
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Labeler - Elanco US Inc, (966985624) |
Mark Image Registration | Serial | Company Trademark Application Date |
---|---|
TRIFEXIS 77540529 3944743 Live/Registered |
ELANCO US INC. 2008-08-06 |