Motrin Dual Action With Tylenol

Manufacturer
Kenvue Brands LLC
Effective date
2026-02-03
Label type
HUMAN OTC DRUG LABEL
Version
7
Source
full-release
Hydrated at
2026-06-01 01:37:06

Label at a glance#

ProductMotrin Dual Action With Tylenol
Active ingredientIBUPROFEN, ACETAMINOPHEN
Label structure10 sections

Indications and uses

■ temporarily relieves minor aches and pains due to: ■ headache ■ toothache ■ backache ■ menstrual cramps ■ muscular aches ■ minor pain of arthritis

Dosage and administration

■ do not take more than directed adults and children 12 years and over ■ take 2 tablets every 8 hours while symptoms persist children under 12 years ■ ask a doctor ■ do not take more than 6 tablets in 24 hours, unless directed by a doctor

Storage and handling

■ read all warnings and directions before use. Keep carton. ■ store at 20-25°C (68-77°F) ■ avoid excessive heat above 40°C (104°F)

Label contents#

Full prescribing information#

SPL UNCLASSIFIED SECTION

Drug Facts

Active ingredients (in each tablet)

OTC - ACTIVE INGREDIENT SECTION

Acetaminophen 250 mg

Ibuprofen 125 mg (NSAID *)

Purposes

OTC - PURPOSE SECTION

Pain reliever

Pain reliever

Uses

INDICATIONS & USAGE SECTION

■ temporarily relieves minor aches and pains due to:

■ headache

■ toothache

■ backache

■ menstrual cramps

■ muscular aches

■ minor pain of arthritis

Warnings

WARNINGS SECTION

Liver damage warning:

SPL UNCLASSIFIED SECTION

This product contains acetaminophen. Severe liver damage may occur if you take:
■ with other drugs containing acetaminophen
■ more than 6 tablets in 24 hours, which is the maximum daily amount for this product
■ 3 or more alcoholic drinks every day while using this product

Allergy alert

SPL UNCLASSIFIED SECTION

Acetaminophen allergy alert: may cause severe skin reactions.
Symptoms may include:
■ skin reddening ■ blisters ■ rash
If skin reaction occurs, stop use and seek medical help right away.


NSAID allergy alert: ibuprofen may cause a severe allergic reaction, especially in people allergic to aspirin.
Symptoms may include:
■ hives ■ facial swelling ■ asthma (wheezing)
■ shock ■ skin reddening ■ rash ■ blisters
If an allergic reaction occurs, stop use and seek medical help right away.

Stomach bleeding warning

SPL UNCLASSIFIED SECTION

This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you:

■ are age 60 or older

■ have had stomach ulcers or bleeding problems

■ take a blood thinning (anticoagulant) or steroid drug

■ take other drugs containing prescription or nonprescription NSAIDs [aspirin, ibuprofen, naproxen, or others]

■ have 3 or more alcoholic drinks every day while using this product

■ take more or for a longer time than directed

Heart attack and stroke warning

SPL UNCLASSIFIED SECTION

NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. These can be fatal. The risk is higher if you use more than directed or for longer than directed.

Do not use

OTC - DO NOT USE SECTION

■ with any other drug containing acetaminophen (prescription or nonprescription). If you are not sure whether a drug contains acetaminophen, ask a doctor or pharmacist
■ if you have ever had an allergic reaction to acetaminophen or any other pain reliever
■ right before or after heart surgery

Ask a doctor before use if

OTC - ASK DOCTOR SECTION

■ you have liver disease
■ stomach bleeding warning applies to you
■ you have problems or serious side effects from taking pain relievers
■ you have a history of stomach problems, such as heartburn
■ you have high blood pressure, heart disease, liver cirrhosis, kidney disease, asthma, or had a stroke
■ you are taking a diuretic

Ask a doctor or pharmacist before use if you are

OTC - ASK DOCTOR/PHARMACIST SECTION

■ under a doctor’s care for any serious condition
■ taking aspirin for heart attack or stroke, because ibuprofen may decrease this benefit of aspirin
■ taking any other drug

When using this product

OTC - WHEN USING SECTION

  • take with food or milk if stomach upset occurs

Stop use and ask a doctor if

OTC - STOP USE SECTION

■ you experience any of the following signs of stomach bleeding:

■ feel faint ■ vomit blood ■ have bloody or black stools
■ have stomach pain that does not get better


■ you have symptoms of heart problems or stroke:
■ chest pain ■ trouble breathing
■ weakness in one part or side of body
■ slurred speech ■ leg swelling
■ pain gets worse or lasts more than 10 days
■ redness or swelling is present in the painful area
■ any new symptoms appear

OTC - PREGNANCY OR BREAST FEEDING SECTION

If pregnant or breast-feeding, ask a health professional before use. It is especially important not to use ibuprofen at 20 weeks or later in pregnancy unless definitely directed to do so by a doctor because it may cause problems in the unborn child or complications during delivery.

