IVERMECTIN SHEEP DRENCH- ivermectin solution
Ivermectin Sheep Drench by
Drug Labeling and Warnings
Ivermectin Sheep Drench by is a Animal medication manufactured, distributed, or labeled by Durvet, First Priority Incorporated. Drug facts, warnings, and ingredients follow.
Drug Details [pdf]
- INDICATIONS & USAGE
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PRODUCT DESCRIPTION
Ivermectin Sheep Drench is a liquid, administered orally to sheep, consisting of an 0.08% solution of ivermectin. Ivermectin is a unique chemical entity, and as such, the chances of cross-resistance in parasites that have developed resistance to other wormers is highly unlikely. Additionally, its convenience, broad spectrum efficacy, and wide therapeutic index make Ivermectin Sheep Drench an exceptionally valuable product for parasite control in sheep.
Consult your veterinarian for assistance in diagnosis, treatment, and control of parasitism.
- DOSING
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ADVANTAGES
Unique chemistry-unrelated to existing formulations.
Because Ivermectin Sheep Drench is chemically different, cross-resistance is unlikely in parasite strains which may have developed resistance to other wormers.
Broad spectrum effectiveness:
One low-volume dose effectively treats and controls many gastrointestinal roundworms (including Haemonchus contortus), lungworms, and nasal bots.
Easy administration:
Ivermectin Sheep Drench can be administered with any standard drenching equipment or any equipment that provides a consistent dose volume.
- FORMULATION
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PRODUCT INDICATIONS
Ivermectin Sheep Drench is indicated for the effective treatment of gatrointestinal roundworms (including Haemonchus contortus), lungworms and nasal bots in sheep.
When used as recommended, it provides effective control of the parasites shown in the table.
IVERMECTIN SHEEP DRENCH KILLS THESE PARASITES Gastrointestinal Roundworms
Adults Larvae (4th stage)
Haemonchus contortus X X Haemonchus placei X Ostertagia circumcincta X X Trichostrongylus axei X X Trichostrongylus colubriformis X X Cooperia curticei X X Cooperia oncophora X Oesophagostomum columbianum X X Oesophagostomum venulosum X Nematodirus battus X X Nematodirus spathiger X X Strongyloides papillosus X Chabertia ovina X Trichuris ovis X Lungworms: Dictyocaulus filaria X X Nasal bots: Oestrus ovis (all larval stages) -
DOSAGE
Ivermectin Sheep Drench should only be administered orally at the recommended dose level of 200 mcg ivermectin per kilogram of body weight. Three mL of Ivermectin Sheep Drench contains sufficient invermectin to treat 26 pounds of body weight.
Volume Sheep Body Weight Dosed 3 mL 26 lbs 6 mL 52 lbs 9 mL 78 lbs 12 mL 104 lbs 15 mL 130 lbs 18 mL 156 lbs 21 mL 182 lbs 24 mL 208 lbs 27 mL 234 lbs 30 mL 260 lbs To avoid underdosing, it is important to get the dose according to the weight of the heavist sheep in a group (ewes, lambs or rams), not the average weight. Several of the largest sheep should be weighed, judgement by the eye can be deceiving.
ADMINISTRATION
Any standard drenching equipment, or any equipment which provides a consistant dose volume, can be used. Dose rates and equipment should be checked before drenching commences. Be sure the head is properly positioned for each sheep to receive the full dose.
Ivermectin Sheep Drench is readily accepted by sheep, but inconsequential coughing may be observed in some animals during and for several minutes after drenching. If slobbering occurs, the dose may be lost, and that sheep should be redosed.
- RESIDUE INFORMATION:
- ADVERSE REACTIONS
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MODE OF ACTION
The avermectin family of compounds, of which ivermectin is a member, kills certain parasitic nematodes (roundworms) and arthropods. The action is unique and not shared by other antiparasitic agents and involves a chemical that serves as a signal from one nerve cell to another, or from a nerve cell to a muscle cell. This chemical, a neurotransmitter, is called gamma aminobutyric acid or GABA. In roundworms, ivermectin stimulates the release of GABA from nerve endings and enhances binding of GABA to special receptors at nerve junctions, thus interrupting nerve impules - thereby paralyzing and killing the parasite.
The enhancement of the GABA effect in arthropods resembles that in roundworms except that nerve impulses are interrupted between the nerve ending and the muscle cell. Again, this leads to paralysis and death in most species. Ivermectin has no measurable effect against flukes or tapeworms, presumably because they do not have GABA as a nerve impulse transmitter. Recommened doses of ivermectin have a wide safety margin in livestock. The principle peripheral neurotransmitter in mammals, acetylcholine, is unaffected by invermectin. Ivermectin does not readily penetrate the central nervous system of mammals where GABA funtions as a neurotransmitter.
