CLEAR DIFFERENCE ADVANCED BLEMISH SERUM

Manufacturer: ESTEE LAUDER INC | ESTEE LAUDER COMPANY, THE | ESTEE LAUDER COSMETICS, LTD. | ESTEE LAUDER N.V. | LEN-RON MANUFACTURING DIVISION OF ARAMIS INC | NORTHTEC INC | PADC 1 | WHITMAN LABORATORIES, LTD. | ESTEE LAUDER COSMETICS, LTD
Effective date: 2018-12-12
Label type: HUMAN OTC DRUG LABEL
Version: 2
Source: legacy-cache
Hydrated at: 2026-08-02 00:42:57

Label at a glance#

ProductCLEAR DIFFERENCE ADVANCED BLEMISH SERUM

Active ingredientSALICYLIC ACID

Label structure8 sections

Dosage and administration

cleanse skin thoroughly before applying cover the entire affected area with one application daily gradually increase to 2 times daily if needed or as directed by a doctor if bothersome dryness or peeling occurs, reduce application to every other day follow with your moisturizer

Label contents#

Full prescribing information#

SPL UNCLASSIFIED SECTION

Drug Facts

Active ingredient

OTC - ACTIVE INGREDIENT SECTION

Salicylic acid 0.50%

Purpose

OTC - PURPOSE SECTION

Acne treatment

Use

INDICATIONS & USAGE SECTION

For the treatment of acne.

Warnings

WARNINGS SECTION

For external use only

OTC - WHEN USING SECTION

When using this product using other topical acne drugs at the same time or right after use of this product may increase dryness or irritation of the skin. If this occurs, only one medication should be used unless directed by a doctor.

OTC - KEEP OUT OF REACH OF CHILDREN SECTION

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Directions

DOSAGE & ADMINISTRATION SECTION

cleanse skin thoroughly before applying
cover the entire affected area with one application daily
gradually increase to 2 times daily if needed or as directed by a doctor
if bothersome dryness or peeling occurs, reduce application to every other day
follow with your moisturizer

Inactive ingredients

INACTIVE INGREDIENT SECTION

water\aqua\eau • dimethicone • hamamelis virginiana (witch hazel) water • ppg-14 butyl ether • acetyl glucosamine • sucrose • isodecyl neopentanoate • steareth-21 • glycine • acrylamide/sodium acryloyldimethyltaurate copolymer • laminaria saccharina extract • caffeine • tocopheryl acetate • isohexadecane • steareth-2 • algae extract • sodium hyaluronate • polysorbate 80 • quaternium-22 • butylene glycol • sodium hydroxide • pentylene glycol • disodium edta • fragrance (parfum) • limonene • linalool • phenoxyethanol • benzalkonium chloride • green 5 (ci 61570) • yellow 5 (ci 19140) <iln40165>