OTC - KEEP OUT OF REACH OF CHILDREN SECTION

Keep out of reach of children. In case of overdose, get medical help or contact a Poison Control Center right away. (1-800-222-1222).

Prompt medical attention is critical for adults as well as for children even if you do not notice any signs or symptoms.

Directions

DOSAGE & ADMINISTRATION SECTION

■ do not take more than directed

adults and children 12 years and over■ take 2 tablets every 8 hours while symptoms persist
children under 12 years■ ask a doctor

■ do not take more than 6 tablets in 24 hours, unless directed by a doctor

Other information

STORAGE AND HANDLING SECTION

■ read all warnings and directions before use. Keep carton.
■ store at 20-25°C (68-77°F)
■ avoid excessive heat above 40°C (104°F)

Inactive ingredients

INACTIVE INGREDIENT SECTION

colloidal silicon dioxide, corn starch, croscarmellose sodium, crospovidone, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, povidone, pregelatinized starch, stearic acid, sucralose, talc, titanium dioxide

Questions?

OTC - QUESTIONS SECTION

Call 1-877-895-3665 (toll-free) or 215-273-8755 (collect) or visit www.motrin.com

PRINCIPAL DISPLAY PANEL

PACKAGE LABEL.PRINCIPAL DISPLAY PANEL

NDC 50580-208-02

Motrin

8HR RELIEF

DUAL ACTION WITH TYLENOL

Acetaminophen 250 mg and
Ibuprofen (NSAID) 125 mg Tablets
Pain Reliever

DYE - FREE

actual size

20 Tablets

motrin.jpgmotrin.jpg

DailyMed RxNorm Mappings#

RxCUI, RxNorm string, TTY table
RxCUIRxNorm stringTTYSPL version
2387532acetaminophen 250 MG / ibuprofen 125 MG Oral TabletPSN7
2387532acetaminophen 250 MG / ibuprofen 125 MG Oral TabletSCD7
2387532APAP 250 MG / ibuprofen 125 MG Oral TabletSY7

DailyMed Pharmacologic Classes#

Class, Version, Type table
ClassVersionTypeEffective
IBUPROFEN Pharmacologic Class Indexing2Indexing - Pharmacologic Class20191108

Product Linked Resources#

Resource, Code type, Value table
ResourceCode typeValueEquivalent identifiersSource image
Data codeCode 12838F60MNC3motrin-1.jpg
Data codeData Matrix30060427motrin-1.jpg

DailyMed Product Concepts#

Product concept, Relation, Version table
Product conceptRelationVersionEffective
1e73f975-1ce7-705e-2bcf-788b1b5e24baProduct name520251124
16cde546-8deb-4df2-a072-dab5566ede95Product name120231003
f6d1b8d7-3bd1-4248-eddd-b60565c88015Product name420230808
874f4e63-49d2-5150-5d77-052172814ebdProduct name620230105
557673c2-8256-b351-e863-4ec71a5a64b0Product name220160714
dbc9a339-6215-4e94-9546-57a3b34902ceProduct name120160517
61c18d4e-b552-5478-8fc0-df38b93e3100Product name120140508
7b2938c9-7eb7-e312-ae90-f54f4240361eProduct name120140508
997601aa-bb5f-6971-6b90-a21132c12c7bProduct name120140508

DailyMed Package Descriptions#

Package NDC, Product, Description table
Package NDCProductDescriptionFormQuantityStrengthSPL version
50580-208-02Motrin Dual Action With Tylenol1 in 1 CARTONTABLET, FILM COATED17
50580-208-02Motrin Dual Action With Tylenol20 in 1 BOTTLETABLET, FILM COATED207
50580-208-08Motrin Dual Action With Tylenol80 in 1 BOTTLETABLET, FILM COATED807
50580-208-08Motrin Dual Action With Tylenol1 in 1 CARTONTABLET, FILM COATED17
50580-208-12Motrin Dual Action With Tylenol1 in 1 CARTONTABLET, FILM COATED17
50580-208-12Motrin Dual Action With Tylenol120 in 1 BOTTLETABLET, FILM COATED1207
50580-208-16Motrin Dual Action With Tylenol2 in 1 CARTONTABLET, FILM COATED27
50580-208-16Motrin Dual Action With Tylenol1 in 1 CARTONTABLET, FILM COATED17

DailyMed Billing Units#

Package NDC, Billing unit, Product NDC table
Package NDCBilling unitProduct NDCDailyMed indexing SPLSPL versionEffective
50580-208-08EA - Each50580-2080544a36e-8d2a-4a70-862a-ce961202330112024-10-04

Products#

Every source-derived product name is available through these pages.

DailyMed product names page 1 of 1 · 16 matching rows.

NDC Codes#

Product NDC, Package NDC table
Product NDCPackage NDC
50580-20850580-208-02, 50580-208-08, 50580-208-12, 50580-208-16

Ingredients#

Every source-derived ingredient row is available through these pages.

