FDA.reportPublic FDA data

REVERSE Brightening Defense Fluid

Manufacturer
Rodan & Fields
Effective date
2025-12-15
Label type
HUMAN OTC DRUG LABEL
Version
4
Source
full-release
Hydrated at
2026-06-01 01:26:38

Label at a glance#

ProductREVERSE Brightening Defense Fluid
Active ingredientAVOBENZONE, HOMOSALATE, OCTOCRYLENE, OCTISALATE
Label structure11 sections

Indications and uses

Helps prevent sunburn. When used as directed with other sun protection measures (see Directions ), decreases the risk of skin cancer and early skin aging caused by the sun.

Dosage and administration

Every AM, apply liberally and evenly over face + neck 15 minutes before sun exposure. Reapply at least every 2 hours. Use a water-resistant sunscreen if swimming or sweating. Sun Protection Measures: Spending time in the sun increases your risk of skin cancer and early skin aging. To decrease this risk, regularly use a sunscreen with a broad spectrum SPF value of 15 or higher and other sun protection measures incl...

Label contents#

Full prescribing information#

SPL UNCLASSIFIED SECTION

Drug Facts

Active Ingredients

OTC - ACTIVE INGREDIENT SECTION

Avobenzone 2.8%,

Homosalate 9.3%,

Octisalate 4.67%,

Octocrylene 6.1%

Purpose

OTC - PURPOSE SECTION

Sunscreen

Uses

INDICATIONS & USAGE SECTION

  • Helps prevent sunburn.
  • When used as directed with other sun protection measures (see Directions), decreases the risk of skin cancer and early skin aging caused by the sun.

Warnings

WARNINGS SECTION

For external use only.

Do not use on

OTC - DO NOT USE SECTION

  • damaged or broken skin.

When using this product

OTC - WHEN USING SECTION

  • keep out of eyes. Rinse with water to remove.

Stop use and ask a doctor if

OTC - STOP USE SECTION

  • rash occurs.
OTC - KEEP OUT OF REACH OF CHILDREN SECTION

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Directions

DOSAGE & ADMINISTRATION SECTION

  • Every AM, apply liberally and evenly over face + neck 15 minutes before sun exposure.
  • Reapply at least every 2 hours.
  • Use a water-resistant sunscreen if swimming or sweating.
  • Sun Protection Measures: Spending time in the sun increases your risk of skin cancer and early skin aging. To decrease this risk, regularly use a sunscreen with a broad spectrum SPF value of 15 or higher and other sun

protection measures including:

  • Limit time in the sun, especially from 10 a.m-2 p.m.
  • Wear long-sleeve shirts, pants, hats and sunglasses.
  • Children under 6 months: Ask a doctor.

Inactive Ingredients

INACTIVE INGREDIENT SECTION

Adenosine, Aminomethyl Propanol, Aqua/Eau/Water, Benzyl Alcohol, Butylene Glycol, C12-15 Alkyl Benzoate, Calcium Gluconate, Citral, Citric Acid, Cynara Scolymus (Artichoke) Leaf Extract, Dimethicone, Dimethicone/Vinyl Dime­thicone Crosspolymer, Dipotassium Glycyrrhizate, Fragrance/Parfum, Glucono­lactone, Glycerin, Glycine Soja (Soybean) Oil, Hydrogenated Lecithin, Limonene, Linalool, Methyl Carboxymethylphenyl Aminocarboxypropylphosphonate, Phenoxyethanol, Propanediol, Rosmarinic Acid, Rutin, Sesamum Indicum (Sesame) Seed Extract, Silica, Sodium Benzoate, Sodium Carbomer, Titanium Dioxide (Cl 77891), Tocopherol, Xanthan Gum.

Other Information

OTHER SAFETY INFORMATION

Protect this product from excessive heat and direct sun.

Questions?

OTC - QUESTIONS SECTION

1-888-995-5656

Principal Display Panel - 30 mL Carton Label

PACKAGE LABEL.PRINCIPAL DISPLAY PANEL

RODAN+FIELDS

REVERSE

Brightening Defense
Fluid Lotion

Broad Spectrum SPF 50

3AM

30 mL/1. Fl. Oz. U.S.

Principal Display Panel - 30 mL Carton Label
Principal Display Panel - 30 mL Carton Label

Principal Display Panel - 30 mL Tube Label

PACKAGE LABEL.PRINCIPAL DISPLAY PANEL

RODAN+FIELDS

REVERSE

Brightening Defense Fluid Lotion

Broad Spectrum SPF 50

3AM

Principal Display Panel - 30 mL Tube Label
Principal Display Panel - 30 mL Tube Label

Product Linked Resources#

Resource, Code type, Value table
ResourceCode typeValueEquivalent identifiersSource image
BarcodeEAN-130884164014321GTIN-13: 0884164014321
EAN-13: 0884164014321
GTIN-12: 884164014321
UPC-A: 884164014321
GTIN storage (14 digits): 00884164014321		rev0c-0004-01.jpg

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
bee4fa8d-8d82-423a-a0b5-40a89dd13a99Product name120250618
baf7f49c-75b6-496b-a00e-8e766a8e4f03Product name120210127
d676a241-be05-4740-b3ee-1a5f2ed422d2Product name420180615
dd8bd48f-20d6-43c7-b471-3ae872868afaProduct name320180125
ebc62596-fc97-4d03-9483-7ba095d25db7Product name120151210
d41954ff-bc63-4b2c-aba0-9146707659d7Product name220151117
0ca1d589-929b-4b33-bc5b-1d84abdafa6aProduct name120150324
fc363c46-397b-4476-ac0f-70e43e8e4592Product name120150324