PRINCIPAL DISPLAY PANEL - 50 ml Bottle Carton

PACKAGE LABEL.PRINCIPAL DISPLAY PANEL

ESTĒE LAUDER

Clear
Difference
Advanced
Blemish Serum

SALICYLIC ACID ACNE TREATMENT

1.7 FL. OZ. LIQ./50 ml e

Principal Display Panel - 50 ml Bottle Carton

DailyMed Socrata Ingredients#

Ingredient, Type, UNII table
Ingredient	Type	UNII	SPL version
SALICYLIC ACID	ACTIVE INGREDIENT	O414PZ4LPZ	1
SALICYLIC ACID	ACTIVE MOIETY	O414PZ4LPZ	1
.alpha.-tocopherol acetate	INACTIVE INGREDIENT	9E8X80D2L0	1
benzalkonium chloride	INACTIVE INGREDIENT	F5UM2KM3W7	1
butylene glycol	INACTIVE INGREDIENT	3XUS85K0RA	1
caffeine	INACTIVE INGREDIENT	3G6A5W338E	1
D&C green no. 5	INACTIVE INGREDIENT	8J6RDU8L9X	1
dimethicone	INACTIVE INGREDIENT	92RU3N3Y1O	1
edetate disodium	INACTIVE INGREDIENT	7FLD91C86K	1
FD&C yellow no. 5	INACTIVE INGREDIENT	I753WB2F1M	1
glycine	INACTIVE INGREDIENT	TE7660XO1C	1
hamamelis virginiana top water	INACTIVE INGREDIENT	NT00Y05A2V	1
hyaluronate sodium	INACTIVE INGREDIENT	YSE9PPT4TH	1
isodecyl neopentanoate	INACTIVE INGREDIENT	W60VYE24XC	1
isohexadecane	INACTIVE INGREDIENT	918X1OUF1E	1
linalool, (+/-)-	INACTIVE INGREDIENT	D81QY6I88E	1
n-acetylglucosamine	INACTIVE INGREDIENT	V956696549	1
pentylene glycol	INACTIVE INGREDIENT	50C1307PZG	1
phenoxyethanol	INACTIVE INGREDIENT	HIE492ZZ3T	1
polysorbate 80	INACTIVE INGREDIENT	6OZP39ZG8H	1
ppg-14 butyl ether	INACTIVE INGREDIENT	R199TJT95T	1
quaternium-22	INACTIVE INGREDIENT	MXO138JCBP	1
saccharina latissima	INACTIVE INGREDIENT	68CMP2MB55	1
sodium hydroxide	INACTIVE INGREDIENT	55X04QC32I	1
steareth-2	INACTIVE INGREDIENT	V56DFE46J5	1
steareth-21	INACTIVE INGREDIENT	53J3F32P58	1
sucrose	INACTIVE INGREDIENT	C151H8M554	1
water	INACTIVE INGREDIENT	059QF0KO0R	1

Products#

Every source-derived product name is available through these pages.

DailyMed product names page 1 of 1 · 28 matching rows.

CLEAR DIFFERENCE ADVANCED BLEMISH SERUM
SALICYLIC ACID
water
dimethicone
hamamelis virginiana top water
ppg-14 butyl ether
n-acetylglucosamine
sucrose
isodecyl neopentanoate
steareth-21
glycine
saccharina latissima
caffeine
.alpha.-tocopherol acetate
isohexadecane
steareth-2
hyaluronate sodium
polysorbate 80
quaternium-22
butylene glycol
sodium hydroxide
pentylene glycol
edetate disodium
linalool, (+/-)-
phenoxyethanol
benzalkonium chloride
D&C green no. 5
FD&C yellow no. 5

NDC Codes#

Product NDC, Package NDC table
Product NDC	Package NDC
11559-041	11559-041-01

Ingredients#

Every source-derived ingredient row is available through these pages.

DailyMed ingredient rows page 1 of 1 · 27 matching rows.

Name, UNII, Kind table
Name	UNII	Kind
SALICYLIC ACID	O414PZ4LPZ	ACTIB
water	059QF0KO0R	IACT
dimethicone	92RU3N3Y1O	IACT
hamamelis virginiana top water	NT00Y05A2V	IACT
ppg-14 butyl ether	R199TJT95T	IACT
n-acetylglucosamine	V956696549	IACT
sucrose	C151H8M554	IACT
isodecyl neopentanoate	W60VYE24XC	IACT
steareth-21	53J3F32P58	IACT
glycine	TE7660XO1C	IACT
saccharina latissima	68CMP2MB55	IACT
caffeine	3G6A5W338E	IACT
.alpha.-tocopherol acetate	9E8X80D2L0	IACT
isohexadecane	918X1OUF1E	IACT
steareth-2	V56DFE46J5	IACT
hyaluronate sodium	YSE9PPT4TH	IACT
polysorbate 80	6OZP39ZG8H	IACT
quaternium-22	MXO138JCBP	IACT
butylene glycol	3XUS85K0RA	IACT
sodium hydroxide	55X04QC32I	IACT
pentylene glycol	50C1307PZG	IACT
edetate disodium	7FLD91C86K	IACT
linalool, (+/-)-	D81QY6I88E	IACT
phenoxyethanol	HIE492ZZ3T	IACT
benzalkonium chloride	F5UM2KM3W7	IACT
D&C green no. 5	8J6RDU8L9X	IACT
FD&C yellow no. 5	I753WB2F1M	IACT

Source Document#

Source XML

Inactive ingredient matches#

Inactive Ingredient Database values describe FDA-listed use contexts. The match method and ambiguity count are shown because ingredient names, routes, and dosage forms are not always unique. Browse recovered IID releases and source provenance.