DailyMed ingredient rows page 1 of 1 · 14 matching rows.

Source Document#

Source XML

Orange Book application contexts#

All distinct exact application/product contexts derived from this label’s complete NDC list are paginated below.

Orange Book application contexts page 1 of 1 · 1 matching rows.

Source provenance: Browse the complete Orange Book source catalog · source snapshot 43.

Orange Book products#

Current product rows page 1 of 1 · 1 matching rows.

Application-product, Trade name, Ingredient table
Application-productTrade nameIngredientStrengthDosage form / routeTE codesRLD / RSApproval date
A214836-001ACETAMINOPHEN AND IBUPROFENACETAMINOPHEN; IBUPROFEN250MG;125MGTABLET / ORAL2023-02-28

Observed Orange Book product history#

Observed FDA ZIP history: Each table is queried independently by exact application/product key from successfully parsed Orange Book snapshots. Capture times identify archived source observations; absence or a change between snapshots is not inferred. FDA publication files that were not recoverable as structured ZIP data are not represented as states.

Captured, Edition, Application-product table
CapturedEditionApplication-productTrade nameStrengthDosage form / routeProduct TE source textRLD / RSApproval dateSource SHA-256
2026-09-14 22:38:342026-08A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-2884e616aacf4f…
2026-08-18 06:07:402026-07A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-28caaa826d4ba7…
2026-02-19 14:30 UTC2026-02A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-28011fe1cb6892…
2025-12-14 10:44 UTC · 2 captures of this ZIP2025-12A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-2831067a03dcf5…
2025-08-23 18:47 UTC2025-08A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-286a471c1ec25d…
2025-03-22 03:13 UTC · 3 captures of this ZIP2025-03A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-28fd3edfee7708…
2025-02-26 10:13 UTC · 3 captures of this ZIP2025-02A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-28b8a1b40f171c…
2025-01-19 17:59 UTC · 7 captures of this ZIP2025-01A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-2803ed91905a0d…
2024-12-13 21:23 UTC · 2 captures of this ZIP2024-12A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-282680178bc6a6…
2024-09-14 05:58 UTC · 2 captures of this ZIP2024-09A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-285bbf6a4d5a75…
2024-11-08 22:44 UTC · 3 captures of this ZIP2024-11A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-28d8e5a09893c0…
2024-10-29 15:01 UTC2024-10A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-28d06236e962d9…
2024-08-13 05:28 UTC · 3 captures of this ZIP2024-08A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-2879d66fd596c7…
2024-07-13 05:37 UTC · 2 captures of this ZIP2024-07A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-28301d65b070ca…
2024-06-18 03:08 UTC · 5 captures of this ZIP2024-06A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-281e350fbaab3a…
2024-05-31 18:47 UTC2024-05A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-288072bd15b7f6…
2024-03-16 18:09 UTC · 4 captures of this ZIP2024-03A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-286a51e52b5d6a…
2024-02-18 07:12 UTC2024-02A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-281c564ffb4f44…
2023-12-20 04:57 UTC2023-12A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-28ea1830bbd6c7…
2023-11-28 05:40 UTC · 2 captures of this ZIP2023-11A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-28a72a2bbeb626…
2023-10-25 00:34 UTC · 2 captures of this ZIP2023-10A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-289b2671bbb829…
2023-07-15 15:27 UTC · 2 captures of this ZIP2023-07A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-28a67488948f0b…
2023-06-13 01:57 UTC · 3 captures of this ZIP2023-06A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-283f0d92c62455…
2023-05-13 08:27 UTC2023-05A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-28053a50430f4f…
2026-07-26 02:55 UTC · 3 captures of this ZIP2026-06A214836-001ACETAMINOPHEN AND IBUPROFEN250MG;125MGTABLET / ORAL2023-02-28a50c72e98297…

openFDA label cross-check#

OpenFDA label data provides additional search and identifier links. DailyMed’s Structured Product Label is the canonical label on FDA.report. Matching records are deduplicated before they are shown below.

Matched openFDA labels page 1 of 1 · 1 matching rows.

Brand, Generic, Manufacturer table
BrandGenericManufacturerSPL set IDEffective dateAvailable safety fieldsJoin
Motrin Dual Action With TylenolACETAMINOPHEN AND IBUPROFENKenvue Brands LLCf2ee9cf5-02b7-6612-e053-2995a90a90c42026-02-03WarningsExact identifier
ndc (package): 50580-208-12
ndc (package): 50580-208-08
ndc (package): 50580-208-02
ndc (package): 50580-208-16
ndc (product): 50580-208
ndc11 (package): 50580020802
ndc11 (package): 50580020816
ndc11 (package): 50580020812
ndc11 (package): 50580020808
spl id: 48d075d6-52f3-6fd7-e063-6394a90ada71
spl set id: f2ee9cf5-02b7-6612-e053-2995a90a90c4

Reported adverse events (FAERS/openFDA)#

Adverse event summaries are temporarily unavailable. Other product information remains available.