- STABILITY
- SAFETY
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ENVIRONMENTAL SAFETY
Studies indicate that when ivermectin comes in contact with the soil, it readily and tightly binds to the soil and becomes inactive over time. Free ivermectin may adversely affect fish and certain water-born organisms on which they feed. Do not permit water runoff from from feedlots to enter lakes, streams, or ground water. Do not contaminate water by direct application or by the improper disposal of drug containers. Spills of Ivermectin Sheep Drench should be contained and soaked up with absorbent towels or into loose soil. Gloves should be worn to prevent skin exposure. All the collected materials (contaminated towels and soil), as well as all used drug containers, should be placed in an impervious film bag (plastic) and disposed of by incineration or in an approved landfill.
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PRECAUTIONS
Ivermectin Sheep Drench has been formulated for use in sheep ONLY. This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result. This product is not to be used parenterally.
Protect from light. Store at controlled room temperature between 15°-30°C (59°-86°F). Keep container tightly closed when not in use.
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HUMAN SAFETY
When used as recommended in sheep, Ivermectin Sheep Drench does not pose a hazard to human health. As a routine precaution, it is advisable to wash hands after use. As with all drugs, the product should be kept out of reach of children. Contact with eyes should be avoided, but protective clothing is not required.
For customer service, contact
Durvet, Inc., Blue Springs, MO 64014
www.durvet.com
FOR ORAL USE IN SHEEP ONLY
Consult your veterinarian for assistance in diagnosis, treatment, and control of parasitism.
- DESCRIPTION:
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INDICATIONS:
Ivermectin Sheep Drench provides treatment and control of adult and fourth-stage larvae of the following parasites: Gastrointestinal Roundworms - Haemonchus contortus, Ostertagia circumcincta, Trichostrongylus axei, T. colubriformis, Cooperia curticei, Nematodirus spathiger, N. battus, and Oseophagostomum columbianum; Lungworms - Dictyocaulus fileria; and all the larval stages of Nasal Bot - Oestrus ovis. It also provides treatment and control of adult forms only of the following Gastrointestinal Roundworms - Haemonchus placei, Cooperia oncophora, Strogyloides papillosus, Oesophagostomum venulosum, Trichuris ovis, and Chabertia ovina.
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DIRECTIONS FOR USE:
Ivermectin Sheep Drench may be used in any standard drenching equipment or in any equipment which provides a consistant dose volume. Ivermectin Sheep Drench is administered orally at a dose of 3.0 mL (2.4 mg ivermectin) per 26 lbs body weight or 200 mcg ivermectin per kilogram of body weight.
Coughing may be observed in some animals during and for several minutes following drenching.
KEEP THIS AND ALL DRUGS OUT OF REACH OF CHILDREN.
Refrain from smoking and eating when handling. Avoid contact with eyes. Immediately wash hands and any spills on the skin with plently of soap and water following use.
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PACKAGING:
Ivermectin Sheep Drench is available in a convenient pack size:
The 8 fl oz (240 mL) pack contains sufficient solution to treat 20 sheep averaging 100 lbs. The packs are high-density polyethylene containers, colored opaque white, with screw caps and tamper-evident seals. They are shipped in cardboard cartons as follows: 6 x 240 mL containers per case.
The 32.46 fl oz (960 mL) pack contains sufficient solution to treat 83 sheep averaging 100 lbs. The packs are high-density polyethylene containers, colored opaque white, with screw caps and tamper-evident seals. They are shipped in cardboard cartons as follows: 4 x 960 mL containers per case.
Restricted Drug (California) - Use Only as Directed
- Image of Base and Onsert labeling for the 240 mL jug (Iss. 01-09)
- Image of Base and Onsert Labeling for the 960 mL jug (ISS15XB11)
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INGREDIENTS AND APPEARANCE
IVERMECTIN SHEEP DRENCH
ivermectin solutionProduct Information Product Type OTC ANIMAL DRUG Item Code (Source) NDC: 30798-637 Route of Administration Oral Active Ingredient/Active Moiety Ingredient Name Basis of Strength Strength IVERMECTIN (UNII: 8883YP2R6D) (IVERMECTIN - UNII:8883YP2R6D) IVERMECTIN 0.8 mg in 1 mL Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC: 30798-637-12 6 in 1 CASE 1 240 mL in 1 JUG 2 NDC: 30798-637-16 4 in 1 CASE 2 960 mL in 1 JUG Marketing Information Marketing Category Application Number or Monograph Citation Marketing Start Date Marketing End Date ANADA ANADA200327 01/30/2009 Labeler - Durvet (056387798) Establishment Name Address ID/FEI Business Operations First Priority Incorporated 179925722 manufacture
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