Inactive ingredient links page 1 of 8 · 474 matching rows.

DailyMed ingredient, IID ingredient, UNII table
DailyMed ingredient	IID ingredient	UNII	Dosage form / route	Potency	Maximum daily exposure	Match
edetate disodium	EDETATE DISODIUM	7FLD91C86K	TABLET / ORAL		100 mg	Exact identifier — unii candidate 77 equally ranked IID candidates
sodium hydroxide	SODIUM HYDROXIDE	55X04QC32I	INJECTION / INTRATHECAL	176 mg		Exact identifier — unii candidate 174 equally ranked IID candidates
benzalkonium chloride	BENZALKONIUM CHLORIDE	F5UM2KM3W7	INJECTION / INTRA-ARTICULAR		1 mg	Exact identifier — unii candidate 24 equally ranked IID candidates
polysorbate 80	POLYSORBATE 80	6OZP39ZG8H	ENEMA / RECTAL	0.01 %w/v		Exact identifier — unii candidate 78 equally ranked IID candidates
sodium hydroxide	SODIUM HYDROXIDE	55X04QC32I	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION / INTRATHECAL	ADJ PH		Exact identifier — unii candidate 174 equally ranked IID candidates
caffeine	CAFFEINE	3G6A5W338E	GRANULE / ORAL	NA		Exact identifier — unii candidate 3 equally ranked IID candidates
sucrose	SUCROSE	C151H8M554	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION / SUBCUTANEOUS		308 mg	Exact identifier — unii candidate 48 equally ranked IID candidates
sucrose	SUCROSE	C151H8M554	LOZENGE / TRANSMUCOSAL		1255 mg	Exact identifier — unii candidate 48 equally ranked IID candidates
edetate disodium	EDETATE DISODIUM	7FLD91C86K	SPRAY / RESPIRATORY (INHALATION)	0.05 %w/w		Exact identifier — unii candidate 77 equally ranked IID candidates
polysorbate 80	POLYSORBATE 80	6OZP39ZG8H	PASTE / ORAL		28 mg	Exact identifier — unii candidate 78 equally ranked IID candidates
sodium hydroxide	SODIUM HYDROXIDE	55X04QC32I	POWDER / RESPIRATORY (INHALATION)	ADJ PH		Exact identifier — unii candidate 174 equally ranked IID candidates
edetate disodium	EDETATE DISODIUM	7FLD91C86K	SUSPENSION, EXTENDED RELEASE / ORAL		40 mg	Exact identifier — unii candidate 77 equally ranked IID candidates
sucrose	SUCROSE	C151H8M554	PASTILLE / ORAL	426 mg		Exact identifier — unii candidate 48 equally ranked IID candidates
edetate disodium	EDETATE DISODIUM	7FLD91C86K	SHAMPOO / TOPICAL	1 %w/w		Exact identifier — unii candidate 77 equally ranked IID candidates
polysorbate 80	POLYSORBATE 80	6OZP39ZG8H	INJECTION, POWDER, FOR SUSPENSION / INTRAMUSCULAR		4 mg	Exact identifier — unii candidate 78 equally ranked IID candidates
benzalkonium chloride	BENZALKONIUM CHLORIDE	F5UM2KM3W7	SPRAY, METERED / NASAL		1 mg	Exact identifier — unii candidate 24 equally ranked IID candidates
sodium hydroxide	SODIUM HYDROXIDE	55X04QC32I	GEL / OPHTHALMIC		6 mg	Exact identifier — unii candidate 174 equally ranked IID candidates
sodium hydroxide	SODIUM HYDROXIDE	55X04QC32I	SPRAY, METERED / NASAL	ADJ PH		Exact identifier — unii candidate 174 equally ranked IID candidates
glycine	GLYCINE	TE7660XO1C	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION / SUBCUTANEOUS	10 mg		Exact identifier — unii candidate 20 equally ranked IID candidates