FDA-Initiated Inactive NDC Indexing#

NDC, Effective, Action table
NDCEffectiveActionDocumentIndexing SPLRelated label
14222-2300-12023-12-04C16284748780-10191ceaa-6354-198a-e063-dbdaa90aec3edc230e1e-bfb8-4d7c-bad5-bff77d78220e
14222-2300-22023-12-04C16284748780-10191ceaa-6354-198a-e063-dbdaa90aec3edc230e1e-bfb8-4d7c-bad5-bff77d78220e
14222-2300-32023-12-04C16284748780-10191ceaa-6354-198a-e063-dbdaa90aec3edc230e1e-bfb8-4d7c-bad5-bff77d78220e
14222-2300-12023-07-28C16284748780-10191ceaa-6354-198a-e063-dbdaa90aec3edc230e1e-bfb8-4d7c-bad5-bff77d78220e
14222-2300-22023-07-28C16284748780-10191ceaa-6354-198a-e063-dbdaa90aec3edc230e1e-bfb8-4d7c-bad5-bff77d78220e
14222-2300-32023-07-28C16284748780-10191ceaa-6354-198a-e063-dbdaa90aec3edc230e1e-bfb8-4d7c-bad5-bff77d78220e

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
14222-2300-1REVERSE Brightening Defense Fluid1 in 1 CARTONLOTION14
14222-2300-1REVERSE Brightening Defense Fluid30 mL in 1 TUBELOTION304
14222-2300-2REVERSE Brightening Defense Fluid7 mL in 1 TUBELOTION74
14222-2300-2REVERSE Brightening Defense Fluid1 in 1 CARTONLOTION14
14222-2300-3REVERSE Brightening Defense Fluid2 mL in 1 PACKETLOTION24

Products#

Every source-derived product name is available through these pages.

DailyMed product names page 1 of 1 · 36 matching rows.

NDC Codes#

Product NDC, Package NDC table
Product NDCPackage NDC
14222-230014222-2300-1, 14222-2300-2, 14222-2300-3

Ingredients#

Every source-derived ingredient row is available through these pages.

DailyMed ingredient rows page 1 of 1 · 34 matching rows.

Name, UNII, Kind table
NameUNIIKind
AVOBENZONEG63QQF2NOXACTIB
HOMOSALATEV06SV4M95SACTIB
OCTOCRYLENE5A68WGF6WMACTIB
OCTISALATE4X49Y0596WACTIB
ADENOSINEK72T3FS567IACT
AMINOMETHYLPROPANOLLU49E6626QIACT
BENZYL ALCOHOLLKG8494WBHIACT
BUTYLENE GLYCOL3XUS85K0RAIACT
ALKYL (C12-15) BENZOATEA9EJ3J61HQIACT
CALCIUM GLUCONATESQE6VB453KIACT
CARBOXYPOLYMETHYLENE0A5MM307FCIACT
CITRALT7EU0O9VPPIACT
CITRIC ACID MONOHYDRATE2968PHW8QPIACT
CYNARA SCOLYMUS LEAFB71UA545DEIACT
DIMETHICONE92RU3N3Y1OIACT
DIMETHICONE/VINYL DIMETHICONE CROSSPOLYMER (SOFT PARTICLE)9E4CO0W6C5IACT
GLYCYRRHIZINATE DIPOTASSIUMCA2Y0FE3FXIACT
GLUCONOLACTONEWQ29KQ9POTIACT
GLYCERINPDC6A3C0OXIACT
HYDROGENATED SOYBEAN LECITHINH1109Z9J4NIACT
LIMONENE, (+)-GFD7C86Q1WIACT
LINALOOL, (+/-)-D81QY6I88EIACT
PHENOXYETHANOLHIE492ZZ3TIACT
PROPANEDIOL5965N8W85TIACT
ROSMARINIC ACIDMQE6XG29YIIACT
RUTIN5G06TVY3R7IACT
SESAME SEED7Y1255HVXRIACT
SILICON DIOXIDEETJ7Z6XBU4IACT
SODIUM BENZOATEOJ245FE5EUIACT
SOYBEAN OIL241ATL177AIACT
TITANIUM DIOXIDE15FIX9V2JPIACT
TOCOPHEROLR0ZB2556P8IACT
WATER059QF0KO0RIACT
XANTHAN GUMTTV12P4NEEIACT

Source Document#

Source XML

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
REVERSE Brightening Defense FluidAVOBENZONE, HOMOSALATE, OCTOCRYLENE, OCTISALATERodan & Fieldsdc230e1e-bfb8-4d7c-bad5-bff77d78220e2025-12-15WarningsExact identifier
ndc (package): 14222-2300-3
ndc (package): 14222-2300-2
ndc (package): 14222-2300-1
ndc (product): 14222-2300
ndc11 (package): 14222230002
ndc11 (package): 14222230003
ndc11 (package): 14222230001
spl id: 4d3635ec-89f9-4280-91f0-beb8d33ca05a
spl set id: dc230e1e-bfb8-4d7c-bad5-bff77d78220e

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.