edetate disodium	EDETATE DISODIUM	7FLD91C86K	TABLET, FILM COATED / ORAL	4 mg		Exact identifier — unii candidate 77 equally ranked IID candidates
sucrose	SUCROSE	C151H8M554	INJECTION, SUSPENSION, EXTENDED RELEASE / SUBCUTANEOUS		1 mg	Exact identifier — unii candidate 48 equally ranked IID candidates
sodium hydroxide	SODIUM HYDROXIDE	55X04QC32I	INJECTION, POWDER, FOR SOLUTION / SUBCUTANEOUS	ADJ PH		Exact identifier — unii candidate 174 equally ranked IID candidates
edetate disodium	EDETATE DISODIUM	7FLD91C86K	CAPSULE / ORAL		5 mg	Exact identifier — unii candidate 77 equally ranked IID candidates
sucrose	SUCROSE	C151H8M554	GRANULE / ORAL	NA		Exact identifier — unii candidate 48 equally ranked IID candidates
edetate disodium	EDETATE DISODIUM	7FLD91C86K	CREAM / VAGINAL		3 mg	Exact identifier — unii candidate 77 equally ranked IID candidates
glycine	GLYCINE	TE7660XO1C	INJECTABLE, LIPOSOMAL / INTRAVENOUS	0.38 %w/v		Exact identifier — unii candidate 20 equally ranked IID candidates
edetate disodium	EDETATE DISODIUM	7FLD91C86K	INJECTION, SUSPENSION / SOFT TISSUE		1 mg	Exact identifier — unii candidate 77 equally ranked IID candidates
polysorbate 80	POLYSORBATE 80	6OZP39ZG8H	TABLET / ORAL		233 mg	Exact identifier — unii candidate 78 equally ranked IID candidates
sodium hydroxide	SODIUM HYDROXIDE	55X04QC32I	SOLUTION / RECTAL	NA		Exact identifier — unii candidate 174 equally ranked IID candidates
edetate disodium	EDETATE DISODIUM	7FLD91C86K	INJECTION / INTRALESIONAL	0.05 %w/v		Exact identifier — unii candidate 77 equally ranked IID candidates
polysorbate 80	POLYSORBATE 80	6OZP39ZG8H	AEROSOL, FOAM / VAGINAL	3 %w/w		Exact identifier — unii candidate 78 equally ranked IID candidates
sodium hydroxide	SODIUM HYDROXIDE	55X04QC32I	AEROSOL, FOAM / TOPICAL	ADJ PH		Exact identifier — unii candidate 174 equally ranked IID candidates
phenoxyethanol	PHENOXYETHANOL	HIE492ZZ3T	GEL / TOPICAL		14 mg	Exact identifier — unii candidate 6 equally ranked IID candidates
FD&C yellow no. 5	FD&C YELLOW NO. 5	I753WB2F1M	TABLET, DELAYED RELEASE / ORAL		3 mg	Exact identifier — unii candidate 22 equally ranked IID candidates
sucrose	SUCROSE	C151H8M554	CONCENTRATE / ORAL		4800 mg	Exact identifier — unii candidate 48 equally ranked IID candidates
D&C green no. 5	D&C GREEN NO. 5	8J6RDU8L9X	SHAMPOO / TOPICAL	0.09 %w/w		Exact identifier — unii candidate 6 equally ranked IID candidates
edetate disodium	EDETATE DISODIUM	7FLD91C86K	INJECTION, SOLUTION / INTRAMUSCULAR		4 mg	Exact identifier — unii candidate 77 equally ranked IID candidates
sodium hydroxide	SODIUM HYDROXIDE	55X04QC32I	INJECTION, SUSPENSION / INTRALESIONAL	ADJ PH		Exact identifier — unii candidate 174 equally ranked IID candidates
sucrose	SUCROSE	C151H8M554	CAPSULE, COATED PELLETS / ORAL	59.8 mg		Exact identifier — unii candidate 48 equally ranked IID candidates
edetate disodium	EDETATE DISODIUM	7FLD91C86K	TABLET, ORALLY DISINTEGRATING / ORAL		3 mg	Exact identifier — unii candidate 77 equally ranked IID candidates
edetate disodium	EDETATE DISODIUM	7FLD91C86K	SYSTEM / IONTOPHORESIS	0.1 mg		Exact identifier — unii candidate 77 equally ranked IID candidates
sucrose	SUCROSE	C151H8M554	POWDER / ORAL		27768 mg	Exact identifier — unii candidate 48 equally ranked IID candidates
edetate disodium	EDETATE DISODIUM	7FLD91C86K	GEL / OPHTHALMIC		396 mg	Exact identifier — unii candidate 77 equally ranked IID candidates
glycine	GLYCINE	TE7660XO1C	POWDER, FOR SUSPENSION / ORAL		400 mg	Exact identifier — unii candidate 20 equally ranked IID candidates
sucrose	SUCROSE	C151H8M554	TABLET, FILM COATED / ORAL		145 mg	Exact identifier — unii candidate 48 equally ranked IID candidates
sodium hydroxide	SODIUM HYDROXIDE	55X04QC32I	INJECTION / INTRACAUDAL	ADJ PH		Exact identifier — unii candidate 174 equally ranked IID candidates
sucrose	SUCROSE	C151H8M554	TROCHE / ORAL	NA		Exact identifier — unii candidate 48 equally ranked IID candidates
sodium hydroxide	SODIUM HYDROXIDE	55X04QC32I	TABLET, EXTENDED RELEASE / ORAL		13 mg	Exact identifier — unii candidate 174 equally ranked IID candidates
sodium hydroxide	SODIUM HYDROXIDE	55X04QC32I	SUSPENSION, EXTENDED RELEASE / INTRA-ARTICULAR	ADJ PH		Exact identifier — unii candidate 174 equally ranked IID candidates
sodium hydroxide	SODIUM HYDROXIDE	55X04QC32I	SOLUTION / URETHRAL	ADJ PH		Exact identifier — unii candidate 174 equally ranked IID candidates
sodium hydroxide	SODIUM HYDROXIDE	55X04QC32I	SYRUP / ORAL	71 mg/5ml		Exact identifier — unii candidate 174 equally ranked IID candidates
sodium hydroxide	SODIUM HYDROXIDE	55X04QC32I	INJECTION / INTRA-ARTICULAR	ADJ PH		Exact identifier — unii candidate 174 equally ranked IID candidates
edetate disodium	EDETATE DISODIUM	7FLD91C86K	DROPS / AURICULAR (OTIC)	0.05 %w/w		Exact identifier — unii candidate 77 equally ranked IID candidates
polysorbate 80	POLYSORBATE 80	6OZP39ZG8H	SPRAY / NASAL	0.01 mg		Exact identifier — unii candidate 78 equally ranked IID candidates
sucrose	SUCROSE	C151H8M554	TABLET / BUCCAL	109 mg		Exact identifier — unii candidate 48 equally ranked IID candidates
sodium hydroxide	SODIUM HYDROXIDE	55X04QC32I	INJECTION, SOLUTION / INTRA-ARTERIAL	ADJ PH		Exact identifier — unii candidate 174 equally ranked IID candidates
edetate disodium	EDETATE DISODIUM	7FLD91C86K	INJECTION / SOFT TISSUE	0.05 %w/v		Exact identifier — unii candidate 77 equally ranked IID candidates
polysorbate 80	POLYSORBATE 80	6OZP39ZG8H	INJECTION, SUSPENSION / INTRAVITREAL	0.02 %w/v		Exact identifier — unii candidate 78 equally ranked IID candidates
sodium hydroxide	SODIUM HYDROXIDE	55X04QC32I	INJECTION, POWDER, FOR SUSPENSION / INTRAVENOUS	ADJ PH		Exact identifier — unii candidate 174 equally ranked IID candidates
D&C green no. 5	D&C GREEN NO. 5	8J6RDU8L9X	TABLET, COATED / ORAL	NA		Exact identifier — unii candidate 6 equally ranked IID candidates

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
Brand	Generic	Manufacturer	SPL set ID	Effective date	Available safety fields	Join
eff699d6-b417-4968-bb2c-f9dbf3d9e860			da677821-44e6-4697-8902-6d794471b0d3	2020-11-17	Warnings	Exact identifier spl set id: da677821-44e6-4697-8902-6d794471b0d3

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.